Tudor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICR1_LEIDO

TriTrypDb:

LdBPK_312630.1 , LdCL_310034300 , LDHU3_31.4680

Length:

883

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	675	679	PF00656	0.588
CLV_C14_Caspase3-7	704	708	PF00656	0.536
CLV_NRD_NRD_1	114	116	PF00675	0.593
CLV_NRD_NRD_1	229	231	PF00675	0.510
CLV_NRD_NRD_1	264	266	PF00675	0.353
CLV_NRD_NRD_1	28	30	PF00675	0.393
CLV_NRD_NRD_1	408	410	PF00675	0.430
CLV_NRD_NRD_1	434	436	PF00675	0.428
CLV_NRD_NRD_1	458	460	PF00675	0.513
CLV_NRD_NRD_1	528	530	PF00675	0.530
CLV_NRD_NRD_1	556	558	PF00675	0.690
CLV_NRD_NRD_1	659	661	PF00675	0.558
CLV_NRD_NRD_1	846	848	PF00675	0.627
CLV_NRD_NRD_1	96	98	PF00675	0.600
CLV_PCSK_KEX2_1	264	266	PF00082	0.353
CLV_PCSK_KEX2_1	28	30	PF00082	0.386
CLV_PCSK_KEX2_1	408	410	PF00082	0.430
CLV_PCSK_KEX2_1	434	436	PF00082	0.428
CLV_PCSK_KEX2_1	458	460	PF00082	0.513
CLV_PCSK_KEX2_1	528	530	PF00082	0.542
CLV_PCSK_KEX2_1	556	558	PF00082	0.690
CLV_PCSK_KEX2_1	659	661	PF00082	0.558
CLV_PCSK_KEX2_1	835	837	PF00082	0.674
CLV_PCSK_KEX2_1	96	98	PF00082	0.598
CLV_PCSK_PC1ET2_1	835	837	PF00082	0.652
CLV_PCSK_SKI1_1	116	120	PF00082	0.440
CLV_PCSK_SKI1_1	252	256	PF00082	0.393
CLV_PCSK_SKI1_1	314	318	PF00082	0.410
CLV_PCSK_SKI1_1	361	365	PF00082	0.381
CLV_PCSK_SKI1_1	458	462	PF00082	0.429
CLV_PCSK_SKI1_1	660	664	PF00082	0.538
CLV_PCSK_SKI1_1	821	825	PF00082	0.574
CLV_Separin_Metazoa	415	419	PF03568	0.362
DEG_APCC_DBOX_1	519	527	PF00400	0.452
DEG_APCC_DBOX_1	563	571	PF00400	0.716
DEG_Nend_Nbox_1	1	3	PF02207	0.370
DEG_SCF_FBW7_1	725	731	PF00400	0.775
DEG_SPOP_SBC_1	607	611	PF00917	0.671
DOC_CKS1_1	725	730	PF01111	0.692
DOC_CYCLIN_RxL_1	455	464	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.498
DOC_MAPK_DCC_7	564	572	PF00069	0.545
DOC_MAPK_gen_1	115	126	PF00069	0.400
DOC_MAPK_gen_1	247	255	PF00069	0.388
DOC_MAPK_gen_1	408	416	PF00069	0.353
DOC_MAPK_gen_1	434	441	PF00069	0.420
DOC_MAPK_gen_1	455	463	PF00069	0.406
DOC_MAPK_MEF2A_6	115	122	PF00069	0.365
DOC_MAPK_MEF2A_6	247	255	PF00069	0.389
DOC_MAPK_MEF2A_6	408	416	PF00069	0.385
DOC_MAPK_MEF2A_6	434	441	PF00069	0.420
DOC_MAPK_NFAT4_5	250	258	PF00069	0.362
DOC_MAPK_RevD_3	84	97	PF00069	0.504
DOC_PP1_RVXF_1	18	25	PF00149	0.373
DOC_PP2B_LxvP_1	86	89	PF13499	0.508
DOC_USP7_MATH_1	155	159	PF00917	0.477
DOC_USP7_MATH_1	223	227	PF00917	0.663
DOC_USP7_MATH_1	442	446	PF00917	0.393
DOC_USP7_MATH_1	591	595	PF00917	0.638
DOC_USP7_MATH_1	607	611	PF00917	0.769
DOC_USP7_MATH_1	669	673	PF00917	0.676
DOC_USP7_MATH_1	677	681	PF00917	0.606
DOC_USP7_MATH_1	700	704	PF00917	0.624
DOC_USP7_MATH_1	79	83	PF00917	0.586
DOC_USP7_MATH_1	834	838	PF00917	0.588
