Spliced leader RNA PSE-promoter transcription factor, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliced leader RNA PSE-promoter transcription factor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICN9_LEIDO

TriTrypDb:

LdBPK_260560.1 , LdCL_260011300 , LDHU3_26.0750

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.595
CLV_C14_Caspase3-7	431	435	PF00656	0.673
CLV_NRD_NRD_1	157	159	PF00675	0.648
CLV_NRD_NRD_1	323	325	PF00675	0.490
CLV_NRD_NRD_1	34	36	PF00675	0.635
CLV_NRD_NRD_1	342	344	PF00675	0.466
CLV_NRD_NRD_1	466	468	PF00675	0.582
CLV_NRD_NRD_1	495	497	PF00675	0.523
CLV_NRD_NRD_1	500	502	PF00675	0.553
CLV_NRD_NRD_1	566	568	PF00675	0.576
CLV_NRD_NRD_1	577	579	PF00675	0.462
CLV_NRD_NRD_1	60	62	PF00675	0.573
CLV_NRD_NRD_1	93	95	PF00675	0.517
CLV_PCSK_FUR_1	58	62	PF00082	0.582
CLV_PCSK_FUR_1	90	94	PF00082	0.564
CLV_PCSK_KEX2_1	157	159	PF00082	0.617
CLV_PCSK_KEX2_1	34	36	PF00082	0.618
CLV_PCSK_KEX2_1	342	344	PF00082	0.466
CLV_PCSK_KEX2_1	466	468	PF00082	0.585
CLV_PCSK_KEX2_1	495	497	PF00082	0.561
CLV_PCSK_KEX2_1	499	501	PF00082	0.581
CLV_PCSK_KEX2_1	566	568	PF00082	0.576
CLV_PCSK_KEX2_1	577	579	PF00082	0.462
CLV_PCSK_KEX2_1	60	62	PF00082	0.575
CLV_PCSK_KEX2_1	75	77	PF00082	0.601
CLV_PCSK_KEX2_1	89	91	PF00082	0.430
CLV_PCSK_KEX2_1	92	94	PF00082	0.400
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.636
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.591
CLV_PCSK_PC7_1	495	501	PF00082	0.618
CLV_PCSK_PC7_1	56	62	PF00082	0.585
CLV_PCSK_SKI1_1	256	260	PF00082	0.476
CLV_PCSK_SKI1_1	347	351	PF00082	0.438
CLV_PCSK_SKI1_1	375	379	PF00082	0.496
CLV_PCSK_SKI1_1	632	636	PF00082	0.405
DEG_APCC_DBOX_1	255	263	PF00400	0.499
DEG_APCC_DBOX_1	355	363	PF00400	0.464
DEG_Nend_UBRbox_4	1	3	PF02207	0.577
DOC_CDC14_PxL_1	264	272	PF14671	0.532
DOC_CYCLIN_RxL_1	31	42	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.652
DOC_MAPK_DCC_7	75	83	PF00069	0.595
DOC_MAPK_gen_1	31	39	PF00069	0.698
DOC_MAPK_gen_1	564	572	PF00069	0.584
DOC_MAPK_gen_1	58	66	PF00069	0.568
DOC_MAPK_JIP1_4	58	64	PF00069	0.574
DOC_MAPK_MEF2A_6	290	297	PF00069	0.447
DOC_PP2B_LxvP_1	23	26	PF13499	0.631
DOC_PP2B_LxvP_1	239	242	PF13499	0.589
DOC_PP2B_LxvP_1	450	453	PF13499	0.769
DOC_PP2B_LxvP_1	531	534	PF13499	0.559
DOC_PP2B_LxvP_1	62	65	PF13499	0.564
DOC_PP2B_LxvP_1	643	646	PF13499	0.634
DOC_USP7_MATH_1	174	178	PF00917	0.819
DOC_USP7_MATH_1	190	194	PF00917	0.693
