Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICQ5_LEIDO

TriTrypDb:

LdBPK_231160.1 , LdCL_230018900 , LDHU3_23.1530

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.803
CLV_NRD_NRD_1	156	158	PF00675	0.598
CLV_NRD_NRD_1	161	163	PF00675	0.544
CLV_NRD_NRD_1	168	170	PF00675	0.468
CLV_NRD_NRD_1	187	189	PF00675	0.377
CLV_NRD_NRD_1	323	325	PF00675	0.721
CLV_NRD_NRD_1	459	461	PF00675	0.738
CLV_NRD_NRD_1	550	552	PF00675	0.723
CLV_NRD_NRD_1	573	575	PF00675	0.749
CLV_NRD_NRD_1	597	599	PF00675	0.752
CLV_PCSK_FUR_1	595	599	PF00082	0.758
CLV_PCSK_KEX2_1	292	294	PF00082	0.772
CLV_PCSK_KEX2_1	323	325	PF00082	0.627
CLV_PCSK_KEX2_1	459	461	PF00082	0.738
CLV_PCSK_KEX2_1	550	552	PF00082	0.723
CLV_PCSK_KEX2_1	597	599	PF00082	0.750
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.736
CLV_PCSK_SKI1_1	151	155	PF00082	0.545
CLV_PCSK_SKI1_1	163	167	PF00082	0.446
CLV_PCSK_SKI1_1	172	176	PF00082	0.544
CLV_PCSK_SKI1_1	28	32	PF00082	0.492
CLV_PCSK_SKI1_1	464	468	PF00082	0.649
DEG_APCC_DBOX_1	550	558	PF00400	0.690
DEG_Nend_Nbox_1	1	3	PF02207	0.723
DEG_SCF_TRCP1_1	254	260	PF00400	0.592
DEG_SCF_TRCP1_1	343	348	PF00400	0.650
DEG_SPOP_SBC_1	431	435	PF00917	0.678
DEG_SPOP_SBC_1	582	586	PF00917	0.725
DOC_CDC14_PxL_1	497	505	PF14671	0.595
DOC_MAPK_DCC_7	558	567	PF00069	0.700
DOC_MAPK_gen_1	274	282	PF00069	0.622
DOC_MAPK_gen_1	28	37	PF00069	0.471
DOC_MAPK_gen_1	323	330	PF00069	0.668
DOC_MAPK_gen_1	550	557	PF00069	0.715
DOC_USP7_MATH_1	304	308	PF00917	0.715
DOC_USP7_MATH_1	578	582	PF00917	0.797
DOC_USP7_MATH_1	583	587	PF00917	0.688
DOC_USP7_MATH_1	641	645	PF00917	0.791
DOC_USP7_MATH_1	9	13	PF00917	0.581
DOC_USP7_UBL2_3	147	151	PF12436	0.545
DOC_USP7_UBL2_3	166	170	PF12436	0.355
DOC_USP7_UBL2_3	178	182	PF12436	0.418
DOC_USP7_UBL2_3	602	606	PF12436	0.720
DOC_WW_Pin1_4	286	291	PF00397	0.710
DOC_WW_Pin1_4	295	300	PF00397	0.753
DOC_WW_Pin1_4	3	8	PF00397	0.609
DOC_WW_Pin1_4	354	359	PF00397	0.737
DOC_WW_Pin1_4	392	397	PF00397	0.695
DOC_WW_Pin1_4	427	432	PF00397	0.680
DOC_WW_Pin1_4	720	725	PF00397	0.736
DOC_WW_Pin1_4	744	749	PF00397	0.663
LIG_14-3-3_CanoR_1	172	181	PF00244	0.626
LIG_14-3-3_CanoR_1	370	374	PF00244	0.684
LIG_14-3-3_CanoR_1	384	391	PF00244	0.569
LIG_14-3-3_CanoR_1	39	47	PF00244	0.534
LIG_14-3-3_CanoR_1	550	555	PF00244	0.773