DOC_USP7_MATH_1	840	844	PF00917	0.564
DOC_USP7_UBL2_3	310	314	PF12436	0.385
DOC_USP7_UBL2_3	844	848	PF12436	0.606
DOC_WW_Pin1_4	158	163	PF00397	0.563
DOC_WW_Pin1_4	234	239	PF00397	0.501
DOC_WW_Pin1_4	35	40	PF00397	0.467
DOC_WW_Pin1_4	387	392	PF00397	0.489
DOC_WW_Pin1_4	408	413	PF00397	0.458
DOC_WW_Pin1_4	565	570	PF00397	0.648
DOC_WW_Pin1_4	596	601	PF00397	0.671
DOC_WW_Pin1_4	654	659	PF00397	0.713
DOC_WW_Pin1_4	724	729	PF00397	0.695
DOC_WW_Pin1_4	741	746	PF00397	0.613
DOC_WW_Pin1_4	793	798	PF00397	0.631
DOC_WW_Pin1_4	858	863	PF00397	0.552
DOC_WW_Pin1_4	88	93	PF00397	0.597
LIG_14-3-3_CanoR_1	180	184	PF00244	0.493
LIG_14-3-3_CanoR_1	230	236	PF00244	0.459
LIG_14-3-3_CanoR_1	256	263	PF00244	0.363
LIG_14-3-3_CanoR_1	687	694	PF00244	0.598
LIG_14-3-3_CanoR_1	770	777	PF00244	0.557
LIG_Actin_WH2_2	127	142	PF00022	0.423
LIG_AP2alpha_2	191	193	PF02296	0.446
LIG_APCC_ABBA_1	147	152	PF00400	0.416
LIG_BRCT_BRCA1_1	10	14	PF00533	0.467
LIG_BRCT_BRCA1_1	377	381	PF00533	0.398
LIG_BRCT_BRCA1_1	743	747	PF00533	0.718
LIG_BRCT_BRCA1_1	753	757	PF00533	0.548
LIG_Clathr_ClatBox_1	144	148	PF01394	0.403
LIG_deltaCOP1_diTrp_1	15	24	PF00928	0.400
LIG_Dynein_DLC8_1	228	234	PF01221	0.515
LIG_EH_1	49	53	PF12763	0.568
LIG_EVH1_1	396	400	PF00568	0.377
LIG_FHA_1	230	236	PF00498	0.492
LIG_FHA_1	306	312	PF00498	0.402
LIG_FHA_1	354	360	PF00498	0.527
LIG_FHA_1	455	461	PF00498	0.433
LIG_FHA_1	683	689	PF00498	0.593
LIG_FHA_1	725	731	PF00498	0.723
LIG_FHA_1	794	800	PF00498	0.563
LIG_FHA_1	803	809	PF00498	0.528
LIG_FHA_2	2	8	PF00498	0.429
LIG_FHA_2	257	263	PF00498	0.364
LIG_FHA_2	673	679	PF00498	0.600
LIG_FHA_2	72	78	PF00498	0.674
LIG_Integrin_RGD_1	322	324	PF01839	0.404
LIG_LIR_Apic_2	761	767	PF02991	0.667
LIG_LIR_Gen_1	197	206	PF02991	0.397
LIG_LIR_Gen_1	315	326	PF02991	0.399
LIG_LIR_Gen_1	378	388	PF02991	0.389
LIG_LIR_Gen_1	425	436	PF02991	0.445
LIG_LIR_Nem_3	197	202	PF02991	0.383
LIG_LIR_Nem_3	260	266	PF02991	0.359
LIG_LIR_Nem_3	308	312	PF02991	0.522
LIG_LIR_Nem_3	315	321	PF02991	0.405
LIG_LIR_Nem_3	370	375	PF02991	0.373
LIG_LIR_Nem_3	378	384	PF02991	0.419
LIG_LIR_Nem_3	425	431	PF02991	0.429
LIG_LIR_Nem_3	49	55	PF02991	0.561
LIG_MLH1_MIPbox_1	10	14	PF16413	0.467
LIG_MYND_1	166	170	PF01753	0.486
LIG_PCNA_yPIPBox_3	293	301	PF02747	0.387
LIG_PCNA_yPIPBox_3	78	87	PF02747	0.592
LIG_Pex14_2	13	17	PF04695	0.499
LIG_PTB_Apo_2	182	189	PF02174	0.433
LIG_PTB_Apo_2	746	753	PF02174	0.581
LIG_REV1ctd_RIR_1	191	200	PF16727	0.380
LIG_SH2_CRK	276	280	PF00017	0.397
LIG_SH2_CRK	284	288	PF00017	0.439
LIG_SH2_CRK	318	322	PF00017	0.361
LIG_SH2_CRK	469	473	PF00017	0.483
LIG_SH2_CRK	764	768	PF00017	0.607
LIG_SH2_GRB2like	372	375	PF00017	0.339
