Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICP2_LEIDO

TriTrypDb:

LdBPK_231900.1 , LdCL_230026200 , LDHU3_23.2500

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.475
CLV_NRD_NRD_1	222	224	PF00675	0.505
CLV_PCSK_KEX2_1	10	12	PF00082	0.514
CLV_PCSK_KEX2_1	222	224	PF00082	0.521
CLV_PCSK_SKI1_1	170	174	PF00082	0.475
CLV_PCSK_SKI1_1	307	311	PF00082	0.473
DEG_SPOP_SBC_1	333	337	PF00917	0.542
DOC_ANK_TNKS_1	18	25	PF00023	0.476
DOC_CDC14_PxL_1	413	421	PF14671	0.525
DOC_CKS1_1	71	76	PF01111	0.534
DOC_MAPK_DCC_7	404	413	PF00069	0.563
DOC_MAPK_gen_1	10	16	PF00069	0.418
DOC_MAPK_gen_1	219	228	PF00069	0.498
DOC_MAPK_MEF2A_6	219	228	PF00069	0.498
DOC_MAPK_MEF2A_6	404	413	PF00069	0.563
DOC_MAPK_NFAT4_5	223	231	PF00069	0.501
DOC_PP4_FxxP_1	213	216	PF00568	0.482
DOC_PP4_FxxP_1	71	74	PF00568	0.515
DOC_USP7_MATH_1	103	107	PF00917	0.485
DOC_USP7_MATH_1	152	156	PF00917	0.472
DOC_USP7_MATH_1	334	338	PF00917	0.588
DOC_USP7_MATH_1	36	40	PF00917	0.416
DOC_USP7_MATH_1	447	451	PF00917	0.558
DOC_USP7_MATH_1	83	87	PF00917	0.689
DOC_WW_Pin1_4	161	166	PF00397	0.482
DOC_WW_Pin1_4	70	75	PF00397	0.514
LIG_14-3-3_CanoR_1	118	123	PF00244	0.459
LIG_14-3-3_CanoR_1	194	202	PF00244	0.592
LIG_14-3-3_CanoR_1	260	268	PF00244	0.688
LIG_14-3-3_CanoR_1	286	293	PF00244	0.552
LIG_14-3-3_CanoR_1	31	35	PF00244	0.451
LIG_14-3-3_CanoR_1	51	57	PF00244	0.509
LIG_AP2alpha_1	360	364	PF02296	0.371
LIG_AP2alpha_2	299	301	PF02296	0.537
LIG_APCC_ABBA_1	12	17	PF00400	0.388
LIG_APCC_ABBAyCdc20_2	11	17	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BIR_III_2	162	166	PF00653	0.459
LIG_BRCT_BRCA1_1	447	451	PF00533	0.510
LIG_CtBP_PxDLS_1	408	412	PF00389	0.592
LIG_FHA_1	151	157	PF00498	0.465
LIG_FHA_1	301	307	PF00498	0.489
LIG_FHA_1	322	328	PF00498	0.475
LIG_FHA_1	334	340	PF00498	0.606
LIG_FHA_1	398	404	PF00498	0.479
LIG_FHA_1	57	63	PF00498	0.447
LIG_FHA_2	180	186	PF00498	0.522
LIG_FHA_2	370	376	PF00498	0.516
LIG_FHA_2	4	10	PF00498	0.608
LIG_LIR_Apic_2	211	216	PF02991	0.489
LIG_LIR_Apic_2	69	74	PF02991	0.499
LIG_LIR_Gen_1	175	183	PF02991	0.503
LIG_LIR_Gen_1	299	309	PF02991	0.523
LIG_LIR_Nem_3	175	179	PF02991	0.528
LIG_LIR_Nem_3	211	215	PF02991	0.368
LIG_LIR_Nem_3	299	304	PF02991	0.560
LIG_LIR_Nem_3	43	49	PF02991	0.524
LIG_NRBOX	452	458	PF00104	0.541
LIG_PCNA_PIPBox_1	206	215	PF02747	0.421
LIG_Pex14_2	360	364	PF04695	0.436
LIG_Pex14_2	391	395	PF04695	0.461
LIG_Pex14_2	71	75	PF04695	0.495
LIG_REV1ctd_RIR_1	13	23	PF16727	0.421
LIG_SH2_STAP1	431	435	PF00017	0.475
LIG_SH2_STAT5	146	149	PF00017	0.421
LIG_SH2_STAT5	394	397	PF00017	0.476
LIG_SH2_STAT5	431	434	PF00017	0.488
LIG_SH2_STAT5	46	49	PF00017	0.514
LIG_SH3_2	417	422	PF14604	0.608
LIG_SH3_3	342	348	PF00018	0.704
LIG_SH3_3	411	417	PF00018	0.587
LIG_SUMO_SIM_par_1	323	332	PF11976	0.488
LIG_SUMO_SIM_par_1	39	45	PF11976	0.466
LIG_TRAF2_1	205	208	PF00917	0.393
LIG_TRAF2_1	372	375	PF00917	0.495
LIG_TRFH_1	212	216	PF08558	0.348
LIG_WRC_WIRS_1	209	214	PF05994	0.331
LIG_WRC_WIRS_1	68	73	PF05994	0.470
MOD_CDK_SPxxK_3	161	168	PF00069	0.460
MOD_CK1_1	145	151	PF00069	0.493
MOD_CK1_1	2	8	PF00069	0.556
MOD_CK1_1	332	338	PF00069	0.592
MOD_CK1_1	343	349	PF00069	0.471
MOD_CK1_1	449	455	PF00069	0.426
MOD_CK1_1	52	58	PF00069	0.530
MOD_CK1_1	70	76	PF00069	0.471
MOD_CK2_1	145	151	PF00069	0.457
MOD_CK2_1	179	185	PF00069	0.534
MOD_CK2_1	288	294	PF00069	0.655
MOD_CK2_1	369	375	PF00069	0.501
MOD_GlcNHglycan	1	4	PF01048	0.617
MOD_GlcNHglycan	130	133	PF01048	0.637
MOD_GlcNHglycan	156	159	PF01048	0.520
MOD_GlcNHglycan	197	200	PF01048	0.572
MOD_GlcNHglycan	262	265	PF01048	0.577
MOD_GlcNHglycan	330	334	PF01048	0.538
MOD_GlcNHglycan	342	345	PF01048	0.626
MOD_GlcNHglycan	458	461	PF01048	0.668
MOD_GlcNHglycan	51	54	PF01048	0.566
MOD_GlcNHglycan	56	59	PF01048	0.426
MOD_GlcNHglycan	85	88	PF01048	0.669
MOD_GlcNHglycan	92	95	PF01048	0.486
MOD_GSK3_1	1	8	PF00069	0.565
MOD_GSK3_1	141	148	PF00069	0.379
MOD_GSK3_1	150	157	PF00069	0.427
MOD_GSK3_1	251	258	PF00069	0.626
MOD_GSK3_1	328	335	PF00069	0.532
MOD_GSK3_1	339	346	PF00069	0.569
MOD_GSK3_1	36	43	PF00069	0.417
MOD_GSK3_1	369	376	PF00069	0.579
MOD_GSK3_1	441	448	PF00069	0.446
MOD_GSK3_1	52	59	PF00069	0.502
MOD_N-GLC_2	108	110	PF02516	0.528
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	130	135	PF00069	0.493
MOD_NEK2_1	141	146	PF00069	0.464
MOD_NEK2_1	277	282	PF00069	0.622
MOD_NEK2_1	30	35	PF00069	0.469
MOD_NEK2_1	321	326	PF00069	0.524
MOD_NEK2_1	329	334	PF00069	0.462
MOD_NEK2_1	339	344	PF00069	0.539
MOD_NEK2_1	42	47	PF00069	0.469
MOD_NEK2_1	456	461	PF00069	0.678
MOD_NEK2_1	56	61	PF00069	0.389
MOD_NEK2_1	75	80	PF00069	0.609
MOD_NEK2_2	300	305	PF00069	0.481
MOD_NEK2_2	397	402	PF00069	0.524
MOD_PIKK_1	130	136	PF00454	0.630
MOD_PIKK_1	150	156	PF00454	0.257
MOD_PIKK_1	36	42	PF00454	0.428
MOD_PK_1	118	124	PF00069	0.475
MOD_PKA_2	193	199	PF00069	0.485
MOD_PKA_2	218	224	PF00069	0.598
MOD_PKA_2	248	254	PF00069	0.612
MOD_PKA_2	259	265	PF00069	0.539
MOD_PKA_2	285	291	PF00069	0.557
MOD_PKA_2	30	36	PF00069	0.522
MOD_Plk_1	103	109	PF00069	0.525
MOD_Plk_1	315	321	PF00069	0.611
MOD_Plk_1	397	403	PF00069	0.491
MOD_Plk_4	118	124	PF00069	0.475
MOD_Plk_4	142	148	PF00069	0.439
MOD_Plk_4	208	214	PF00069	0.514
MOD_Plk_4	235	241	PF00069	0.416
MOD_Plk_4	251	257	PF00069	0.625
MOD_Plk_4	288	294	PF00069	0.727
MOD_Plk_4	30	36	PF00069	0.445
MOD_Plk_4	315	321	PF00069	0.608
MOD_Plk_4	42	48	PF00069	0.425
MOD_ProDKin_1	161	167	PF00069	0.468
MOD_ProDKin_1	70	76	PF00069	0.526
MOD_SUMO_rev_2	423	430	PF00179	0.648
TRG_ENDOCYTIC_2	242	245	PF00928	0.568
TRG_ENDOCYTIC_2	27	30	PF00928	0.472
TRG_ER_diArg_1	10	12	PF00400	0.470
TRG_ER_diArg_1	222	224	PF00400	0.503
TRG_ER_diArg_1	401	404	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G3	Leptomonas seymouri	36%	100%
A4HD34	Leishmania braziliensis	74%	100%
A4I0M1	Leishmania infantum	99%	100%
E9AWI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAY8	Leishmania major	93%	100%
V5ARA2	Trypanosoma cruzi	24%	100%