Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC zinc finger domain-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ICN3_LEIDO

TriTrypDb:

LdBPK_231700.1 , LdCL_230024100 , LDHU3_23.2260

Length:

450

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8ICN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICN3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.606
CLV_C14_Caspase3-7	200	204	PF00656	0.516
CLV_NRD_NRD_1	408	410	PF00675	0.609
CLV_NRD_NRD_1	429	431	PF00675	0.549
CLV_PCSK_KEX2_1	393	395	PF00082	0.615
CLV_PCSK_KEX2_1	429	431	PF00082	0.549
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.613
CLV_PCSK_SKI1_1	333	337	PF00082	0.291
CLV_PCSK_SKI1_1	364	368	PF00082	0.433
DOC_CYCLIN_RxL_1	361	368	PF00134	0.230
DOC_MAPK_gen_1	429	436	PF00069	0.349
DOC_MAPK_MEF2A_6	202	209	PF00069	0.441
DOC_MAPK_MEF2A_6	300	309	PF00069	0.251
DOC_MAPK_MEF2A_6	40	49	PF00069	0.302
DOC_PP1_RVXF_1	257	263	PF00149	0.284
DOC_PP1_RVXF_1	337	343	PF00149	0.482
DOC_PP2B_LxvP_1	112	115	PF13499	0.491
DOC_PP4_FxxP_1	226	229	PF00568	0.482
DOC_PP4_FxxP_1	67	70	PF00568	0.310
DOC_USP7_MATH_1	129	133	PF00917	0.575
DOC_USP7_MATH_1	150	154	PF00917	0.461
DOC_USP7_MATH_1	20	24	PF00917	0.369
DOC_USP7_MATH_1	85	89	PF00917	0.509
DOC_WW_Pin1_4	121	126	PF00397	0.521
DOC_WW_Pin1_4	166	171	PF00397	0.508
DOC_WW_Pin1_4	182	187	PF00397	0.473
DOC_WW_Pin1_4	210	215	PF00397	0.524
DOC_WW_Pin1_4	230	235	PF00397	0.475
DOC_WW_Pin1_4	395	400	PF00397	0.397
DOC_WW_Pin1_4	422	427	PF00397	0.396
DOC_WW_Pin1_4	66	71	PF00397	0.302
LIG_14-3-3_CanoR_1	131	136	PF00244	0.525
LIG_14-3-3_CanoR_1	140	149	PF00244	0.489
LIG_14-3-3_CanoR_1	415	421	PF00244	0.416
LIG_AP2alpha_2	76	78	PF02296	0.376
LIG_APCC_ABBA_1	205	210	PF00400	0.485
LIG_BRCT_BRCA1_1	68	72	PF00533	0.322
LIG_eIF4E_1	360	366	PF01652	0.303
LIG_EVH1_2	222	226	PF00568	0.470
LIG_FHA_1	142	148	PF00498	0.523
LIG_FHA_1	225	231	PF00498	0.445
LIG_FHA_2	250	256	PF00498	0.341
LIG_FHA_2	439	445	PF00498	0.480
LIG_GBD_Chelix_1	46	54	PF00786	0.289
LIG_IBAR_NPY_1	247	249	PF08397	0.397
LIG_LIR_Apic_2	224	229	PF02991	0.439
LIG_LIR_Apic_2	76	81	PF02991	0.333
LIG_LIR_Apic_2	83	87	PF02991	0.373
LIG_LIR_Gen_1	61	70	PF02991	0.340
LIG_LIR_Nem_3	37	42	PF02991	0.564
LIG_LIR_Nem_3	425	431	PF02991	0.401
LIG_LIR_Nem_3	61	66	PF02991	0.304
LIG_MYND_1	395	399	PF01753	0.387
LIG_MYND_1	87	91	PF01753	0.441
LIG_PCNA_yPIPBox_3	364	378	PF02747	0.261
LIG_RPA_C_Fungi	30	42	PF08784	0.317
LIG_SH2_CRK	104	108	PF00017	0.509
LIG_SH2_CRK	312	316	PF00017	0.304
LIG_SH2_CRK	431	435	PF00017	0.504
LIG_SH2_CRK	6	10	PF00017	0.278
LIG_SH2_CRK	63	67	PF00017	0.304
LIG_SH2_CRK	84	88	PF00017	0.468
LIG_SH2_NCK_1	312	316	PF00017	0.270
LIG_SH2_NCK_1	63	67	PF00017	0.369
LIG_SH2_SRC	104	107	PF00017	0.506
LIG_SH2_STAP1	26	30	PF00017	0.358
LIG_SH2_STAP1	63	67	PF00017	0.369
LIG_SH2_STAT3	106	109	PF00017	0.518