LIG_SH2_GRB2like	509	512	PF00017	0.524
LIG_SH2_NCK_1	545	549	PF00017	0.549
LIG_SH2_PTP2	335	338	PF00017	0.367
LIG_SH2_SRC	545	548	PF00017	0.548
LIG_SH2_SRC	764	767	PF00017	0.538
LIG_SH2_STAP1	33	37	PF00017	0.428
LIG_SH2_STAT3	268	271	PF00017	0.358
LIG_SH2_STAT5	268	271	PF00017	0.358
LIG_SH2_STAT5	3	6	PF00017	0.465
LIG_SH2_STAT5	318	321	PF00017	0.351
LIG_SH2_STAT5	335	338	PF00017	0.409
LIG_SH2_STAT5	342	345	PF00017	0.329
LIG_SH2_STAT5	771	774	PF00017	0.581
LIG_SH3_2	831	836	PF14604	0.556
LIG_SH3_3	100	106	PF00018	0.657
LIG_SH3_3	286	292	PF00018	0.405
LIG_SH3_3	385	391	PF00018	0.424
LIG_SH3_3	394	400	PF00018	0.372
LIG_SH3_3	538	544	PF00018	0.640
LIG_SH3_3	655	661	PF00018	0.619
LIG_SH3_3	688	694	PF00018	0.582
LIG_SH3_3	73	79	PF00018	0.693
LIG_SH3_3	828	834	PF00018	0.551
LIG_SH3_3	86	92	PF00018	0.587
LIG_SUMO_SIM_anti_2	348	356	PF11976	0.393
LIG_SUMO_SIM_anti_2	413	418	PF11976	0.369
LIG_SUMO_SIM_par_1	459	464	PF11976	0.352
LIG_SUMO_SIM_par_1	660	665	PF11976	0.593
LIG_SxIP_EBH_1	293	307	PF03271	0.381
LIG_TRAF2_1	544	547	PF00917	0.579
LIG_TYR_ITIM	274	279	PF00017	0.382
LIG_TYR_ITIM	316	321	PF00017	0.360
LIG_Vh1_VBS_1	301	319	PF01044	0.329
LIG_WRC_WIRS_1	317	322	PF05994	0.360
LIG_WRC_WIRS_1	446	451	PF05994	0.576
MOD_CDC14_SPxK_1	38	41	PF00782	0.469
MOD_CDC14_SPxK_1	599	602	PF00782	0.607
MOD_CDC14_SPxK_1	657	660	PF00782	0.565
MOD_CDK_SPK_2	234	239	PF00069	0.501
MOD_CDK_SPK_2	654	659	PF00069	0.712
MOD_CDK_SPK_2	858	863	PF00069	0.541
MOD_CDK_SPxK_1	35	41	PF00069	0.462
MOD_CDK_SPxK_1	596	602	PF00069	0.617
MOD_CDK_SPxK_1	654	660	PF00069	0.563
MOD_CDK_SPxxK_3	234	241	PF00069	0.516
MOD_CDK_SPxxK_3	858	865	PF00069	0.548
MOD_CK1_1	158	164	PF00069	0.608
MOD_CK1_1	445	451	PF00069	0.398
MOD_CK1_1	499	505	PF00069	0.432
MOD_CK1_1	58	64	PF00069	0.634
MOD_CK1_1	582	588	PF00069	0.714
MOD_CK1_1	593	599	PF00069	0.598
MOD_CK1_1	642	648	PF00069	0.651
MOD_CK1_1	650	656	PF00069	0.640
MOD_CK1_1	672	678	PF00069	0.830
MOD_CK1_1	689	695	PF00069	0.645
MOD_CK1_1	751	757	PF00069	0.608
MOD_CK1_1	843	849	PF00069	0.603
MOD_CK1_1	861	867	PF00069	0.707
MOD_CK2_1	1	7	PF00069	0.376
MOD_CK2_1	256	262	PF00069	0.403
MOD_CK2_1	445	451	PF00069	0.468
MOD_CK2_1	642	648	PF00069	0.718
MOD_CK2_1	71	77	PF00069	0.630
MOD_CK2_1	770	776	PF00069	0.553
MOD_CK2_1	806	812	PF00069	0.569
MOD_CK2_1	876	882	PF00069	0.830
MOD_GlcNHglycan	157	160	PF01048	0.576
MOD_GlcNHglycan	170	173	PF01048	0.427
MOD_GlcNHglycan	174	177	PF01048	0.428
MOD_GlcNHglycan	225	228	PF01048	0.599
MOD_GlcNHglycan	279	282	PF01048	0.419
MOD_GlcNHglycan	328	331	PF01048	0.385
MOD_GlcNHglycan	596	599	PF01048	0.677
MOD_GlcNHglycan	631	634	PF01048	0.677
