Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ICM5_LEIDO

TriTrypDb:

LdBPK_230650.1 , LdCL_230012000 , LDHU3_23.0900

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.716
CLV_MEL_PAP_1	587	593	PF00089	0.706
CLV_NRD_NRD_1	238	240	PF00675	0.634
CLV_NRD_NRD_1	514	516	PF00675	0.615
CLV_NRD_NRD_1	556	558	PF00675	0.480
CLV_PCSK_KEX2_1	238	240	PF00082	0.634
CLV_PCSK_KEX2_1	516	518	PF00082	0.730
CLV_PCSK_KEX2_1	556	558	PF00082	0.480
CLV_PCSK_KEX2_1	63	65	PF00082	0.463
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.730
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.463
CLV_PCSK_SKI1_1	320	324	PF00082	0.484
CLV_PCSK_SKI1_1	368	372	PF00082	0.476
CLV_PCSK_SKI1_1	38	42	PF00082	0.527
CLV_PCSK_SKI1_1	444	448	PF00082	0.481
CLV_PCSK_SKI1_1	556	560	PF00082	0.492
CLV_PCSK_SKI1_1	63	67	PF00082	0.634
DEG_Nend_UBRbox_3	1	3	PF02207	0.567
DEG_SPOP_SBC_1	358	362	PF00917	0.605
DOC_ANK_TNKS_1	219	226	PF00023	0.518
DOC_CDC14_PxL_1	474	482	PF14671	0.469
DOC_CYCLIN_RxL_1	32	42	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.577
DOC_MAPK_DCC_7	444	453	PF00069	0.520
DOC_MAPK_gen_1	63	71	PF00069	0.450
DOC_MAPK_MEF2A_6	267	274	PF00069	0.555
DOC_MAPK_MEF2A_6	368	375	PF00069	0.470
DOC_MAPK_NFAT4_5	267	275	PF00069	0.584
DOC_MAPK_NFAT4_5	368	376	PF00069	0.471
DOC_PP1_RVXF_1	7	13	PF00149	0.501
DOC_PP2B_LxvP_1	171	174	PF13499	0.715
DOC_PP2B_LxvP_1	272	275	PF13499	0.480
DOC_USP7_MATH_1	116	120	PF00917	0.830
DOC_USP7_MATH_1	155	159	PF00917	0.738
DOC_USP7_MATH_1	182	186	PF00917	0.739
DOC_USP7_MATH_1	193	197	PF00917	0.662
DOC_USP7_MATH_1	198	202	PF00917	0.637
DOC_USP7_MATH_1	242	246	PF00917	0.786
DOC_USP7_MATH_1	306	310	PF00917	0.700
DOC_USP7_MATH_1	335	339	PF00917	0.495
DOC_USP7_MATH_1	579	583	PF00917	0.569
DOC_USP7_MATH_1	589	593	PF00917	0.545
DOC_USP7_MATH_1	595	599	PF00917	0.511
DOC_USP7_UBL2_3	54	58	PF12436	0.576
DOC_WW_Pin1_4	105	110	PF00397	0.703
DOC_WW_Pin1_4	111	116	PF00397	0.758
DOC_WW_Pin1_4	134	139	PF00397	0.689
DOC_WW_Pin1_4	158	163	PF00397	0.685
DOC_WW_Pin1_4	191	196	PF00397	0.710
DOC_WW_Pin1_4	22	27	PF00397	0.702
DOC_WW_Pin1_4	233	238	PF00397	0.697
DOC_WW_Pin1_4	359	364	PF00397	0.507
DOC_WW_Pin1_4	446	451	PF00397	0.510
DOC_WW_Pin1_4	509	514	PF00397	0.717
DOC_WW_Pin1_4	585	590	PF00397	0.767
LIG_14-3-3_CanoR_1	139	148	PF00244	0.629
LIG_14-3-3_CanoR_1	38	44	PF00244	0.522
LIG_14-3-3_CanoR_1	556	564	PF00244	0.479
LIG_14-3-3_CanoR_1	607	611	PF00244	0.578
LIG_14-3-3_CanoR_1	64	69	PF00244	0.451
LIG_BIR_III_4	577	581	PF00653	0.552
LIG_BRCT_BRCA1_1	386	390	PF00533	0.588
LIG_BRCT_BRCA1_1	564	568	PF00533	0.452
LIG_BRCT_BRCA1_1	78	82	PF00533	0.584
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.482
LIG_FHA_1	127	133	PF00498	0.545
LIG_FHA_1	267	273	PF00498	0.429
LIG_FHA_1	359	365	PF00498	0.506
LIG_FHA_1	377	383	PF00498	0.481
LIG_FHA_1	40	46	PF00498	0.586
