Aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Aminopeptidase

Gene product:

aminopeptidase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ICL6_LEIDO

TriTrypDb:

LdBPK_260290.1 , LdCL_260008400 , LDHU3_26.0400

Length:

883

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICL6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0006518	peptide metabolic process	4	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043171	peptide catabolic process	4	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004177	aminopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0008238	exopeptidase activity	4	11
GO:0008270	zinc ion binding	6	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0008235	metalloexopeptidase activity	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0070006	metalloaminopeptidase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.303
CLV_NRD_NRD_1	175	177	PF00675	0.297
CLV_NRD_NRD_1	492	494	PF00675	0.420
CLV_NRD_NRD_1	664	666	PF00675	0.395
CLV_NRD_NRD_1	803	805	PF00675	0.239
CLV_PCSK_KEX2_1	142	144	PF00082	0.283
CLV_PCSK_KEX2_1	492	494	PF00082	0.451
CLV_PCSK_KEX2_1	664	666	PF00082	0.297
CLV_PCSK_KEX2_1	700	702	PF00082	0.395
CLV_PCSK_KEX2_1	803	805	PF00082	0.239
CLV_PCSK_PC1ET2_1	700	702	PF00082	0.297
CLV_PCSK_SKI1_1	142	146	PF00082	0.320
CLV_PCSK_SKI1_1	238	242	PF00082	0.314
CLV_PCSK_SKI1_1	250	254	PF00082	0.283
CLV_PCSK_SKI1_1	461	465	PF00082	0.412
CLV_PCSK_SKI1_1	486	490	PF00082	0.445
CLV_PCSK_SKI1_1	492	496	PF00082	0.431
CLV_PCSK_SKI1_1	630	634	PF00082	0.349
CLV_PCSK_SKI1_1	641	645	PF00082	0.258
CLV_PCSK_SKI1_1	816	820	PF00082	0.283
CLV_PCSK_SKI1_1	834	838	PF00082	0.349
CLV_PCSK_SKI1_1	94	98	PF00082	0.404
CLV_Separin_Metazoa	563	567	PF03568	0.297
DOC_AGCK_PIF_2	185	190	PF00069	0.206
DOC_CYCLIN_RxL_1	669	680	PF00134	0.349
DOC_CYCLIN_RxL_1	813	824	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	568	574	PF00134	0.349
DOC_MAPK_FxFP_2	267	270	PF00069	0.297
DOC_MAPK_gen_1	313	320	PF00069	0.349
DOC_MAPK_MEF2A_6	154	163	PF00069	0.394
DOC_MAPK_MEF2A_6	384	393	PF00069	0.264
DOC_MAPK_MEF2A_6	410	417	PF00069	0.349
DOC_MAPK_NFAT4_5	410	418	PF00069	0.349
DOC_PP1_RVXF_1	673	680	PF00149	0.388
DOC_PP2B_LxvP_1	229	232	PF13499	0.340
DOC_PP2B_LxvP_1	829	832	PF13499	0.297
DOC_PP4_FxxP_1	267	270	PF00568	0.349
DOC_SPAK_OSR1_1	493	497	PF12202	0.361
DOC_USP7_MATH_1	230	234	PF00917	0.572
DOC_USP7_MATH_1	382	386	PF00917	0.409
DOC_USP7_MATH_1	439	443	PF00917	0.341
DOC_USP7_MATH_1	534	538	PF00917	0.344
DOC_USP7_MATH_1	754	758	PF00917	0.308
DOC_USP7_MATH_1	771	775	PF00917	0.404
DOC_USP7_MATH_2	841	847	PF00917	0.349
DOC_WW_Pin1_4	19	24	PF00397	0.299
DOC_WW_Pin1_4	238	243	PF00397	0.331
DOC_WW_Pin1_4	634	639	PF00397	0.297
DOC_WW_Pin1_4	650	655	PF00397	0.417
DOC_WW_Pin1_4	704	709	PF00397	0.293
LIG_14-3-3_CanoR_1	250	256	PF00244	0.297
LIG_14-3-3_CanoR_1	384	388	PF00244	0.291
LIG_14-3-3_CanoR_1	557	565	PF00244	0.378
LIG_14-3-3_CanoR_1	681	688	PF00244	0.331
LIG_14-3-3_CanoR_1	701	710	PF00244	0.313
LIG_14-3-3_CanoR_1	847	853	PF00244	0.297
LIG_14-3-3_CanoR_1	87	91	PF00244	0.461
LIG_14-3-3_CanoR_1	94	102	PF00244	0.403
LIG_Actin_WH2_2	445	463	PF00022	0.349
LIG_Actin_WH2_2	615	632	PF00022	0.308
LIG_APCC_ABBA_1	260	265	PF00400	0.242
LIG_BIR_II_1	1	5	PF00653	0.517
LIG_BRCT_BRCA1_1	374	378	PF00533	0.271
LIG_deltaCOP1_diTrp_1	290	297	PF00928	0.394
LIG_deltaCOP1_diTrp_1	340	347	PF00928	0.267
LIG_deltaCOP1_diTrp_1	362	369	PF00928	0.283
LIG_FHA_1	105	111	PF00498	0.319
LIG_FHA_1	126	132	PF00498	0.349
LIG_FHA_1	154	160	PF00498	0.408
LIG_FHA_1	196	202	PF00498	0.269
LIG_FHA_1	208	214	PF00498	0.340
LIG_FHA_1	351	357	PF00498	0.289
LIG_FHA_1	365	371	PF00498	0.247
LIG_FHA_1	44	50	PF00498	0.343
LIG_FHA_1	482	488	PF00498	0.388
LIG_FHA_1	524	530	PF00498	0.482
LIG_FHA_1	533	539	PF00498	0.371
LIG_FHA_1	571	577	PF00498	0.350
LIG_FHA_1	598	604	PF00498	0.365
LIG_FHA_1	701	707	PF00498	0.314
LIG_FHA_1	777	783	PF00498	0.397
LIG_FHA_1	788	794	PF00498	0.393
LIG_FHA_2	294	300	PF00498	0.264
LIG_FHA_2	53	59	PF00498	0.284
LIG_FHA_2	736	742	PF00498	0.311
LIG_Integrin_RGD_1	665	667	PF01839	0.232
LIG_LIR_Apic_2	264	270	PF02991	0.285
LIG_LIR_Gen_1	400	408	PF02991	0.264
LIG_LIR_Gen_1	55	63	PF02991	0.315
LIG_LIR_Gen_1	580	591	PF02991	0.284
LIG_LIR_Gen_1	617	625	PF02991	0.264
LIG_LIR_Gen_1	776	785	PF02991	0.382
LIG_LIR_Nem_3	112	118	PF02991	0.358
LIG_LIR_Nem_3	290	295	PF02991	0.264
LIG_LIR_Nem_3	345	350	PF02991	0.273
LIG_LIR_Nem_3	400	406	PF02991	0.264
LIG_LIR_Nem_3	470	476	PF02991	0.439
LIG_LIR_Nem_3	55	59	PF02991	0.345
LIG_LIR_Nem_3	580	586	PF02991	0.284
LIG_LIR_Nem_3	588	592	PF02991	0.241
LIG_LIR_Nem_3	617	622	PF02991	0.264
LIG_LIR_Nem_3	800	805	PF02991	0.339
LIG_LYPXL_yS_3	473	476	PF13949	0.292
LIG_NRBOX	855	861	PF00104	0.240
LIG_PALB2_WD40_1	324	332	PF16756	0.264
LIG_PCNA_PIPBox_1	428	437	PF02747	0.283
LIG_PCNA_yPIPBox_3	425	435	PF02747	0.292
LIG_Pex14_2	269	273	PF04695	0.297
LIG_PTB_Apo_2	24	31	PF02174	0.271
LIG_PTB_Apo_2	280	287	PF02174	0.349
LIG_PTB_Apo_2	646	653	PF02174	0.401
LIG_PTB_Phospho_1	646	652	PF10480	0.401
LIG_SH2_CRK	583	587	PF00017	0.336
LIG_SH2_NCK_1	440	444	PF00017	0.297
LIG_SH2_PTP2	271	274	PF00017	0.260
LIG_SH2_SRC	438	441	PF00017	0.349
LIG_SH2_SRC	713	716	PF00017	0.232
LIG_SH2_STAP1	106	110	PF00017	0.349
LIG_SH2_STAP1	263	267	PF00017	0.264
LIG_SH2_STAP1	560	564	PF00017	0.394
LIG_SH2_STAP1	583	587	PF00017	0.345
LIG_SH2_STAP1	589	593	PF00017	0.286
LIG_SH2_STAP1	715	719	PF00017	0.297
LIG_SH2_STAT5	106	109	PF00017	0.302
LIG_SH2_STAT5	130	133	PF00017	0.272
LIG_SH2_STAT5	199	202	PF00017	0.273
LIG_SH2_STAT5	271	274	PF00017	0.259
LIG_SH2_STAT5	434	437	PF00017	0.264
LIG_SH2_STAT5	475	478	PF00017	0.395
LIG_SH2_STAT5	515	518	PF00017	0.428
LIG_SH2_STAT5	560	563	PF00017	0.462
LIG_SH2_STAT5	597	600	PF00017	0.282
LIG_SH2_STAT5	616	619	PF00017	0.169
LIG_SH2_STAT5	713	716	PF00017	0.282
LIG_SH2_STAT5	746	749	PF00017	0.283
LIG_SH2_STAT5	766	769	PF00017	0.371
LIG_SH2_STAT5	876	879	PF00017	0.477
LIG_SH3_3	176	182	PF00018	0.349
LIG_SH3_3	210	216	PF00018	0.427
LIG_SH3_3	452	458	PF00018	0.340
LIG_SH3_3	750	756	PF00018	0.349
LIG_SUMO_SIM_par_1	71	78	PF11976	0.320
LIG_TRAF2_1	304	307	PF00917	0.297
LIG_UBA3_1	402	410	PF00899	0.264
LIG_UBA3_1	813	819	PF00899	0.394
MOD_CDK_SPK_2	238	243	PF00069	0.450
MOD_CDK_SPxxK_3	238	245	PF00069	0.355
MOD_CDK_SPxxK_3	634	641	PF00069	0.206
MOD_CK1_1	346	352	PF00069	0.283
MOD_CK1_1	442	448	PF00069	0.380
MOD_CK1_1	57	63	PF00069	0.332
MOD_CK1_1	704	710	PF00069	0.349
MOD_CK2_1	293	299	PF00069	0.264
MOD_CK2_1	633	639	PF00069	0.324
MOD_CK2_1	683	689	PF00069	0.323
MOD_CK2_1	735	741	PF00069	0.391
MOD_CK2_1	75	81	PF00069	0.347
MOD_CK2_1	821	827	PF00069	0.434
MOD_DYRK1A_RPxSP_1	238	242	PF00069	0.339
MOD_GlcNHglycan	217	220	PF01048	0.540
MOD_GlcNHglycan	225	228	PF01048	0.484
MOD_GlcNHglycan	30	33	PF01048	0.349
MOD_GlcNHglycan	306	311	PF01048	0.269
MOD_GlcNHglycan	441	444	PF01048	0.424
MOD_GlcNHglycan	452	455	PF01048	0.311
MOD_GlcNHglycan	703	706	PF01048	0.416
MOD_GSK3_1	104	111	PF00069	0.304
MOD_GSK3_1	149	156	PF00069	0.327
MOD_GSK3_1	298	305	PF00069	0.308
MOD_GSK3_1	346	353	PF00069	0.232
MOD_GSK3_1	532	539	PF00069	0.379
MOD_GSK3_1	577	584	PF00069	0.379
MOD_GSK3_1	605	612	PF00069	0.348
MOD_GSK3_1	677	684	PF00069	0.426
MOD_GSK3_1	700	707	PF00069	0.291
MOD_GSK3_1	75	82	PF00069	0.364
MOD_GSK3_1	8	15	PF00069	0.418
MOD_N-GLC_1	26	31	PF02516	0.336
MOD_N-GLC_1	343	348	PF02516	0.283
MOD_N-GLC_1	577	582	PF02516	0.401
MOD_NEK2_1	104	109	PF00069	0.404
MOD_NEK2_1	117	122	PF00069	0.192
MOD_NEK2_1	159	164	PF00069	0.273
MOD_NEK2_1	194	199	PF00069	0.310
MOD_NEK2_1	251	256	PF00069	0.412
MOD_NEK2_1	343	348	PF00069	0.283
MOD_NEK2_1	383	388	PF00069	0.264
MOD_NEK2_1	487	492	PF00069	0.368
MOD_NEK2_1	633	638	PF00069	0.313
MOD_NEK2_1	677	682	PF00069	0.356
