Dihydrouridine synthase (Dus), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase (Dus), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICM1_LEIDO

TriTrypDb:

LdBPK_311970.1 , LdCL_310027500 , LDHU3_31.3540

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8ICM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICM1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10
GO:0017150	tRNA dihydrouridine synthase activity	5	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0050660	flavin adenine dinucleotide binding	4	10
GO:0097159	organic cyclic compound binding	2	10
GO:0106413	dihydrouridine synthase activity	4	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140101	catalytic activity, acting on a tRNA	4	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	555	559	PF00656	0.427
CLV_NRD_NRD_1	296	298	PF00675	0.246
CLV_NRD_NRD_1	32	34	PF00675	0.702
CLV_NRD_NRD_1	421	423	PF00675	0.263
CLV_NRD_NRD_1	58	60	PF00675	0.527
CLV_NRD_NRD_1	623	625	PF00675	0.484
CLV_NRD_NRD_1	88	90	PF00675	0.763
CLV_PCSK_KEX2_1	296	298	PF00082	0.246
CLV_PCSK_KEX2_1	32	34	PF00082	0.702
CLV_PCSK_KEX2_1	345	347	PF00082	0.510
CLV_PCSK_KEX2_1	421	423	PF00082	0.278
CLV_PCSK_KEX2_1	623	625	PF00082	0.491
CLV_PCSK_KEX2_1	88	90	PF00082	0.763
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.510
CLV_PCSK_PC7_1	84	90	PF00082	0.583
CLV_PCSK_SKI1_1	22	26	PF00082	0.537
CLV_PCSK_SKI1_1	33	37	PF00082	0.546
CLV_PCSK_SKI1_1	375	379	PF00082	0.470
CLV_PCSK_SKI1_1	405	409	PF00082	0.288
CLV_PCSK_SKI1_1	424	428	PF00082	0.288
CLV_PCSK_SKI1_1	88	92	PF00082	0.506
DEG_APCC_DBOX_1	532	540	PF00400	0.529
DOC_ANK_TNKS_1	623	630	PF00023	0.511
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.463
DOC_MAPK_gen_1	547	556	PF00069	0.564
DOC_MAPK_gen_1	641	649	PF00069	0.614
DOC_MAPK_MEF2A_6	505	513	PF00069	0.447
DOC_PP2B_LxvP_1	322	325	PF13499	0.463
DOC_PP4_FxxP_1	333	336	PF00568	0.529
DOC_PP4_FxxP_1	470	473	PF00568	0.463
DOC_SPAK_OSR1_1	232	236	PF12202	0.392
DOC_USP7_MATH_1	20	24	PF00917	0.519
DOC_USP7_MATH_1	367	371	PF00917	0.624
DOC_USP7_MATH_1	568	572	PF00917	0.759
DOC_USP7_MATH_1	595	599	PF00917	0.615
DOC_USP7_UBL2_3	639	643	PF12436	0.641
DOC_WW_Pin1_4	139	144	PF00397	0.446
DOC_WW_Pin1_4	176	181	PF00397	0.712
DOC_WW_Pin1_4	63	68	PF00397	0.536
LIG_14-3-3_CanoR_1	22	27	PF00244	0.508
LIG_14-3-3_CanoR_1	490	498	PF00244	0.543
LIG_14-3-3_CanoR_1	623	628	PF00244	0.566
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BIR_III_4	425	429	PF00653	0.471
LIG_FHA_1	140	146	PF00498	0.529
LIG_FHA_1	206	212	PF00498	0.487
LIG_FHA_1	315	321	PF00498	0.534
LIG_FHA_1	325	331	PF00498	0.529
LIG_FHA_1	428	434	PF00498	0.529
LIG_FHA_1	494	500	PF00498	0.587
LIG_FHA_1	89	95	PF00498	0.496
LIG_FHA_2	367	373	PF00498	0.549
LIG_FHA_2	439	445	PF00498	0.462
LIG_FHA_2	450	456	PF00498	0.462
LIG_FHA_2	544	550	PF00498	0.694
LIG_FHA_2	93	99	PF00498	0.449
LIG_GBD_Chelix_1	314	322	PF00786	0.340
LIG_Integrin_isoDGR_2	30	32	PF01839	0.516
LIG_LIR_Gen_1	158	166	PF02991	0.592
LIG_LIR_Gen_1	306	315	PF02991	0.446
LIG_LIR_Gen_1	383	393	PF02991	0.315
LIG_LIR_Gen_1	441	449	PF02991	0.446
LIG_LIR_Nem_3	125	131	PF02991	0.446
LIG_LIR_Nem_3	158	163	PF02991	0.573
LIG_LIR_Nem_3	306	311	PF02991	0.446
LIG_LIR_Nem_3	441	445	PF02991	0.446
LIG_LIR_Nem_3	9	14	PF02991	0.452
LIG_PDZ_Class_2	655	660	PF00595	0.659
LIG_Pex14_1	503	507	PF04695	0.529
LIG_Pex14_2	519	523	PF04695	0.488
LIG_SH2_CRK	11	15	PF00017	0.470
LIG_SH2_CRK	61	65	PF00017	0.498
LIG_SH2_NCK_1	61	65	PF00017	0.454
LIG_SH2_SRC	442	445	PF00017	0.529
LIG_SH2_STAP1	386	390	PF00017	0.446