LIG_14-3-3_CanoR_1	579	587	PF00244	0.803
LIG_14-3-3_CanoR_1	632	642	PF00244	0.759
LIG_Actin_WH2_2	118	136	PF00022	0.588
LIG_BIR_III_2	410	414	PF00653	0.702
LIG_BRCT_BRCA1_1	312	316	PF00533	0.646
LIG_BRCT_BRCA1_1	398	402	PF00533	0.592
LIG_Clathr_ClatBox_1	562	566	PF01394	0.789
LIG_CtBP_PxDLS_1	675	679	PF00389	0.713
LIG_FHA_1	137	143	PF00498	0.467
LIG_FHA_1	226	232	PF00498	0.461
LIG_FHA_1	470	476	PF00498	0.692
LIG_FHA_1	550	556	PF00498	0.718
LIG_FHA_1	582	588	PF00498	0.727
LIG_FHA_1	671	677	PF00498	0.621
LIG_FHA_1	703	709	PF00498	0.635
LIG_FHA_2	201	207	PF00498	0.512
LIG_FHA_2	217	223	PF00498	0.512
LIG_FHA_2	431	437	PF00498	0.798
LIG_FHA_2	469	475	PF00498	0.704
LIG_LIR_Gen_1	202	213	PF02991	0.597
LIG_LIR_Gen_1	221	231	PF02991	0.478
LIG_LIR_Gen_1	348	358	PF02991	0.652
LIG_LIR_Gen_1	57	65	PF02991	0.479
LIG_LIR_Gen_1	77	87	PF02991	0.349
LIG_LIR_Nem_3	112	117	PF02991	0.501
LIG_LIR_Nem_3	154	159	PF02991	0.433
LIG_LIR_Nem_3	202	208	PF02991	0.487
LIG_LIR_Nem_3	313	319	PF02991	0.627
LIG_LIR_Nem_3	348	354	PF02991	0.654
LIG_LIR_Nem_3	57	61	PF02991	0.470
LIG_LIR_Nem_3	77	82	PF02991	0.374
LIG_NRBOX	258	264	PF00104	0.607
LIG_PDZ_Class_1	744	749	PF00595	0.692
LIG_SH2_CRK	351	355	PF00017	0.665
LIG_SH2_GRB2like	320	323	PF00017	0.707
LIG_SH2_NCK_1	386	390	PF00017	0.721
LIG_SH2_SRC	329	332	PF00017	0.671
LIG_SH2_STAP1	14	18	PF00017	0.495
LIG_SH2_STAP1	194	198	PF00017	0.498
LIG_SH2_STAP1	205	209	PF00017	0.499
LIG_SH2_STAT3	180	183	PF00017	0.527
LIG_SH2_STAT3	416	419	PF00017	0.609
LIG_SH2_STAT5	167	170	PF00017	0.594
LIG_SH2_STAT5	180	183	PF00017	0.469
LIG_SH2_STAT5	214	217	PF00017	0.490
LIG_SH2_STAT5	230	233	PF00017	0.340
LIG_SH2_STAT5	329	332	PF00017	0.658
LIG_SH2_STAT5	36	39	PF00017	0.585
LIG_SH2_STAT5	416	419	PF00017	0.706
LIG_SH2_STAT5	79	82	PF00017	0.606
LIG_SH3_3	388	394	PF00018	0.700
LIG_SH3_3	397	403	PF00018	0.683
LIG_SH3_3	486	492	PF00018	0.700
LIG_SH3_3	496	502	PF00018	0.683
LIG_SH3_3	553	559	PF00018	0.536
LIG_SH3_3	584	590	PF00018	0.723
LIG_SH3_CIN85_PxpxPR_1	403	408	PF14604	0.584
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.482
LIG_SUMO_SIM_par_1	563	571	PF11976	0.752
LIG_UBA3_1	105	109	PF00899	0.496
LIG_UBA3_1	554	558	PF00899	0.671
LIG_WRC_WIRS_1	198	203	PF05994	0.488
LIG_WRC_WIRS_1	79	84	PF05994	0.681
