Stealth_CR2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8ICR3_LEIDO

TriTrypDb:

LdBPK_231320.1 , LdCL_230020300 , LDHU3_23.1740

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8ICR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICR3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	738	742	PF00656	0.446
CLV_NRD_NRD_1	194	196	PF00675	0.472
CLV_NRD_NRD_1	231	233	PF00675	0.527
CLV_NRD_NRD_1	256	258	PF00675	0.522
CLV_NRD_NRD_1	499	501	PF00675	0.602
CLV_NRD_NRD_1	523	525	PF00675	0.500
CLV_NRD_NRD_1	550	552	PF00675	0.647
CLV_NRD_NRD_1	556	558	PF00675	0.805
CLV_NRD_NRD_1	612	614	PF00675	0.687
CLV_NRD_NRD_1	725	727	PF00675	0.466
CLV_NRD_NRD_1	745	747	PF00675	0.433
CLV_NRD_NRD_1	785	787	PF00675	0.419
CLV_PCSK_FUR_1	554	558	PF00082	0.605
CLV_PCSK_KEX2_1	194	196	PF00082	0.438
CLV_PCSK_KEX2_1	231	233	PF00082	0.527
CLV_PCSK_KEX2_1	256	258	PF00082	0.541
CLV_PCSK_KEX2_1	373	375	PF00082	0.572
CLV_PCSK_KEX2_1	499	501	PF00082	0.594
CLV_PCSK_KEX2_1	523	525	PF00082	0.500
CLV_PCSK_KEX2_1	554	556	PF00082	0.836
CLV_PCSK_KEX2_1	612	614	PF00082	0.671
CLV_PCSK_KEX2_1	725	727	PF00082	0.466
CLV_PCSK_KEX2_1	785	787	PF00082	0.419
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.589
CLV_PCSK_PC7_1	190	196	PF00082	0.493
CLV_PCSK_PC7_1	551	557	PF00082	0.565
CLV_PCSK_SKI1_1	119	123	PF00082	0.537
CLV_PCSK_SKI1_1	159	163	PF00082	0.528
CLV_PCSK_SKI1_1	281	285	PF00082	0.502
CLV_PCSK_SKI1_1	318	322	PF00082	0.481
CLV_PCSK_SKI1_1	346	350	PF00082	0.556
CLV_PCSK_SKI1_1	477	481	PF00082	0.490
CLV_PCSK_SKI1_1	546	550	PF00082	0.520
CLV_PCSK_SKI1_1	619	623	PF00082	0.614
CLV_PCSK_SKI1_1	640	644	PF00082	0.622
CLV_Separin_Metazoa	743	747	PF03568	0.427
DEG_APCC_DBOX_1	202	210	PF00400	0.416
DEG_APCC_DBOX_1	393	401	PF00400	0.481
DEG_APCC_DBOX_1	476	484	PF00400	0.259
DEG_APCC_DBOX_1	499	507	PF00400	0.237
DOC_CKS1_1	160	165	PF01111	0.466
DOC_CYCLIN_RxL_1	328	337	PF00134	0.270
DOC_CYCLIN_RxL_1	634	647	PF00134	0.580
DOC_CYCLIN_RxL_1	766	775	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	338	344	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.473
DOC_MAPK_gen_1	25	33	PF00069	0.529
DOC_MAPK_gen_1	256	262	PF00069	0.341
DOC_MAPK_gen_1	373	379	PF00069	0.511
DOC_MAPK_MEF2A_6	159	168	PF00069	0.437
DOC_MAPK_MEF2A_6	25	33	PF00069	0.531
DOC_MAPK_MEF2A_6	672	680	PF00069	0.570
DOC_PP1_RVXF_1	185	192	PF00149	0.478
DOC_PP1_RVXF_1	329	336	PF00149	0.279
DOC_PP1_RVXF_1	423	430	PF00149	0.378
DOC_PP1_RVXF_1	767	773	PF00149	0.470
DOC_PP2B_LxvP_1	342	345	PF13499	0.537
DOC_PP4_FxxP_1	172	175	PF00568	0.528
DOC_PP4_FxxP_1	436	439	PF00568	0.551
DOC_SPAK_OSR1_1	692	696	PF12202	0.467
DOC_USP7_MATH_1	32	36	PF00917	0.530
DOC_USP7_MATH_1	392	396	PF00917	0.487
DOC_USP7_MATH_1	606	610	PF00917	0.533
DOC_USP7_MATH_1	717	721	PF00917	0.558
DOC_USP7_MATH_1	79	83	PF00917	0.522
DOC_USP7_MATH_1	87	91	PF00917	0.431
DOC_USP7_MATH_2	565	571	PF00917	0.612
DOC_WW_Pin1_4	11	16	PF00397	0.660
DOC_WW_Pin1_4	128	133	PF00397	0.579
DOC_WW_Pin1_4	159	164	PF00397	0.476
DOC_WW_Pin1_4	340	345	PF00397	0.541
DOC_WW_Pin1_4	507	512	PF00397	0.322
DOC_WW_Pin1_4	598	603	PF00397	0.682
DOC_WW_Pin1_4	727	732	PF00397	0.418
DOC_WW_Pin1_4	83	88	PF00397	0.587
DOC_WW_Pin1_4	94	99	PF00397	0.600
LIG_14-3-3_CanoR_1	104	112	PF00244	0.588
LIG_14-3-3_CanoR_1	123	129	PF00244	0.471
LIG_14-3-3_CanoR_1	203	207	PF00244	0.416
LIG_14-3-3_CanoR_1	281	289	PF00244	0.302
LIG_14-3-3_CanoR_1	331	336	PF00244	0.279
LIG_14-3-3_CanoR_1	394	398	PF00244	0.498
LIG_14-3-3_CanoR_1	46	55	PF00244	0.481
LIG_14-3-3_CanoR_1	523	531	PF00244	0.498
LIG_14-3-3_CanoR_1	537	543	PF00244	0.415
LIG_14-3-3_CanoR_1	546	553	PF00244	0.482
LIG_14-3-3_CanoR_1	555	565	PF00244	0.755
LIG_14-3-3_CanoR_1	574	584	PF00244	0.678
LIG_14-3-3_CanoR_1	619	625	PF00244	0.646
LIG_14-3-3_CanoR_1	646	651	PF00244	0.554
LIG_14-3-3_CanoR_1	672	677	PF00244	0.489
LIG_14-3-3_CanoR_1	725	730	PF00244	0.496
LIG_Actin_WH2_2	737	752	PF00022	0.451
LIG_AP2alpha_1	335	339	PF02296	0.279
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BRCT_BRCA1_1	316	320	PF00533	0.322
LIG_BRCT_BRCA1_1	729	733	PF00533	0.404
LIG_CaM_IQ_9	529	545	PF13499	0.493
LIG_DLG_GKlike_1	331	338	PF00625	0.322
LIG_FHA_1	363	369	PF00498	0.518
LIG_FHA_1	417	423	PF00498	0.554
LIG_FHA_1	525	531	PF00498	0.506
LIG_FHA_1	570	576	PF00498	0.535
LIG_FHA_1	595	601	PF00498	0.576
LIG_FHA_1	7	13	PF00498	0.562
LIG_FHA_1	749	755	PF00498	0.508
LIG_FHA_2	282	288	PF00498	0.269
LIG_FHA_2	480	486	PF00498	0.237
LIG_FHA_2	492	498	PF00498	0.204
LIG_FHA_2	733	739	PF00498	0.469
LIG_FHA_2	84	90	PF00498	0.498
LIG_LIR_Apic_2	171	175	PF02991	0.408
LIG_LIR_Apic_2	293	299	PF02991	0.338
LIG_LIR_Gen_1	118	129	PF02991	0.552
LIG_LIR_Gen_1	138	149	PF02991	0.410
LIG_LIR_Gen_1	167	178	PF02991	0.362
LIG_LIR_Gen_1	198	206	PF02991	0.372
LIG_LIR_Gen_1	27	38	PF02991	0.473
LIG_LIR_Gen_1	334	344	PF02991	0.247
