WD domain, G-beta repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynein intermediate chain 1, axonemal

Species:

Leishmania donovani

UniProt:

A0A3Q8ICR4_LEIDO

TriTrypDb:

LdBPK_240270.1 , LdCL_240007600 , LDHU3_24.0310

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036157	outer dynein arm	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3Q8ICR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICR4

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033058	directional locomotion	2	1
GO:0036158	outer dynein arm assembly	7	1
GO:0040011	locomotion	1	1
GO:0043056	forward locomotion	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0060294	cilium movement involved in cell motility	5	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.548
CLV_C14_Caspase3-7	564	568	PF00656	0.370
CLV_NRD_NRD_1	118	120	PF00675	0.457
CLV_NRD_NRD_1	206	208	PF00675	0.593
CLV_NRD_NRD_1	26	28	PF00675	0.593
CLV_NRD_NRD_1	301	303	PF00675	0.501
CLV_NRD_NRD_1	645	647	PF00675	0.483
CLV_PCSK_FUR_1	116	120	PF00082	0.431
CLV_PCSK_KEX2_1	118	120	PF00082	0.457
CLV_PCSK_KEX2_1	206	208	PF00082	0.577
CLV_PCSK_KEX2_1	454	456	PF00082	0.453
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.453
CLV_PCSK_SKI1_1	143	147	PF00082	0.530
CLV_PCSK_SKI1_1	252	256	PF00082	0.425
CLV_PCSK_SKI1_1	295	299	PF00082	0.387
CLV_PCSK_SKI1_1	304	308	PF00082	0.304
CLV_PCSK_SKI1_1	455	459	PF00082	0.511
CLV_PCSK_SKI1_1	460	464	PF00082	0.516
CLV_PCSK_SKI1_1	57	61	PF00082	0.483
CLV_PCSK_SKI1_1	611	615	PF00082	0.366
CLV_PCSK_SKI1_1	681	685	PF00082	0.420
DEG_APCC_DBOX_1	251	259	PF00400	0.416
DEG_Nend_UBRbox_3	1	3	PF02207	0.578
DEG_SCF_FBW7_1	430	437	PF00400	0.311
DEG_SPOP_SBC_1	576	580	PF00917	0.303
DOC_MAPK_DCC_7	554	562	PF00069	0.423
DOC_MAPK_gen_1	116	125	PF00069	0.574
DOC_MAPK_gen_1	302	311	PF00069	0.334
DOC_MAPK_gen_1	611	620	PF00069	0.318
DOC_MAPK_gen_1	679	686	PF00069	0.440
DOC_MAPK_HePTP_8	551	563	PF00069	0.472
DOC_MAPK_MEF2A_6	554	563	PF00069	0.340
DOC_MAPK_MEF2A_6	633	641	PF00069	0.340
DOC_MAPK_MEF2A_6	669	678	PF00069	0.340
DOC_PP4_FxxP_1	328	331	PF00568	0.513
DOC_USP7_MATH_1	16	20	PF00917	0.722
DOC_USP7_MATH_1	174	178	PF00917	0.449
DOC_USP7_MATH_1	212	216	PF00917	0.640
DOC_USP7_MATH_1	227	231	PF00917	0.534
DOC_USP7_MATH_1	346	350	PF00917	0.545
DOC_USP7_MATH_1	576	580	PF00917	0.331
DOC_USP7_MATH_1	7	11	PF00917	0.683
DOC_USP7_UBL2_3	300	304	PF12436	0.496
DOC_USP7_UBL2_3	550	554	PF12436	0.430
DOC_WW_Pin1_4	103	108	PF00397	0.561
DOC_WW_Pin1_4	245	250	PF00397	0.498
DOC_WW_Pin1_4	3	8	PF00397	0.689
DOC_WW_Pin1_4	430	435	PF00397	0.326
DOC_WW_Pin1_4	487	492	PF00397	0.495
DOC_WW_Pin1_4	530	535	PF00397	0.519
DOC_WW_Pin1_4	553	558	PF00397	0.483
DOC_WW_Pin1_4	639	644	PF00397	0.314
LIG_14-3-3_CanoR_1	154	160	PF00244	0.470
LIG_14-3-3_CanoR_1	166	172	PF00244	0.477
