Protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICP0_LEIDO

TriTrypDb:

LdBPK_312280.1 , LdCL_310030800 , LDHU3_31.4070

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.700
CLV_C14_Caspase3-7	316	320	PF00656	0.674
CLV_C14_Caspase3-7	682	686	PF00656	0.580
CLV_NRD_NRD_1	201	203	PF00675	0.661
CLV_NRD_NRD_1	272	274	PF00675	0.705
CLV_NRD_NRD_1	344	346	PF00675	0.663
CLV_NRD_NRD_1	434	436	PF00675	0.669
CLV_NRD_NRD_1	488	490	PF00675	0.652
CLV_NRD_NRD_1	674	676	PF00675	0.628
CLV_NRD_NRD_1	831	833	PF00675	0.475
CLV_NRD_NRD_1	837	839	PF00675	0.510
CLV_PCSK_FUR_1	672	676	PF00082	0.625
CLV_PCSK_KEX2_1	201	203	PF00082	0.661
CLV_PCSK_KEX2_1	272	274	PF00082	0.707
CLV_PCSK_KEX2_1	344	346	PF00082	0.663
CLV_PCSK_KEX2_1	434	436	PF00082	0.669
CLV_PCSK_KEX2_1	488	490	PF00082	0.593
CLV_PCSK_KEX2_1	551	553	PF00082	0.629
CLV_PCSK_KEX2_1	674	676	PF00082	0.628
CLV_PCSK_KEX2_1	718	720	PF00082	0.739
CLV_PCSK_KEX2_1	814	816	PF00082	0.608
CLV_PCSK_KEX2_1	830	832	PF00082	0.447
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.669
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.626
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.551
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.597
CLV_PCSK_PC1ET2_1	830	832	PF00082	0.442
CLV_PCSK_PC7_1	430	436	PF00082	0.668
CLV_PCSK_SKI1_1	201	205	PF00082	0.653
CLV_PCSK_SKI1_1	44	48	PF00082	0.684
CLV_PCSK_SKI1_1	565	569	PF00082	0.678
CLV_PCSK_SKI1_1	583	587	PF00082	0.601
CLV_PCSK_SKI1_1	814	818	PF00082	0.558
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DEG_SPOP_SBC_1	22	26	PF00917	0.666
DEG_SPOP_SBC_1	354	358	PF00917	0.618
DEG_SPOP_SBC_1	414	418	PF00917	0.652
DOC_CDC14_PxL_1	109	117	PF14671	0.689
DOC_CKS1_1	379	384	PF01111	0.643
DOC_CKS1_1	420	425	PF01111	0.663
DOC_MAPK_gen_1	488	495	PF00069	0.573
DOC_MAPK_gen_1	551	558	PF00069	0.539
DOC_PP1_RVXF_1	370	376	PF00149	0.648
DOC_PP1_RVXF_1	796	803	PF00149	0.608
DOC_PP2B_LxvP_1	250	253	PF13499	0.646
DOC_PP2B_LxvP_1	57	60	PF13499	0.691
DOC_PP2B_LxvP_1	585	588	PF13499	0.760
DOC_PP4_FxxP_1	379	382	PF00568	0.639
DOC_PP4_FxxP_1	420	423	PF00568	0.657
DOC_USP7_MATH_1	133	137	PF00917	0.656
DOC_USP7_MATH_1	144	148	PF00917	0.561
DOC_USP7_MATH_1	180	184	PF00917	0.695
DOC_USP7_MATH_1	23	27	PF00917	0.685
DOC_USP7_MATH_1	235	239	PF00917	0.582
DOC_USP7_MATH_1	331	335	PF00917	0.735
DOC_USP7_MATH_1	353	357	PF00917	0.680
