WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICP9_LEIDO

TriTrypDb:

LdBPK_312450.1 , LdCL_310032500 , LDHU3_31.4430

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	346	352	PF00089	0.463
CLV_NRD_NRD_1	137	139	PF00675	0.433
CLV_NRD_NRD_1	189	191	PF00675	0.613
CLV_NRD_NRD_1	309	311	PF00675	0.612
CLV_NRD_NRD_1	45	47	PF00675	0.574
CLV_NRD_NRD_1	75	77	PF00675	0.649
CLV_PCSK_KEX2_1	149	151	PF00082	0.518
CLV_PCSK_KEX2_1	309	311	PF00082	0.667
CLV_PCSK_KEX2_1	45	47	PF00082	0.651
CLV_PCSK_KEX2_1	59	61	PF00082	0.733
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.518
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.743
CLV_PCSK_SKI1_1	119	123	PF00082	0.406
CLV_PCSK_SKI1_1	173	177	PF00082	0.341
CLV_PCSK_SKI1_1	290	294	PF00082	0.476
CLV_PCSK_SKI1_1	379	383	PF00082	0.389
DEG_APCC_DBOX_1	17	25	PF00400	0.473
DEG_APCC_DBOX_1	487	495	PF00400	0.423
DEG_COP1_1	78	89	PF00400	0.495
DEG_Nend_UBRbox_3	1	3	PF02207	0.516
DEG_SCF_SKP2-CKS1_1	401	408	PF00560	0.472
DOC_AGCK_PIF_1	347	352	PF00069	0.466
DOC_CKS1_1	435	440	PF01111	0.525
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	447	453	PF00134	0.527
DOC_MAPK_gen_1	138	146	PF00069	0.408
DOC_MAPK_MEF2A_6	256	263	PF00069	0.467
DOC_MAPK_MEF2A_6	329	337	PF00069	0.483
DOC_MIT_MIM_1	198	207	PF04212	0.459
DOC_PP1_RVXF_1	341	348	PF00149	0.438
DOC_PP1_RVXF_1	377	383	PF00149	0.328
DOC_USP7_MATH_1	103	107	PF00917	0.589
DOC_USP7_MATH_1	117	121	PF00917	0.494
DOC_USP7_MATH_1	222	226	PF00917	0.512
DOC_USP7_MATH_1	29	33	PF00917	0.759
DOC_USP7_MATH_1	303	307	PF00917	0.695
DOC_USP7_MATH_1	362	366	PF00917	0.464
DOC_USP7_MATH_1	80	84	PF00917	0.684
DOC_USP7_MATH_1	89	93	PF00917	0.649
DOC_USP7_MATH_1	96	100	PF00917	0.625
DOC_USP7_UBL2_3	141	145	PF12436	0.478
DOC_USP7_UBL2_3	290	294	PF12436	0.476
DOC_USP7_UBL2_3	55	59	PF12436	0.692
DOC_WW_Pin1_4	30	35	PF00397	0.770
DOC_WW_Pin1_4	335	340	PF00397	0.377
DOC_WW_Pin1_4	402	407	PF00397	0.590
DOC_WW_Pin1_4	434	439	PF00397	0.455
DOC_WW_Pin1_4	85	90	PF00397	0.660
LIG_14-3-3_CanoR_1	154	159	PF00244	0.468
LIG_14-3-3_CanoR_1	349	353	PF00244	0.445
LIG_14-3-3_CanoR_1	482	489	PF00244	0.576
LIG_14-3-3_CanoR_1	62	67	PF00244	0.814
LIG_Actin_WH2_2	436	454	PF00022	0.541
LIG_BRCT_BRCA1_1	464	468	PF00533	0.444
LIG_BRCT_BRCA1_1	495	499	PF00533	0.296
LIG_CtBP_PxDLS_1	409	413	PF00389	0.473
LIG_FHA_1	106	112	PF00498	0.705
LIG_FHA_1	215	221	PF00498	0.526
LIG_FHA_1	248	254	PF00498	0.431
LIG_FHA_1	340	346	PF00498	0.510
LIG_FHA_1	384	390	PF00498	0.411
LIG_FHA_1	411	417	PF00498	0.543
LIG_FHA_1	5	11	PF00498	0.513
LIG_FHA_2	250	256	PF00498	0.423
LIG_FHA_2	272	278	PF00498	0.450
LIG_FHA_2	420	426	PF00498	0.515
LIG_FHA_2	481	487	PF00498	0.454
LIG_FHA_2	502	508	PF00498	0.369
LIG_LIR_Apic_2	507	512	PF02991	0.398
LIG_LIR_Gen_1	140	148	PF02991	0.516
LIG_LIR_Gen_1	348	357	PF02991	0.398
LIG_LIR_Nem_3	140	146	PF02991	0.521
LIG_LIR_Nem_3	348	353	PF02991	0.389
LIG_PDZ_Class_2	508	513	PF00595	0.409
LIG_Pex14_2	142	146	PF04695	0.379
LIG_RPA_C_Fungi	477	489	PF08784	0.431
LIG_SH2_CRK	11	15	PF00017	0.508
LIG_SH2_STAP1	355	359	PF00017	0.462
LIG_SH2_STAT5	11	14	PF00017	0.476
LIG_SH2_STAT5	143	146	PF00017	0.516
LIG_SH2_STAT5	164	167	PF00017	0.376
LIG_SH2_STAT5	493	496	PF00017	0.398
LIG_SH3_3	356	362	PF00018	0.488
LIG_SH3_3	368	374	PF00018	0.286
LIG_SH3_3	403	409	PF00018	0.541
LIG_SH3_3	418	424	PF00018	0.289
LIG_SH3_3	83	89	PF00018	0.745
LIG_SUMO_SIM_anti_2	120	127	PF11976	0.406
LIG_SUMO_SIM_par_1	120	127	PF11976	0.336
LIG_SUMO_SIM_par_1	248	255	PF11976	0.496
LIG_SUMO_SIM_par_1	277	285	PF11976	0.393
LIG_SUMO_SIM_par_1	417	422	PF11976	0.508
MOD_CDK_SPxK_1	402	408	PF00069	0.473
MOD_CDK_SPxK_1	434	440	PF00069	0.520
MOD_CK1_1	214	220	PF00069	0.402
MOD_CK1_1	246	252	PF00069	0.430
MOD_CK1_1	267	273	PF00069	0.520
MOD_CK1_1	30	36	PF00069	0.703
MOD_CK1_1	308	314	PF00069	0.747
MOD_CK1_1	348	354	PF00069	0.464
MOD_CK1_1	469	475	PF00069	0.420
MOD_CK1_1	79	85	PF00069	0.706
MOD_CK1_1	88	94	PF00069	0.617
MOD_CK2_1	249	255	PF00069	0.416
MOD_CK2_1	271	277	PF00069	0.482
MOD_CK2_1	324	330	PF00069	0.661
MOD_CK2_1	381	387	PF00069	0.536
MOD_CK2_1	419	425	PF00069	0.485
MOD_CK2_1	480	486	PF00069	0.337
MOD_CK2_1	501	507	PF00069	0.501
MOD_CK2_1	62	68	PF00069	0.724
MOD_CK2_1	72	78	PF00069	0.622
MOD_GlcNHglycan	105	108	PF01048	0.714
MOD_GlcNHglycan	119	122	PF01048	0.319
MOD_GlcNHglycan	167	170	PF01048	0.360
MOD_GlcNHglycan	29	32	PF01048	0.647
MOD_GlcNHglycan	326	329	PF01048	0.687
MOD_GlcNHglycan	471	475	PF01048	0.425
MOD_GlcNHglycan	495	498	PF01048	0.369
MOD_GlcNHglycan	50	53	PF01048	0.717
MOD_GlcNHglycan	78	81	PF01048	0.780
MOD_GSK3_1	101	108	PF00069	0.545
MOD_GSK3_1	154	161	PF00069	0.445
MOD_GSK3_1	243	250	PF00069	0.377
MOD_GSK3_1	25	32	PF00069	0.731
MOD_GSK3_1	267	274	PF00069	0.491
MOD_GSK3_1	320	327	PF00069	0.678
MOD_GSK3_1	335	342	PF00069	0.284
MOD_GSK3_1	37	44	PF00069	0.646
MOD_GSK3_1	419	426	PF00069	0.447
MOD_GSK3_1	462	469	PF00069	0.401
MOD_GSK3_1	68	75	PF00069	0.713
MOD_GSK3_1	76	83	PF00069	0.676
MOD_GSK3_1	85	92	PF00069	0.585
MOD_N-GLC_1	410	415	PF02516	0.551
MOD_NEK2_1	1	6	PF00069	0.566
MOD_NEK2_1	123	128	PF00069	0.473
MOD_NEK2_1	175	180	PF00069	0.368
MOD_NEK2_1	271	276	PF00069	0.330
MOD_NEK2_1	410	415	PF00069	0.595
MOD_NEK2_2	362	367	PF00069	0.474
MOD_PIKK_1	222	228	PF00454	0.387
MOD_PK_1	154	160	PF00069	0.469
MOD_PK_1	243	249	PF00069	0.399
MOD_PK_1	62	68	PF00069	0.708
MOD_PKA_1	76	82	PF00069	0.682
MOD_PKA_2	183	189	PF00069	0.604
MOD_PKA_2	308	314	PF00069	0.663
MOD_PKA_2	320	326	PF00069	0.674
MOD_PKA_2	348	354	PF00069	0.466
MOD_PKA_2	481	487	PF00069	0.466
MOD_PKA_2	501	507	PF00069	0.356
MOD_PKA_2	72	78	PF00069	0.712
MOD_PKB_1	241	249	PF00069	0.378
MOD_PKB_1	60	68	PF00069	0.760
MOD_Plk_1	214	220	PF00069	0.481
MOD_Plk_1	243	249	PF00069	0.386
MOD_Plk_1	355	361	PF00069	0.376
MOD_Plk_4	206	212	PF00069	0.399
MOD_Plk_4	320	326	PF00069	0.611
MOD_Plk_4	355	361	PF00069	0.508
MOD_Plk_4	463	469	PF00069	0.392
MOD_ProDKin_1	30	36	PF00069	0.775
MOD_ProDKin_1	335	341	PF00069	0.372
MOD_ProDKin_1	402	408	PF00069	0.594
MOD_ProDKin_1	434	440	PF00069	0.457
MOD_ProDKin_1	85	91	PF00069	0.658
TRG_DiLeu_BaEn_1	215	220	PF01217	0.412
TRG_ENDOCYTIC_2	143	146	PF00928	0.516
TRG_ER_diArg_1	240	243	PF00400	0.354
TRG_NLS_Bipartite_1	45	63	PF00514	0.810
TRG_NLS_MonoExtC_3	189	194	PF00514	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P1	Leptomonas seymouri	64%	100%
A0A0S4JK75	Bodo saltans	32%	100%
A0A1X0NFD4	Trypanosomatidae	36%	99%
A0A3R7KS12	Trypanosoma rangeli	46%	100%
A4HJM1	Leishmania braziliensis	79%	100%
A4I743	Leishmania infantum	99%	100%
C9ZME4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
C9ZWN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
E9B237	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q624	Leishmania major	90%	100%
V5B2M4	Trypanosoma cruzi	44%	100%