TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICL8_LEIDO

TriTrypDb:

LdBPK_252000.1 , LdCL_250025800 , LDHU3_25.2470

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4
GO:0031514	motile cilium	5	3

Expansion

Sequence features

A0A3Q8ICL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICL8

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.526
CLV_NRD_NRD_1	195	197	PF00675	0.376
CLV_NRD_NRD_1	9	11	PF00675	0.697
CLV_PCSK_KEX2_1	109	111	PF00082	0.636
CLV_PCSK_KEX2_1	195	197	PF00082	0.376
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.636
CLV_PCSK_SKI1_1	171	175	PF00082	0.506
CLV_Separin_Metazoa	192	196	PF03568	0.351
DEG_APCC_DBOX_1	482	490	PF00400	0.547
DEG_Nend_UBRbox_3	1	3	PF02207	0.681
DOC_CKS1_1	73	78	PF01111	0.646
DOC_MAPK_MEF2A_6	343	350	PF00069	0.398
DOC_MAPK_NFAT4_5	343	351	PF00069	0.398
DOC_PP1_RVXF_1	178	184	PF00149	0.376
DOC_PP2B_LxvP_1	403	406	PF13499	0.398
DOC_PP2B_LxvP_1	93	96	PF13499	0.638
DOC_PP4_FxxP_1	174	177	PF00568	0.355
DOC_USP7_MATH_1	13	17	PF00917	0.720
DOC_USP7_MATH_1	21	25	PF00917	0.792
DOC_USP7_MATH_1	300	304	PF00917	0.350
DOC_USP7_MATH_1	35	39	PF00917	0.514
DOC_USP7_MATH_1	419	423	PF00917	0.287
DOC_USP7_MATH_1	487	491	PF00917	0.566
DOC_USP7_MATH_1	61	65	PF00917	0.465
DOC_WW_Pin1_4	72	77	PF00397	0.708
LIG_14-3-3_CanoR_1	195	204	PF00244	0.372
LIG_14-3-3_CanoR_1	311	321	PF00244	0.359
LIG_14-3-3_CanoR_1	50	58	PF00244	0.686
LIG_14-3-3_CanoR_1	71	76	PF00244	0.698
LIG_Actin_WH2_2	286	304	PF00022	0.476
LIG_BRCT_BRCA1_1	133	137	PF00533	0.375
LIG_BRCT_BRCA1_1	169	173	PF00533	0.529
LIG_BRCT_BRCA1_1	73	77	PF00533	0.646
LIG_FHA_1	113	119	PF00498	0.710
LIG_FHA_1	371	377	PF00498	0.362
LIG_FHA_1	411	417	PF00498	0.302
LIG_FHA_1	449	455	PF00498	0.506
LIG_FHA_1	53	59	PF00498	0.735
LIG_FHA_1	73	79	PF00498	0.661
LIG_FHA_2	203	209	PF00498	0.441
LIG_FHA_2	250	256	PF00498	0.517
LIG_FHA_2	313	319	PF00498	0.367
LIG_FHA_2	390	396	PF00498	0.405
LIG_FHA_2	82	88	PF00498	0.718
LIG_Integrin_RGD_1	343	345	PF01839	0.405
LIG_Integrin_RGD_1	460	462	PF01839	0.504
LIG_LIR_Gen_1	151	159	PF02991	0.337
LIG_LIR_Gen_1	198	204	PF02991	0.393
LIG_LIR_Nem_3	151	155	PF02991	0.329
LIG_LIR_Nem_3	170	176	PF02991	0.512
LIG_LIR_Nem_3	198	203	PF02991	0.377
LIG_MAD2	116	124	PF02301	0.612
LIG_Pex14_2	200	204	PF04695	0.390
LIG_Pex14_2	433	437	PF04695	0.324
LIG_SH2_CRK	333	337	PF00017	0.367
LIG_SH2_NCK_1	220	224	PF00017	0.469
LIG_SH2_NCK_1	313	317	PF00017	0.398
LIG_SH2_SRC	220	223	PF00017	0.475
LIG_SH2_STAP1	220	224	PF00017	0.381
LIG_SH2_STAP1	267	271	PF00017	0.331
LIG_SH2_STAP1	313	317	PF00017	0.398