DOC_USP7_MATH_1	456	460	PF00917	0.656
DOC_USP7_MATH_1	588	592	PF00917	0.669
DOC_USP7_MATH_1	647	651	PF00917	0.660
DOC_USP7_MATH_1	683	687	PF00917	0.718
DOC_USP7_MATH_1	77	81	PF00917	0.581
DOC_USP7_MATH_1	773	777	PF00917	0.626
DOC_USP7_MATH_2	640	646	PF00917	0.597
DOC_USP7_UBL2_3	507	511	PF12436	0.530
DOC_WW_Pin1_4	115	120	PF00397	0.692
DOC_WW_Pin1_4	129	134	PF00397	0.558
DOC_WW_Pin1_4	142	147	PF00397	0.550
DOC_WW_Pin1_4	151	156	PF00397	0.576
DOC_WW_Pin1_4	181	186	PF00397	0.691
DOC_WW_Pin1_4	253	258	PF00397	0.578
DOC_WW_Pin1_4	35	40	PF00397	0.628
DOC_WW_Pin1_4	378	383	PF00397	0.638
DOC_WW_Pin1_4	419	424	PF00397	0.657
DOC_WW_Pin1_4	636	641	PF00397	0.693
DOC_WW_Pin1_4	80	85	PF00397	0.679
DOC_WW_Pin1_4	815	820	PF00397	0.633
LIG_14-3-3_CanoR_1	272	280	PF00244	0.698
LIG_14-3-3_CanoR_1	336	341	PF00244	0.644
LIG_14-3-3_CanoR_1	344	353	PF00244	0.668
LIG_14-3-3_CanoR_1	519	528	PF00244	0.587
LIG_14-3-3_CanoR_1	598	608	PF00244	0.570
LIG_14-3-3_CanoR_1	67	76	PF00244	0.606
LIG_14-3-3_CanoR_1	809	816	PF00244	0.663
LIG_14-3-3_CterR_2	838	840	PF00244	0.628
LIG_Actin_WH2_2	529	545	PF00022	0.532
LIG_BIR_III_2	660	664	PF00653	0.554
LIG_BIR_III_4	579	583	PF00653	0.616
LIG_BRCT_BRCA1_1	554	558	PF00533	0.616
LIG_BRCT_BRCA1_1	605	609	PF00533	0.657
LIG_BRCT_BRCA1_1	78	82	PF00533	0.685
LIG_CtBP_PxDLS_1	424	428	PF00389	0.682
LIG_deltaCOP1_diTrp_1	592	597	PF00928	0.616
LIG_FHA_1	138	144	PF00498	0.658
LIG_FHA_1	151	157	PF00498	0.572
LIG_FHA_1	202	208	PF00498	0.714
LIG_FHA_1	247	253	PF00498	0.596
LIG_FHA_1	420	426	PF00498	0.666
LIG_FHA_1	482	488	PF00498	0.613
LIG_FHA_2	132	138	PF00498	0.522
LIG_FHA_2	217	223	PF00498	0.650
LIG_FHA_2	23	29	PF00498	0.699
LIG_FHA_2	314	320	PF00498	0.647
LIG_FHA_2	396	402	PF00498	0.557
LIG_FHA_2	452	458	PF00498	0.661
LIG_FHA_2	465	471	PF00498	0.553
LIG_FHA_2	568	574	PF00498	0.527
LIG_FHA_2	614	620	PF00498	0.660
LIG_LIR_Apic_2	377	382	PF02991	0.637
LIG_LIR_Apic_2	417	423	PF02991	0.552
LIG_LIR_Apic_2	785	790	PF02991	0.631
LIG_LIR_Gen_1	368	378	PF02991	0.646
LIG_LIR_Gen_1	797	805	PF02991	0.604
LIG_LIR_Nem_3	196	200	PF02991	0.715
LIG_LIR_Nem_3	368	373	PF02991	0.651
LIG_LIR_Nem_3	374	378	PF02991	0.607
LIG_LIR_Nem_3	496	501	PF02991	0.546
LIG_LIR_Nem_3	591	597	PF02991	0.615
LIG_LIR_Nem_3	699	705	PF02991	0.667
LIG_LIR_Nem_3	797	802	PF02991	0.609
LIG_LIR_Nem_3	818	824	PF02991	0.562
LIG_LYPXL_yS_3	197	200	PF13949	0.544