LIG_FHA_1	436	442	PF00498	0.531
LIG_FHA_1	447	453	PF00498	0.545
LIG_FHA_2	14	20	PF00498	0.717
LIG_FHA_2	165	171	PF00498	0.810
LIG_FHA_2	244	250	PF00498	0.573
LIG_FHA_2	328	334	PF00498	0.565
LIG_FHA_2	386	392	PF00498	0.479
LIG_FHA_2	402	408	PF00498	0.655
LIG_FHA_2	97	103	PF00498	0.708
LIG_LIR_Apic_2	494	500	PF02991	0.634
LIG_LIR_Gen_1	353	363	PF02991	0.429
LIG_LIR_Gen_1	46	56	PF02991	0.623
LIG_LIR_Gen_1	467	478	PF02991	0.408
LIG_LIR_Gen_1	62	71	PF02991	0.472
LIG_LIR_Gen_1	75	85	PF02991	0.429
LIG_LIR_Nem_3	11	15	PF02991	0.528
LIG_LIR_Nem_3	353	358	PF02991	0.425
LIG_LIR_Nem_3	467	473	PF02991	0.412
LIG_LIR_Nem_3	565	571	PF02991	0.420
LIG_LIR_Nem_3	75	81	PF02991	0.485
LIG_NRBOX	479	485	PF00104	0.482
LIG_PDZ_Class_2	607	612	PF00595	0.604
LIG_Pex14_1	78	82	PF04695	0.482
LIG_SH2_CRK	497	501	PF00017	0.650
LIG_SH2_GRB2like	49	52	PF00017	0.511
LIG_SH2_GRB2like	570	573	PF00017	0.398
LIG_SH2_NCK_1	571	575	PF00017	0.473
LIG_SH2_STAP1	268	272	PF00017	0.578
LIG_SH2_STAP1	386	390	PF00017	0.465
LIG_SH2_STAP1	468	472	PF00017	0.466
LIG_SH2_STAP1	49	53	PF00017	0.628
LIG_SH2_STAP1	493	497	PF00017	0.616
LIG_SH2_STAP1	546	550	PF00017	0.560
LIG_SH2_STAT5	268	271	PF00017	0.561
LIG_SH2_STAT5	468	471	PF00017	0.555
LIG_SH2_STAT5	482	485	PF00017	0.368
LIG_SH2_STAT5	491	494	PF00017	0.595
LIG_SH2_STAT5	563	566	PF00017	0.399
LIG_SH3_3	112	118	PF00018	0.737
LIG_SH3_3	23	29	PF00018	0.765
LIG_SH3_3	290	296	PF00018	0.434
LIG_SUMO_SIM_anti_2	438	443	PF11976	0.414
LIG_SUMO_SIM_par_1	437	443	PF11976	0.484
LIG_SUMO_SIM_par_1	444	449	PF11976	0.489
LIG_TRAF2_1	121	124	PF00917	0.591
LIG_TRAF2_1	17	20	PF00917	0.756
LIG_TRAF2_1	409	412	PF00917	0.717
LIG_UBA3_1	3	9	PF00899	0.491
LIG_WRC_WIRS_1	40	45	PF05994	0.510
MOD_CDC14_SPxK_1	236	239	PF00782	0.697
MOD_CDC14_SPxK_1	512	515	PF00782	0.600
MOD_CDK_SPK_2	134	139	PF00069	0.694
MOD_CDK_SPK_2	233	238	PF00069	0.697
MOD_CDK_SPK_2	585	590	PF00069	0.691
MOD_CDK_SPxK_1	233	239	PF00069	0.700
MOD_CDK_SPxK_1	509	515	PF00069	0.604
MOD_CDK_SPxxK_3	509	516	PF00069	0.721
MOD_CK1_1	119	125	PF00069	0.688
MOD_CK1_1	158	164	PF00069	0.801
MOD_CK1_1	166	172	PF00069	0.622
MOD_CK1_1	226	232	PF00069	0.660
MOD_CK1_1	266	272	PF00069	0.476
MOD_CK1_1	359	365	PF00069	0.506
MOD_CK1_1	435	441	PF00069	0.432
MOD_CK1_1	509	515	PF00069	0.817
MOD_CK1_1	562	568	PF00069	0.549
MOD_CK1_1	582	588	PF00069	0.739
MOD_CK2_1	104	110	PF00069	0.787
MOD_CK2_1	117	123	PF00069	0.534
MOD_CK2_1	13	19	PF00069	0.695
MOD_CK2_1	164	170	PF00069	0.815
MOD_CK2_1	243	249	PF00069	0.579
MOD_CK2_1	327	333	PF00069	0.575
MOD_CK2_1	548	554	PF00069	0.489
MOD_CK2_1	96	102	PF00069	0.693
MOD_GlcNHglycan	119	122	PF01048	0.744
MOD_GlcNHglycan	157	160	PF01048	0.792
MOD_GlcNHglycan	202	205	PF01048	0.752
MOD_GlcNHglycan	215	218	PF01048	0.457
MOD_GlcNHglycan	308	311	PF01048	0.698
MOD_GlcNHglycan	337	340	PF01048	0.554
