RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICN8_LEIDO

TriTrypDb:

LdBPK_161600.1 , LdCL_160021000 , LDHU3_16.1900

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	416	420	PF00656	0.563
CLV_NRD_NRD_1	139	141	PF00675	0.412
CLV_NRD_NRD_1	147	149	PF00675	0.392
CLV_NRD_NRD_1	216	218	PF00675	0.507
CLV_NRD_NRD_1	267	269	PF00675	0.491
CLV_NRD_NRD_1	3	5	PF00675	0.652
CLV_NRD_NRD_1	475	477	PF00675	0.528
CLV_NRD_NRD_1	48	50	PF00675	0.434
CLV_NRD_NRD_1	556	558	PF00675	0.540
CLV_NRD_NRD_1	567	569	PF00675	0.536
CLV_PCSK_KEX2_1	11	13	PF00082	0.512
CLV_PCSK_KEX2_1	139	141	PF00082	0.488
CLV_PCSK_KEX2_1	147	149	PF00082	0.436
CLV_PCSK_KEX2_1	216	218	PF00082	0.568
CLV_PCSK_KEX2_1	267	269	PF00082	0.491
CLV_PCSK_KEX2_1	3	5	PF00082	0.599
CLV_PCSK_KEX2_1	31	33	PF00082	0.376
CLV_PCSK_KEX2_1	475	477	PF00082	0.528
CLV_PCSK_KEX2_1	48	50	PF00082	0.434
CLV_PCSK_KEX2_1	556	558	PF00082	0.540
CLV_PCSK_KEX2_1	567	569	PF00082	0.536
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.555
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.376
CLV_PCSK_SKI1_1	186	190	PF00082	0.510
CLV_PCSK_SKI1_1	267	271	PF00082	0.430
CLV_PCSK_SKI1_1	309	313	PF00082	0.415
CLV_PCSK_SKI1_1	461	465	PF00082	0.624
CLV_PCSK_SKI1_1	475	479	PF00082	0.475
CLV_PCSK_SKI1_1	545	549	PF00082	0.577
CLV_PCSK_SKI1_1	66	70	PF00082	0.504
CLV_PCSK_SKI1_1	74	78	PF00082	0.464
CLV_Separin_Metazoa	223	227	PF03568	0.449
DEG_APCC_DBOX_1	326	334	PF00400	0.297
DEG_APCC_DBOX_1	474	482	PF00400	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DOC_CKS1_1	346	351	PF01111	0.591
DOC_CYCLIN_RxL_1	61	72	PF00134	0.563
DOC_MAPK_gen_1	147	153	PF00069	0.520
DOC_MAPK_gen_1	3	9	PF00069	0.571
DOC_MAPK_gen_1	84	94	PF00069	0.461
DOC_MAPK_MEF2A_6	293	302	PF00069	0.501
DOC_MAPK_MEF2A_6	87	95	PF00069	0.439
DOC_PP2B_LxvP_1	343	346	PF13499	0.473
DOC_PP4_FxxP_1	375	378	PF00568	0.456
DOC_USP7_MATH_1	396	400	PF00917	0.593
DOC_WW_Pin1_4	10	15	PF00397	0.553
DOC_WW_Pin1_4	173	178	PF00397	0.447
DOC_WW_Pin1_4	193	198	PF00397	0.417
DOC_WW_Pin1_4	315	320	PF00397	0.422
DOC_WW_Pin1_4	345	350	PF00397	0.652
DOC_WW_Pin1_4	374	379	PF00397	0.719
LIG_14-3-3_CanoR_1	170	178	PF00244	0.555
LIG_14-3-3_CanoR_1	20	25	PF00244	0.464
LIG_14-3-3_CanoR_1	249	255	PF00244	0.441
LIG_14-3-3_CanoR_1	283	289	PF00244	0.407
LIG_14-3-3_CanoR_1	293	299	PF00244	0.537
LIG_14-3-3_CanoR_1	3	8	PF00244	0.619
LIG_14-3-3_CanoR_1	556	566	PF00244	0.579
LIG_Actin_WH2_2	236	251	PF00022	0.452