LIG_MYND_1	584	588	PF01753	0.611
LIG_Pex14_2	375	379	PF04695	0.639
LIG_PTAP_UEV_1	236	241	PF05743	0.543
LIG_PTB_Apo_2	279	286	PF02174	0.587
LIG_PTB_Apo_2	393	400	PF02174	0.545
LIG_Rb_LxCxE_1	381	401	PF01857	0.646
LIG_SH2_CRK	217	221	PF00017	0.607
LIG_SH2_CRK	242	246	PF00017	0.670
LIG_SH2_CRK	787	791	PF00017	0.629
LIG_SH2_GRB2like	221	224	PF00017	0.645
LIG_SH2_GRB2like	694	697	PF00017	0.657
LIG_SH2_PTP2	500	503	PF00017	0.540
LIG_SH2_SRC	221	224	PF00017	0.645
LIG_SH2_SRC	692	695	PF00017	0.660
LIG_SH2_SRC	705	708	PF00017	0.544
LIG_SH2_STAP1	822	826	PF00017	0.527
LIG_SH2_STAT3	651	654	PF00017	0.605
LIG_SH2_STAT3	793	796	PF00017	0.628
LIG_SH2_STAT5	500	503	PF00017	0.540
LIG_SH2_STAT5	566	569	PF00017	0.638
LIG_SH2_STAT5	793	796	PF00017	0.628
LIG_SH3_1	659	665	PF00018	0.680
LIG_SH3_2	155	160	PF14604	0.657
LIG_SH3_3	152	158	PF00018	0.677
LIG_SH3_3	171	177	PF00018	0.538
LIG_SH3_3	234	240	PF00018	0.600
LIG_SH3_3	249	255	PF00018	0.616
LIG_SH3_3	283	289	PF00018	0.689
LIG_SH3_3	29	35	PF00018	0.770
LIG_SH3_3	634	640	PF00018	0.693
LIG_SH3_3	659	665	PF00018	0.693
LIG_SH3_3	750	756	PF00018	0.650
LIG_SH3_3	813	819	PF00018	0.591
LIG_SH3_CIN85_PxpxPR_1	707	712	PF14604	0.526
LIG_SUMO_SIM_par_1	524	529	PF11976	0.492
LIG_TYR_ITIM	215	220	PF00017	0.571
LIG_UBA3_1	1	10	PF00899	0.521
LIG_WW_3	165	169	PF00397	0.663
MOD_CDC14_SPxK_1	132	135	PF00782	0.607
MOD_CDK_SPK_2	181	186	PF00069	0.691
MOD_CDK_SPK_2	35	40	PF00069	0.681
MOD_CDK_SPxK_1	129	135	PF00069	0.616
MOD_CDK_SPxxK_3	253	260	PF00069	0.582
MOD_CK1_1	101	107	PF00069	0.589
MOD_CK1_1	21	27	PF00069	0.600
MOD_CK1_1	347	353	PF00069	0.712
MOD_CK1_1	365	371	PF00069	0.613
MOD_CK1_1	418	424	PF00069	0.642
MOD_CK1_1	426	432	PF00069	0.619
MOD_CK1_1	45	51	PF00069	0.611
MOD_CK1_1	476	482	PF00069	0.645
MOD_CK1_1	599	605	PF00069	0.648
MOD_CK1_1	61	67	PF00069	0.617
MOD_CK1_1	68	74	PF00069	0.629
MOD_CK1_1	80	86	PF00069	0.525
MOD_CK2_1	221	227	PF00069	0.678
MOD_CK2_1	451	457	PF00069	0.643
MOD_CK2_1	464	470	PF00069	0.572
MOD_CK2_1	599	605	PF00069	0.801
MOD_CK2_1	636	642	PF00069	0.618
MOD_DYRK1A_RPxSP_1	636	640	PF00069	0.691
MOD_DYRK1A_RPxSP_1	815	819	PF00069	0.580
MOD_GlcNHglycan	109	112	PF01048	0.572
MOD_GlcNHglycan	129	132	PF01048	0.517
MOD_GlcNHglycan	178	181	PF01048	0.588
MOD_GlcNHglycan	20	23	PF01048	0.563
MOD_GlcNHglycan	222	226	PF01048	0.642
MOD_GlcNHglycan	237	240	PF01048	0.530