LIG_14-3-3_CanoR_1	314	321	PF00244	0.427
LIG_14-3-3_CanoR_1	89	95	PF00244	0.486
LIG_Actin_WH2_2	632	648	PF00022	0.416
LIG_APCC_ABBA_1	69	74	PF00400	0.467
LIG_BIR_III_4	567	571	PF00653	0.388
LIG_BRCT_BRCA1_1	174	178	PF00533	0.439
LIG_BRCT_BRCA1_1	247	251	PF00533	0.520
LIG_BRCT_BRCA1_1	315	319	PF00533	0.336
LIG_BRCT_BRCA1_1	324	328	PF00533	0.303
LIG_BRCT_BRCA1_1	578	582	PF00533	0.283
LIG_BRCT_BRCA1_1	91	95	PF00533	0.557
LIG_BRCT_BRCA1_2	324	330	PF00533	0.430
LIG_Clathr_ClatBox_1	560	564	PF01394	0.319
LIG_Clathr_ClatBox_1	94	98	PF01394	0.517
LIG_deltaCOP1_diTrp_1	422	429	PF00928	0.318
LIG_deltaCOP1_diTrp_1	546	552	PF00928	0.419
LIG_FHA_1	140	146	PF00498	0.421
LIG_FHA_1	431	437	PF00498	0.431
LIG_FHA_1	546	552	PF00498	0.425
LIG_FHA_1	599	605	PF00498	0.421
LIG_FHA_1	614	620	PF00498	0.293
LIG_FHA_1	636	642	PF00498	0.488
LIG_FHA_1	662	668	PF00498	0.413
LIG_FHA_1	86	92	PF00498	0.551
LIG_FHA_2	129	135	PF00498	0.576
LIG_FHA_2	212	218	PF00498	0.488
LIG_FHA_2	456	462	PF00498	0.498
LIG_FHA_2	675	681	PF00498	0.354
LIG_Integrin_isoDGR_2	312	314	PF01839	0.400
LIG_LIR_Apic_2	325	331	PF02991	0.503
LIG_LIR_Gen_1	325	331	PF02991	0.531
LIG_LIR_Gen_1	422	430	PF02991	0.457
LIG_LIR_Gen_1	579	587	PF02991	0.419
LIG_LIR_LC3C_4	558	562	PF02991	0.360
LIG_LIR_Nem_3	175	181	PF02991	0.473
LIG_LIR_Nem_3	183	188	PF02991	0.361
LIG_LIR_Nem_3	325	329	PF02991	0.521
LIG_LIR_Nem_3	437	441	PF02991	0.348
LIG_LIR_Nem_3	529	535	PF02991	0.430
LIG_LIR_Nem_3	571	577	PF02991	0.292
LIG_LIR_Nem_3	579	585	PF02991	0.282
LIG_PDZ_Class_2	681	686	PF00595	0.539
LIG_REV1ctd_RIR_1	294	304	PF16727	0.372
LIG_SH2_CRK	326	330	PF00017	0.447
LIG_SH2_STAP1	315	319	PF00017	0.443
LIG_SH2_STAP1	528	532	PF00017	0.419
LIG_SH2_STAP1	577	581	PF00017	0.319
LIG_SH2_STAT5	528	531	PF00017	0.425
LIG_SH3_1	531	537	PF00018	0.427
LIG_SH3_3	351	357	PF00018	0.408
LIG_SH3_3	531	537	PF00018	0.458
LIG_SH3_3	645	651	PF00018	0.419
LIG_SUMO_SIM_par_1	558	564	PF11976	0.392
LIG_SUMO_SIM_par_1	663	668	PF11976	0.392
LIG_SUMO_SIM_par_1	672	677	PF11976	0.342
LIG_TYR_ITAM	312	329	PF00017	0.376
MOD_CDK_SPK_2	3	8	PF00069	0.681
MOD_CDK_SPxxK_3	245	252	PF00069	0.423
MOD_CDK_SPxxK_3	639	646	PF00069	0.320
MOD_CK1_1	398	404	PF00069	0.495
MOD_CK1_1	437	443	PF00069	0.306
MOD_CK2_1	212	218	PF00069	0.586
MOD_CK2_1	450	456	PF00069	0.480
MOD_GlcNHglycan	174	177	PF01048	0.468
MOD_GlcNHglycan	18	21	PF01048	0.708
MOD_GlcNHglycan	252	255	PF01048	0.526
MOD_GlcNHglycan	30	33	PF01048	0.623
MOD_GlcNHglycan	348	351	PF01048	0.515
MOD_GlcNHglycan	543	546	PF01048	0.230
MOD_GSK3_1	149	156	PF00069	0.532
MOD_GSK3_1	3	10	PF00069	0.653
MOD_GSK3_1	394	401	PF00069	0.452
MOD_GSK3_1	430	437	PF00069	0.488
MOD_GSK3_1	464	471	PF00069	0.477
MOD_GSK3_1	483	490	PF00069	0.399
MOD_GSK3_1	526	533	PF00069	0.485
MOD_GSK3_1	541	548	PF00069	0.367
MOD_GSK3_1	635	642	PF00069	0.398
