LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Bardet-Biedl syndrome 5 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Bardet-Biedl syndrome 5 protein
Gene product:
Bardet-Biedl syndrome 5 protein
Species:
Leishmania donovani
UniProt:
A0A3Q8ICM0_LEIDO
TriTrypDb:
LdBPK_120630.1 , LdCL_120012000 , LDHU3_12.0970
Length:
432

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 10
GO:0005815 microtubule organizing center 2 11
GO:0016020 membrane 2 11
GO:0031090 organelle membrane 3 11
GO:0031253 cell projection membrane 4 11
GO:0032991 protein-containing complex 1 11
GO:0034464 BBSome 2 11
GO:0060170 ciliary membrane 5 11
GO:0098588 bounding membrane of organelle 4 11
GO:0098590 plasma membrane region 3 11
GO:0110165 cellular anatomical entity 1 11
GO:0012506 vesicle membrane 4 1
GO:0020018 ciliary pocket membrane 6 1
GO:0030659 cytoplasmic vesicle membrane 5 1
GO:0030662 coated vesicle membrane 5 1
GO:0030665 clathrin-coated vesicle membrane 6 1
GO:0036064 ciliary basal body 3 1

Expansion

Sequence features

A0A3Q8ICM0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICM0

Function

Biological processes
Term Name Level Count
GO:0000041 transition metal ion transport 7 1
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0006812 monoatomic cation transport 5 1
GO:0006826 iron ion transport 8 1
GO:0006996 organelle organization 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030001 metal ion transport 6 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0033036 macromolecule localization 2 1
GO:0033572 transferrin transport 5 1
GO:0044782 cilium organization 5 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0060271 cilium assembly 6 1
GO:0070727 cellular macromolecule localization 3 1
GO:0070925 organelle assembly 5 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005543 phospholipid binding 3 1
GO:0008289 lipid binding 2 1
GO:0032266 phosphatidylinositol-3-phosphate binding 6 1
GO:0035091 phosphatidylinositol binding 4 1
GO:1901981 phosphatidylinositol phosphate binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 1 3 PF00675 0.687
CLV_NRD_NRD_1 165 167 PF00675 0.329
CLV_NRD_NRD_1 395 397 PF00675 0.227
CLV_NRD_NRD_1 4 6 PF00675 0.667
CLV_NRD_NRD_1 401 403 PF00675 0.198
CLV_NRD_NRD_1 416 418 PF00675 0.217
CLV_PCSK_FUR_1 162 166 PF00082 0.234
CLV_PCSK_FUR_1 2 6 PF00082 0.518
CLV_PCSK_KEX2_1 164 166 PF00082 0.332
CLV_PCSK_KEX2_1 3 5 PF00082 0.521
CLV_PCSK_KEX2_1 401 403 PF00082 0.243
CLV_PCSK_PC1ET2_1 3 5 PF00082 0.521
CLV_PCSK_SKI1_1 17 21 PF00082 0.461
CLV_PCSK_SKI1_1 316 320 PF00082 0.297
DEG_Nend_UBRbox_1 1 4 PF02207 0.580
