Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICK9_LEIDO

TriTrypDb:

LdBPK_161140.1 , LdCL_160016500 , LDHU3_16.1400

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.762
CLV_NRD_NRD_1	109	111	PF00675	0.540
CLV_NRD_NRD_1	203	205	PF00675	0.679
CLV_NRD_NRD_1	22	24	PF00675	0.681
CLV_NRD_NRD_1	294	296	PF00675	0.813
CLV_NRD_NRD_1	422	424	PF00675	0.671
CLV_NRD_NRD_1	450	452	PF00675	0.684
CLV_NRD_NRD_1	480	482	PF00675	0.552
CLV_PCSK_FUR_1	201	205	PF00082	0.679
CLV_PCSK_KEX2_1	13	15	PF00082	0.705
CLV_PCSK_KEX2_1	203	205	PF00082	0.679
CLV_PCSK_KEX2_1	22	24	PF00082	0.563
CLV_PCSK_KEX2_1	27	29	PF00082	0.497
CLV_PCSK_KEX2_1	422	424	PF00082	0.671
CLV_PCSK_KEX2_1	450	452	PF00082	0.684
CLV_PCSK_KEX2_1	470	472	PF00082	0.363
CLV_PCSK_KEX2_1	474	476	PF00082	0.562
CLV_PCSK_KEX2_1	480	482	PF00082	0.495
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.705
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.497
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.681
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.638
CLV_PCSK_PC7_1	23	29	PF00082	0.582
CLV_PCSK_SKI1_1	102	106	PF00082	0.619
CLV_PCSK_SKI1_1	369	373	PF00082	0.831
DEG_APCC_DBOX_1	75	83	PF00400	0.700
DOC_CKS1_1	370	375	PF01111	0.831
DOC_CKS1_1	377	382	PF01111	0.714
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.704
DOC_MAPK_gen_1	71	79	PF00069	0.643
DOC_PP4_FxxP_1	406	409	PF00568	0.723
DOC_USP7_MATH_1	129	133	PF00917	0.759
DOC_USP7_MATH_1	153	157	PF00917	0.652
DOC_USP7_MATH_1	275	279	PF00917	0.549
DOC_USP7_MATH_1	335	339	PF00917	0.758
DOC_USP7_UBL2_3	167	171	PF12436	0.752
DOC_USP7_UBL2_3	470	474	PF12436	0.687
DOC_WW_Pin1_4	325	330	PF00397	0.838
DOC_WW_Pin1_4	369	374	PF00397	0.833
DOC_WW_Pin1_4	376	381	PF00397	0.717
DOC_WW_Pin1_4	405	410	PF00397	0.727
LIG_14-3-3_CanoR_1	125	129	PF00244	0.585
LIG_14-3-3_CanoR_1	28	32	PF00244	0.643
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BIR_III_4	39	43	PF00653	0.730
LIG_BRCT_BRCA1_1	391	395	PF00533	0.719
LIG_CtBP_PxDLS_1	351	355	PF00389	0.763
LIG_eIF4E_1	100	106	PF01652	0.686
LIG_FHA_1	370	376	PF00498	0.831
LIG_FHA_1	377	383	PF00498	0.705
LIG_FHA_1	409	415	PF00498	0.678
LIG_FHA_1	519	525	PF00498	0.657
LIG_FHA_2	125	131	PF00498	0.690
LIG_FHA_2	140	146	PF00498	0.546
LIG_FHA_2	42	48	PF00498	0.789
LIG_FHA_2	483	489	PF00498	0.690
LIG_FHA_2	7	13	PF00498	0.721
LIG_LIR_Apic_2	126	131	PF02991	0.688
LIG_LIR_Apic_2	135	140	PF02991	0.573
LIG_LIR_Apic_2	403	409	PF02991	0.715
LIG_LIR_Nem_3	132	137	PF02991	0.660
LIG_LIR_Nem_3	263	268	PF02991	0.506
LIG_LIR_Nem_3	29	34	PF02991	0.740
LIG_LIR_Nem_3	393	399	PF02991	0.693
LIG_MYND_1	380	384	PF01753	0.799
LIG_Pex14_1	402	406	PF04695	0.687
LIG_SH2_CRK	61	65	PF00017	0.751
LIG_SH2_NCK_1	137	141	PF00017	0.667
LIG_SH2_SRC	137	140	PF00017	0.729
LIG_SH2_SRC	61	64	PF00017	0.752
LIG_SH2_STAP1	100	104	PF00017	0.686
LIG_SH2_STAP1	265	269	PF00017	0.609
LIG_SH2_STAT3	268	271	PF00017	0.608
LIG_SH2_STAT5	123	126	PF00017	0.750
LIG_SH2_STAT5	162	165	PF00017	0.768