DOC_USP7_MATH_1	209	213	PF00917	0.629
DOC_USP7_MATH_1	388	392	PF00917	0.445
DOC_USP7_MATH_1	428	432	PF00917	0.591
DOC_USP7_MATH_1	442	446	PF00917	0.669
DOC_USP7_MATH_1	539	543	PF00917	0.540
DOC_USP7_MATH_1	559	563	PF00917	0.290
DOC_USP7_MATH_1	655	659	PF00917	0.705
DOC_WW_Pin1_4	132	137	PF00397	0.491
DOC_WW_Pin1_4	180	185	PF00397	0.768
DOC_WW_Pin1_4	191	196	PF00397	0.582
DOC_WW_Pin1_4	201	206	PF00397	0.587
DOC_WW_Pin1_4	21	26	PF00397	0.741
DOC_WW_Pin1_4	234	239	PF00397	0.453
DOC_WW_Pin1_4	445	450	PF00397	0.662
DOC_WW_Pin1_4	541	546	PF00397	0.517
DOC_WW_Pin1_4	565	570	PF00397	0.575
DOC_WW_Pin1_4	644	649	PF00397	0.640
DOC_WW_Pin1_4	691	696	PF00397	0.645
LIG_14-3-3_CanoR_1	34	38	PF00244	0.633
LIG_14-3-3_CanoR_1	640	646	PF00244	0.679
LIG_14-3-3_CanoR_1	693	703	PF00244	0.690
LIG_Actin_WH2_2	403	419	PF00022	0.495
LIG_APCC_ABBA_1	360	365	PF00400	0.427
LIG_BRCT_BRCA1_1	197	201	PF00533	0.643
LIG_BRCT_BRCA1_1	375	379	PF00533	0.470
LIG_BRCT_BRCA1_1	50	54	PF00533	0.703
LIG_CaM_IQ_9	328	344	PF13499	0.522
LIG_CaM_NSCaTE_8	346	353	PF13499	0.439
LIG_FHA_1	123	129	PF00498	0.581
LIG_FHA_1	219	225	PF00498	0.598
LIG_FHA_1	281	287	PF00498	0.505
LIG_FHA_1	4	10	PF00498	0.590
LIG_FHA_1	445	451	PF00498	0.776
LIG_FHA_1	511	517	PF00498	0.570
LIG_FHA_1	671	677	PF00498	0.696
LIG_FHA_2	136	142	PF00498	0.582
LIG_FHA_2	215	221	PF00498	0.648
LIG_FHA_2	388	394	PF00498	0.479
LIG_FHA_2	477	483	PF00498	0.494
LIG_FHA_2	651	657	PF00498	0.689
LIG_FHA_2	694	700	PF00498	0.676
LIG_Integrin_isoDGR_2	666	668	PF01839	0.655
LIG_Integrin_RGD_1	250	252	PF01839	0.533
LIG_LIR_Gen_1	228	239	PF02991	0.529
LIG_LIR_Gen_1	376	387	PF02991	0.331
LIG_LIR_Gen_1	585	594	PF02991	0.554
LIG_LIR_Nem_3	114	119	PF02991	0.570
LIG_LIR_Nem_3	228	234	PF02991	0.458
LIG_LIR_Nem_3	261	267	PF02991	0.446
LIG_LIR_Nem_3	376	382	PF02991	0.325
LIG_LIR_Nem_3	51	57	PF02991	0.690
LIG_LIR_Nem_3	526	531	PF02991	0.552
LIG_LIR_Nem_3	585	591	PF02991	0.537
LIG_LYPXL_SIV_4	148	156	PF13949	0.558
LIG_LYPXL_yS_3	267	270	PF13949	0.453
LIG_MLH1_MIPbox_1	50	54	PF16413	0.703
LIG_MYND_1	21	25	PF01753	0.628
LIG_NRBOX	141	147	PF00104	0.505
LIG_PCNA_PIPBox_1	631	640	PF02747	0.426
LIG_PDZ_Class_2	698	703	PF00595	0.633
LIG_Pex14_1	373	377	PF04695	0.507
LIG_Pex14_2	377	381	PF04695	0.490
LIG_PTB_Apo_2	76	83	PF02174	0.565
LIG_SH2_CRK	116	120	PF00017	0.480
LIG_SH2_CRK	588	592	PF00017	0.575
LIG_SH2_NCK_1	197	201	PF00017	0.643
LIG_SH2_STAP1	197	201	PF00017	0.643