LIG_APCC_ABBA_1	326	331	PF00400	0.406
LIG_APCC_ABBA_1	434	439	PF00400	0.526
LIG_BRCT_BRCA1_1	313	317	PF00533	0.517
LIG_DLG_GKlike_1	20	27	PF00625	0.640
LIG_FHA_1	187	193	PF00498	0.512
LIG_FHA_1	204	210	PF00498	0.425
LIG_FHA_1	283	289	PF00498	0.477
LIG_FHA_1	346	352	PF00498	0.734
LIG_FHA_1	360	366	PF00498	0.695
LIG_FHA_1	462	468	PF00498	0.496
LIG_FHA_1	489	495	PF00498	0.468
LIG_FHA_1	524	530	PF00498	0.572
LIG_FHA_1	558	564	PF00498	0.577
LIG_FHA_1	75	81	PF00498	0.523
LIG_FHA_2	159	165	PF00498	0.461
LIG_FHA_2	174	180	PF00498	0.297
LIG_FHA_2	23	29	PF00498	0.532
LIG_FHA_2	316	322	PF00498	0.401
LIG_GBD_Chelix_1	298	306	PF00786	0.537
LIG_LIR_Apic_2	373	378	PF02991	0.454
LIG_LIR_Gen_1	115	125	PF02991	0.500
LIG_LIR_Gen_1	205	214	PF02991	0.507
LIG_LIR_Gen_1	355	365	PF02991	0.524
LIG_LIR_Gen_1	422	431	PF02991	0.512
LIG_LIR_Nem_3	115	120	PF02991	0.483
LIG_LIR_Nem_3	143	149	PF02991	0.417
LIG_LIR_Nem_3	205	210	PF02991	0.506
LIG_LIR_Nem_3	355	361	PF02991	0.528
LIG_LIR_Nem_3	422	427	PF02991	0.537
LIG_LIR_Nem_3	72	76	PF02991	0.393
LIG_LYPXL_SIV_4	423	431	PF13949	0.568
LIG_NRBOX	493	499	PF00104	0.444
LIG_PCNA_PIPBox_1	430	439	PF02747	0.492
LIG_PCNA_yPIPBox_3	215	228	PF02747	0.475
LIG_Pex14_2	100	104	PF04695	0.400
LIG_SH2_CRK	146	150	PF00017	0.489
LIG_SH2_SRC	329	332	PF00017	0.479
LIG_SH2_SRC	437	440	PF00017	0.455
LIG_SH2_STAT5	16	19	PF00017	0.515
LIG_SH2_STAT5	329	332	PF00017	0.417
LIG_SH2_STAT5	34	37	PF00017	0.461
LIG_SH2_STAT5	424	427	PF00017	0.464
LIG_SH2_STAT5	437	440	PF00017	0.405
LIG_SH2_STAT5	75	78	PF00017	0.505
LIG_SH3_3	152	158	PF00018	0.542
LIG_SH3_3	218	224	PF00018	0.496
LIG_SH3_3	343	349	PF00018	0.624
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.442
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.394
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.530
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.475
LIG_SUMO_SIM_par_1	490	496	PF11976	0.473
LIG_TRAF2_1	161	164	PF00917	0.467
LIG_TRAF2_1	520	523	PF00917	0.414
LIG_UBA3_1	485	490	PF00899	0.562
MOD_CK1_1	10	16	PF00069	0.544
MOD_CK1_1	22	28	PF00069	0.529
MOD_CK1_1	337	343	PF00069	0.516
MOD_CK1_1	368	374	PF00069	0.697
MOD_CK1_1	379	385	PF00069	0.583
MOD_CK1_1	399	405	PF00069	0.489
MOD_CK1_1	426	432	PF00069	0.466
MOD_CK2_1	158	164	PF00069	0.397
MOD_CK2_1	173	179	PF00069	0.304
MOD_CK2_1	20	26	PF00069	0.532
MOD_CK2_1	315	321	PF00069	0.400
MOD_CK2_1	426	432	PF00069	0.516
MOD_CK2_1	490	496	PF00069	0.468
MOD_CK2_1	52	58	PF00069	0.579
MOD_GlcNHglycan	289	292	PF01048	0.508
MOD_GlcNHglycan	336	339	PF01048	0.442
MOD_GlcNHglycan	370	373	PF01048	0.716
MOD_GlcNHglycan	410	413	PF01048	0.428
MOD_GlcNHglycan	419	422	PF01048	0.450
MOD_GlcNHglycan	508	511	PF01048	0.566
MOD_GlcNHglycan	535	538	PF01048	0.534
MOD_GSK3_1	277	284	PF00069	0.370
MOD_GSK3_1	3	10	PF00069	0.645
MOD_GSK3_1	311	318	PF00069	0.435
MOD_GSK3_1	370	377	PF00069	0.714
MOD_GSK3_1	419	426	PF00069	0.536
MOD_LATS_1	554	560	PF00433	0.557
MOD_NEK2_1	180	185	PF00069	0.529
MOD_NEK2_1	2	7	PF00069	0.560
MOD_NEK2_1	27	32	PF00069	0.574
MOD_NEK2_1	287	292	PF00069	0.445
MOD_NEK2_1	365	370	PF00069	0.722
MOD_NEK2_1	417	422	PF00069	0.496
MOD_NEK2_1	480	485	PF00069	0.390
MOD_PIKK_1	186	192	PF00454	0.519
MOD_PIKK_1	426	432	PF00454	0.479
MOD_PKA_1	3	9	PF00069	0.571
MOD_PKA_1	556	562	PF00069	0.590
MOD_PKA_2	19	25	PF00069	0.486
MOD_PKA_2	2	8	PF00069	0.588
MOD_PKA_2	282	288	PF00069	0.401
MOD_PKA_2	292	298	PF00069	0.536
MOD_PKA_2	556	562	PF00069	0.567
MOD_PKB_1	543	551	PF00069	0.599
MOD_Plk_2-3	159	165	PF00069	0.535
MOD_Plk_4	180	186	PF00069	0.409
MOD_Plk_4	3	9	PF00069	0.716
MOD_Plk_4	354	360	PF00069	0.755
MOD_Plk_4	370	376	PF00069	0.664
MOD_ProDKin_1	10	16	PF00069	0.544
MOD_ProDKin_1	173	179	PF00069	0.451
MOD_ProDKin_1	193	199	PF00069	0.412
MOD_ProDKin_1	315	321	PF00069	0.414
MOD_ProDKin_1	345	351	PF00069	0.657
MOD_ProDKin_1	374	380	PF00069	0.717
TRG_DiLeu_BaEn_1	124	129	PF01217	0.514
TRG_DiLeu_BaEn_1	496	501	PF01217	0.433
TRG_ENDOCYTIC_2	146	149	PF00928	0.433
TRG_ENDOCYTIC_2	424	427	PF00928	0.504
TRG_ENDOCYTIC_2	73	76	PF00928	0.405
TRG_ER_diArg_1	138	140	PF00400	0.474
TRG_ER_diArg_1	146	148	PF00400	0.439
TRG_ER_diArg_1	2	4	PF00400	0.619
TRG_ER_diArg_1	216	219	PF00400	0.555
TRG_ER_diArg_1	225	228	PF00400	0.532
TRG_ER_diArg_1	267	269	PF00400	0.491
TRG_ER_diArg_1	387	390	PF00400	0.653
TRG_ER_diArg_1	48	50	PF00400	0.434
TRG_ER_diArg_1	556	558	PF00400	0.507
TRG_ER_diArg_1	566	568	PF00400	0.492
TRG_NES_CRM1_1	321	331	PF08389	0.383
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	389	394	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T4	Leptomonas seymouri	65%	98%
A0A1X0NYU8	Trypanosomatidae	42%	100%
A0A422N437	Trypanosoma rangeli	40%	100%
A4H8S9	Leishmania braziliensis	82%	100%
A4HX48	Leishmania infantum	99%	100%
C9ZVU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QEL5	Leishmania major	94%	99%
V5B2M3	Trypanosoma cruzi	39%	100%