Zinc finger, C3HC4 type (RING finger)/Ring finger domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger)/Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICQ4_LEIDO

TriTrypDb:

LdCL_240005700 , LDHU3_24.0100

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICQ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.306
CLV_NRD_NRD_1	119	121	PF00675	0.385
CLV_NRD_NRD_1	436	438	PF00675	0.299
CLV_PCSK_KEX2_1	119	121	PF00082	0.385
CLV_PCSK_SKI1_1	55	59	PF00082	0.435
DEG_Nend_UBRbox_2	1	3	PF02207	0.539
DOC_MAPK_gen_1	13	22	PF00069	0.419
DOC_MAPK_gen_1	52	62	PF00069	0.380
DOC_MAPK_MEF2A_6	8	16	PF00069	0.416
DOC_PP1_RVXF_1	11	17	PF00149	0.417
DOC_PP2B_PxIxI_1	31	37	PF00149	0.418
DOC_PP4_FxxP_1	42	45	PF00568	0.442
DOC_USP7_MATH_1	162	166	PF00917	0.332
DOC_USP7_MATH_1	255	259	PF00917	0.335
DOC_USP7_MATH_1	293	297	PF00917	0.593
DOC_USP7_MATH_1	516	520	PF00917	0.488
DOC_WW_Pin1_4	110	115	PF00397	0.337
DOC_WW_Pin1_4	278	283	PF00397	0.497
DOC_WW_Pin1_4	423	428	PF00397	0.505
LIG_14-3-3_CanoR_1	135	142	PF00244	0.434
LIG_14-3-3_CanoR_1	15	20	PF00244	0.485
LIG_14-3-3_CanoR_1	253	263	PF00244	0.444
LIG_BRCT_BRCA1_1	36	40	PF00533	0.434
LIG_BRCT_BRCA1_1	491	495	PF00533	0.363
LIG_BRCT_BRCA1_1	518	522	PF00533	0.495
LIG_deltaCOP1_diTrp_1	327	336	PF00928	0.463
LIG_FHA_1	153	159	PF00498	0.383
LIG_FHA_1	165	171	PF00498	0.328
LIG_FHA_1	203	209	PF00498	0.450
LIG_FHA_1	212	218	PF00498	0.489
LIG_FHA_1	344	350	PF00498	0.324
LIG_FHA_2	255	261	PF00498	0.514
LIG_FHA_2	292	298	PF00498	0.505
LIG_FHA_2	388	394	PF00498	0.385
LIG_FHA_2	509	515	PF00498	0.533
LIG_LIR_Apic_2	41	45	PF02991	0.439
LIG_LIR_Gen_1	183	191	PF02991	0.313
LIG_LIR_Gen_1	370	381	PF02991	0.412
LIG_LIR_Gen_1	519	529	PF02991	0.468
LIG_LIR_Gen_1	54	65	PF02991	0.328
LIG_LIR_Nem_3	171	177	PF02991	0.398
LIG_LIR_Nem_3	183	189	PF02991	0.248
LIG_LIR_Nem_3	370	376	PF02991	0.400
LIG_LIR_Nem_3	393	399	PF02991	0.384
LIG_LIR_Nem_3	519	525	PF02991	0.538
LIG_MYND_1	482	486	PF01753	0.487
LIG_PCNA_yPIPBox_3	194	208	PF02747	0.378
LIG_Pex14_2	196	200	PF04695	0.370
LIG_Pex14_2	464	468	PF04695	0.532
LIG_REV1ctd_RIR_1	139	148	PF16727	0.429
LIG_SH2_CRK	160	164	PF00017	0.436
LIG_SH2_CRK	174	178	PF00017	0.472
LIG_SH2_NCK_1	373	377	PF00017	0.406
LIG_SH2_STAP1	223	227	PF00017	0.364
LIG_SH2_STAT5	108	111	PF00017	0.335
LIG_SH2_STAT5	320	323	PF00017	0.324
LIG_SH2_STAT5	373	376	PF00017	0.554
LIG_SH2_STAT5	399	402	PF00017	0.351
LIG_SH2_STAT5	454	457	PF00017	0.360
LIG_SH3_3	156	162	PF00018	0.312
LIG_SH3_3	249	255	PF00018	0.493
LIG_SH3_3	355	361	PF00018	0.467
LIG_SH3_3	72	78	PF00018	0.514