LIG_SH2_STAP1	442	446	PF00017	0.529
LIG_SH2_STAT5	141	144	PF00017	0.462
LIG_SH2_STAT5	28	31	PF00017	0.459
LIG_SH3_2	476	481	PF14604	0.529
LIG_SH3_3	160	166	PF00018	0.488
LIG_SH3_3	208	214	PF00018	0.500
LIG_SH3_3	253	259	PF00018	0.698
LIG_SH3_3	470	476	PF00018	0.482
LIG_SH3_3	61	67	PF00018	0.575
LIG_SUMO_SIM_anti_2	379	386	PF11976	0.449
LIG_SUMO_SIM_par_1	614	620	PF11976	0.378
LIG_SUMO_SIM_par_1	645	652	PF11976	0.647
LIG_TRAF2_1	165	168	PF00917	0.502
LIG_TRAF2_1	356	359	PF00917	0.520
LIG_TRAF2_1	642	645	PF00917	0.631
LIG_WRC_WIRS_1	300	305	PF05994	0.463
MOD_CDK_SPxxK_3	63	70	PF00069	0.454
MOD_CK1_1	176	182	PF00069	0.631
MOD_CK1_1	471	477	PF00069	0.498
MOD_CK2_1	265	271	PF00069	0.691
MOD_CK2_1	366	372	PF00069	0.554
MOD_CK2_1	449	455	PF00069	0.501
MOD_CK2_1	528	534	PF00069	0.471
MOD_CK2_1	543	549	PF00069	0.609
MOD_CK2_1	92	98	PF00069	0.537
MOD_CMANNOS	50	53	PF00535	0.367
MOD_Cter_Amidation	30	33	PF01082	0.508
MOD_GlcNHglycan	109	112	PF01048	0.495
MOD_GlcNHglycan	246	249	PF01048	0.556
MOD_GlcNHglycan	353	356	PF01048	0.483
MOD_GlcNHglycan	47	50	PF01048	0.612
MOD_GlcNHglycan	491	494	PF01048	0.329
MOD_GlcNHglycan	541	544	PF01048	0.271
MOD_GlcNHglycan	551	554	PF01048	0.634
MOD_GlcNHglycan	574	577	PF01048	0.698
MOD_GlcNHglycan	583	589	PF01048	0.647
MOD_GlcNHglycan	599	602	PF01048	0.599
MOD_GlcNHglycan	633	636	PF01048	0.750
MOD_GlcNHglycan	79	83	PF01048	0.741
MOD_GSK3_1	135	142	PF00069	0.456
MOD_GSK3_1	155	162	PF00069	0.516
MOD_GSK3_1	246	253	PF00069	0.612
MOD_GSK3_1	310	317	PF00069	0.529
MOD_GSK3_1	347	354	PF00069	0.511
MOD_GSK3_1	41	48	PF00069	0.631
MOD_GSK3_1	489	496	PF00069	0.522
MOD_GSK3_1	539	546	PF00069	0.470
MOD_GSK3_1	568	575	PF00069	0.761
MOD_GSK3_1	595	602	PF00069	0.525
MOD_GSK3_1	88	95	PF00069	0.517
MOD_N-GLC_1	350	355	PF02516	0.464
MOD_NEK2_1	106	111	PF00069	0.521
MOD_NEK2_1	173	178	PF00069	0.498
MOD_NEK2_1	310	315	PF00069	0.518
MOD_NEK2_1	427	432	PF00069	0.462
MOD_NEK2_1	449	454	PF00069	0.446
MOD_NEK2_1	528	533	PF00069	0.553
MOD_NEK2_1	539	544	PF00069	0.532
MOD_NEK2_2	189	194	PF00069	0.610
MOD_PIKK_1	471	477	PF00454	0.498
MOD_PK_1	623	629	PF00069	0.472
MOD_PKA_1	623	629	PF00069	0.472
MOD_PKA_1	88	94	PF00069	0.499
MOD_PKA_2	489	495	PF00069	0.520
MOD_PKA_2	623	629	PF00069	0.535
MOD_PKA_2	88	94	PF00069	0.555
MOD_Plk_1	173	179	PF00069	0.454
MOD_Plk_1	33	39	PF00069	0.575
MOD_Plk_1	569	575	PF00069	0.580
MOD_Plk_1	78	84	PF00069	0.590
MOD_Plk_4	223	229	PF00069	0.317
MOD_Plk_4	299	305	PF00069	0.455
MOD_Plk_4	310	316	PF00069	0.431
MOD_Plk_4	380	386	PF00069	0.479
MOD_ProDKin_1	139	145	PF00069	0.446
MOD_ProDKin_1	176	182	PF00069	0.718
MOD_ProDKin_1	63	69	PF00069	0.530
MOD_SUMO_for_1	642	645	PF00179	0.631
MOD_SUMO_rev_2	162	172	PF00179	0.542
MOD_SUMO_rev_2	461	470	PF00179	0.529
TRG_DiLeu_BaEn_1	306	311	PF01217	0.451
TRG_DiLeu_BaEn_4	534	540	PF01217	0.498
TRG_DiLeu_BaEn_4	651	657	PF01217	0.537
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.463
TRG_ENDOCYTIC_2	11	14	PF00928	0.440
TRG_ENDOCYTIC_2	141	144	PF00928	0.446
TRG_ENDOCYTIC_2	300	303	PF00928	0.465
TRG_ENDOCYTIC_2	386	389	PF00928	0.446
TRG_ENDOCYTIC_2	442	445	PF00928	0.529
TRG_ENDOCYTIC_2	61	64	PF00928	0.505
TRG_ER_diArg_1	420	422	PF00400	0.463
TRG_ER_diArg_1	87	89	PF00400	0.585
TRG_NES_CRM1_1	309	323	PF08389	0.456
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS31	Leptomonas seymouri	61%	100%
A0A0S4JUA9	Bodo saltans	38%	100%
A4HJH5	Leishmania braziliensis	79%	100%
A4I6W8	Leishmania infantum	100%	100%
C9ZWQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q669	Leishmania major	92%	100%
V5D2B4	Trypanosoma cruzi	41%	100%