MOD_CDC14_SPxK_1	303	306	PF00782	0.583
MOD_CDK_SPxK_1	286	292	PF00069	0.729
MOD_CDK_SPxK_1	295	301	PF00069	0.647
MOD_CDK_SPxK_1	354	360	PF00069	0.827
MOD_CDK_SPxxK_3	286	293	PF00069	0.794
MOD_CK1_1	286	292	PF00069	0.711
MOD_CK1_1	344	350	PF00069	0.748
MOD_CK1_1	364	370	PF00069	0.804
MOD_CK1_1	427	433	PF00069	0.712
MOD_CK1_1	49	55	PF00069	0.537
MOD_CK1_1	568	574	PF00069	0.667
MOD_CK1_1	581	587	PF00069	0.740
MOD_CK1_1	631	637	PF00069	0.740
MOD_CK1_1	709	715	PF00069	0.837
MOD_CK2_1	158	164	PF00069	0.526
MOD_CK2_1	200	206	PF00069	0.469
MOD_CK2_1	384	390	PF00069	0.703
MOD_CK2_1	468	474	PF00069	0.704
MOD_CK2_1	54	60	PF00069	0.492
MOD_Cter_Amidation	457	460	PF01082	0.736
MOD_DYRK1A_RPxSP_1	744	748	PF00069	0.598
MOD_GlcNHglycan	101	104	PF01048	0.439
MOD_GlcNHglycan	254	257	PF01048	0.666
MOD_GlcNHglycan	343	346	PF01048	0.788
MOD_GlcNHglycan	354	357	PF01048	0.522
MOD_GlcNHglycan	374	377	PF01048	0.658
MOD_GlcNHglycan	386	389	PF01048	0.592
MOD_GlcNHglycan	455	459	PF01048	0.595
MOD_GlcNHglycan	461	464	PF01048	0.575
MOD_GlcNHglycan	535	538	PF01048	0.708
MOD_GlcNHglycan	580	583	PF01048	0.738
MOD_GlcNHglycan	621	624	PF01048	0.822
MOD_GlcNHglycan	688	691	PF01048	0.715
MOD_GlcNHglycan	708	711	PF01048	0.502
MOD_GlcNHglycan	71	74	PF01048	0.623
MOD_GSK3_1	113	120	PF00069	0.516
MOD_GSK3_1	200	207	PF00069	0.504
MOD_GSK3_1	225	232	PF00069	0.578
MOD_GSK3_1	282	289	PF00069	0.697
MOD_GSK3_1	3	10	PF00069	0.572
MOD_GSK3_1	300	307	PF00069	0.647
MOD_GSK3_1	310	317	PF00069	0.573
MOD_GSK3_1	341	348	PF00069	0.779
MOD_GSK3_1	350	357	PF00069	0.707
MOD_GSK3_1	380	387	PF00069	0.682
MOD_GSK3_1	392	399	PF00069	0.567
MOD_GSK3_1	427	434	PF00069	0.765
MOD_GSK3_1	464	471	PF00069	0.804
MOD_GSK3_1	545	552	PF00069	0.687
MOD_GSK3_1	577	584	PF00069	0.784
MOD_GSK3_1	585	592	PF00069	0.644
MOD_GSK3_1	626	633	PF00069	0.733
MOD_GSK3_1	65	72	PF00069	0.559
MOD_GSK3_1	670	677	PF00069	0.821
MOD_GSK3_1	702	709	PF00069	0.688
MOD_GSK3_1	720	727	PF00069	0.805
MOD_GSK3_1	738	745	PF00069	0.504
MOD_N-GLC_1	117	122	PF02516	0.586
MOD_N-GLC_1	283	288	PF02516	0.676
MOD_N-GLC_1	314	319	PF02516	0.723
MOD_N-GLC_1	364	369	PF02516	0.805
MOD_N-GLC_1	65	70	PF02516	0.569
MOD_NEK2_1	174	179	PF00069	0.532
MOD_NEK2_1	283	288	PF00069	0.688
MOD_NEK2_1	424	429	PF00069	0.744
MOD_NEK2_1	630	635	PF00069	0.712
