BRO1-like_domain_containing_protein_putative/Pfam:PF03097

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRO1-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICM9_LEIDO

TriTrypDb:

LdBPK_252240.1 , LdCL_250028200 , LDHU3_25.2710

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.394
CLV_C14_Caspase3-7	84	88	PF00656	0.354
CLV_NRD_NRD_1	54	56	PF00675	0.403
CLV_NRD_NRD_1	59	61	PF00675	0.429
CLV_PCSK_KEX2_1	276	278	PF00082	0.362
CLV_PCSK_KEX2_1	43	45	PF00082	0.343
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.362
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.347
CLV_PCSK_SKI1_1	277	281	PF00082	0.378
CLV_PCSK_SKI1_1	77	81	PF00082	0.413
CLV_PCSK_SKI1_1	8	12	PF00082	0.349
DEG_APCC_DBOX_1	126	134	PF00400	0.325
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DOC_MAPK_DCC_7	8	16	PF00069	0.526
DOC_MAPK_gen_1	187	193	PF00069	0.387
DOC_MAPK_gen_1	42	50	PF00069	0.416
DOC_MAPK_gen_1	77	85	PF00069	0.249
DOC_MAPK_MEF2A_6	378	385	PF00069	0.342
DOC_MAPK_MEF2A_6	8	16	PF00069	0.476
DOC_PP2B_LxvP_1	326	329	PF13499	0.362
DOC_PP2B_LxvP_1	369	372	PF13499	0.328
DOC_USP7_MATH_1	194	198	PF00917	0.460
DOC_USP7_MATH_1	231	235	PF00917	0.355
DOC_USP7_MATH_1	389	393	PF00917	0.445
DOC_USP7_UBL2_3	38	42	PF12436	0.401
DOC_WW_Pin1_4	387	392	PF00397	0.518
DOC_WW_Pin1_4	97	102	PF00397	0.444
LIG_14-3-3_CanoR_1	102	107	PF00244	0.224
LIG_14-3-3_CanoR_1	152	156	PF00244	0.413
LIG_14-3-3_CanoR_1	17	24	PF00244	0.362
LIG_14-3-3_CanoR_1	240	248	PF00244	0.374
LIG_14-3-3_CanoR_1	344	353	PF00244	0.317
LIG_14-3-3_CanoR_1	60	66	PF00244	0.382
LIG_APCC_ABBA_1	206	211	PF00400	0.362
LIG_BRCT_BRCA1_1	172	176	PF00533	0.413
LIG_BRCT_BRCA1_1	223	227	PF00533	0.404
LIG_BRCT_BRCA1_1	289	293	PF00533	0.325
LIG_BRCT_BRCA1_1	381	385	PF00533	0.535
LIG_EH1_1	134	142	PF00400	0.300
LIG_FHA_1	236	242	PF00498	0.348
LIG_FHA_1	269	275	PF00498	0.413
LIG_FHA_1	331	337	PF00498	0.471
LIG_FHA_1	345	351	PF00498	0.387
LIG_FHA_1	393	399	PF00498	0.603
LIG_FHA_1	88	94	PF00498	0.369
LIG_FHA_2	259	265	PF00498	0.312
LIG_LIR_Gen_1	100	109	PF02991	0.476
LIG_LIR_Gen_1	125	135	PF02991	0.371
LIG_LIR_Gen_1	264	274	PF02991	0.308
LIG_LIR_Gen_1	278	288	PF02991	0.273
LIG_LIR_Gen_1	49	58	PF02991	0.325
LIG_LIR_Nem_3	100	106	PF02991	0.381
LIG_LIR_Nem_3	120	126	PF02991	0.371
LIG_LIR_Nem_3	164	169	PF02991	0.281
LIG_LIR_Nem_3	173	178	PF02991	0.281
LIG_LIR_Nem_3	264	269	PF02991	0.326
LIG_LIR_Nem_3	278	283	PF02991	0.273
LIG_LIR_Nem_3	333	338	PF02991	0.369
LIG_LIR_Nem_3	49	54	PF02991	0.337
LIG_MLH1_MIPbox_1	172	176	PF16413	0.413
LIG_Pex14_2	50	54	PF04695	0.402
LIG_SH2_CRK	166	170	PF00017	0.281
LIG_SH2_CRK	9	13	PF00017	0.481
LIG_SH2_GRB2like	134	137	PF00017	0.325
LIG_SH2_STAP1	89	93	PF00017	0.281
