Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICQ0_LEIDO

TriTrypDb:

LdBPK_271280.1 , LdCL_270019300 , LDHU3_27.1970

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.557
CLV_NRD_NRD_1	187	189	PF00675	0.537
CLV_NRD_NRD_1	219	221	PF00675	0.436
CLV_NRD_NRD_1	300	302	PF00675	0.547
CLV_NRD_NRD_1	317	319	PF00675	0.425
CLV_NRD_NRD_1	349	351	PF00675	0.584
CLV_NRD_NRD_1	357	359	PF00675	0.520
CLV_NRD_NRD_1	364	366	PF00675	0.491
CLV_NRD_NRD_1	394	396	PF00675	0.538
CLV_NRD_NRD_1	410	412	PF00675	0.549
CLV_NRD_NRD_1	418	420	PF00675	0.535
CLV_NRD_NRD_1	512	514	PF00675	0.679
CLV_NRD_NRD_1	77	79	PF00675	0.752
CLV_PCSK_FUR_1	75	79	PF00082	0.751
CLV_PCSK_KEX2_1	142	144	PF00082	0.511
CLV_PCSK_KEX2_1	219	221	PF00082	0.597
CLV_PCSK_KEX2_1	246	248	PF00082	0.579
CLV_PCSK_KEX2_1	300	302	PF00082	0.547
CLV_PCSK_KEX2_1	315	317	PF00082	0.450
CLV_PCSK_KEX2_1	349	351	PF00082	0.624
CLV_PCSK_KEX2_1	357	359	PF00082	0.630
CLV_PCSK_KEX2_1	364	366	PF00082	0.578
CLV_PCSK_KEX2_1	394	396	PF00082	0.550
CLV_PCSK_KEX2_1	409	411	PF00082	0.598
CLV_PCSK_KEX2_1	418	420	PF00082	0.530
CLV_PCSK_KEX2_1	511	513	PF00082	0.627
CLV_PCSK_KEX2_1	525	527	PF00082	0.626
CLV_PCSK_KEX2_1	77	79	PF00082	0.752
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.512
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.579
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.562
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.605
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.627
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.659
CLV_PCSK_PC7_1	215	221	PF00082	0.438
CLV_PCSK_SKI1_1	197	201	PF00082	0.547
CLV_PCSK_SKI1_1	235	239	PF00082	0.531
CLV_PCSK_SKI1_1	288	292	PF00082	0.665
CLV_PCSK_SKI1_1	394	398	PF00082	0.540
CLV_Separin_Metazoa	443	447	PF03568	0.576
DEG_APCC_DBOX_1	157	165	PF00400	0.645
DEG_APCC_DBOX_1	394	402	PF00400	0.583
DEG_Kelch_actinfilin_1	97	101	PF01344	0.626
DEG_SIAH_1	610	618	PF03145	0.669
DEG_SPOP_SBC_1	537	541	PF00917	0.690
DEG_SPOP_SBC_1	548	552	PF00917	0.692
DOC_CKS1_1	103	108	PF01111	0.384
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.649
DOC_MAPK_gen_1	315	324	PF00069	0.586
DOC_MAPK_gen_1	379	388	PF00069	0.432
DOC_MAPK_MEF2A_6	130	137	PF00069	0.551
DOC_MAPK_MEF2A_6	29	37	PF00069	0.601
DOC_PP1_RVXF_1	195	202	PF00149	0.543
DOC_PP2B_LxvP_1	564	567	PF13499	0.692
DOC_PP2B_LxvP_1	569	572	PF13499	0.623
DOC_PP2B_LxvP_1	95	98	PF13499	0.644
DOC_PP4_FxxP_1	2	5	PF00568	0.643
DOC_PP4_FxxP_1	634	637	PF00568	0.706
DOC_PP4_MxPP_1	621	624	PF00568	0.755
DOC_SPAK_OSR1_1	121	125	PF12202	0.547
DOC_USP7_MATH_1	175	179	PF00917	0.559
DOC_USP7_MATH_1	276	280	PF00917	0.657
DOC_USP7_MATH_1	42	46	PF00917	0.693
DOC_USP7_MATH_1	528	532	PF00917	0.721
DOC_USP7_MATH_1	544	548	PF00917	0.742
DOC_USP7_MATH_1	575	579	PF00917	0.754
DOC_USP7_MATH_1	59	63	PF00917	0.680
DOC_USP7_MATH_1	595	599	PF00917	0.649
DOC_USP7_UBL2_3	339	343	PF12436	0.636
DOC_WW_Pin1_4	1	6	PF00397	0.639
DOC_WW_Pin1_4	102	107	PF00397	0.399
DOC_WW_Pin1_4	292	297	PF00397	0.704
DOC_WW_Pin1_4	551	556	PF00397	0.743
DOC_WW_Pin1_4	673	678	PF00397	0.665
DOC_WW_Pin1_4	76	81	PF00397	0.749
LIG_14-3-3_CanoR_1	143	147	PF00244	0.540
LIG_14-3-3_CanoR_1	174	180	PF00244	0.586
LIG_14-3-3_CanoR_1	254	258	PF00244	0.693
LIG_14-3-3_CanoR_1	536	543	PF00244	0.711
LIG_Actin_WH2_2	20	38	PF00022	0.605
LIG_CaM_IQ_9	134	150	PF13499	0.568
LIG_deltaCOP1_diTrp_1	147	157	PF00928	0.547
LIG_FHA_1	10	16	PF00498	0.609
LIG_FHA_1	258	264	PF00498	0.648
LIG_FHA_1	289	295	PF00498	0.739
LIG_FHA_1	538	544	PF00498	0.803
LIG_FHA_1	552	558	PF00498	0.654
LIG_LIR_Gen_1	129	140	PF02991	0.484
LIG_LIR_Gen_1	193	202	PF02991	0.500
LIG_LIR_Gen_1	577	587	PF02991	0.538
LIG_LIR_Nem_3	129	135	PF02991	0.485
LIG_LIR_Nem_3	193	198	PF02991	0.515
LIG_LIR_Nem_3	30	34	PF02991	0.580
LIG_LIR_Nem_3	577	582	PF02991	0.666
LIG_LIR_Nem_3	585	591	PF02991	0.754
LIG_LIR_Nem_3	628	632	PF02991	0.647
LIG_LYPXL_yS_3	658	661	PF13949	0.728
LIG_SH2_CRK	366	370	PF00017	0.513
LIG_SH2_CRK	579	583	PF00017	0.582
LIG_SH2_CRK	588	592	PF00017	0.581
LIG_SH2_NCK_1	678	682	PF00017	0.567
LIG_SH2_PTP2	132	135	PF00017	0.524
LIG_SH2_SRC	274	277	PF00017	0.755
LIG_SH2_SRC	588	591	PF00017	0.659
LIG_SH2_SRC	606	609	PF00017	0.665
LIG_SH2_STAP1	128	132	PF00017	0.621
LIG_SH2_STAP1	195	199	PF00017	0.548
LIG_SH2_STAP1	366	370	PF00017	0.615
LIG_SH2_STAP1	579	583	PF00017	0.580
LIG_SH2_STAT5	118	121	PF00017	0.562
LIG_SH2_STAT5	132	135	PF00017	0.411
LIG_SH2_STAT5	502	505	PF00017	0.632
LIG_SH2_STAT5	579	582	PF00017	0.627
LIG_SH2_STAT5	606	609	PF00017	0.743
LIG_SH3_1	646	652	PF00018	0.649
LIG_SH3_3	554	560	PF00018	0.701
LIG_SH3_3	569	575	PF00018	0.671
LIG_SH3_3	584	590	PF00018	0.583
LIG_SH3_3	621	627	PF00018	0.642
LIG_SH3_3	635	641	PF00018	0.480
LIG_SH3_3	646	652	PF00018	0.653
LIG_SH3_3	656	662	PF00018	0.587
LIG_SH3_3	674	680	PF00018	0.664
LIG_SH3_3	98	104	PF00018	0.573
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.553
LIG_SUMO_SIM_par_1	97	102	PF11976	0.656
LIG_TRAF2_1	402	405	PF00917	0.531
LIG_TRAF2_1	421	424	PF00917	0.397
LIG_TRAF2_1	478	481	PF00917	0.663
LIG_TRAF2_1	69	72	PF00917	0.736
MOD_CDC14_SPxK_1	83	86	PF00782	0.721
MOD_CDK_SPxK_1	80	86	PF00069	0.731
MOD_CDK_SPxxK_3	102	109	PF00069	0.390
MOD_CK1_1	156	162	PF00069	0.646
MOD_CK1_1	279	285	PF00069	0.692
MOD_CK1_1	4	10	PF00069	0.528
MOD_CK1_1	44	50	PF00069	0.691
MOD_CK1_1	538	544	PF00069	0.706
MOD_CK1_1	547	553	PF00069	0.704
MOD_CK1_1	577	583	PF00069	0.646
MOD_CK1_1	676	682	PF00069	0.661
MOD_CK2_1	292	298	PF00069	0.649
MOD_CK2_1	419	425	PF00069	0.593
MOD_CK2_1	622	628	PF00069	0.665
MOD_CK2_1	64	70	PF00069	0.708
MOD_Cter_Amidation	244	247	PF01082	0.555
MOD_Cter_Amidation	75	78	PF01082	0.753
MOD_GlcNHglycan	37	40	PF01048	0.641
MOD_GlcNHglycan	44	47	PF01048	0.680
