Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICN6_LEIDO

TriTrypDb:

LdBPK_271110.1 , LdCL_270017600 , LDHU3_27.1740

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.551
CLV_C14_Caspase3-7	84	88	PF00656	0.498
CLV_NRD_NRD_1	132	134	PF00675	0.480
CLV_NRD_NRD_1	185	187	PF00675	0.463
CLV_NRD_NRD_1	237	239	PF00675	0.526
CLV_NRD_NRD_1	255	257	PF00675	0.390
CLV_NRD_NRD_1	319	321	PF00675	0.464
CLV_NRD_NRD_1	345	347	PF00675	0.545
CLV_NRD_NRD_1	428	430	PF00675	0.718
CLV_PCSK_FUR_1	234	238	PF00082	0.618
CLV_PCSK_FUR_1	317	321	PF00082	0.461
CLV_PCSK_KEX2_1	236	238	PF00082	0.504
CLV_PCSK_KEX2_1	255	257	PF00082	0.416
CLV_PCSK_KEX2_1	294	296	PF00082	0.570
CLV_PCSK_KEX2_1	319	321	PF00082	0.464
CLV_PCSK_KEX2_1	322	324	PF00082	0.495
CLV_PCSK_KEX2_1	428	430	PF00082	0.623
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.487
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.616
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.514
CLV_PCSK_PC7_1	424	430	PF00082	0.659
CLV_PCSK_SKI1_1	125	129	PF00082	0.445
CLV_PCSK_SKI1_1	148	152	PF00082	0.467
CLV_PCSK_SKI1_1	319	323	PF00082	0.503
CLV_PCSK_SKI1_1	366	370	PF00082	0.521
CLV_PCSK_SKI1_1	469	473	PF00082	0.680
CLV_Separin_Metazoa	159	163	PF03568	0.479
CLV_Separin_Metazoa	197	201	PF03568	0.441
DEG_APCC_DBOX_1	147	155	PF00400	0.441
DOC_MAPK_FxFP_2	408	411	PF00069	0.582
DOC_MAPK_JIP1_4	275	281	PF00069	0.549
DOC_PP1_RVXF_1	308	315	PF00149	0.527
DOC_PP4_FxxP_1	33	36	PF00568	0.501
DOC_PP4_FxxP_1	368	371	PF00568	0.508
DOC_PP4_FxxP_1	408	411	PF00568	0.582
DOC_USP7_MATH_1	243	247	PF00917	0.596
DOC_USP7_MATH_1	460	464	PF00917	0.782
DOC_USP7_MATH_1	496	500	PF00917	0.801
DOC_USP7_UBL2_3	290	294	PF12436	0.546
DOC_WW_Pin1_4	446	451	PF00397	0.710
DOC_WW_Pin1_4	453	458	PF00397	0.699
DOC_WW_Pin1_4	463	468	PF00397	0.630
DOC_WW_Pin1_4	497	502	PF00397	0.665
DOC_WW_Pin1_4	505	510	PF00397	0.698
LIG_14-3-3_CanoR_1	221	227	PF00244	0.510
LIG_14-3-3_CanoR_1	484	490	PF00244	0.697
LIG_Actin_WH2_2	112	127	PF00022	0.484
LIG_APCC_ABBA_1	331	336	PF00400	0.511
LIG_APCC_ABBA_1	395	400	PF00400	0.594
LIG_Clathr_ClatBox_1	442	446	PF01394	0.641
LIG_Clathr_ClatBox_1	55	59	PF01394	0.553
LIG_FHA_1	155	161	PF00498	0.485
LIG_FHA_1	316	322	PF00498	0.479
LIG_FHA_1	50	56	PF00498	0.576
LIG_FHA_1	68	74	PF00498	0.636
LIG_FHA_2	142	148	PF00498	0.439
LIG_FHA_2	203	209	PF00498	0.592
LIG_FHA_2	223	229	PF00498	0.373
LIG_FHA_2	266	272	PF00498	0.498
LIG_FHA_2	391	397	PF00498	0.709
LIG_FHA_2	43	49	PF00498	0.701
LIG_FHA_2	509	515	PF00498	0.777
LIG_FHA_2	58	64	PF00498	0.468
LIG_FHA_2	79	85	PF00498	0.524
LIG_LIR_Apic_2	30	36	PF02991	0.496
LIG_LIR_Gen_1	110	119	PF02991	0.475
LIG_LIR_Gen_1	376	384	PF02991	0.489
LIG_LIR_Gen_1	81	89	PF02991	0.504
LIG_LIR_Nem_3	110	115	PF02991	0.487
LIG_LIR_Nem_3	163	168	PF02991	0.553
LIG_LIR_Nem_3	376	381	PF02991	0.488
LIG_PTB_Apo_2	280	287	PF02174	0.570
LIG_SH2_CRK	112	116	PF00017	0.481
LIG_SH2_GRB2like	78	81	PF00017	0.511
LIG_SH2_STAP1	297	301	PF00017	0.508
