Polyprenol reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICQ8_LEIDO

TriTrypDb:

LdBPK_271410.1 , LdCL_270020900 , LDHU3_27.2150

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	9
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8ICQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	10
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	10
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	10
GO:0006629	lipid metabolic process	3	10
GO:0006720	isoprenoid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008300	isoprenoid catabolic process	5	10
GO:0009056	catabolic process	2	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0016042	lipid catabolic process	4	10
GO:0016093	polyprenol metabolic process	4	10
GO:0016095	polyprenol catabolic process	5	10
GO:0019348	dolichol metabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044242	cellular lipid catabolic process	4	10
GO:0044248	cellular catabolic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044282	small molecule catabolic process	3	10
GO:0046164	alcohol catabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901137	carbohydrate derivative biosynthetic process	4	10
GO:1901575	organic substance catabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901615	organic hydroxy compound metabolic process	3	10
GO:1901616	organic hydroxy compound catabolic process	4	10
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0016094	polyprenol biosynthetic process	5	1
GO:0019408	dolichol biosynthetic process	6	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	5	10
GO:0016229	steroid dehydrogenase activity	3	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	9
GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors	4	10
GO:0102389	polyprenol reductase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.610
CLV_NRD_NRD_1	269	271	PF00675	0.482
CLV_NRD_NRD_1	300	302	PF00675	0.461
CLV_NRD_NRD_1	403	405	PF00675	0.357
CLV_NRD_NRD_1	413	415	PF00675	0.369
CLV_NRD_NRD_1	420	422	PF00675	0.401
CLV_NRD_NRD_1	95	97	PF00675	0.326
CLV_PCSK_KEX2_1	269	271	PF00082	0.474
CLV_PCSK_KEX2_1	300	302	PF00082	0.459
CLV_PCSK_KEX2_1	403	405	PF00082	0.357
CLV_PCSK_KEX2_1	413	415	PF00082	0.369
CLV_PCSK_SKI1_1	217	221	PF00082	0.463
CLV_PCSK_SKI1_1	421	425	PF00082	0.440
DEG_Nend_Nbox_1	1	3	PF02207	0.360
DOC_CKS1_1	289	294	PF01111	0.684
DOC_MAPK_gen_1	169	178	PF00069	0.581
DOC_PP2B_LxvP_1	146	149	PF13499	0.363
DOC_USP7_MATH_1	121	125	PF00917	0.419
DOC_USP7_MATH_1	192	196	PF00917	0.353
DOC_USP7_MATH_1	204	208	PF00917	0.362
DOC_USP7_MATH_1	276	280	PF00917	0.673
DOC_USP7_MATH_1	372	376	PF00917	0.479
DOC_WW_Pin1_4	134	139	PF00397	0.466
DOC_WW_Pin1_4	282	287	PF00397	0.761
DOC_WW_Pin1_4	288	293	PF00397	0.753
DOC_WW_Pin1_4	47	52	PF00397	0.724
DOC_WW_Pin1_4	76	81	PF00397	0.652
LIG_14-3-3_CanoR_1	160	167	PF00244	0.620
LIG_14-3-3_CanoR_1	205	213	PF00244	0.484
LIG_14-3-3_CanoR_1	247	253	PF00244	0.695
LIG_14-3-3_CanoR_1	288	292	PF00244	0.680
LIG_14-3-3_CanoR_1	96	101	PF00244	0.527
LIG_Actin_WH2_2	436	454	PF00022	0.640
LIG_BRCT_BRCA1_1	18	22	PF00533	0.440
LIG_EH1_1	102	110	PF00400	0.399
LIG_EH1_1	326	334	PF00400	0.480
LIG_FHA_1	104	110	PF00498	0.355
LIG_FHA_1	162	168	PF00498	0.565
LIG_FHA_1	173	179	PF00498	0.514
LIG_FHA_1	184	190	PF00498	0.357
LIG_FHA_1	319	325	PF00498	0.540
LIG_FHA_1	329	335	PF00498	0.440
LIG_FHA_1	410	416	PF00498	0.631
LIG_FHA_2	289	295	PF00498	0.677
LIG_FHA_2	396	402	PF00498	0.541
LIG_LIR_Gen_1	177	187	PF02991	0.355
LIG_LIR_Gen_1	19	30	PF02991	0.418
LIG_LIR_Gen_1	33	40	PF02991	0.599
LIG_LIR_Gen_1	365	376	PF02991	0.507
LIG_LIR_Gen_1	99	108	PF02991	0.379
LIG_LIR_Nem_3	177	182	PF02991	0.355
LIG_LIR_Nem_3	19	25	PF02991	0.409
LIG_LIR_Nem_3	265	271	PF02991	0.643
LIG_LIR_Nem_3	33	37	PF02991	0.641
LIG_LIR_Nem_3	375	381	PF02991	0.383
LIG_LIR_Nem_3	99	103	PF02991	0.379
LIG_NRBOX	209	215	PF00104	0.317
LIG_Pex14_1	18	22	PF04695	0.438
LIG_Pex14_2	115	119	PF04695	0.449
LIG_Pex14_2	30	34	PF04695	0.643
LIG_Pex14_2	466	470	PF04695	0.645
LIG_Pex14_2	88	92	PF04695	0.597
LIG_PTB_Apo_2	306	313	PF02174	0.600
LIG_SH2_CRK	302	306	PF00017	0.549
LIG_SH2_STAP1	320	324	PF00017	0.523
LIG_SH2_STAP1	64	68	PF00017	0.690
LIG_SH2_STAT5	104	107	PF00017	0.335
LIG_SH2_STAT5	188	191	PF00017	0.331
LIG_SH2_STAT5	306	309	PF00017	0.567
LIG_SH2_STAT5	320	323	PF00017	0.533
LIG_SH3_3	135	141	PF00018	0.539
LIG_SH3_3	312	318	PF00018	0.533
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.387
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.410
LIG_Vh1_VBS_1	9	27	PF01044	0.349
MOD_CDC14_SPxK_1	285	288	PF00782	0.514
MOD_CDK_SPxK_1	282	288	PF00069	0.503
MOD_CK2_1	288	294	PF00069	0.625
MOD_CK2_1	395	401	PF00069	0.411
MOD_GlcNHglycan	127	130	PF01048	0.700
MOD_GlcNHglycan	194	197	PF01048	0.414
MOD_GlcNHglycan	278	281	PF01048	0.517
MOD_GlcNHglycan	362	365	PF01048	0.652
MOD_GlcNHglycan	398	401	PF01048	0.458
MOD_GlcNHglycan	417	420	PF01048	0.517
MOD_GlcNHglycan	43	46	PF01048	0.614
MOD_GlcNHglycan	63	67	PF01048	0.600
MOD_GSK3_1	103	110	PF00069	0.293
MOD_GSK3_1	121	128	PF00069	0.378
MOD_GSK3_1	192	199	PF00069	0.453
MOD_GSK3_1	246	253	PF00069	0.652
MOD_GSK3_1	340	347	PF00069	0.641
MOD_GSK3_1	356	363	PF00069	0.595
MOD_GSK3_1	377	384	PF00069	0.447
MOD_GSK3_1	92	99	PF00069	0.436
MOD_N-GLC_1	121	126	PF02516	0.441
MOD_N-GLC_1	409	414	PF02516	0.490
MOD_N-GLC_2	309	311	PF02516	0.490
MOD_NEK2_1	103	108	PF00069	0.372
MOD_NEK2_1	161	166	PF00069	0.481
MOD_NEK2_1	275	280	PF00069	0.626
MOD_NEK2_1	381	386	PF00069	0.322
MOD_NEK2_1	395	400	PF00069	0.366
MOD_NEK2_1	415	420	PF00069	0.222
MOD_NEK2_1	84	89	PF00069	0.448
MOD_NEK2_2	183	188	PF00069	0.355
MOD_PIKK_1	204	210	PF00454	0.576
MOD_PKA_1	96	102	PF00069	0.361
MOD_PKA_2	159	165	PF00069	0.512
MOD_PKA_2	204	210	PF00069	0.615
MOD_PKA_2	246	252	PF00069	0.635
MOD_PKA_2	287	293	PF00069	0.610
MOD_PKA_2	92	98	PF00069	0.435
MOD_Plk_1	35	41	PF00069	0.421
MOD_Plk_4	129	135	PF00069	0.619
MOD_Plk_4	174	180	PF00069	0.328
MOD_Plk_4	18	24	PF00069	0.424
MOD_Plk_4	183	189	PF00069	0.311
MOD_Plk_4	198	204	PF00069	0.467
MOD_Plk_4	236	242	PF00069	0.470
MOD_Plk_4	328	334	PF00069	0.391
MOD_Plk_4	377	383	PF00069	0.429
MOD_Plk_4	385	391	PF00069	0.422
MOD_Plk_4	84	90	PF00069	0.456
MOD_ProDKin_1	134	140	PF00069	0.586
MOD_ProDKin_1	282	288	PF00069	0.729
MOD_ProDKin_1	47	53	PF00069	0.673
MOD_ProDKin_1	76	82	PF00069	0.573
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.416
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.384
TRG_ENDOCYTIC_2	17	20	PF00928	0.378
TRG_ENDOCYTIC_2	304	307	PF00928	0.496
TRG_ER_diArg_1	244	247	PF00400	0.516
TRG_ER_diArg_1	268	270	PF00400	0.605
TRG_ER_diArg_1	299	301	PF00400	0.593
TRG_ER_diArg_1	403	405	PF00400	0.440
TRG_ER_diArg_1	413	415	PF00400	0.457
TRG_NES_CRM1_1	150	163	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXY2	Leptomonas seymouri	43%	100%
A0A0S4JTN4	Bodo saltans	29%	100%
A0A1X0P483	Trypanosomatidae	32%	100%
A0A3R7NH72	Trypanosoma rangeli	33%	100%
A4HFS9	Leishmania braziliensis	72%	100%
A4I367	Leishmania infantum	100%	100%
D0A619	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ADD0	Leishmania major	92%	100%
E9AZ55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%