LIG_SH2_STAT5	147	150	PF00017	0.374
LIG_SH2_STAT5	175	178	PF00017	0.294
LIG_SH2_STAT5	317	320	PF00017	0.438
LIG_SH2_STAT5	78	81	PF00017	0.483
LIG_SH2_STAT5	89	92	PF00017	0.259
LIG_SH3_1	9	15	PF00018	0.472
LIG_SH3_2	12	17	PF14604	0.413
LIG_SH3_3	193	199	PF00018	0.429
LIG_SH3_3	368	374	PF00018	0.410
LIG_SH3_3	9	15	PF00018	0.454
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.371
LIG_SUMO_SIM_anti_2	395	400	PF11976	0.549
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.249
LIG_SUMO_SIM_par_1	197	203	PF11976	0.468
LIG_SUMO_SIM_par_1	394	400	PF11976	0.547
LIG_SUMO_SIM_par_1	81	87	PF11976	0.249
LIG_TYR_ITIM	247	252	PF00017	0.362
MOD_CDK_SPK_2	97	102	PF00069	0.299
MOD_CK1_1	113	119	PF00069	0.423
MOD_CK1_1	234	240	PF00069	0.415
MOD_CK1_1	392	398	PF00069	0.588
MOD_CK2_1	156	162	PF00069	0.325
MOD_CK2_1	23	29	PF00069	0.345
MOD_CK2_1	258	264	PF00069	0.321
MOD_CK2_1	30	36	PF00069	0.315
MOD_GlcNHglycan	172	175	PF01048	0.394
MOD_GlcNHglycan	33	36	PF01048	0.413
MOD_GlcNHglycan	391	394	PF01048	0.654
MOD_GlcNHglycan	71	74	PF01048	0.452
MOD_GSK3_1	109	116	PF00069	0.322
MOD_GSK3_1	231	238	PF00069	0.350
MOD_GSK3_1	251	258	PF00069	0.172
MOD_N-GLC_1	262	267	PF02516	0.344
MOD_N-GLC_1	330	335	PF02516	0.312
MOD_N-GLC_1	344	349	PF02516	0.372
MOD_NEK2_1	209	214	PF00069	0.375
MOD_NEK2_1	248	253	PF00069	0.271
MOD_NEK2_1	318	323	PF00069	0.362
MOD_NEK2_1	330	335	PF00069	0.234
MOD_NEK2_1	338	343	PF00069	0.231
MOD_NEK2_1	69	74	PF00069	0.411
MOD_NEK2_2	339	344	PF00069	0.287
MOD_PIKK_1	23	29	PF00454	0.414
MOD_PIKK_1	302	308	PF00454	0.330
MOD_PIKK_1	318	324	PF00454	0.268
MOD_PK_1	61	67	PF00069	0.413
MOD_PKA_2	151	157	PF00069	0.413
MOD_PKA_2	16	22	PF00069	0.360
MOD_PKA_2	239	245	PF00069	0.348
MOD_Plk_1	262	268	PF00069	0.327
MOD_Plk_1	379	385	PF00069	0.409
MOD_Plk_4	156	162	PF00069	0.374
MOD_Plk_4	262	268	PF00069	0.302
MOD_Plk_4	352	358	PF00069	0.281
MOD_ProDKin_1	387	393	PF00069	0.531
MOD_ProDKin_1	97	103	PF00069	0.444
MOD_SUMO_rev_2	224	234	PF00179	0.347
MOD_SUMO_rev_2	31	40	PF00179	0.397
MOD_SUMO_rev_2	64	70	PF00179	0.356
TRG_ENDOCYTIC_2	128	131	PF00928	0.306
TRG_ENDOCYTIC_2	134	137	PF00928	0.283
TRG_ENDOCYTIC_2	166	169	PF00928	0.281
TRG_ENDOCYTIC_2	175	178	PF00928	0.281
TRG_ENDOCYTIC_2	249	252	PF00928	0.488
TRG_NES_CRM1_1	205	219	PF08389	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN4	Leptomonas seymouri	69%	100%
A0A0S4JPD3	Bodo saltans	26%	93%
A0A1X0NY42	Trypanosomatidae	37%	100%
A0A422P4K0	Trypanosoma rangeli	38%	97%
A4HEB8	Leishmania braziliensis	84%	100%
A4I1R3	Leishmania infantum	100%	100%
C9ZKB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AXU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9M3	Leishmania major	92%	100%