MOD_GlcNHglycan	25	28	PF01048	0.539
MOD_GlcNHglycan	306	309	PF01048	0.676
MOD_GlcNHglycan	321	324	PF01048	0.656
MOD_GlcNHglycan	333	336	PF01048	0.695
MOD_GlcNHglycan	350	353	PF01048	0.569
MOD_GlcNHglycan	357	360	PF01048	0.672
MOD_GlcNHglycan	366	370	PF01048	0.636
MOD_GlcNHglycan	406	409	PF01048	0.643
MOD_GlcNHglycan	417	420	PF01048	0.641
MOD_GlcNHglycan	439	443	PF01048	0.699
MOD_GlcNHglycan	44	47	PF01048	0.555
MOD_GlcNHglycan	5	8	PF01048	0.587
MOD_GlcNHglycan	528	531	PF01048	0.631
MOD_GlcNHglycan	544	548	PF01048	0.687
MOD_GlcNHglycan	644	647	PF01048	0.682
MOD_GlcNHglycan	681	684	PF01048	0.583
MOD_GlcNHglycan	70	73	PF01048	0.633
MOD_GlcNHglycan	765	768	PF01048	0.744
MOD_GlcNHglycan	775	778	PF01048	0.604
MOD_GlcNHglycan	78	82	PF01048	0.637
MOD_GlcNHglycan	805	808	PF01048	0.585
MOD_GlcNHglycan	92	95	PF01048	0.573
MOD_GSK3_1	101	108	PF00069	0.553
MOD_GSK3_1	127	134	PF00069	0.674
MOD_GSK3_1	138	145	PF00069	0.571
MOD_GSK3_1	176	183	PF00069	0.691
MOD_GSK3_1	18	25	PF00069	0.622
MOD_GSK3_1	272	279	PF00069	0.697
MOD_GSK3_1	300	307	PF00069	0.683
MOD_GSK3_1	311	318	PF00069	0.724
MOD_GSK3_1	336	343	PF00069	0.762
MOD_GSK3_1	344	351	PF00069	0.719
MOD_GSK3_1	361	368	PF00069	0.648
MOD_GSK3_1	374	381	PF00069	0.581
MOD_GSK3_1	409	416	PF00069	0.656
MOD_GSK3_1	419	426	PF00069	0.583
MOD_GSK3_1	515	522	PF00069	0.535
MOD_GSK3_1	596	603	PF00069	0.639
MOD_GSK3_1	61	68	PF00069	0.684
MOD_GSK3_1	632	639	PF00069	0.633
MOD_GSK3_1	642	649	PF00069	0.629
MOD_GSK3_1	679	686	PF00069	0.640
MOD_GSK3_1	692	699	PF00069	0.606
MOD_GSK3_1	76	83	PF00069	0.557
MOD_GSK3_1	90	97	PF00069	0.568
MOD_N-GLC_1	331	336	PF02516	0.685
MOD_N-GLC_1	354	359	PF02516	0.617
MOD_N-GLC_1	395	400	PF02516	0.656
MOD_N-GLC_1	552	557	PF02516	0.647
MOD_N-GLC_1	588	593	PF02516	0.601
MOD_N-GLC_1	600	605	PF02516	0.570
MOD_N-GLC_1	679	684	PF02516	0.696
MOD_NEK2_1	300	305	PF00069	0.732
MOD_NEK2_1	340	345	PF00069	0.708
MOD_NEK2_1	404	409	PF00069	0.641
MOD_NEK2_1	413	418	PF00069	0.751
MOD_NEK2_1	464	469	PF00069	0.736
MOD_NEK2_1	473	478	PF00069	0.611
MOD_NEK2_1	493	498	PF00069	0.544
MOD_NEK2_1	526	531	PF00069	0.602
MOD_NEK2_1	597	602	PF00069	0.561
MOD_NEK2_1	632	637	PF00069	0.759
MOD_NEK2_1	76	81	PF00069	0.573
MOD_NEK2_2	216	221	PF00069	0.543
MOD_NEK2_2	820	825	PF00069	0.562
MOD_PIKK_1	144	150	PF00454	0.653
MOD_PIKK_1	476	482	PF00454	0.645
MOD_PIKK_1	493	499	PF00454	0.548