MOD_GSK3_1	85	92	PF00069	0.424
MOD_LATS_1	373	379	PF00433	0.514
MOD_N-GLC_1	149	154	PF02516	0.530
MOD_N-GLC_1	598	603	PF02516	0.499
MOD_N-GLC_2	265	267	PF02516	0.377
MOD_NEK2_1	394	399	PF00069	0.536
MOD_NEK2_1	506	511	PF00069	0.344
MOD_NEK2_2	227	232	PF00069	0.600
MOD_NEK2_2	332	337	PF00069	0.433
MOD_NEK2_2	357	362	PF00069	0.318
MOD_NEK2_2	434	439	PF00069	0.285
MOD_NEK2_2	545	550	PF00069	0.460
MOD_NEK2_2	577	582	PF00069	0.292
MOD_PIKK_1	153	159	PF00454	0.506
MOD_PIKK_1	497	503	PF00454	0.325
MOD_PKA_1	27	33	PF00069	0.598
MOD_PKA_1	646	652	PF00069	0.496
MOD_PKA_2	153	159	PF00069	0.506
MOD_PKA_2	212	218	PF00069	0.571
MOD_PKA_2	313	319	PF00069	0.446
MOD_PKA_2	394	400	PF00069	0.557
MOD_PKA_2	43	49	PF00069	0.622
MOD_PKA_2	632	638	PF00069	0.307
MOD_PKA_2	7	13	PF00069	0.674
MOD_Plk_1	164	170	PF00069	0.542
MOD_Plk_1	227	233	PF00069	0.633
MOD_Plk_1	357	363	PF00069	0.258
MOD_Plk_1	375	381	PF00069	0.502
MOD_Plk_1	545	551	PF00069	0.430
MOD_Plk_1	674	680	PF00069	0.356
MOD_Plk_4	286	292	PF00069	0.487
MOD_Plk_4	375	381	PF00069	0.454
MOD_Plk_4	434	440	PF00069	0.475
MOD_Plk_4	577	583	PF00069	0.288
MOD_Plk_4	605	611	PF00069	0.373
MOD_Plk_4	632	638	PF00069	0.305
MOD_Plk_4	90	96	PF00069	0.537
MOD_ProDKin_1	103	109	PF00069	0.555
MOD_ProDKin_1	245	251	PF00069	0.493
MOD_ProDKin_1	3	9	PF00069	0.689
MOD_ProDKin_1	430	436	PF00069	0.321
MOD_ProDKin_1	487	493	PF00069	0.500
MOD_ProDKin_1	530	536	PF00069	0.519
MOD_ProDKin_1	553	559	PF00069	0.480
MOD_ProDKin_1	639	645	PF00069	0.315
TRG_DiLeu_BaEn_1	286	291	PF01217	0.345
TRG_DiLeu_BaEn_1	502	507	PF01217	0.453
TRG_ENDOCYTIC_2	315	318	PF00928	0.320
TRG_ENDOCYTIC_2	326	329	PF00928	0.355
TRG_ENDOCYTIC_2	82	85	PF00928	0.418
TRG_ER_diArg_1	116	119	PF00400	0.458
TRG_LysEnd_GGAAcLL_1	680	686	PF00790	0.501
TRG_NES_CRM1_1	668	680	PF08389	0.487
TRG_NLS_MonoExtN_4	300	306	PF00514	0.432
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I862	Leptomonas seymouri	81%	100%
A0A0S4INJ7	Bodo saltans	57%	100%
A0A1X0NJ43	Trypanosomatidae	60%	100%
A0A422P471	Trypanosoma rangeli	61%	100%
A4HD84	Leishmania braziliensis	90%	100%
A4HK88	Leishmania braziliensis	26%	100%
C9ZJC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
D0A6Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AH39	Leishmania infantum	100%	100%
E9AWL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9PYY5	Mus musculus	26%	85%
F1QHZ6	Danio rerio	28%	88%
Q16959	Heliocidaris crassispina	40%	98%
Q32KS2	Bos taurus	36%	98%
Q39578	Chlamydomonas reinhardtii	39%	100%
Q4QAV3	Leishmania major	97%	100%
Q4V8G4	Rattus norvegicus	25%	85%
Q5U4F6	Mus musculus	25%	100%
Q5VTH9	Homo sapiens	26%	81%
Q5XIL8	Rattus norvegicus	37%	97%
Q6GPB9	Xenopus laevis	28%	92%
Q8C0M8	Mus musculus	38%	98%
Q9UI46	Homo sapiens	38%	98%
V5BJK6	Trypanosoma cruzi	30%	83%
V5DSN6	Trypanosoma cruzi	60%	100%