LIG_SUMO_SIM_par_1	243	248	PF11976	0.515
LIG_SxIP_EBH_1	88	97	PF03271	0.354
LIG_TRAF2_1	426	429	PF00917	0.382
LIG_TYR_ITIM	158	163	PF00017	0.266
LIG_TYR_ITIM	172	177	PF00017	0.359
LIG_WRC_WIRS_1	19	24	PF05994	0.438
LIG_WRC_WIRS_1	213	218	PF05994	0.373
MOD_CK1_1	112	118	PF00069	0.428
MOD_CK1_1	151	157	PF00069	0.325
MOD_CK1_1	21	27	PF00069	0.492
MOD_CK1_1	212	218	PF00069	0.445
MOD_CK1_1	278	284	PF00069	0.532
MOD_CK1_1	291	297	PF00069	0.397
MOD_CK1_1	463	469	PF00069	0.440
MOD_CK1_1	97	103	PF00069	0.483
MOD_CK2_1	162	168	PF00069	0.445
MOD_CK2_1	240	246	PF00069	0.476
MOD_CK2_1	264	270	PF00069	0.421
MOD_CK2_1	291	297	PF00069	0.498
MOD_CK2_1	387	393	PF00069	0.395
MOD_CK2_1	423	429	PF00069	0.387
MOD_GlcNHglycan	123	126	PF01048	0.464
MOD_GlcNHglycan	150	153	PF01048	0.514
MOD_GlcNHglycan	277	280	PF01048	0.511
MOD_GlcNHglycan	46	49	PF01048	0.477
MOD_GlcNHglycan	68	71	PF01048	0.366
MOD_GlcNHglycan	79	82	PF01048	0.521
MOD_GlcNHglycan	96	99	PF01048	0.285
MOD_GSK3_1	148	155	PF00069	0.512
MOD_GSK3_1	164	171	PF00069	0.233
MOD_GSK3_1	21	28	PF00069	0.503
MOD_GSK3_1	236	243	PF00069	0.486
MOD_GSK3_1	271	278	PF00069	0.457
MOD_GSK3_1	287	294	PF00069	0.456
MOD_GSK3_1	34	41	PF00069	0.515
MOD_GSK3_1	363	370	PF00069	0.541
MOD_LATS_1	53	59	PF00433	0.445
MOD_NEK2_1	148	153	PF00069	0.260
MOD_NEK2_1	264	269	PF00069	0.395
MOD_NEK2_1	288	293	PF00069	0.529
MOD_NEK2_1	363	368	PF00069	0.363
MOD_NEK2_1	387	392	PF00069	0.509
MOD_OFUCOSY	487	493	PF10250	0.383
MOD_PIKK_1	135	141	PF00454	0.329
MOD_PIKK_1	288	294	PF00454	0.531
MOD_PIKK_1	34	40	PF00454	0.435
MOD_PIKK_1	457	463	PF00454	0.457
MOD_PKB_1	13	21	PF00069	0.415
MOD_Plk_2-3	240	246	PF00069	0.519
MOD_Plk_2-3	311	317	PF00069	0.399
MOD_Plk_4	112	118	PF00069	0.390
MOD_Plk_4	15	21	PF00069	0.439
MOD_Plk_4	212	218	PF00069	0.379
MOD_Plk_4	240	246	PF00069	0.408
MOD_Plk_4	86	92	PF00069	0.378
MOD_ProDKin_1	110	116	PF00069	0.337
MOD_ProDKin_1	278	284	PF00069	0.500
MOD_ProDKin_1	423	429	PF00069	0.508
MOD_SUMO_for_1	338	341	PF00179	0.427
TRG_ENDOCYTIC_2	108	111	PF00928	0.255
TRG_ENDOCYTIC_2	160	163	PF00928	0.438
TRG_ENDOCYTIC_2	174	177	PF00928	0.468
TRG_ENDOCYTIC_2	373	376	PF00928	0.437
TRG_ER_diArg_1	12	15	PF00400	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Y9	Leptomonas seymouri	57%	100%
A0A1X0NKC7	Trypanosomatidae	32%	100%
A0A3R7LDY0	Trypanosoma rangeli	34%	100%
A4HD66	Leishmania braziliensis	78%	100%
A4I0N1	Leishmania infantum	99%	100%
D0A6X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AWJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QAX2	Leishmania major	93%	100%
V5DSQ1	Trypanosoma cruzi	35%	100%