MOD_GlcNHglycan	343	346	PF01048	0.429
MOD_GlcNHglycan	530	533	PF01048	0.707
MOD_GlcNHglycan	550	553	PF01048	0.306
MOD_GlcNHglycan	591	594	PF01048	0.705
MOD_GlcNHglycan	597	600	PF01048	0.516
MOD_GSK3_1	100	107	PF00069	0.701
MOD_GSK3_1	119	126	PF00069	0.646
MOD_GSK3_1	169	176	PF00069	0.737
MOD_GSK3_1	178	185	PF00069	0.747
MOD_GSK3_1	187	194	PF00069	0.534
MOD_GSK3_1	198	205	PF00069	0.611
MOD_GSK3_1	323	330	PF00069	0.615
MOD_GSK3_1	358	365	PF00069	0.508
MOD_GSK3_1	373	380	PF00069	0.478
MOD_GSK3_1	39	46	PF00069	0.585
MOD_GSK3_1	431	438	PF00069	0.511
MOD_GSK3_1	440	447	PF00069	0.501
MOD_GSK3_1	528	535	PF00069	0.744
MOD_GSK3_1	581	588	PF00069	0.790
MOD_GSK3_1	92	99	PF00069	0.660
MOD_N-GLC_1	198	203	PF02516	0.725
MOD_N-GLC_1	371	376	PF02516	0.465
MOD_N-GLC_1	431	436	PF02516	0.685
MOD_N-GLC_1	580	585	PF02516	0.708
MOD_NEK2_1	140	145	PF00069	0.697
MOD_NEK2_1	163	168	PF00069	0.721
MOD_NEK2_1	177	182	PF00069	0.635
MOD_NEK2_1	263	268	PF00069	0.482
MOD_NEK2_1	3	8	PF00069	0.508
MOD_NEK2_1	323	328	PF00069	0.536
MOD_NEK2_1	356	361	PF00069	0.438
MOD_NEK2_1	371	376	PF00069	0.504
MOD_NEK2_1	385	390	PF00069	0.480
MOD_NEK2_1	392	397	PF00069	0.483
MOD_NEK2_1	43	48	PF00069	0.472
MOD_NEK2_1	483	488	PF00069	0.479
MOD_NEK2_1	559	564	PF00069	0.480
MOD_NEK2_1	594	599	PF00069	0.615
MOD_NEK2_2	128	133	PF00069	0.493
MOD_PIKK_1	327	333	PF00454	0.621
MOD_PIKK_1	483	489	PF00454	0.619
MOD_PKA_2	126	132	PF00069	0.643
MOD_PKA_2	146	152	PF00069	0.778
MOD_PKA_2	213	219	PF00069	0.516
MOD_PKA_2	266	272	PF00069	0.403
MOD_PKA_2	43	49	PF00069	0.471
MOD_PKA_2	506	512	PF00069	0.819
MOD_PKA_2	589	595	PF00069	0.745
MOD_PKA_2	606	612	PF00069	0.349
MOD_PKB_1	145	153	PF00069	0.710
MOD_Plk_1	169	175	PF00069	0.679
MOD_Plk_1	371	377	PF00069	0.461
MOD_Plk_1	431	437	PF00069	0.676
MOD_Plk_1	546	552	PF00069	0.613
MOD_Plk_2-3	466	472	PF00069	0.481
MOD_Plk_4	128	134	PF00069	0.492
MOD_Plk_4	173	179	PF00069	0.696
MOD_Plk_4	3	9	PF00069	0.506
MOD_Plk_4	419	425	PF00069	0.744
MOD_Plk_4	559	565	PF00069	0.415
MOD_Plk_4	64	70	PF00069	0.601
MOD_ProDKin_1	105	111	PF00069	0.705
MOD_ProDKin_1	134	140	PF00069	0.684
MOD_ProDKin_1	158	164	PF00069	0.687
MOD_ProDKin_1	191	197	PF00069	0.713
MOD_ProDKin_1	22	28	PF00069	0.701
MOD_ProDKin_1	233	239	PF00069	0.700
MOD_ProDKin_1	359	365	PF00069	0.506
MOD_ProDKin_1	446	452	PF00069	0.518
MOD_ProDKin_1	509	515	PF00069	0.720
MOD_ProDKin_1	585	591	PF00069	0.762
TRG_ENDOCYTIC_2	49	52	PF00928	0.613
TRG_ENDOCYTIC_2	570	573	PF00928	0.506
TRG_ER_diArg_1	237	239	PF00400	0.702
TRG_ER_diArg_1	555	557	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.747

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ40	Leptomonas seymouri	50%	98%
A4HCS5	Leishmania braziliensis	75%	98%
A4I099	Leishmania infantum	100%	100%
E9AW64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QBB4	Leishmania major	92%	100%