CRAL/TRIO domain containing protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICN0_LEIDO

TriTrypDb:

LdBPK_312110.1 , LdCL_310029100 , LDHU3_31.3800

Length:

497

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICN0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.220
CLV_MEL_PAP_1	106	112	PF00089	0.409
CLV_NRD_NRD_1	153	155	PF00675	0.453
CLV_NRD_NRD_1	29	31	PF00675	0.493
CLV_NRD_NRD_1	42	44	PF00675	0.503
CLV_NRD_NRD_1	61	63	PF00675	0.448
CLV_NRD_NRD_1	67	69	PF00675	0.412
CLV_NRD_NRD_1	89	91	PF00675	0.419
CLV_PCSK_FUR_1	151	155	PF00082	0.389
CLV_PCSK_KEX2_1	153	155	PF00082	0.462
CLV_PCSK_KEX2_1	42	44	PF00082	0.506
CLV_PCSK_KEX2_1	61	63	PF00082	0.448
CLV_PCSK_KEX2_1	67	69	PF00082	0.411
CLV_PCSK_KEX2_1	87	89	PF00082	0.430
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.505
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.417
CLV_PCSK_PC7_1	83	89	PF00082	0.395
CLV_PCSK_SKI1_1	135	139	PF00082	0.470
CLV_PCSK_SKI1_1	313	317	PF00082	0.305
CLV_PCSK_SKI1_1	395	399	PF00082	0.308
CLV_PCSK_SKI1_1	425	429	PF00082	0.398
CLV_PCSK_SKI1_1	437	441	PF00082	0.422
CLV_PCSK_SKI1_1	97	101	PF00082	0.438
CLV_Separin_Metazoa	257	261	PF03568	0.375
DEG_COP1_1	450	460	PF00400	0.255
DEG_SCF_FBW7_1	198	203	PF00400	0.402
DEG_SCF_FBW7_2	156	163	PF00400	0.428
DOC_CKS1_1	122	127	PF01111	0.381
DOC_CYCLIN_yClb5_NLxxxL_5	306	315	PF00134	0.221
DOC_CYCLIN_yCln2_LP_2	4	7	PF00134	0.446
DOC_MAPK_gen_1	162	172	PF00069	0.426
DOC_MAPK_gen_1	437	447	PF00069	0.246
DOC_MAPK_gen_1	67	73	PF00069	0.407
DOC_MAPK_MEF2A_6	366	374	PF00069	0.384
DOC_MAPK_MEF2A_6	380	389	PF00069	0.445
DOC_PP1_RVXF_1	79	85	PF00149	0.379
DOC_PP2B_LxvP_1	4	7	PF13499	0.446
DOC_USP7_MATH_1	141	145	PF00917	0.431
DOC_USP7_MATH_1	439	443	PF00917	0.310
DOC_USP7_UBL2_3	380	384	PF12436	0.326
DOC_WW_Pin1_4	101	106	PF00397	0.412
DOC_WW_Pin1_4	121	126	PF00397	0.374
DOC_WW_Pin1_4	156	161	PF00397	0.509
DOC_WW_Pin1_4	188	193	PF00397	0.475
DOC_WW_Pin1_4	196	201	PF00397	0.417
LIG_14-3-3_CanoR_1	22	27	PF00244	0.482
LIG_14-3-3_CanoR_1	366	374	PF00244	0.301
LIG_14-3-3_CanoR_1	68	74	PF00244	0.406
LIG_14-3-3_CanoR_1	97	102	PF00244	0.429
LIG_BRCT_BRCA1_1	69	73	PF00533	0.401
LIG_DCNL_PONY_1	1	4	PF03556	0.454
LIG_eIF4E_1	207	213	PF01652	0.378
LIG_FHA_1	101	107	PF00498	0.414
LIG_FHA_1	165	171	PF00498	0.487
LIG_FHA_1	316	322	PF00498	0.304
LIG_FHA_1	366	372	PF00498	0.291
LIG_FHA_1	55	61	PF00498	0.470