LIG_SH2_STAT5	220	223	PF00017	0.551
LIG_SH3_3	114	120	PF00018	0.727
LIG_SH3_3	284	290	PF00018	0.675
LIG_SH3_3	309	315	PF00018	0.749
LIG_SH3_3	323	329	PF00018	0.708
LIG_SH3_3	367	373	PF00018	0.769
LIG_SH3_3	374	380	PF00018	0.721
LIG_SH3_3	384	390	PF00018	0.508
LIG_TRAF2_1	241	244	PF00917	0.711
LIG_TRAF2_1	269	272	PF00917	0.607
LIG_TRAF2_1	304	307	PF00917	0.819
LIG_TRAF2_1	359	362	PF00917	0.702
LIG_TRAF2_1	537	540	PF00917	0.649
LIG_TRAF2_1	67	70	PF00917	0.715
MOD_CDK_SPxxK_3	369	376	PF00069	0.833
MOD_CK1_1	132	138	PF00069	0.634
MOD_CK1_1	328	334	PF00069	0.808
MOD_CK1_1	408	414	PF00069	0.677
MOD_CK1_1	551	557	PF00069	0.721
MOD_CK2_1	220	226	PF00069	0.695
MOD_CK2_1	41	47	PF00069	0.789
MOD_CK2_1	534	540	PF00069	0.653
MOD_CK2_1	6	12	PF00069	0.727
MOD_CK2_1	64	70	PF00069	0.725
MOD_DYRK1A_RPxSP_1	325	329	PF00069	0.840
MOD_DYRK1A_RPxSP_1	369	373	PF00069	0.831
MOD_DYRK1A_RPxSP_1	376	380	PF00069	0.719
MOD_GlcNHglycan	159	162	PF01048	0.779
MOD_GlcNHglycan	298	301	PF01048	0.818
MOD_GlcNHglycan	336	340	PF01048	0.821
MOD_GlcNHglycan	551	554	PF01048	0.654
MOD_GSK3_1	119	126	PF00069	0.690
MOD_GSK3_1	153	160	PF00069	0.785
MOD_GSK3_1	325	332	PF00069	0.838
MOD_GSK3_1	350	357	PF00069	0.761
MOD_GSK3_1	41	48	PF00069	0.674
MOD_GSK3_1	84	91	PF00069	0.692
MOD_N-GLC_1	414	419	PF02516	0.704
MOD_N-GLC_1	518	523	PF02516	0.656
MOD_NEK2_1	106	111	PF00069	0.626
MOD_NEK2_1	124	129	PF00069	0.469
MOD_NEK2_1	26	31	PF00069	0.725
MOD_NEK2_1	460	465	PF00069	0.686
MOD_NEK2_1	548	553	PF00069	0.691
MOD_PIKK_1	267	273	PF00454	0.607
MOD_PIKK_1	354	360	PF00454	0.830
MOD_PIKK_1	382	388	PF00454	0.784
MOD_PIKK_1	438	444	PF00454	0.660
MOD_PIKK_1	482	488	PF00454	0.617
MOD_PIKK_1	518	524	PF00454	0.657
MOD_PKA_1	27	33	PF00069	0.606
MOD_PKA_2	124	130	PF00069	0.686
MOD_PKA_2	234	240	PF00069	0.741
MOD_PKA_2	27	33	PF00069	0.701
MOD_PKA_2	437	443	PF00069	0.623
MOD_PKA_2	88	94	PF00069	0.694
MOD_Plk_1	518	524	PF00069	0.657
MOD_Plk_2-3	45	51	PF00069	0.669
MOD_Plk_4	119	125	PF00069	0.749
MOD_Plk_4	220	226	PF00069	0.640
MOD_Plk_4	27	33	PF00069	0.733
MOD_Plk_4	350	356	PF00069	0.760
MOD_ProDKin_1	325	331	PF00069	0.838
MOD_ProDKin_1	369	375	PF00069	0.833
MOD_ProDKin_1	376	382	PF00069	0.715
MOD_ProDKin_1	405	411	PF00069	0.726
MOD_SUMO_rev_2	357	365	PF00179	0.704
TRG_DiLeu_BaEn_1	101	106	PF01217	0.684
TRG_DiLeu_BaEn_4	49	55	PF01217	0.785
TRG_DiLeu_BaEn_4	541	547	PF01217	0.659
TRG_ENDOCYTIC_2	31	34	PF00928	0.751
TRG_ENDOCYTIC_2	61	64	PF00928	0.752
TRG_ER_diArg_1	201	204	PF00400	0.682
TRG_ER_diArg_1	21	23	PF00400	0.703
TRG_ER_diArg_1	228	231	PF00400	0.741
TRG_ER_diArg_1	283	286	PF00400	0.715
TRG_ER_diArg_1	421	423	PF00400	0.607
TRG_ER_diArg_1	450	452	PF00400	0.681
TRG_ER_diArg_1	71	74	PF00400	0.710
TRG_ER_diArg_1	76	79	PF00400	0.624
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.709
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HX07	Leishmania infantum	100%	100%
E9AQR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEQ7	Leishmania major	92%	100%