MOD_NEK2_1	642	647	PF00069	0.725
MOD_NEK2_1	683	688	PF00069	0.727
MOD_NEK2_1	715	720	PF00069	0.746
MOD_NEK2_1	86	91	PF00069	0.544
MOD_NEK2_2	117	122	PF00069	0.586
MOD_PIKK_1	38	44	PF00454	0.530
MOD_PIKK_1	589	595	PF00454	0.719
MOD_PIKK_1	633	639	PF00454	0.822
MOD_PIKK_1	709	715	PF00454	0.720
MOD_PIKK_1	738	744	PF00454	0.802
MOD_PKA_1	151	157	PF00069	0.525
MOD_PKA_1	459	465	PF00069	0.744
MOD_PKA_1	550	556	PF00069	0.715
MOD_PKA_2	369	375	PF00069	0.711
MOD_PKA_2	38	44	PF00069	0.530
MOD_PKA_2	459	465	PF00069	0.779
MOD_PKA_2	469	475	PF00069	0.675
MOD_PKA_2	549	555	PF00069	0.690
MOD_PKA_2	578	584	PF00069	0.791
MOD_PKA_2	631	637	PF00069	0.726
MOD_PKA_2	670	676	PF00069	0.798
MOD_Plk_1	117	123	PF00069	0.515
MOD_Plk_1	314	320	PF00069	0.596
MOD_Plk_1	364	370	PF00069	0.551
MOD_Plk_1	473	479	PF00069	0.699
MOD_Plk_1	568	574	PF00069	0.763
MOD_Plk_1	626	632	PF00069	0.739
MOD_Plk_1	642	648	PF00069	0.725
MOD_Plk_1	738	744	PF00069	0.802
MOD_Plk_4	204	210	PF00069	0.587
MOD_Plk_4	225	231	PF00069	0.478
MOD_Plk_4	315	321	PF00069	0.588
MOD_Plk_4	49	55	PF00069	0.478
MOD_Plk_4	550	556	PF00069	0.727
MOD_Plk_4	96	102	PF00069	0.498
MOD_ProDKin_1	286	292	PF00069	0.713
MOD_ProDKin_1	295	301	PF00069	0.751
MOD_ProDKin_1	3	9	PF00069	0.601
MOD_ProDKin_1	354	360	PF00069	0.738
MOD_ProDKin_1	392	398	PF00069	0.697
MOD_ProDKin_1	427	433	PF00069	0.681
MOD_ProDKin_1	720	726	PF00069	0.734
MOD_SUMO_for_1	146	149	PF00179	0.513
MOD_SUMO_rev_2	141	148	PF00179	0.591
MOD_SUMO_rev_2	161	168	PF00179	0.286
MOD_SUMO_rev_2	191	198	PF00179	0.496
TRG_DiLeu_BaEn_1	204	209	PF01217	0.478
TRG_DiLeu_BaEn_1	21	26	PF01217	0.570
TRG_ENDOCYTIC_2	205	208	PF00928	0.454
TRG_ENDOCYTIC_2	351	354	PF00928	0.667
TRG_ENDOCYTIC_2	58	61	PF00928	0.471
TRG_ENDOCYTIC_2	79	82	PF00928	0.696
TRG_ER_diArg_1	595	598	PF00400	0.733
TRG_NLS_Bipartite_1	151	173	PF00514	0.539
TRG_NLS_MonoExtC_3	168	173	PF00514	0.528
TRG_NLS_MonoExtN_4	166	173	PF00514	0.533
TRG_NLS_MonoExtN_4	598	605	PF00514	0.819
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.729
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R4	Leptomonas seymouri	40%	99%
A4HCW8	Leishmania braziliensis	60%	100%
A4I0E8	Leishmania infantum	99%	100%
E9AWB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QB64	Leishmania major	92%	100%