LIG_SH2_STAT5	213	216	PF00017	0.338
LIG_SH2_STAT5	464	467	PF00017	0.429
LIG_SH2_STAT5	474	477	PF00017	0.418
LIG_SH2_STAT5	479	482	PF00017	0.426
LIG_SH3_3	124	130	PF00018	0.580
LIG_SH3_3	27	33	PF00018	0.630
LIG_SH3_3	6	12	PF00018	0.669
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.356
LIG_TRAF2_1	252	255	PF00917	0.469
LIG_TYR_ITIM	477	482	PF00017	0.530
LIG_WRC_WIRS_1	250	255	PF05994	0.427
MOD_CK1_1	3	9	PF00069	0.720
MOD_CK1_1	37	43	PF00069	0.766
MOD_CK1_1	64	70	PF00069	0.671
MOD_CK2_1	186	192	PF00069	0.354
MOD_CK2_1	195	201	PF00069	0.502
MOD_CK2_1	202	208	PF00069	0.458
MOD_CK2_1	249	255	PF00069	0.509
MOD_CK2_1	312	318	PF00069	0.330
MOD_CK2_1	389	395	PF00069	0.375
MOD_CK2_1	81	87	PF00069	0.717
MOD_GlcNHglycan	119	124	PF01048	0.720
MOD_GlcNHglycan	188	191	PF01048	0.346
MOD_GlcNHglycan	2	5	PF01048	0.762
MOD_GlcNHglycan	23	26	PF01048	0.797
MOD_GlcNHglycan	333	336	PF01048	0.330
MOD_GlcNHglycan	489	492	PF01048	0.582
MOD_GlcNHglycan	59	62	PF01048	0.453
MOD_GSK3_1	234	241	PF00069	0.499
MOD_GSK3_1	33	40	PF00069	0.722
MOD_GSK3_1	57	64	PF00069	0.691
MOD_NEK2_1	387	392	PF00069	0.405
MOD_NEK2_1	39	44	PF00069	0.678
MOD_NEK2_1	433	438	PF00069	0.398
MOD_NEK2_1	448	453	PF00069	0.514
MOD_NEK2_1	51	56	PF00069	0.759
MOD_NEK2_1	57	62	PF00069	0.718
MOD_NEK2_2	352	357	PF00069	0.466
MOD_NEK2_2	370	375	PF00069	0.310
MOD_NEK2_2	389	394	PF00069	0.220
MOD_PK_1	86	92	PF00069	0.543
MOD_PKA_1	195	201	PF00069	0.370
MOD_PKA_2	131	137	PF00069	0.538
MOD_PKA_2	195	201	PF00069	0.386
MOD_Plk_1	238	244	PF00069	0.548
MOD_Plk_1	433	439	PF00069	0.398
MOD_Plk_4	148	154	PF00069	0.319
MOD_ProDKin_1	72	78	PF00069	0.709
MOD_SUMO_for_1	385	388	PF00179	0.405
TRG_DiLeu_BaEn_4	261	267	PF01217	0.496
TRG_DiLeu_BaEn_4	380	386	PF01217	0.405
TRG_ENDOCYTIC_2	152	155	PF00928	0.432
TRG_ENDOCYTIC_2	226	229	PF00928	0.376
TRG_ENDOCYTIC_2	250	253	PF00928	0.379
TRG_ENDOCYTIC_2	267	270	PF00928	0.342
TRG_ENDOCYTIC_2	333	336	PF00928	0.335
TRG_ENDOCYTIC_2	474	477	PF00928	0.408
TRG_ENDOCYTIC_2	479	482	PF00928	0.423
TRG_ER_diArg_1	194	196	PF00400	0.355
TRG_ER_diArg_1	420	423	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG68	Leptomonas seymouri	59%	93%
A0A1X0NYE0	Trypanosomatidae	49%	97%
A0A3R7MX90	Trypanosoma rangeli	51%	100%
A4HE94	Leishmania braziliensis	79%	98%
A4I1P0	Leishmania infantum	99%	100%
C9ZK89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AXS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q32NR4	Xenopus laevis	22%	100%
Q4Q9P7	Leishmania major	95%	100%
Q4R6M4	Macaca fascicularis	23%	100%
Q8NA56	Homo sapiens	23%	100%
V5B2E8	Trypanosoma cruzi	44%	100%