DOC_MAPK_gen_1 79 88 PF00069 0.455
DOC_MAPK_HePTP_8 76 88 PF00069 0.434
DOC_MAPK_MEF2A_6 316 325 PF00069 0.445
DOC_MAPK_MEF2A_6 402 411 PF00069 0.443
DOC_MAPK_MEF2A_6 79 88 PF00069 0.477
DOC_PP1_RVXF_1 241 248 PF00149 0.412
DOC_PP1_RVXF_1 27 34 PF00149 0.425
DOC_PP1_RVXF_1 73 79 PF00149 0.468
DOC_USP7_MATH_1 145 149 PF00917 0.451
DOC_USP7_MATH_1 167 171 PF00917 0.382
DOC_USP7_MATH_1 187 191 PF00917 0.425
DOC_WW_Pin1_4 8 13 PF00397 0.658
LIG_14-3-3_CanoR_1 110 117 PF00244 0.438
LIG_14-3-3_CanoR_1 311 319 PF00244 0.542
LIG_APCC_ABBA_1 323 328 PF00400 0.434
LIG_APCC_ABBAyCdc20_2 322 328 PF00400 0.434
LIG_Clathr_ClatBox_1 209 213 PF01394 0.469
LIG_FHA_1 110 116 PF00498 0.463
LIG_FHA_1 219 225 PF00498 0.515
LIG_FHA_1 234 240 PF00498 0.353
LIG_FHA_1 327 333 PF00498 0.425
LIG_FHA_1 382 388 PF00498 0.416
LIG_FHA_1 44 50 PF00498 0.507
LIG_FHA_1 66 72 PF00498 0.469
LIG_FHA_2 50 56 PF00498 0.451
LIG_FHA_2 97 103 PF00498 0.469
LIG_HCF-1_HBM_1 47 50 PF13415 0.506
LIG_LIR_Gen_1 124 133 PF02991 0.412
LIG_LIR_Gen_1 256 265 PF02991 0.425
LIG_LIR_Gen_1 301 309 PF02991 0.515
LIG_LIR_Gen_1 47 56 PF02991 0.520
LIG_LIR_Nem_3 124 129 PF02991 0.438
LIG_LIR_Nem_3 191 197 PF02991 0.417
LIG_LIR_Nem_3 251 255 PF02991 0.439
LIG_LIR_Nem_3 256 262 PF02991 0.413
LIG_LIR_Nem_3 301 306 PF02991 0.494
LIG_LIR_Nem_3 47 53 PF02991 0.520
LIG_LIR_Nem_3 89 95 PF02991 0.443
LIG_Pex14_2 126 130 PF04695 0.425
LIG_Pex14_2 287 291 PF04695 0.485
LIG_SH2_CRK 178 182 PF00017 0.504
LIG_SH2_NCK_1 303 307 PF00017 0.506
LIG_SH2_SRC 303 306 PF00017 0.548
LIG_SH2_SRC 405 408 PF00017 0.494
LIG_SH2_STAT5 259 262 PF00017 0.468
LIG_SH2_STAT5 93 96 PF00017 0.506
LIG_SH3_3 252 258 PF00018 0.443
LIG_SH3_3 329 335 PF00018 0.389
LIG_SH3_3 401 407 PF00018 0.468
LIG_SUMO_SIM_par_1 208 213 PF11976 0.506
LIG_SUMO_SIM_par_1 67 72 PF11976 0.489
LIG_TRAF2_1 99 102 PF00917 0.506
LIG_TYR_ITIM 90 95 PF00017 0.293
LIG_UBA3_1 318 322 PF00899 0.446
LIG_WRC_WIRS_1 234 239 PF05994 0.306
LIG_WRC_WIRS_1 50 55 PF05994 0.362
MOD_CK1_1 10 16 PF00069 0.631
MOD_CK1_1 143 149 PF00069 0.264
MOD_CK1_1 168 174 PF00069 0.410
MOD_CK1_1 219 225 PF00069 0.292
MOD_CK1_1 267 273 PF00069 0.381
MOD_CK2_1 225 231 PF00069 0.387
MOD_CK2_1 96 102 PF00069 0.381
MOD_CMANNOS 310 313 PF00535 0.293
MOD_Cter_Amidation 394 397 PF01082 0.280
MOD_GlcNHglycan 12 15 PF01048 0.615
MOD_GlcNHglycan 142 145 PF01048 0.441
MOD_GlcNHglycan 149 152 PF01048 0.348
MOD_GlcNHglycan 200 203 PF01048 0.441
MOD_GlcNHglycan 221 224 PF01048 0.387
MOD_GlcNHglycan 347 351 PF01048 0.252
MOD_GSK3_1 109 116 PF00069 0.390
MOD_GSK3_1 139 146 PF00069 0.443