LIG_FHA_2	191	197	PF00498	0.468
LIG_FHA_2	483	489	PF00498	0.658
LIG_GBD_Chelix_1	230	238	PF00786	0.298
LIG_LIR_Apic_2	292	297	PF02991	0.242
LIG_LIR_Gen_1	127	137	PF02991	0.372
LIG_LIR_Gen_1	206	213	PF02991	0.281
LIG_LIR_LC3C_4	115	119	PF02991	0.416
LIG_LIR_Nem_3	127	132	PF02991	0.376
LIG_LIR_Nem_3	175	180	PF02991	0.487
LIG_LIR_Nem_3	206	212	PF02991	0.348
LIG_LIR_Nem_3	339	345	PF02991	0.367
LIG_LIR_Nem_3	378	382	PF02991	0.378
LIG_LIR_Nem_3	396	401	PF02991	0.350
LIG_LIR_Nem_3	418	424	PF02991	0.354
LIG_MYND_1	3	7	PF01753	0.446
LIG_NRBOX	183	189	PF00104	0.402
LIG_NRBOX	332	338	PF00104	0.213
LIG_PCNA_PIPBox_1	329	338	PF02747	0.276
LIG_Pex14_1	342	346	PF04695	0.314
LIG_Pex14_2	110	114	PF04695	0.411
LIG_SH2_CRK	177	181	PF00017	0.416
LIG_SH2_CRK	209	213	PF00017	0.328
LIG_SH2_CRK	294	298	PF00017	0.295
LIG_SH2_CRK	421	425	PF00017	0.333
LIG_SH2_STAT3	232	235	PF00017	0.394
LIG_SH2_STAT3	345	348	PF00017	0.261
LIG_SH2_STAT5	155	158	PF00017	0.461
LIG_SH2_STAT5	207	210	PF00017	0.393
LIG_SH2_STAT5	283	286	PF00017	0.400
LIG_SH2_STAT5	300	303	PF00017	0.353
LIG_SH2_STAT5	456	459	PF00017	0.319
LIG_SH3_1	31	37	PF00018	0.491
LIG_SH3_2	37	42	PF14604	0.499
LIG_SH3_2	7	12	PF14604	0.449
LIG_SH3_3	116	122	PF00018	0.407
LIG_SH3_3	31	37	PF00018	0.491
LIG_SH3_3	4	10	PF00018	0.446
LIG_SH3_3	408	414	PF00018	0.332
LIG_SH3_3	99	105	PF00018	0.414
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.414
LIG_SUMO_SIM_anti_2	442	450	PF11976	0.339
LIG_SUMO_SIM_par_1	368	373	PF11976	0.313
LIG_TYR_ITIM	298	303	PF00017	0.376
LIG_UBA3_1	311	316	PF00899	0.336
LIG_WRC_WIRS_1	416	421	PF05994	0.230
LIG_WW_2	7	10	PF00397	0.444
MOD_CDK_SPxK_1	156	162	PF00069	0.433
MOD_CK1_1	191	197	PF00069	0.352
MOD_CK1_1	246	252	PF00069	0.456
MOD_CK1_1	29	35	PF00069	0.490
MOD_CK1_1	415	421	PF00069	0.490
MOD_CK1_1	482	488	PF00069	0.479
MOD_CK1_1	54	60	PF00069	0.470
MOD_CK2_1	302	308	PF00069	0.369
MOD_CK2_1	491	497	PF00069	0.661
MOD_GlcNHglycan	143	146	PF01048	0.447
MOD_GlcNHglycan	147	150	PF01048	0.450
MOD_GlcNHglycan	245	248	PF01048	0.468
MOD_GlcNHglycan	338	341	PF01048	0.237
MOD_GlcNHglycan	481	484	PF01048	0.615
MOD_GlcNHglycan	493	496	PF01048	0.692
MOD_GSK3_1	141	148	PF00069	0.436
MOD_GSK3_1	196	203	PF00069	0.474
MOD_GSK3_1	22	29	PF00069	0.483
MOD_GSK3_1	239	246	PF00069	0.402
MOD_GSK3_1	389	396	PF00069	0.495
MOD_GSK3_1	479	486	PF00069	0.739
MOD_GSK3_1	51	58	PF00069	0.480
MOD_GSK3_1	97	104	PF00069	0.425
MOD_N-GLC_1	201	206	PF02516	0.300
MOD_NEK2_1	375	380	PF00069	0.373
MOD_NEK2_1	389	394	PF00069	0.386
MOD_NEK2_2	393	398	PF00069	0.204
MOD_NEK2_2	69	74	PF00069	0.404
MOD_PIKK_1	164	170	PF00454	0.415
MOD_PIKK_1	489	495	PF00454	0.502
MOD_PKA_1	67	73	PF00069	0.407
MOD_PKA_2	266	272	PF00069	0.476
MOD_PKA_2	29	35	PF00069	0.490
MOD_PKA_2	365	371	PF00069	0.340
MOD_PKA_2	67	73	PF00069	0.407
MOD_Plk_4	366	372	PF00069	0.341
MOD_Plk_4	393	399	PF00069	0.499
MOD_Plk_4	412	418	PF00069	0.270
MOD_Plk_4	69	75	PF00069	0.404
MOD_ProDKin_1	101	107	PF00069	0.414
MOD_ProDKin_1	121	127	PF00069	0.373
MOD_ProDKin_1	156	162	PF00069	0.502
MOD_ProDKin_1	188	194	PF00069	0.480
MOD_ProDKin_1	196	202	PF00069	0.410
MOD_SUMO_for_1	278	281	PF00179	0.250
MOD_SUMO_rev_2	157	167	PF00179	0.415
MOD_SUMO_rev_2	308	318	PF00179	0.219
TRG_DiLeu_BaEn_1	443	448	PF01217	0.310
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.410
TRG_ENDOCYTIC_2	155	158	PF00928	0.508
TRG_ENDOCYTIC_2	177	180	PF00928	0.419
TRG_ENDOCYTIC_2	209	212	PF00928	0.349
TRG_ENDOCYTIC_2	300	303	PF00928	0.384
TRG_ENDOCYTIC_2	346	349	PF00928	0.460
TRG_ENDOCYTIC_2	379	382	PF00928	0.309
TRG_ENDOCYTIC_2	421	424	PF00928	0.333
TRG_ER_diArg_1	150	153	PF00400	0.531
TRG_ER_diArg_1	60	62	PF00400	0.464
TRG_ER_diArg_1	66	68	PF00400	0.417
TRG_ER_diArg_1	81	84	PF00400	0.376
TRG_ER_diArg_1	88	90	PF00400	0.428
TRG_NLS_MonoCore_2	86	91	PF00514	0.413
TRG_NLS_MonoExtC_3	29	34	PF00514	0.492
TRG_NLS_MonoExtN_4	27	34	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	260	265	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	36%	95%
A0A0N0P991	Leptomonas seymouri	30%	100%
A0A0N1PCS4	Leptomonas seymouri	66%	100%
A0A0S4KJL3	Bodo saltans	26%	100%
A0A3Q8IGQ2	Leishmania donovani	30%	100%
A0A3S7X4P4	Leishmania donovani	39%	96%
A0A3S7X4R1	Leishmania donovani	51%	100%
A4HJI7	Leishmania braziliensis	40%	100%
A4HJI8	Leishmania braziliensis	51%	100%
A4HJI9	Leishmania braziliensis	77%	100%
A4HKB3	Leishmania braziliensis	30%	100%
A4I6Y2	Leishmania infantum	40%	100%
A4I6Y3	Leishmania infantum	51%	100%
A4I6Y4	Leishmania infantum	99%	100%
A4I7U3	Leishmania infantum	30%	100%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q5F6	Leishmania major	30%	100%
Q4Q655	Leishmania major	86%	100%
Q4Q656	Leishmania major	50%	100%
Q4Q657	Leishmania major	38%	100%
Q92503	Homo sapiens	21%	70%