LeishMANIAdb
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EMG1/NEP1_methyltransferase_putative/Pfam:PF03587

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EMG1/NEP1_methyltransferase_putative/Pfam:PF03587
Gene product:
EMG1/NEP1 methyltransferase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ICM7_LEIDO
TriTrypDb:
LdBPK_161470.1 , LdCL_160019700 , LDHU3_16.1750
Length:
287

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005730 nucleolus 5 1
GO:0030684 preribosome 3 1
GO:0032040 small-subunit processome 4 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:1990904 ribonucleoprotein complex 2 1
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Expansion

Sequence features

A0A3Q8ICM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICM7

Function

Biological processes
TermNameLevelCount
GO:0000154 rRNA modification 6 12
GO:0001510 RNA methylation 4 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006364 rRNA processing 8 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009451 RNA modification 5 12
GO:0009987 cellular process 1 12
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Molecular functions
TermNameLevelCount
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0008168 methyltransferase activity 4 12
GO:0008173 RNA methyltransferase activity 4 12
GO:0008649 rRNA methyltransferase activity 5 12
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 12
GO:0016740 transferase activity 2 12
GO:0016741 transferase activity, transferring one-carbon groups 3 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 192 194 PF00675 0.418
CLV_NRD_NRD_1 218 220 PF00675 0.382
CLV_NRD_NRD_1 224 226 PF00675 0.328
CLV_PCSK_FUR_1 19 23 PF00082 0.365
CLV_PCSK_KEX2_1 192 194 PF00082 0.448
CLV_PCSK_KEX2_1 21 23 PF00082 0.369
CLV_PCSK_KEX2_1 224 226 PF00082 0.385
CLV_PCSK_PC1ET2_1 21 23 PF00082 0.462
CLV_PCSK_SKI1_1 192 196 PF00082 0.418
DEG_Nend_UBRbox_2 1 3 PF02207 0.576
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PB82 Leptomonas seymouri 91% 100%
A0A0S4IWL3 Bodo saltans 56% 100%
A0A1X0NZ96 Trypanosomatidae 60% 96%
A0A3R7KPC0 Trypanosoma rangeli 65% 100%
A4H8R8 Leishmania braziliensis 91% 100%
A4HX36 Leishmania infantum 100% 100%
C9ZVV5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9AQV1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O35130 Mus musculus 33% 100%
Q06287 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS