Adenylate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Adenylate kinase

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ICN4_LEIDO

TriTrypDb:

LdBPK_231730.1 , LdCL_230024400 , LDHU3_23.2290

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICN4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0017076	purine nucleotide binding	4	1
GO:0019205	nucleobase-containing compound kinase activity	5	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	236	238	PF00675	0.545
CLV_PCSK_KEX2_1	236	238	PF00082	0.549
CLV_PCSK_SKI1_1	108	112	PF00082	0.550
CLV_PCSK_SKI1_1	133	137	PF00082	0.496
CLV_PCSK_SKI1_1	276	280	PF00082	0.463
CLV_PCSK_SKI1_1	42	46	PF00082	0.594
DEG_APCC_DBOX_1	275	283	PF00400	0.462
DEG_APCC_DBOX_1	37	45	PF00400	0.649
DEG_ODPH_VHL_1	65	77	PF01847	0.449
DEG_SPOP_SBC_1	146	150	PF00917	0.428
DOC_CKS1_1	183	188	PF01111	0.561
DOC_CKS1_1	69	74	PF01111	0.483
DOC_MAPK_gen_1	8	16	PF00069	0.491
DOC_MAPK_RevD_3	222	237	PF00069	0.480
DOC_USP7_MATH_1	102	106	PF00917	0.397
DOC_USP7_MATH_1	147	151	PF00917	0.472
DOC_WW_Pin1_4	182	187	PF00397	0.604
DOC_WW_Pin1_4	236	241	PF00397	0.521
DOC_WW_Pin1_4	36	41	PF00397	0.557
DOC_WW_Pin1_4	68	73	PF00397	0.458
LIG_14-3-3_CanoR_1	141	145	PF00244	0.521
LIG_14-3-3_CanoR_1	190	196	PF00244	0.452
LIG_14-3-3_CanoR_1	245	250	PF00244	0.504
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BIR_III_3	1	5	PF00653	0.546
LIG_BRCT_BRCA1_1	192	196	PF00533	0.495
LIG_CtBP_PxDLS_1	157	161	PF00389	0.459
LIG_FHA_1	273	279	PF00498	0.441
LIG_FHA_1	69	75	PF00498	0.526
LIG_FHA_2	203	209	PF00498	0.394
LIG_FHA_2	214	220	PF00498	0.363
LIG_LIR_Nem_3	193	199	PF02991	0.449
LIG_LIR_Nem_3	251	255	PF02991	0.438
LIG_LYPXL_SIV_4	254	262	PF13949	0.410
LIG_MYND_1	68	72	PF01753	0.376
LIG_PCNA_yPIPBox_3	18	29	PF02747	0.471
LIG_Pex14_2	252	256	PF04695	0.435
LIG_SH2_STAT3	7	10	PF00017	0.543
LIG_SH2_STAT5	123	126	PF00017	0.599
LIG_SH3_1	237	243	PF00018	0.523
LIG_SH3_2	240	245	PF14604	0.465
LIG_SH3_2	37	42	PF14604	0.590
LIG_SH3_3	119	125	PF00018	0.496
LIG_SH3_3	180	186	PF00018	0.567
LIG_SH3_3	237	243	PF00018	0.523
LIG_SH3_3	34	40	PF00018	0.497
LIG_SUMO_SIM_par_1	73	78	PF11976	0.437
LIG_SxIP_EBH_1	234	245	PF03271	0.409
LIG_TRAF2_1	216	219	PF00917	0.477
LIG_WRC_WIRS_1	249	254	PF05994	0.408
MOD_CDC14_SPxK_1	39	42	PF00782	0.691
MOD_CDK_SPK_2	68	73	PF00069	0.456
MOD_CDK_SPxK_1	36	42	PF00069	0.685
MOD_CK1_1	151	157	PF00069	0.438
MOD_CK1_1	248	254	PF00069	0.510
MOD_CK2_1	202	208	PF00069	0.392
MOD_CK2_1	213	219	PF00069	0.366
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.581
MOD_GlcNHglycan	153	156	PF01048	0.409
MOD_GlcNHglycan	2	5	PF01048	0.543
MOD_GlcNHglycan	256	259	PF01048	0.461
MOD_GlcNHglycan	57	60	PF01048	0.580
MOD_GSK3_1	147	154	PF00069	0.502
MOD_GSK3_1	218	225	PF00069	0.443
MOD_GSK3_1	32	39	PF00069	0.525
MOD_GSK3_1	83	90	PF00069	0.505
MOD_NEK2_2	191	196	PF00069	0.463
MOD_PKA_2	140	146	PF00069	0.544
MOD_Plk_1	218	224	PF00069	0.371
MOD_Plk_4	102	108	PF00069	0.433
MOD_Plk_4	148	154	PF00069	0.499
MOD_Plk_4	191	197	PF00069	0.410
MOD_ProDKin_1	182	188	PF00069	0.608
MOD_ProDKin_1	236	242	PF00069	0.520
MOD_ProDKin_1	36	42	PF00069	0.560
MOD_ProDKin_1	68	74	PF00069	0.447
MOD_SUMO_for_1	17	20	PF00179	0.487
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ILX8	Bodo saltans	25%	100%
A4HD19	Leishmania braziliensis	74%	96%
A4I0K5	Leishmania infantum	100%	100%
E9AWG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QB05	Leishmania major	94%	100%