MOD_GSK3_1 218 225 PF00069 0.386
MOD_GSK3_1 233 240 PF00069 0.207
MOD_GSK3_1 305 312 PF00069 0.414
MOD_GSK3_1 417 424 PF00069 0.320
MOD_GSK3_1 425 432 PF00069 0.476
MOD_GSK3_1 65 72 PF00069 0.386
MOD_GSK3_1 8 15 PF00069 0.620
MOD_N-GLC_1 160 165 PF02516 0.280
MOD_N-GLC_1 168 173 PF02516 0.215
MOD_N-GLC_1 253 258 PF02516 0.250
MOD_N-GLC_1 86 91 PF02516 0.250
MOD_N-GLC_2 63 65 PF02516 0.280
MOD_NEK2_1 128 133 PF00069 0.305
MOD_NEK2_1 177 182 PF00069 0.331
MOD_NEK2_1 237 242 PF00069 0.250
MOD_NEK2_1 253 258 PF00069 0.250
MOD_NEK2_1 309 314 PF00069 0.401
MOD_NEK2_1 425 430 PF00069 0.587
MOD_NEK2_1 69 74 PF00069 0.250
MOD_PIKK_1 264 270 PF00454 0.381
MOD_PKA_1 165 171 PF00069 0.329
MOD_PKA_1 417 423 PF00069 0.280
MOD_PKA_2 109 115 PF00069 0.280
MOD_PKA_2 165 171 PF00069 0.349
MOD_PKA_2 219 225 PF00069 0.362
MOD_PKB_1 41 49 PF00069 0.217
MOD_Plk_1 188 194 PF00069 0.251
MOD_Plk_1 253 259 PF00069 0.254
MOD_Plk_1 278 284 PF00069 0.293
MOD_Plk_1 304 310 PF00069 0.322
MOD_Plk_1 426 432 PF00069 0.609
MOD_Plk_1 86 92 PF00069 0.250
MOD_Plk_4 233 239 PF00069 0.296
MOD_Plk_4 305 311 PF00069 0.281
MOD_Plk_4 421 427 PF00069 0.328
MOD_Plk_4 65 71 PF00069 0.368
MOD_ProDKin_1 8 14 PF00069 0.654
MOD_SUMO_for_1 321 324 PF00179 0.370
MOD_SUMO_rev_2 102 108 PF00179 0.280
MOD_SUMO_rev_2 294 299 PF00179 0.330
TRG_DiLeu_BaLyEn_6 314 319 PF01217 0.330
TRG_DiLeu_BaLyEn_6 72 77 PF01217 0.328
TRG_ENDOCYTIC_2 178 181 PF00928 0.345
TRG_ENDOCYTIC_2 194 197 PF00928 0.152
TRG_ENDOCYTIC_2 259 262 PF00928 0.328
TRG_ENDOCYTIC_2 303 306 PF00928 0.392
TRG_ENDOCYTIC_2 50 53 PF00928 0.381
TRG_ENDOCYTIC_2 92 95 PF00928 0.268
TRG_ER_diArg_1 1 4 PF00400 0.517
TRG_ER_diArg_1 162 165 PF00400 0.426
TRG_ER_diArg_1 197 200 PF00400 0.268
TRG_ER_diArg_1 40 43 PF00400 0.217
TRG_ER_diArg_1 401 403 PF00400 0.293
TRG_NES_CRM1_1 268 279 PF08389 0.381
TRG_NLS_MonoCore_2 1 6 PF00514 0.517
TRG_NLS_MonoExtN_4 2 7 PF00514 0.518

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2P9 Leptomonas seymouri 60% 100%
A0A0S4JE34 Bodo saltans 41% 100%
A0A1X0NMY8 Trypanosomatidae 40% 100%
A0A3R7K3V6 Trypanosoma rangeli 38% 100%
A4H6Y1 Leishmania braziliensis 69% 96%
C9ZHY7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AGF5 Leishmania infantum 100% 100%
E9ANZ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 97%
Q21626 Caenorhabditis elegans 32% 100%
Q4QGM5 Leishmania major 92% 100%
Q4R649 Macaca fascicularis 36% 100%
Q66IS6 Xenopus laevis 39% 100%
Q7ZWB7 Danio rerio 37% 100%
Q8N3I7 Homo sapiens 36% 100%
Q9CZQ9 Mus musculus 37% 100%
V5BJR9 Trypanosoma cruzi 41% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS