Stealth_CR2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8ICL5_LEIDO

TriTrypDb:

LdBPK_231330.1 , LdBPK_231340.1 , LdCL_230020400 , LDHU3_23.1770

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8ICL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICL5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.431
CLV_NRD_NRD_1	138	140	PF00675	0.483
CLV_NRD_NRD_1	163	165	PF00675	0.491
CLV_NRD_NRD_1	405	407	PF00675	0.413
CLV_NRD_NRD_1	488	490	PF00675	0.538
CLV_NRD_NRD_1	541	543	PF00675	0.523
CLV_PCSK_KEX2_1	101	103	PF00082	0.431
CLV_PCSK_KEX2_1	138	140	PF00082	0.483
CLV_PCSK_KEX2_1	163	165	PF00082	0.491
CLV_PCSK_KEX2_1	405	407	PF00082	0.410
CLV_PCSK_KEX2_1	488	490	PF00082	0.551
CLV_PCSK_KEX2_1	541	543	PF00082	0.523
CLV_PCSK_PC7_1	97	103	PF00082	0.508
CLV_PCSK_SKI1_1	188	192	PF00082	0.472
CLV_PCSK_SKI1_1	225	229	PF00082	0.493
CLV_PCSK_SKI1_1	26	30	PF00082	0.527
CLV_PCSK_SKI1_1	280	284	PF00082	0.522
CLV_PCSK_SKI1_1	341	345	PF00082	0.522
CLV_PCSK_SKI1_1	603	607	PF00082	0.404
CLV_PCSK_SKI1_1	638	642	PF00082	0.377
CLV_PCSK_SKI1_1	66	70	PF00082	0.506
DEG_APCC_DBOX_1	109	117	PF00400	0.350
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DOC_ANK_TNKS_1	381	388	PF00023	0.541
DOC_CKS1_1	67	72	PF01111	0.489
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	480	486	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	616	622	PF00134	0.475
DOC_MAPK_gen_1	163	169	PF00069	0.291
DOC_MAPK_gen_1	405	412	PF00069	0.410
DOC_MAPK_MEF2A_6	382	390	PF00069	0.629
DOC_MAPK_MEF2A_6	66	75	PF00069	0.399
DOC_PP1_RVXF_1	236	243	PF00149	0.291
DOC_PP1_RVXF_1	486	493	PF00149	0.543
DOC_PP1_RVXF_1	636	642	PF00149	0.473
DOC_PP1_RVXF_1	92	99	PF00149	0.495
DOC_PP4_FxxP_1	354	357	PF00568	0.577
DOC_PP4_FxxP_1	79	82	PF00568	0.446
DOC_USP7_MATH_1	316	320	PF00917	0.480
DOC_USP7_MATH_1	499	503	PF00917	0.524
DOC_USP7_MATH_1	569	573	PF00917	0.520
DOC_WW_Pin1_4	1	6	PF00397	0.639
DOC_WW_Pin1_4	247	252	PF00397	0.531
DOC_WW_Pin1_4	35	40	PF00397	0.558
DOC_WW_Pin1_4	361	366	PF00397	0.589
DOC_WW_Pin1_4	392	397	PF00397	0.466
DOC_WW_Pin1_4	428	433	PF00397	0.538
DOC_WW_Pin1_4	562	567	PF00397	0.542
DOC_WW_Pin1_4	66	71	PF00397	0.498
LIG_14-3-3_CanoR_1	11	19	PF00244	0.529
LIG_14-3-3_CanoR_1	110	114	PF00244	0.350
LIG_14-3-3_CanoR_1	188	196	PF00244	0.272
LIG_14-3-3_CanoR_1	238	243	PF00244	0.302
LIG_14-3-3_CanoR_1	30	36	PF00244	0.549
LIG_14-3-3_CanoR_1	488	493	PF00244	0.593
LIG_AP2alpha_1	242	246	PF02296	0.291
LIG_BRCT_BRCA1_1	223	227	PF00533	0.291
LIG_Clathr_ClatBox_1	398	402	PF01394	0.424
LIG_deltaCOP1_diTrp_1	614	621	PF00928	0.386
LIG_DLG_GKlike_1	238	245	PF00625	0.291
LIG_FHA_1	276	282	PF00498	0.670
LIG_FHA_1	509	515	PF00498	0.597
LIG_FHA_2	189	195	PF00498	0.295
LIG_FHA_2	301	307	PF00498	0.553
LIG_FHA_2	585	591	PF00498	0.476
LIG_HCF-1_HBM_1	574	577	PF13415	0.536
LIG_LIR_Apic_2	200	206	PF02991	0.287
LIG_LIR_Apic_2	351	357	PF02991	0.522
LIG_LIR_Apic_2	78	82	PF02991	0.368
LIG_LIR_Gen_1	105	113	PF02991	0.358
LIG_LIR_Gen_1	224	235	PF02991	0.315
LIG_LIR_Gen_1	241	251	PF02991	0.291
LIG_LIR_Gen_1	25	36	PF02991	0.538
LIG_LIR_Gen_1	434	444	PF02991	0.490
LIG_LIR_Gen_1	45	56	PF02991	0.472
LIG_LIR_Gen_1	462	471	PF02991	0.541
LIG_LIR_Gen_1	574	584	PF02991	0.499
LIG_LIR_Gen_1	592	602	PF02991	0.410
LIG_LIR_Gen_1	74	85	PF02991	0.369
LIG_LIR_Nem_3	105	109	PF02991	0.294
LIG_LIR_Nem_3	181	187	PF02991	0.295
LIG_LIR_Nem_3	224	229	PF02991	0.308
LIG_LIR_Nem_3	241	246	PF02991	0.307
LIG_LIR_Nem_3	25	31	PF02991	0.544
LIG_LIR_Nem_3	372	378	PF02991	0.530
LIG_LIR_Nem_3	402	407	PF02991	0.439
LIG_LIR_Nem_3	434	439	PF02991	0.534
LIG_LIR_Nem_3	45	51	PF02991	0.482
LIG_LIR_Nem_3	462	467	PF02991	0.545
LIG_LIR_Nem_3	502	507	PF02991	0.536
LIG_LIR_Nem_3	524	530	PF02991	0.552
LIG_LIR_Nem_3	573	579	PF02991	0.503
LIG_LIR_Nem_3	592	598	PF02991	0.421
LIG_LIR_Nem_3	74	80	PF02991	0.360
LIG_LIR_Nem_3	86	91	PF02991	0.384
LIG_MLH1_MIPbox_1	223	227	PF16413	0.291
LIG_PCNA_PIPBox_1	444	453	PF02747	0.488
LIG_Pex14_2	242	246	PF04695	0.291
LIG_RPA_C_Fungi	638	650	PF08784	0.353
LIG_SH2_CRK	404	408	PF00017	0.412
LIG_SH2_CRK	577	581	PF00017	0.522
LIG_SH2_CRK	77	81	PF00017	0.363
LIG_SH2_NCK_1	14	18	PF00017	0.632
LIG_SH2_NCK_1	430	434	PF00017	0.480
LIG_SH2_NCK_1	550	554	PF00017	0.580
LIG_SH2_SRC	392	395	PF00017	0.456
LIG_SH2_SRC	550	553	PF00017	0.575
LIG_SH2_STAP1	423	427	PF00017	0.487
LIG_SH2_STAP1	48	52	PF00017	0.528
LIG_SH2_STAP1	577	581	PF00017	0.522
LIG_SH2_STAT5	166	169	PF00017	0.331
LIG_SH2_STAT5	35	38	PF00017	0.552
LIG_SH2_STAT5	77	80	PF00017	0.365
LIG_SH3_2	248	253	PF14604	0.541
LIG_SH3_2	536	541	PF14604	0.523
LIG_SH3_3	245	251	PF00018	0.503
LIG_SH3_3	33	39	PF00018	0.556
LIG_SH3_3	340	346	PF00018	0.522
LIG_SH3_3	426	432	PF00018	0.523
LIG_SH3_3	533	539	PF00018	0.525
LIG_SH3_3	64	70	PF00018	0.446
LIG_SH3_3	650	656	PF00018	0.480
LIG_SH3_3	79	85	PF00018	0.378
LIG_SUMO_SIM_par_1	397	402	PF11976	0.426
LIG_TYR_ITIM	525	530	PF00017	0.547
LIG_TYR_ITIM	611	616	PF00017	0.413
LIG_TYR_ITIM	75	80	PF00017	0.361
LIG_UBA3_1	594	603	PF00899	0.518
LIG_WRC_WIRS_1	76	81	PF05994	0.441
MOD_CDC14_SPxK_1	250	253	PF00782	0.542
MOD_CDK_SPK_2	361	366	PF00069	0.547
MOD_CDK_SPxK_1	247	253	PF00069	0.534
MOD_CK1_1	112	118	PF00069	0.355
MOD_CK1_1	15	21	PF00069	0.616
MOD_CK1_1	262	268	PF00069	0.529
MOD_CK1_1	272	278	PF00069	0.565
MOD_CK1_1	347	353	PF00069	0.539
MOD_CK1_1	495	501	PF00069	0.504
MOD_CK2_1	112	118	PF00069	0.402
MOD_CK2_1	19	25	PF00069	0.570
MOD_CK2_1	194	200	PF00069	0.340
MOD_CK2_1	300	306	PF00069	0.613
MOD_CK2_1	35	41	PF00069	0.506
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.528
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.504
MOD_GlcNHglycan	122	125	PF01048	0.435
MOD_GlcNHglycan	196	199	PF01048	0.495
MOD_GlcNHglycan	21	24	PF01048	0.572
MOD_GlcNHglycan	214	217	PF01048	0.212
MOD_GlcNHglycan	334	337	PF01048	0.490
MOD_GlcNHglycan	44	47	PF01048	0.541
MOD_GlcNHglycan	495	498	PF01048	0.532
MOD_GlcNHglycan	62	65	PF01048	0.385
MOD_GSK3_1	15	22	PF00069	0.676
MOD_GSK3_1	262	269	PF00069	0.534
MOD_GSK3_1	31	38	PF00069	0.690
MOD_GSK3_1	344	351	PF00069	0.658
MOD_GSK3_1	488	495	PF00069	0.553
MOD_GSK3_1	62	69	PF00069	0.606
MOD_N-GLC_1	147	152	PF02516	0.466
MOD_N-GLC_1	269	274	PF02516	0.538
MOD_N-GLC_1	275	280	PF02516	0.484
MOD_N-GLC_1	416	421	PF02516	0.406
MOD_N-GLC_1	54	59	PF02516	0.463
MOD_N-GLC_1	632	637	PF02516	0.555
MOD_NEK2_1	109	114	PF00069	0.349
MOD_NEK2_1	413	418	PF00069	0.475
MOD_NEK2_1	451	456	PF00069	0.491
MOD_NEK2_1	584	589	PF00069	0.558
MOD_NEK2_2	499	504	PF00069	0.548
MOD_PIKK_1	290	296	PF00454	0.496
MOD_PK_1	643	649	PF00069	0.345
MOD_PKA_1	488	494	PF00069	0.554
MOD_PKA_2	109	115	PF00069	0.348
MOD_PKA_2	262	268	PF00069	0.577
MOD_PKA_2	467	473	PF00069	0.584
MOD_PKA_2	488	494	PF00069	0.561
MOD_PKA_2	537	543	PF00069	0.577
MOD_Plk_1	15	21	PF00069	0.522
MOD_Plk_1	269	275	PF00069	0.546
MOD_Plk_1	499	505	PF00069	0.515
MOD_Plk_1	54	60	PF00069	0.452
MOD_Plk_1	589	595	PF00069	0.493
MOD_Plk_4	157	163	PF00069	0.426
MOD_Plk_4	238	244	PF00069	0.335
MOD_Plk_4	31	37	PF00069	0.624
MOD_Plk_4	451	457	PF00069	0.495
MOD_Plk_4	470	476	PF00069	0.491
MOD_Plk_4	499	505	PF00069	0.555
MOD_Plk_4	54	60	PF00069	0.443
MOD_Plk_4	575	581	PF00069	0.544
MOD_Plk_4	589	595	PF00069	0.507
MOD_Plk_4	75	81	PF00069	0.360
MOD_Plk_4	83	89	PF00069	0.389
MOD_ProDKin_1	1	7	PF00069	0.637
MOD_ProDKin_1	247	253	PF00069	0.534
MOD_ProDKin_1	35	41	PF00069	0.559
MOD_ProDKin_1	361	367	PF00069	0.587
MOD_ProDKin_1	392	398	PF00069	0.458
MOD_ProDKin_1	428	434	PF00069	0.532
MOD_ProDKin_1	562	568	PF00069	0.540
MOD_ProDKin_1	66	72	PF00069	0.496
MOD_SUMO_for_1	298	301	PF00179	0.579
MOD_SUMO_rev_2	596	605	PF00179	0.390
TRG_DiLeu_BaEn_1	340	345	PF01217	0.506
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.464
TRG_ENDOCYTIC_2	166	169	PF00928	0.331
TRG_ENDOCYTIC_2	375	378	PF00928	0.523
TRG_ENDOCYTIC_2	404	407	PF00928	0.635
TRG_ENDOCYTIC_2	430	433	PF00928	0.543
TRG_ENDOCYTIC_2	436	439	PF00928	0.579
TRG_ENDOCYTIC_2	47	50	PF00928	0.498
TRG_ENDOCYTIC_2	527	530	PF00928	0.541
TRG_ENDOCYTIC_2	576	579	PF00928	0.492
TRG_ENDOCYTIC_2	581	584	PF00928	0.484
TRG_ENDOCYTIC_2	599	602	PF00928	0.334
TRG_ENDOCYTIC_2	613	616	PF00928	0.417
TRG_ENDOCYTIC_2	77	80	PF00928	0.365
TRG_ER_diArg_1	101	103	PF00400	0.433
TRG_ER_diArg_1	137	139	PF00400	0.452
TRG_ER_diArg_1	162	164	PF00400	0.331
TRG_ER_diArg_1	252	255	PF00400	0.567
TRG_ER_diArg_1	311	314	PF00400	0.502
TRG_ER_diArg_1	404	406	PF00400	0.404
TRG_ER_diArg_1	488	490	PF00400	0.547
TRG_ER_diArg_1	541	543	PF00400	0.514
TRG_ER_diArg_1	610	613	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV0	Leptomonas seymouri	63%	87%
A0A3Q8ICR3	Leishmania donovani	48%	83%
A0A3S7WXU9	Leishmania donovani	100%	100%
A4HCY1	Leishmania braziliensis	45%	97%
A4I0G4	Leishmania infantum	49%	98%
A4I0G5	Leishmania infantum	100%	100%
E9AWC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	97%
E9AWC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QB44	Leishmania major	89%	100%
Q4QB45	Leishmania major	47%	98%