MOD_GlcNHglycan	636	639	PF01048	0.665
MOD_GlcNHglycan	640	644	PF01048	0.621
MOD_GlcNHglycan	648	652	PF01048	0.621
MOD_GlcNHglycan	664	667	PF01048	0.671
MOD_GlcNHglycan	678	682	PF01048	0.541
MOD_GlcNHglycan	690	694	PF01048	0.706
MOD_GlcNHglycan	696	699	PF01048	0.663
MOD_GlcNHglycan	703	706	PF01048	0.595
MOD_GlcNHglycan	838	841	PF01048	0.629
MOD_GlcNHglycan	855	858	PF01048	0.601
MOD_GSK3_1	168	175	PF00069	0.429
MOD_GSK3_1	31	38	PF00069	0.387
MOD_GSK3_1	312	319	PF00069	0.549
MOD_GSK3_1	383	390	PF00069	0.358
MOD_GSK3_1	423	430	PF00069	0.408
MOD_GSK3_1	51	58	PF00069	0.563
MOD_GSK3_1	556	563	PF00069	0.593
MOD_GSK3_1	575	582	PF00069	0.669
MOD_GSK3_1	590	597	PF00069	0.593
MOD_GSK3_1	602	609	PF00069	0.635
MOD_GSK3_1	650	657	PF00069	0.695
MOD_GSK3_1	682	689	PF00069	0.612
MOD_GSK3_1	724	731	PF00069	0.767
MOD_GSK3_1	748	755	PF00069	0.626
MOD_GSK3_1	802	809	PF00069	0.713
MOD_GSK3_1	836	843	PF00069	0.644
MOD_GSK3_1	876	883	PF00069	0.614
MOD_N-GLC_1	373	378	PF02516	0.374
MOD_N-GLC_1	510	515	PF02516	0.551
MOD_N-GLC_1	669	674	PF02516	0.578
MOD_N-GLC_1	694	699	PF02516	0.593
MOD_N-GLC_1	748	753	PF02516	0.583
MOD_N-GLC_1	813	818	PF02516	0.619
MOD_N-GLC_1	819	824	PF02516	0.538
MOD_N-GLC_2	179	181	PF02516	0.426
MOD_NEK2_1	1	6	PF00069	0.366
MOD_NEK2_1	13	18	PF00069	0.483
MOD_NEK2_1	134	139	PF00069	0.443
MOD_NEK2_1	296	301	PF00069	0.352
MOD_NEK2_1	312	317	PF00069	0.290
MOD_NEK2_1	334	339	PF00069	0.549
MOD_NEK2_1	353	358	PF00069	0.404
MOD_NEK2_1	572	577	PF00069	0.561
MOD_NEK2_1	606	611	PF00069	0.696
MOD_NEK2_1	647	652	PF00069	0.828
MOD_NEK2_1	710	715	PF00069	0.565
MOD_NEK2_1	730	735	PF00069	0.583
MOD_NEK2_1	752	757	PF00069	0.615
MOD_NEK2_1	826	831	PF00069	0.683
MOD_NEK2_2	23	28	PF00069	0.434
MOD_NEK2_2	442	447	PF00069	0.399
MOD_OFUCOSY	468	475	PF10250	0.497
MOD_PIKK_1	229	235	PF00454	0.500
MOD_PIKK_1	575	581	PF00454	0.627
MOD_PIKK_1	642	648	PF00454	0.583
MOD_PIKK_1	708	714	PF00454	0.646
MOD_PIKK_1	715	721	PF00454	0.611
MOD_PIKK_1	752	758	PF00454	0.593
MOD_PIKK_1	79	85	PF00454	0.682
MOD_PK_1	241	247	PF00069	0.482
MOD_PK_1	496	502	PF00069	0.451
MOD_PK_1	8	14	PF00069	0.429
MOD_PKA_1	556	562	PF00069	0.785
MOD_PKA_1	847	853	PF00069	0.551
MOD_PKA_2	179	185	PF00069	0.460
MOD_PKA_2	229	235	PF00069	0.500
MOD_PKA_2	246	252	PF00069	0.458
MOD_PKA_2	353	359	PF00069	0.430
MOD_PKA_2	454	460	PF00069	0.434
MOD_PKA_2	533	539	PF00069	0.565
MOD_PKA_2	556	562	PF00069	0.688
MOD_PKA_2	686	692	PF00069	0.632
MOD_PKA_2	715	721	PF00069	0.603
MOD_PKA_2	867	873	PF00069	0.613
MOD_Plk_1	134	140	PF00069	0.511
MOD_Plk_1	312	318	PF00069	0.358
MOD_Plk_1	442	448	PF00069	0.391
MOD_Plk_1	513	519	PF00069	0.528
MOD_Plk_1	58	64	PF00069	0.587