LIG_LIR_Gen_1	465	475	PF02991	0.289
LIG_LIR_Gen_1	697	706	PF02991	0.553
LIG_LIR_Gen_1	730	740	PF02991	0.560
LIG_LIR_Nem_3	118	124	PF02991	0.614
LIG_LIR_Nem_3	138	144	PF02991	0.417
LIG_LIR_Nem_3	167	173	PF02991	0.354
LIG_LIR_Nem_3	179	184	PF02991	0.371
LIG_LIR_Nem_3	198	202	PF02991	0.384
LIG_LIR_Nem_3	27	33	PF02991	0.484
LIG_LIR_Nem_3	274	280	PF02991	0.316
LIG_LIR_Nem_3	317	323	PF02991	0.335
LIG_LIR_Nem_3	334	339	PF02991	0.227
LIG_LIR_Nem_3	605	610	PF02991	0.685
LIG_LIR_Nem_3	688	694	PF02991	0.728
LIG_LIR_Nem_3	697	702	PF02991	0.531
LIG_LIR_Nem_3	730	736	PF02991	0.548
LIG_MLH1_MIPbox_1	316	320	PF16413	0.322
LIG_PDZ_Class_2	785	790	PF00595	0.505
LIG_Pex14_2	319	323	PF04695	0.288
LIG_Pex14_2	335	339	PF04695	0.269
LIG_Pex14_2	379	383	PF04695	0.467
LIG_SH2_CRK	170	174	PF00017	0.355
LIG_SH2_CRK	607	611	PF00017	0.517
LIG_SH2_GRB2like	322	325	PF00017	0.293
LIG_SH2_NCK_1	107	111	PF00017	0.628
LIG_SH2_STAP1	141	145	PF00017	0.450
LIG_SH2_STAP1	515	519	PF00017	0.341
LIG_SH2_STAP1	587	591	PF00017	0.529
LIG_SH2_STAT3	453	456	PF00017	0.466
LIG_SH2_STAT5	128	131	PF00017	0.579
LIG_SH2_STAT5	170	173	PF00017	0.369
LIG_SH2_STAT5	259	262	PF00017	0.297
LIG_SH2_STAT5	322	325	PF00017	0.259
LIG_SH2_STAT5	388	391	PF00017	0.618
LIG_SH2_STAT5	454	457	PF00017	0.510
LIG_SH2_STAT5	502	505	PF00017	0.259
LIG_SH3_2	341	346	PF14604	0.592
LIG_SH3_2	599	604	PF14604	0.493
LIG_SH3_3	126	132	PF00018	0.594
LIG_SH3_3	157	163	PF00018	0.474
LIG_SH3_3	172	178	PF00018	0.414
LIG_SH3_3	338	344	PF00018	0.435
LIG_SH3_3	386	392	PF00018	0.726
LIG_SH3_3	559	565	PF00018	0.612
LIG_SH3_3	596	602	PF00018	0.598
LIG_SH3_3	776	782	PF00018	0.491
LIG_SH3_3	9	15	PF00018	0.509
LIG_SUMO_SIM_anti_2	35	41	PF11976	0.470
LIG_SUMO_SIM_par_1	8	14	PF11976	0.518
LIG_SUMO_SIM_par_1	89	97	PF11976	0.397
LIG_TRAF2_1	586	589	PF00917	0.509
LIG_TYR_ITIM	168	173	PF00017	0.426
LIG_WRC_WIRS_1	169	174	PF05994	0.425
LIG_WRC_WIRS_1	332	337	PF05994	0.213
LIG_WRC_WIRS_1	515	520	PF05994	0.245
LIG_WW_3	343	347	PF00397	0.558
MOD_CDC14_SPxK_1	14	17	PF00782	0.521
MOD_CDC14_SPxK_1	343	346	PF00782	0.615
MOD_CDC14_SPxK_1	601	604	PF00782	0.653
MOD_CDK_SPxK_1	11	17	PF00069	0.531
MOD_CDK_SPxK_1	340	346	PF00069	0.582
MOD_CDK_SPxK_1	598	604	PF00069	0.651
MOD_CK1_1	108	114	PF00069	0.663
MOD_CK1_1	13	19	PF00069	0.527
MOD_CK1_1	205	211	PF00069	0.357
MOD_CK1_1	393	399	PF00069	0.493
MOD_CK1_1	593	599	PF00069	0.759
MOD_CK1_1	611	617	PF00069	0.504