LIG_SH2_STAT5	225	228	PF00017	0.733
LIG_SH3_3	111	117	PF00018	0.607
LIG_SH3_3	135	141	PF00018	0.629
LIG_SH3_3	144	150	PF00018	0.823
LIG_SH3_3	164	170	PF00018	0.576
LIG_SH3_3	237	243	PF00018	0.541
LIG_SH3_3	71	77	PF00018	0.377
LIG_SUMO_SIM_par_1	45	52	PF11976	0.328
LIG_SUMO_SIM_par_1	55	61	PF11976	0.312
LIG_TYR_ITIM	310	315	PF00017	0.304
LIG_UBA3_1	324	333	PF00899	0.248
LIG_WW_1	222	225	PF00397	0.581
LIG_WW_1	81	84	PF00397	0.416
MOD_CDC14_SPxK_1	213	216	PF00782	0.604
MOD_CDK_SPxK_1	182	188	PF00069	0.564
MOD_CDK_SPxK_1	210	216	PF00069	0.608
MOD_CDK_SPxxK_3	395	402	PF00069	0.490
MOD_CDK_SPxxK_3	422	429	PF00069	0.448
MOD_CK1_1	124	130	PF00069	0.650
MOD_CK1_1	133	139	PF00069	0.575
MOD_CK1_1	153	159	PF00069	0.613
MOD_CK1_1	388	394	PF00069	0.459
MOD_CK2_1	172	178	PF00069	0.719
MOD_CK2_1	369	375	PF00069	0.325
MOD_GlcNHglycan	135	138	PF01048	0.580
MOD_GlcNHglycan	255	259	PF01048	0.400
MOD_GlcNHglycan	385	388	PF01048	0.569
MOD_GSK3_1	127	134	PF00069	0.659
MOD_GSK3_1	136	143	PF00069	0.588
MOD_GSK3_1	153	160	PF00069	0.650
MOD_GSK3_1	182	189	PF00069	0.725
MOD_GSK3_1	20	27	PF00069	0.325
MOD_GSK3_1	250	257	PF00069	0.437
MOD_GSK3_1	311	318	PF00069	0.287
MOD_GSK3_1	365	372	PF00069	0.311
MOD_GSK3_1	373	380	PF00069	0.409
MOD_GSK3_1	438	445	PF00069	0.613
MOD_N-GLC_2	295	297	PF02516	0.304
MOD_NEK2_1	254	259	PF00069	0.385
MOD_NEK2_1	310	315	PF00069	0.320
MOD_NEK2_1	324	329	PF00069	0.384
MOD_NEK2_1	352	357	PF00069	0.322
MOD_NEK2_1	358	363	PF00069	0.354
MOD_NEK2_1	365	370	PF00069	0.368
MOD_NEK2_1	377	382	PF00069	0.387
MOD_NEK2_1	48	53	PF00069	0.305
MOD_NEK2_2	158	163	PF00069	0.584
MOD_OFUCOSY	385	392	PF10250	0.452
MOD_PIKK_1	358	364	PF00454	0.325
MOD_PIKK_1	377	383	PF00454	0.423
MOD_PKA_2	130	136	PF00069	0.640
MOD_Plk_1	442	448	PF00069	0.594
MOD_Plk_4	324	330	PF00069	0.325
MOD_Plk_4	352	358	PF00069	0.292
MOD_Plk_4	373	379	PF00069	0.325
MOD_Plk_4	49	55	PF00069	0.351
MOD_ProDKin_1	121	127	PF00069	0.655
MOD_ProDKin_1	166	172	PF00069	0.640
MOD_ProDKin_1	182	188	PF00069	0.593
MOD_ProDKin_1	210	216	PF00069	0.661
MOD_ProDKin_1	230	236	PF00069	0.590
MOD_ProDKin_1	395	401	PF00069	0.482
MOD_ProDKin_1	422	428	PF00069	0.482
MOD_ProDKin_1	66	72	PF00069	0.352
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.337
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.248
TRG_ENDOCYTIC_2	303	306	PF00928	0.355
TRG_ENDOCYTIC_2	312	315	PF00928	0.262
TRG_ENDOCYTIC_2	431	434	PF00928	0.497
TRG_ENDOCYTIC_2	62	65	PF00928	0.304
TRG_ER_diArg_1	259	262	PF00400	0.325
TRG_ER_diArg_1	394	397	PF00400	0.488
TRG_ER_diArg_1	428	430	PF00400	0.420
TRG_NLS_MonoCore_2	392	397	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G9	Leptomonas seymouri	45%	90%
A4HD16	Leishmania braziliensis	55%	97%
A4I0K2	Leishmania infantum	100%	100%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QB08	Leishmania major	82%	100%