MOD_PIKK_1	519	525	PF00454	0.597
MOD_PIKK_1	61	67	PF00454	0.655
MOD_PIKK_1	748	754	PF00454	0.673
MOD_PIKK_1	98	104	PF00454	0.649
MOD_PK_1	524	530	PF00069	0.520
MOD_PKA_1	201	207	PF00069	0.654
MOD_PKA_1	272	278	PF00069	0.699
MOD_PKA_1	344	350	PF00069	0.664
MOD_PKA_2	201	207	PF00069	0.654
MOD_PKA_2	266	272	PF00069	0.677
MOD_PKA_2	340	346	PF00069	0.693
MOD_PKA_2	361	367	PF00069	0.570
MOD_PKA_2	429	435	PF00069	0.590
MOD_PKA_2	515	521	PF00069	0.595
MOD_PKA_2	597	603	PF00069	0.642
MOD_PKA_2	808	814	PF00069	0.591
MOD_PKB_1	541	549	PF00069	0.554
MOD_Plk_1	395	401	PF00069	0.628
MOD_Plk_1	473	479	PF00069	0.654
MOD_Plk_1	552	558	PF00069	0.619
MOD_Plk_1	573	579	PF00069	0.610
MOD_Plk_1	603	609	PF00069	0.656
MOD_Plk_1	647	653	PF00069	0.605
MOD_Plk_1	683	689	PF00069	0.645
MOD_Plk_1	800	806	PF00069	0.516
MOD_Plk_2-3	573	579	PF00069	0.610
MOD_Plk_2-3	613	619	PF00069	0.632
MOD_Plk_4	138	144	PF00069	0.551
MOD_Plk_4	216	222	PF00069	0.662
MOD_Plk_4	240	246	PF00069	0.747
MOD_Plk_4	374	380	PF00069	0.641
MOD_Plk_4	395	401	PF00069	0.628
MOD_Plk_4	510	516	PF00069	0.545
MOD_Plk_4	552	558	PF00069	0.646
MOD_Plk_4	573	579	PF00069	0.629
MOD_Plk_4	603	609	PF00069	0.656
MOD_ProDKin_1	115	121	PF00069	0.690
MOD_ProDKin_1	129	135	PF00069	0.557
MOD_ProDKin_1	142	148	PF00069	0.550
MOD_ProDKin_1	151	157	PF00069	0.578
MOD_ProDKin_1	181	187	PF00069	0.688
MOD_ProDKin_1	253	259	PF00069	0.580
MOD_ProDKin_1	35	41	PF00069	0.623
MOD_ProDKin_1	378	384	PF00069	0.642
MOD_ProDKin_1	419	425	PF00069	0.661
MOD_ProDKin_1	636	642	PF00069	0.694
MOD_ProDKin_1	80	86	PF00069	0.678
MOD_ProDKin_1	815	821	PF00069	0.633
MOD_SUMO_rev_2	806	816	PF00179	0.591
MOD_SUMO_rev_2	834	840	PF00179	0.552
TRG_DiLeu_BaEn_1	510	515	PF01217	0.584
TRG_DiLeu_BaLyEn_6	581	586	PF01217	0.607
TRG_ENDOCYTIC_2	197	200	PF00928	0.686
TRG_ENDOCYTIC_2	217	220	PF00928	0.581
TRG_ENDOCYTIC_2	242	245	PF00928	0.670
TRG_ENDOCYTIC_2	500	503	PF00928	0.540
TRG_ER_diArg_1	200	202	PF00400	0.659
TRG_ER_diArg_1	271	273	PF00400	0.706
TRG_ER_diArg_1	487	489	PF00400	0.693
TRG_ER_diArg_1	672	675	PF00400	0.625
TRG_ER_diArg_1	719	722	PF00400	0.706
TRG_NLS_MonoExtC_3	433	439	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.732
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I704	Leishmania infantum	99%	100%
E9B222	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q640	Leishmania major	84%	100%