Leucine Rich repeat/Leucine Rich Repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICP4_LEIDO

TriTrypDb:

LdBPK_231890.1 , LdCL_230026100 , LDHU3_23.2480

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

A0A3Q8ICP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICP4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.431
CLV_NRD_NRD_1	230	232	PF00675	0.516
CLV_NRD_NRD_1	244	246	PF00675	0.278
CLV_NRD_NRD_1	281	283	PF00675	0.575
CLV_PCSK_FUR_1	143	147	PF00082	0.498
CLV_PCSK_KEX2_1	145	147	PF00082	0.446
CLV_PCSK_KEX2_1	230	232	PF00082	0.516
CLV_PCSK_KEX2_1	244	246	PF00082	0.278
CLV_PCSK_SKI1_1	12	16	PF00082	0.442
CLV_PCSK_SKI1_1	200	204	PF00082	0.501
CLV_PCSK_SKI1_1	34	38	PF00082	0.474
CLV_PCSK_SKI1_1	43	47	PF00082	0.449
CLV_Separin_Metazoa	241	245	PF03568	0.607
DEG_APCC_DBOX_1	116	124	PF00400	0.513
DEG_SPOP_SBC_1	112	116	PF00917	0.474
DOC_CDC14_PxL_1	130	138	PF14671	0.424
DOC_CYCLIN_RxL_1	194	205	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.505
DOC_MAPK_MEF2A_6	153	162	PF00069	0.514
DOC_MAPK_MEF2A_6	67	74	PF00069	0.430
DOC_PP2B_LxvP_1	156	159	PF13499	0.488
DOC_PP4_MxPP_1	132	135	PF00568	0.542
DOC_USP7_MATH_1	111	115	PF00917	0.569
DOC_USP7_MATH_1	119	123	PF00917	0.448
DOC_USP7_MATH_1	168	172	PF00917	0.465
DOC_USP7_MATH_1	84	88	PF00917	0.580
DOC_USP7_UBL2_3	34	38	PF12436	0.531
DOC_USP7_UBL2_3	93	97	PF12436	0.574
LIG_14-3-3_CanoR_1	12	21	PF00244	0.467
LIG_14-3-3_CanoR_1	146	156	PF00244	0.471
LIG_14-3-3_CanoR_1	230	235	PF00244	0.524
LIG_14-3-3_CanoR_1	67	73	PF00244	0.545
LIG_Actin_WH2_2	29	45	PF00022	0.493
LIG_BRCT_BRCA1_1	213	217	PF00533	0.522
LIG_Clathr_ClatBox_1	69	73	PF01394	0.458
LIG_CtBP_PxDLS_1	159	163	PF00389	0.565
LIG_FHA_1	113	119	PF00498	0.551
LIG_FHA_1	13	19	PF00498	0.476
LIG_FHA_1	153	159	PF00498	0.493
LIG_FHA_1	182	188	PF00498	0.504
LIG_FHA_1	21	27	PF00498	0.515
LIG_FHA_1	210	216	PF00498	0.459
LIG_FHA_1	238	244	PF00498	0.489
LIG_FHA_1	31	37	PF00498	0.441
LIG_FHA_1	39	45	PF00498	0.407
LIG_FHA_2	152	158	PF00498	0.481
LIG_FHA_2	3	9	PF00498	0.636
LIG_IRF3_LxIS_1	119	126	PF10401	0.488
LIG_LIR_Gen_1	28	36	PF02991	0.487
LIG_LIR_Nem_3	193	199	PF02991	0.476
LIG_LIR_Nem_3	28	32	PF02991	0.461
LIG_LIR_Nem_3	64	69	PF02991	0.390
LIG_NRBOX	198	204	PF00104	0.419
LIG_PDZ_Class_3	300	305	PF00595	0.733
LIG_SH2_NCK_1	10	14	PF00017	0.534
LIG_SH2_STAP1	10	14	PF00017	0.612
LIG_SH2_STAP1	58	62	PF00017	0.496
LIG_SH3_3	189	195	PF00018	0.533
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.475
LIG_SUMO_SIM_par_1	15	23	PF11976	0.477
LIG_SUMO_SIM_par_1	43	48	PF11976	0.488
LIG_SUMO_SIM_par_1	68	73	PF11976	0.469
LIG_TRAF2_1	219	222	PF00917	0.625
LIG_UBA3_1	18	25	PF00899	0.617
LIG_WRC_WIRS_1	182	187	PF05994	0.452
MOD_CK1_1	28	34	PF00069	0.510
MOD_CK2_1	230	236	PF00069	0.517
MOD_GlcNHglycan	125	128	PF01048	0.518
MOD_GSK3_1	119	126	PF00069	0.413
MOD_GSK3_1	13	20	PF00069	0.485
MOD_GSK3_1	147	154	PF00069	0.507
MOD_GSK3_1	271	278	PF00069	0.509
MOD_GSK3_1	30	37	PF00069	0.481
MOD_GSK3_1	61	68	PF00069	0.476
MOD_N-GLC_1	123	128	PF02516	0.423
MOD_N-GLC_1	151	156	PF02516	0.574
MOD_NEK2_1	123	128	PF00069	0.423
MOD_NEK2_1	209	214	PF00069	0.449
MOD_NEK2_1	65	70	PF00069	0.382
MOD_NEK2_1	72	77	PF00069	0.373
MOD_NEK2_1	91	96	PF00069	0.535
MOD_NMyristoyl	1	7	PF02799	0.597
MOD_PIKK_1	20	26	PF00454	0.543
MOD_PKA_1	230	236	PF00069	0.527
MOD_PKA_2	230	236	PF00069	0.527
MOD_Plk_1	151	157	PF00069	0.576
MOD_Plk_4	181	187	PF00069	0.584
MOD_Plk_4	271	277	PF00069	0.543
MOD_Plk_4	61	67	PF00069	0.499
MOD_SUMO_rev_2	233	240	PF00179	0.387
MOD_SUMO_rev_2	290	296	PF00179	0.660
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.436
TRG_ER_diArg_1	100	103	PF00400	0.551
TRG_ER_diArg_1	142	145	PF00400	0.452
TRG_ER_diArg_1	229	231	PF00400	0.513
TRG_ER_diArg_1	243	245	PF00400	0.275
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL46	Leptomonas seymouri	54%	100%
A0A3R7NP81	Trypanosoma rangeli	37%	100%
A4HD33	Leishmania braziliensis	77%	100%
A4I0M0	Leishmania infantum	99%	100%
E9AWI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAY9	Leishmania major	93%	100%