MOD_NEK2_1	683	688	PF00069	0.362
MOD_NEK2_2	293	298	PF00069	0.394
MOD_PIKK_1	131	137	PF00454	0.235
MOD_PIKK_1	364	370	PF00454	0.264
MOD_PIKK_1	487	493	PF00454	0.349
MOD_PIKK_1	668	674	PF00454	0.347
MOD_PIKK_1	771	777	PF00454	0.306
MOD_PIKK_1	787	793	PF00454	0.394
MOD_PK_1	525	531	PF00069	0.491
MOD_PK_1	808	814	PF00069	0.349
MOD_PKA_1	700	706	PF00069	0.395
MOD_PKA_2	104	110	PF00069	0.462
MOD_PKA_2	12	18	PF00069	0.426
MOD_PKA_2	383	389	PF00069	0.264
MOD_PKA_2	581	587	PF00069	0.283
MOD_PKA_2	700	706	PF00069	0.339
MOD_PKA_2	848	854	PF00069	0.297
MOD_PKA_2	86	92	PF00069	0.371
MOD_Plk_1	159	165	PF00069	0.401
MOD_Plk_1	26	32	PF00069	0.380
MOD_Plk_1	298	304	PF00069	0.422
MOD_Plk_1	306	312	PF00069	0.357
MOD_Plk_1	343	349	PF00069	0.283
MOD_Plk_1	57	63	PF00069	0.308
MOD_Plk_1	614	620	PF00069	0.264
MOD_Plk_1	688	694	PF00069	0.274
MOD_Plk_2-3	398	404	PF00069	0.349
MOD_Plk_2-3	822	828	PF00069	0.349
MOD_Plk_4	126	132	PF00069	0.342
MOD_Plk_4	195	201	PF00069	0.276
MOD_Plk_4	231	237	PF00069	0.339
MOD_Plk_4	298	304	PF00069	0.349
MOD_Plk_4	346	352	PF00069	0.264
MOD_Plk_4	398	404	PF00069	0.361
MOD_Plk_4	43	49	PF00069	0.299
MOD_Plk_4	581	587	PF00069	0.434
MOD_Plk_4	614	620	PF00069	0.299
MOD_Plk_4	808	814	PF00069	0.287
MOD_ProDKin_1	19	25	PF00069	0.299
MOD_ProDKin_1	238	244	PF00069	0.340
MOD_ProDKin_1	634	640	PF00069	0.297
MOD_ProDKin_1	650	656	PF00069	0.417
MOD_ProDKin_1	704	710	PF00069	0.293
TRG_DiLeu_BaEn_1	729	734	PF01217	0.411
TRG_DiLeu_BaLyEn_6	672	677	PF01217	0.349
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.283
TRG_ENDOCYTIC_2	473	476	PF00928	0.305
TRG_ENDOCYTIC_2	583	586	PF00928	0.293
TRG_ENDOCYTIC_2	589	592	PF00928	0.237
TRG_ER_diArg_1	142	144	PF00400	0.349
TRG_ER_diArg_1	492	494	PF00400	0.426
TRG_ER_diArg_1	663	665	PF00400	0.418
TRG_ER_diArg_1	802	804	PF00400	0.239
TRG_ER_diArg_1	847	850	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	695	699	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	803	807	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R5	Leptomonas seymouri	29%	100%
A0A0S4JBK9	Bodo saltans	38%	100%
A0A1X0NMW3	Trypanosomatidae	41%	100%
A0A3R7K1R9	Trypanosoma rangeli	40%	100%
A0A6J2ATK2	Acinonyx jubatus	27%	89%
A2RI32	Lactococcus lactis subsp. cremoris (strain MG1363)	29%	100%
A5HUI5	Gloydius brevicaudus	27%	92%
A6QPT7	Bos taurus	27%	93%
D0A6I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D3UW23	Bitis rhinoceros	28%	92%
E9AHB1	Leishmania infantum	100%	100%
E9AIS1	Leishmania braziliensis	80%	100%
E9AY12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