MOD_CK1_1	644	650	PF00069	0.578
MOD_CK1_1	720	726	PF00069	0.631
MOD_CK1_1	760	766	PF00069	0.546
MOD_CK1_1	81	87	PF00069	0.758
MOD_CK2_1	112	118	PF00069	0.695
MOD_CK2_1	128	134	PF00069	0.460
MOD_CK2_1	205	211	PF00069	0.398
MOD_CK2_1	287	293	PF00069	0.332
MOD_CK2_1	491	497	PF00069	0.259
MOD_CK2_1	582	588	PF00069	0.512
MOD_CK2_1	61	67	PF00069	0.515
MOD_CK2_1	704	710	PF00069	0.497
MOD_CK2_1	79	85	PF00069	0.731
MOD_DYRK1A_RPxSP_1	159	163	PF00069	0.466
MOD_DYRK1A_RPxSP_1	340	344	PF00069	0.563
MOD_GlcNHglycan	114	117	PF01048	0.570
MOD_GlcNHglycan	137	140	PF01048	0.523
MOD_GlcNHglycan	155	158	PF01048	0.394
MOD_GlcNHglycan	215	218	PF01048	0.474
MOD_GlcNHglycan	289	292	PF01048	0.403
MOD_GlcNHglycan	3	6	PF01048	0.559
MOD_GlcNHglycan	307	310	PF01048	0.378
MOD_GlcNHglycan	34	37	PF01048	0.444
MOD_GlcNHglycan	613	616	PF01048	0.563
MOD_GlcNHglycan	626	629	PF01048	0.612
MOD_GlcNHglycan	648	651	PF01048	0.688
MOD_GlcNHglycan	659	662	PF01048	0.606
MOD_GlcNHglycan	710	714	PF01048	0.509
MOD_GlcNHglycan	719	722	PF01048	0.757
MOD_GSK3_1	1	8	PF00069	0.566
MOD_GSK3_1	108	115	PF00069	0.627
MOD_GSK3_1	124	131	PF00069	0.572
MOD_GSK3_1	155	162	PF00069	0.502
MOD_GSK3_1	378	385	PF00069	0.469
MOD_GSK3_1	44	51	PF00069	0.555
MOD_GSK3_1	590	597	PF00069	0.596
MOD_GSK3_1	598	605	PF00069	0.577
MOD_GSK3_1	613	620	PF00069	0.549
MOD_GSK3_1	664	671	PF00069	0.574
MOD_GSK3_1	79	86	PF00069	0.563
MOD_LATS_1	544	550	PF00433	0.517
MOD_N-GLC_1	147	152	PF02516	0.436
MOD_N-GLC_1	240	245	PF02516	0.495
MOD_N-GLC_1	507	512	PF02516	0.424
MOD_N-GLC_1	557	562	PF02516	0.562
MOD_N-GLC_1	757	762	PF02516	0.558
MOD_NEK2_1	1	6	PF00069	0.565
MOD_NEK2_1	10	15	PF00069	0.669
MOD_NEK2_1	202	207	PF00069	0.355
MOD_NEK2_1	378	383	PF00069	0.502
MOD_NEK2_1	44	49	PF00069	0.563
MOD_NEK2_1	491	496	PF00069	0.360
MOD_NEK2_1	709	714	PF00069	0.469
MOD_NEK2_1	732	737	PF00069	0.647
MOD_NEK2_1	749	754	PF00069	0.565
MOD_NEK2_2	538	543	PF00069	0.510
MOD_NEK2_2	569	574	PF00069	0.622
MOD_PIKK_1	567	573	PF00454	0.608
MOD_PIKK_1	633	639	PF00454	0.586
MOD_PIKK_1	760	766	PF00454	0.408
MOD_PK_1	613	619	PF00069	0.635
MOD_PKA_1	556	562	PF00069	0.786
MOD_PKA_1	725	731	PF00069	0.431
MOD_PKA_2	202	208	PF00069	0.420
MOD_PKA_2	24	30	PF00069	0.539
MOD_PKA_2	393	399	PF00069	0.493
MOD_PKA_2	556	562	PF00069	0.711
MOD_PKA_2	582	588	PF00069	0.631
MOD_PKA_2	61	67	PF00069	0.594
MOD_PKA_2	611	617	PF00069	0.616
MOD_PKA_2	664	670	PF00069	0.542
MOD_PKA_2	725	731	PF00069	0.492