MOD_GlcNHglycan	540	543	PF01048	0.758
MOD_GlcNHglycan	551	554	PF01048	0.688
MOD_GlcNHglycan	56	59	PF01048	0.648
MOD_GlcNHglycan	597	600	PF01048	0.699
MOD_GlcNHglycan	6	9	PF01048	0.529
MOD_GlcNHglycan	66	69	PF01048	0.691
MOD_GSK3_1	149	156	PF00069	0.512
MOD_GSK3_1	175	182	PF00069	0.586
MOD_GSK3_1	253	260	PF00069	0.602
MOD_GSK3_1	284	291	PF00069	0.653
MOD_GSK3_1	41	48	PF00069	0.705
MOD_GSK3_1	544	551	PF00069	0.716
MOD_GSK3_1	574	581	PF00069	0.623
MOD_GSK3_1	611	618	PF00069	0.723
MOD_GSK3_1	669	676	PF00069	0.723
MOD_GSK3_1	76	83	PF00069	0.790
MOD_N-GLC_1	52	57	PF02516	0.776
MOD_NEK2_1	257	262	PF00069	0.638
MOD_NEK2_1	35	40	PF00069	0.563
MOD_PIKK_1	279	285	PF00454	0.713
MOD_PIKK_1	528	534	PF00454	0.663
MOD_PKA_1	142	148	PF00069	0.542
MOD_PKA_1	246	252	PF00069	0.587
MOD_PKA_1	419	425	PF00069	0.609
MOD_PKA_2	142	148	PF00069	0.617
MOD_PKA_2	246	252	PF00069	0.570
MOD_PKA_2	253	259	PF00069	0.624
MOD_PKA_2	35	41	PF00069	0.627
MOD_PKA_2	535	541	PF00069	0.705
MOD_Plk_1	128	134	PF00069	0.551
MOD_Plk_1	202	208	PF00069	0.516
MOD_Plk_1	252	258	PF00069	0.747
MOD_Plk_1	372	378	PF00069	0.492
MOD_Plk_4	10	16	PF00069	0.615
MOD_Plk_4	175	181	PF00069	0.570
MOD_Plk_4	578	584	PF00069	0.665
MOD_Plk_4	611	617	PF00069	0.650
MOD_ProDKin_1	1	7	PF00069	0.636
MOD_ProDKin_1	102	108	PF00069	0.390
MOD_ProDKin_1	292	298	PF00069	0.697
MOD_ProDKin_1	551	557	PF00069	0.745
MOD_ProDKin_1	673	679	PF00069	0.662
MOD_ProDKin_1	76	82	PF00069	0.748
MOD_SUMO_for_1	370	373	PF00179	0.546
MOD_SUMO_rev_2	156	164	PF00179	0.610
MOD_SUMO_rev_2	518	527	PF00179	0.638
TRG_DiLeu_BaEn_1	320	325	PF01217	0.583
TRG_DiLeu_LyEn_5	30	35	PF01217	0.565
TRG_DiLeu_LyEn_5	320	325	PF01217	0.637
TRG_ENDOCYTIC_2	132	135	PF00928	0.490
TRG_ENDOCYTIC_2	195	198	PF00928	0.475
TRG_ENDOCYTIC_2	366	369	PF00928	0.514
TRG_ENDOCYTIC_2	579	582	PF00928	0.662
TRG_ENDOCYTIC_2	588	591	PF00928	0.734
TRG_ENDOCYTIC_2	658	661	PF00928	0.752
TRG_ER_diArg_1	219	221	PF00400	0.436
TRG_ER_diArg_1	299	301	PF00400	0.528
TRG_ER_diArg_1	316	318	PF00400	0.506
TRG_ER_diArg_1	349	352	PF00400	0.662
TRG_ER_diArg_1	364	366	PF00400	0.629
TRG_ER_diArg_1	408	411	PF00400	0.620
TRG_ER_diArg_1	445	448	PF00400	0.546
TRG_ER_diArg_1	476	479	PF00400	0.450
TRG_ER_diArg_1	512	515	PF00400	0.635
TRG_ER_diArg_1	74	77	PF00400	0.705
TRG_NLS_Bipartite_1	496	515	PF00514	0.685
TRG_NLS_MonoCore_2	140	145	PF00514	0.564
TRG_NLS_MonoExtC_3	141	147	PF00514	0.564
TRG_NLS_MonoExtC_3	510	515	PF00514	0.680
TRG_NLS_MonoExtN_4	141	146	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	512	516	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL8	Leptomonas seymouri	53%	99%
A0A422NFT2	Trypanosoma rangeli	30%	100%
A4HFR3	Leishmania braziliensis	73%	98%
A4I2T9	Leishmania infantum	99%	100%
D0A604	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ADB7	Leishmania major	93%	100%
E9AZ42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%