M3XFH7	Felis catus	27%	89%
O57579	Gallus gallus	25%	91%
O93654	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	28%	100%
O93655	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	30%	100%
P0C2T8	Lactococcus lactis subsp. cremoris	29%	100%
P15144	Homo sapiens	32%	91%
P15145	Sus scrofa	27%	92%
P15541	Oryctolagus cuniculus	27%	91%
P15684	Rattus norvegicus	27%	92%
P16406	Mus musculus	28%	93%
P32454	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	93%
P37896	Lactobacillus delbrueckii subsp. lactis	29%	100%
P37898	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P40462	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	93%
P50123	Rattus norvegicus	28%	93%
P55786	Homo sapiens	33%	96%
P79143	Canis lupus familiaris	27%	91%
P79171	Felis catus	27%	91%
P91885	Manduca sexta	26%	94%
P91887	Plutella xylostella	30%	93%
P95928	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	100%
P97449	Mus musculus	27%	91%
P97629	Rattus norvegicus	29%	86%
Q07075	Homo sapiens	28%	92%
Q0J2B5	Oryza sativa subsp. japonica	32%	100%
Q0J5V5	Oryza sativa subsp. japonica	33%	100%
Q10730	Lactobacillus helveticus	27%	100%
Q10737	Haemonchus contortus	29%	91%
Q10836	Rattus norvegicus	27%	86%
Q11000	Heliothis virescens	29%	88%
Q11001	Manduca sexta	26%	89%
Q11011	Mus musculus	33%	96%
Q17405	Caenorhabditis elegans	21%	81%
Q32LQ0	Bos taurus	27%	92%
Q48656	Lactococcus lactis subsp. lactis	27%	100%
Q4Q9G1	Leishmania major	93%	100%
Q4TT88	Caenorhabditis elegans	31%	93%
Q59KZ1	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	96%
Q5RFP3	Pongo abelii	27%	92%
Q6K4E7	Oryza sativa subsp. japonica	32%	100%
Q6P179	Homo sapiens	26%	92%
Q6Q4G3	Homo sapiens	26%	89%
Q6Z6L4	Oryza sativa subsp. japonica	33%	100%
Q8C129	Mus musculus	29%	86%
Q8K093	Mus musculus	27%	86%
Q8SQI6	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q8SRG3	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q8VZH2	Arabidopsis thaliana	32%	100%
Q95334	Sus scrofa	28%	94%
Q974N6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	30%	100%
Q978U3	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	28%	100%
Q97AJ6	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	30%	100%
Q97VF1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	30%	100%
Q9CIQ1	Lactococcus lactis subsp. lactis (strain IL1403)	29%	100%
Q9EQH2	Mus musculus	30%	95%
Q9JJ22	Rattus norvegicus	26%	95%
Q9NZ08	Homo sapiens	27%	94%
Q9UIQ6	Homo sapiens	30%	86%
Q9UKU6	Homo sapiens	27%	86%
Q9USX1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
V5BSI2	Trypanosoma cruzi	28%	100%
V5D7P4	Trypanosoma cruzi	41%	100%