LIG_SH2_STAT3	557	560	PF00017	0.615
LIG_SH2_STAT5	53	56	PF00017	0.694
LIG_SH2_STAT5	602	605	PF00017	0.420
LIG_SH2_STAT5	612	615	PF00017	0.431
LIG_SH2_STAT5	638	641	PF00017	0.427
LIG_SH3_3	19	25	PF00018	0.629
LIG_SH3_3	434	440	PF00018	0.631
LIG_SH3_3	446	452	PF00018	0.679
LIG_SH3_3	62	68	PF00018	0.585
LIG_SH3_3	684	690	PF00018	0.761
LIG_Sin3_3	551	558	PF02671	0.552
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.591
LIG_SUMO_SIM_par_1	220	226	PF11976	0.602
LIG_SUMO_SIM_par_1	257	263	PF11976	0.526
LIG_SUMO_SIM_par_1	5	11	PF11976	0.529
LIG_SUMO_SIM_par_1	568	573	PF11976	0.453
LIG_SUMO_SIM_par_1	578	585	PF11976	0.493
LIG_TRAF2_1	696	699	PF00917	0.684
LIG_WRC_WIRS_1	374	379	PF05994	0.500
MOD_CDC14_SPxK_1	651	654	PF00782	0.643
MOD_CDK_SPK_2	132	137	PF00069	0.476
MOD_CDK_SPK_2	180	185	PF00069	0.737
MOD_CDK_SPxK_1	648	654	PF00069	0.602
MOD_CK1_1	16	22	PF00069	0.733
MOD_CK1_1	212	218	PF00069	0.715
MOD_CK1_1	24	30	PF00069	0.718
MOD_CK1_1	445	451	PF00069	0.704
MOD_CK1_1	644	650	PF00069	0.669
MOD_CK1_1	659	665	PF00069	0.696
MOD_CK1_1	694	700	PF00069	0.748
MOD_CK2_1	170	176	PF00069	0.806
MOD_CK2_1	220	226	PF00069	0.592
MOD_CK2_1	476	482	PF00069	0.510
MOD_CK2_1	644	650	PF00069	0.653
MOD_CK2_1	693	699	PF00069	0.610
MOD_GlcNHglycan	158	161	PF01048	0.579
MOD_GlcNHglycan	162	165	PF01048	0.728
MOD_GlcNHglycan	172	175	PF01048	0.685
MOD_GlcNHglycan	214	217	PF01048	0.689
MOD_GlcNHglycan	264	267	PF01048	0.522
MOD_GlcNHglycan	351	354	PF01048	0.443
MOD_GlcNHglycan	389	393	PF01048	0.437
MOD_GlcNHglycan	444	447	PF01048	0.719
MOD_GlcNHglycan	505	509	PF01048	0.566
MOD_GlcNHglycan	623	626	PF01048	0.571
MOD_GlcNHglycan	643	646	PF01048	0.387
MOD_GSK3_1	156	163	PF00069	0.571
MOD_GSK3_1	170	177	PF00069	0.778
MOD_GSK3_1	191	198	PF00069	0.612
MOD_GSK3_1	208	215	PF00069	0.625
MOD_GSK3_1	21	28	PF00069	0.532
MOD_GSK3_1	29	36	PF00069	0.501
MOD_GSK3_1	444	451	PF00069	0.698
MOD_GSK3_1	644	651	PF00069	0.596
MOD_GSK3_1	655	662	PF00069	0.696
MOD_GSK3_1	66	73	PF00069	0.540
MOD_GSK3_1	8	15	PF00069	0.587
MOD_NEK2_1	156	161	PF00069	0.627
MOD_NEK2_1	254	259	PF00069	0.408
MOD_NEK2_1	260	265	PF00069	0.435
MOD_NEK2_1	279	284	PF00069	0.268
MOD_NEK2_1	33	38	PF00069	0.718
MOD_NEK2_1	387	392	PF00069	0.484
MOD_NEK2_1	39	44	PF00069	0.693
MOD_NEK2_1	405	410	PF00069	0.403
MOD_NEK2_1	504	509	PF00069	0.565
MOD_NEK2_1	540	545	PF00069	0.516
MOD_PIKK_1	122	128	PF00454	0.569
MOD_PIKK_1	405	411	PF00454	0.416
MOD_PIKK_1	510	516	PF00454	0.573
MOD_PK_1	108	114	PF00069	0.585
MOD_PKA_2	156	162	PF00069	0.635
MOD_PKA_2	33	39	PF00069	0.635
MOD_PKB_1	691	699	PF00069	0.630
MOD_Plk_1	108	114	PF00069	0.476
MOD_Plk_1	260	266	PF00069	0.500
MOD_Plk_1	457	463	PF00069	0.556
MOD_Plk_1	600	606	PF00069	0.428
MOD_Plk_1	627	633	PF00069	0.477
MOD_Plk_2-3	220	226	PF00069	0.650
MOD_Plk_4	141	147	PF00069	0.548
MOD_Plk_4	618	624	PF00069	0.472
MOD_ProDKin_1	132	138	PF00069	0.486
MOD_ProDKin_1	180	186	PF00069	0.767
MOD_ProDKin_1	191	197	PF00069	0.575
MOD_ProDKin_1	201	207	PF00069	0.591
MOD_ProDKin_1	21	27	PF00069	0.742
MOD_ProDKin_1	234	240	PF00069	0.455
MOD_ProDKin_1	445	451	PF00069	0.661
MOD_ProDKin_1	541	547	PF00069	0.509
MOD_ProDKin_1	565	571	PF00069	0.570
MOD_ProDKin_1	644	650	PF00069	0.643
MOD_ProDKin_1	691	697	PF00069	0.651
TRG_DiLeu_BaEn_2	280	286	PF01217	0.449
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.570
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.412
TRG_DiLeu_BaLyEn_6	531	536	PF01217	0.508
TRG_ENDOCYTIC_2	116	119	PF00928	0.527
TRG_ENDOCYTIC_2	267	270	PF00928	0.424
TRG_ENDOCYTIC_2	403	406	PF00928	0.482
TRG_ENDOCYTIC_2	528	531	PF00928	0.606
TRG_ENDOCYTIC_2	588	591	PF00928	0.568
TRG_ENDOCYTIC_2	597	600	PF00928	0.433
TRG_ENDOCYTIC_2	638	641	PF00928	0.491
TRG_ER_diArg_1	156	158	PF00400	0.638
TRG_ER_diArg_1	268	271	PF00400	0.414
TRG_ER_diArg_1	319	322	PF00400	0.531
TRG_ER_diArg_1	33	35	PF00400	0.643
TRG_ER_diArg_1	342	344	PF00400	0.466
TRG_ER_diArg_1	397	400	PF00400	0.572
TRG_ER_diArg_1	414	417	PF00400	0.381
TRG_ER_diArg_1	466	468	PF00400	0.579
TRG_ER_diArg_1	499	501	PF00400	0.665
TRG_ER_diArg_1	565	567	PF00400	0.567
TRG_ER_diArg_1	57	60	PF00400	0.591
TRG_ER_diArg_1	576	578	PF00400	0.476
TRG_ER_diArg_1	690	693	PF00400	0.685
TRG_ER_diArg_1	90	93	PF00400	0.510
TRG_NES_CRM1_1	312	326	PF08389	0.510
TRG_NLS_Bipartite_1	75	93	PF00514	0.584
TRG_NLS_MonoExtC_3	88	93	PF00514	0.572
TRG_NLS_MonoExtN_4	86	93	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A3	Leptomonas seymouri	64%	100%
A0A0S4JUQ3	Bodo saltans	38%	100%
A0A1X0NT43	Trypanosomatidae	47%	100%
A0A422N5D7	Trypanosoma rangeli	47%	100%
A4HER4	Leishmania braziliensis	81%	100%
A4I1Z1	Leishmania infantum	100%	100%
C9ZS25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AY38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9D5	Leishmania major	95%	100%
V5BPZ1	Trypanosoma cruzi	48%	100%