MOD_Plk_1	582	588	PF00069	0.667
MOD_Plk_1	669	675	PF00069	0.581
MOD_Plk_1	748	754	PF00069	0.643
MOD_Plk_1	819	825	PF00069	0.590
MOD_Plk_1	876	882	PF00069	0.651
MOD_Plk_2-3	877	883	PF00069	0.601
MOD_Plk_4	241	247	PF00069	0.467
MOD_Plk_4	269	275	PF00069	0.356
MOD_Plk_4	312	318	PF00069	0.389
MOD_Plk_4	346	352	PF00069	0.378
MOD_Plk_4	496	502	PF00069	0.489
MOD_Plk_4	787	793	PF00069	0.627
MOD_Plk_4	8	14	PF00069	0.492
MOD_ProDKin_1	158	164	PF00069	0.572
MOD_ProDKin_1	234	240	PF00069	0.505
MOD_ProDKin_1	35	41	PF00069	0.472
MOD_ProDKin_1	387	393	PF00069	0.481
MOD_ProDKin_1	408	414	PF00069	0.452
MOD_ProDKin_1	565	571	PF00069	0.649
MOD_ProDKin_1	596	602	PF00069	0.671
MOD_ProDKin_1	654	660	PF00069	0.712
MOD_ProDKin_1	724	730	PF00069	0.651
MOD_ProDKin_1	741	747	PF00069	0.614
MOD_ProDKin_1	793	799	PF00069	0.631
MOD_ProDKin_1	858	864	PF00069	0.550
MOD_ProDKin_1	88	94	PF00069	0.598
MOD_SUMO_rev_2	845	855	PF00179	0.629
TRG_AP2beta_CARGO_1	425	435	PF09066	0.447
TRG_DiLeu_BaEn_1	129	134	PF01217	0.454
TRG_DiLeu_BaEn_2	183	189	PF01217	0.431
TRG_DiLeu_BaEn_2	261	267	PF01217	0.334
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.517
TRG_ENDOCYTIC_2	199	202	PF00928	0.403
TRG_ENDOCYTIC_2	276	279	PF00928	0.394
TRG_ENDOCYTIC_2	284	287	PF00928	0.450
TRG_ENDOCYTIC_2	318	321	PF00928	0.355
TRG_ENDOCYTIC_2	335	338	PF00928	0.409
TRG_ENDOCYTIC_2	342	345	PF00928	0.329
TRG_ENDOCYTIC_2	372	375	PF00928	0.377
TRG_ENDOCYTIC_2	469	472	PF00928	0.500
TRG_ER_diArg_1	255	258	PF00400	0.439
TRG_ER_diArg_1	263	265	PF00400	0.385
TRG_ER_diArg_1	27	29	PF00400	0.404
TRG_ER_diArg_1	407	409	PF00400	0.451
TRG_ER_diArg_1	417	420	PF00400	0.449
TRG_ER_diArg_1	433	435	PF00400	0.371
TRG_ER_diArg_1	458	460	PF00400	0.486
TRG_ER_diArg_1	528	530	PF00400	0.540
TRG_ER_diArg_1	658	660	PF00400	0.557
TRG_ER_diArg_1	862	865	PF00400	0.550
TRG_NES_CRM1_1	200	214	PF08389	0.413
TRG_NLS_MonoExtC_3	114	119	PF00514	0.368
TRG_NLS_MonoExtN_4	115	120	PF00514	0.398
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	459	464	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	528	533	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	770	774	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW18	Leptomonas seymouri	62%	99%
A0A0N1PBA0	Leptomonas seymouri	45%	100%
A0A3Q8ISU5	Leishmania donovani	42%	100%
A4HJP3	Leishmania braziliensis	41%	100%
A4HJP4	Leishmania braziliensis	74%	100%
A4I760	Leishmania infantum	42%	100%
A4I761	Leishmania infantum	100%	100%
E9B254	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B255	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q605	Leishmania major	92%	100%
Q4Q606	Leishmania major	43%	100%