LIG_SH2_STAP1	375	379	PF00017	0.538
LIG_SH2_STAT5	16	19	PF00017	0.551
LIG_SH2_STAT5	204	207	PF00017	0.503
LIG_SH2_STAT5	215	218	PF00017	0.441
LIG_SH2_STAT5	57	60	PF00017	0.569
LIG_SH2_STAT5	78	81	PF00017	0.511
LIG_SH2_STAT5	82	85	PF00017	0.503
LIG_SH3_3	124	130	PF00018	0.482
LIG_SH3_3	155	161	PF00018	0.480
LIG_SH3_3	454	460	PF00018	0.774
LIG_TRAF2_1	205	208	PF00917	0.493
LIG_TRAF2_1	268	271	PF00917	0.536
LIG_TRAF2_1	340	343	PF00917	0.554
MOD_CDC14_SPxK_1	466	469	PF00782	0.574
MOD_CDK_SPxK_1	463	469	PF00069	0.578
MOD_CK1_1	463	469	PF00069	0.778
MOD_CK1_1	497	503	PF00069	0.744
MOD_CK1_1	508	514	PF00069	0.689
MOD_CK2_1	141	147	PF00069	0.463
MOD_CK2_1	202	208	PF00069	0.492
MOD_CK2_1	222	228	PF00069	0.379
MOD_CK2_1	229	235	PF00069	0.459
MOD_CK2_1	243	249	PF00069	0.530
MOD_CK2_1	265	271	PF00069	0.493
MOD_CK2_1	336	342	PF00069	0.533
MOD_CK2_1	390	396	PF00069	0.561
MOD_CK2_1	398	404	PF00069	0.560
MOD_CK2_1	62	68	PF00069	0.555
MOD_CK2_1	78	84	PF00069	0.601
MOD_GlcNHglycan	338	341	PF01048	0.527
MOD_GlcNHglycan	399	404	PF01048	0.668
MOD_GlcNHglycan	481	484	PF01048	0.637
MOD_GlcNHglycan	485	488	PF01048	0.617
MOD_GlcNHglycan	496	499	PF01048	0.648
MOD_GlcNHglycan	96	99	PF01048	0.547
MOD_GSK3_1	355	362	PF00069	0.551
MOD_GSK3_1	446	453	PF00069	0.712
MOD_GSK3_1	465	472	PF00069	0.772
MOD_GSK3_1	479	486	PF00069	0.609
MOD_GSK3_1	58	65	PF00069	0.613
MOD_N-GLC_1	306	311	PF02516	0.480
MOD_N-GLC_1	355	360	PF02516	0.485
MOD_N-GLC_2	218	220	PF02516	0.450
MOD_NEK2_1	141	146	PF00069	0.493
MOD_NEK2_1	315	320	PF00069	0.452
MOD_NEK2_1	355	360	PF00069	0.468
MOD_NEK2_2	324	329	PF00069	0.518
MOD_NMyristoyl	1	7	PF02799	0.582
MOD_PIKK_1	160	166	PF00454	0.513
MOD_PIKK_1	359	365	PF00454	0.627
MOD_PKA_2	336	342	PF00069	0.533
MOD_PKA_2	483	489	PF00069	0.693
MOD_Plk_1	263	269	PF00069	0.547
MOD_Plk_1	355	361	PF00069	0.491
MOD_Plk_1	91	97	PF00069	0.587
MOD_Plk_4	110	116	PF00069	0.516
MOD_Plk_4	78	84	PF00069	0.507
MOD_Plk_4	91	97	PF00069	0.571
MOD_ProDKin_1	446	452	PF00069	0.711
MOD_ProDKin_1	453	459	PF00069	0.701
MOD_ProDKin_1	463	469	PF00069	0.631
MOD_ProDKin_1	497	503	PF00069	0.667
MOD_ProDKin_1	505	511	PF00069	0.699
MOD_SUMO_for_1	210	213	PF00179	0.584
TRG_DiLeu_BaEn_1	110	115	PF01217	0.473
TRG_ENDOCYTIC_2	112	115	PF00928	0.475
TRG_ENDOCYTIC_2	293	296	PF00928	0.519
TRG_ENDOCYTIC_2	375	378	PF00928	0.518
TRG_ENDOCYTIC_2	82	85	PF00928	0.503
TRG_ER_diArg_1	115	118	PF00400	0.484
TRG_ER_diArg_1	255	257	PF00400	0.498
TRG_ER_diArg_1	317	320	PF00400	0.459
TRG_NLS_MonoExtC_3	132	138	PF00514	0.517
TRG_NLS_MonoExtN_4	130	137	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB65	Leptomonas seymouri	77%	100%
A0A0S4IYS9	Bodo saltans	64%	100%
A0A1X0P4B6	Trypanosomatidae	73%	100%
A4HFP8	Leishmania braziliensis	86%	100%
A4I2S3	Leishmania infantum	100%	100%
D0A5Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9ADA1	Leishmania major	97%	100%
E9AZ26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5D978	Trypanosoma cruzi	72%	100%