MOD_PKA_2	749	755	PF00069	0.492
MOD_PKB_1	554	562	PF00069	0.577
MOD_Plk_1	108	114	PF00069	0.541
MOD_Plk_1	147	153	PF00069	0.410
MOD_Plk_1	423	429	PF00069	0.426
MOD_Plk_1	668	674	PF00069	0.545
MOD_Plk_1	687	693	PF00069	0.604
MOD_Plk_1	757	763	PF00069	0.486
MOD_Plk_1	79	85	PF00069	0.591
MOD_Plk_1	88	94	PF00069	0.399
MOD_Plk_4	124	130	PF00069	0.600
MOD_Plk_4	147	153	PF00069	0.413
MOD_Plk_4	168	174	PF00069	0.368
MOD_Plk_4	176	182	PF00069	0.423
MOD_Plk_4	250	256	PF00069	0.497
MOD_Plk_4	331	337	PF00069	0.325
MOD_Plk_4	378	384	PF00069	0.478
MOD_Plk_4	479	485	PF00069	0.247
MOD_Plk_4	6	12	PF00069	0.688
MOD_Plk_4	672	678	PF00069	0.547
MOD_Plk_4	88	94	PF00069	0.453
MOD_ProDKin_1	11	17	PF00069	0.661
MOD_ProDKin_1	128	134	PF00069	0.583
MOD_ProDKin_1	159	165	PF00069	0.474
MOD_ProDKin_1	340	346	PF00069	0.550
MOD_ProDKin_1	507	513	PF00069	0.378
MOD_ProDKin_1	598	604	PF00069	0.685
MOD_ProDKin_1	727	733	PF00069	0.412
MOD_ProDKin_1	83	89	PF00069	0.580
MOD_ProDKin_1	94	100	PF00069	0.609
MOD_SUMO_rev_2	370	375	PF00179	0.522
MOD_SUMO_rev_2	585	592	PF00179	0.521
TRG_DiLeu_BaEn_3	457	463	PF01217	0.463
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.213
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.485
TRG_DiLeu_BaLyEn_6	766	771	PF01217	0.480
TRG_ENDOCYTIC_2	140	143	PF00928	0.418
TRG_ENDOCYTIC_2	170	173	PF00928	0.369
TRG_ENDOCYTIC_2	259	262	PF00928	0.321
TRG_ENDOCYTIC_2	468	471	PF00928	0.328
TRG_ENDOCYTIC_2	515	518	PF00928	0.318
TRG_ENDOCYTIC_2	607	610	PF00928	0.651
TRG_ER_diArg_1	194	196	PF00400	0.472
TRG_ER_diArg_1	230	232	PF00400	0.500
TRG_ER_diArg_1	255	257	PF00400	0.378
TRG_ER_diArg_1	498	500	PF00400	0.478
TRG_ER_diArg_1	522	524	PF00400	0.478
TRG_ER_diArg_1	553	556	PF00400	0.713
TRG_ER_diArg_1	785	787	PF00400	0.418
TRG_NES_CRM1_1	674	688	PF08389	0.538
TRG_NLS_MonoExtC_3	550	555	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.734
TRG_Pf-PMV_PEXEL_1	640	645	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV0	Leptomonas seymouri	40%	100%
A0A0S4JIS6	Bodo saltans	27%	70%
A0A3Q8ICL5	Leishmania donovani	48%	90%
A0A3S7WXU9	Leishmania donovani	48%	100%
A4HCY1	Leishmania braziliensis	77%	99%
A4I0G4	Leishmania infantum	100%	100%
A4I0G5	Leishmania infantum	48%	90%
E9AWC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AWC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QB44	Leishmania major	63%	100%
Q4QB45	Leishmania major	92%	100%