Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICK8_LEIDO

TriTrypDb:

LdBPK_231170.1 , LdCL_230019000 , LDHU3_23.1550

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.412
CLV_NRD_NRD_1	28	30	PF00675	0.556
CLV_PCSK_KEX2_1	148	150	PF00082	0.529
CLV_PCSK_KEX2_1	203	205	PF00082	0.420
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.529
CLV_PCSK_SKI1_1	125	129	PF00082	0.474
CLV_PCSK_SKI1_1	15	19	PF00082	0.502
CLV_PCSK_SKI1_1	158	162	PF00082	0.561
DEG_APCC_DBOX_1	148	156	PF00400	0.375
DEG_APCC_DBOX_1	28	36	PF00400	0.415
DOC_MAPK_gen_1	191	200	PF00069	0.565
DOC_MAPK_gen_1	203	211	PF00069	0.340
DOC_MAPK_MEF2A_6	179	186	PF00069	0.506
DOC_USP7_MATH_1	108	112	PF00917	0.436
DOC_USP7_MATH_1	20	24	PF00917	0.531
DOC_USP7_MATH_1	37	41	PF00917	0.462
DOC_USP7_MATH_1	77	81	PF00917	0.578
DOC_USP7_UBL2_3	11	15	PF12436	0.485
DOC_USP7_UBL2_3	125	129	PF12436	0.420
DOC_USP7_UBL2_3	133	137	PF12436	0.421
DOC_USP7_UBL2_3	144	148	PF12436	0.501
DOC_USP7_UBL2_3	158	162	PF12436	0.441
DOC_USP7_UBL2_3	171	175	PF12436	0.384
DOC_WW_Pin1_4	2	7	PF00397	0.714
LIG_14-3-3_CanoR_1	203	209	PF00244	0.519
LIG_14-3-3_CanoR_1	213	223	PF00244	0.491
LIG_14-3-3_CanoR_1	67	73	PF00244	0.508
LIG_14-3-3_CanoR_1	92	99	PF00244	0.679
LIG_Actin_WH2_2	110	127	PF00022	0.468
LIG_APCC_Cbox_2	73	79	PF00515	0.551
LIG_BRCT_BRCA1_1	95	99	PF00533	0.589
LIG_Dynein_DLC8_1	201	207	PF01221	0.348
LIG_FHA_1	112	118	PF00498	0.464
LIG_FHA_1	203	209	PF00498	0.498
LIG_FHA_1	88	94	PF00498	0.540
LIG_FHA_2	68	74	PF00498	0.558
LIG_LIR_Gen_1	196	201	PF02991	0.519
LIG_LIR_Gen_1	220	230	PF02991	0.492
LIG_LIR_Nem_3	103	109	PF02991	0.486
LIG_LIR_Nem_3	196	200	PF02991	0.504
LIG_LIR_Nem_3	220	226	PF02991	0.463
LIG_SH2_NCK_1	24	28	PF00017	0.447
LIG_SH2_STAP1	172	176	PF00017	0.498
LIG_SH2_STAP1	24	28	PF00017	0.430
LIG_SH2_STAT5	31	34	PF00017	0.392
LIG_SUMO_SIM_par_1	59	66	PF11976	0.417
LIG_UBA3_1	127	133	PF00899	0.419
MOD_CK1_1	111	117	PF00069	0.527
MOD_CK1_1	224	230	PF00069	0.526
MOD_CK1_1	23	29	PF00069	0.468
MOD_CK1_1	85	91	PF00069	0.548
MOD_CK2_1	164	170	PF00069	0.628
MOD_CK2_1	37	43	PF00069	0.428
MOD_CK2_1	50	56	PF00069	0.499
MOD_GlcNHglycan	118	121	PF01048	0.452
MOD_GlcNHglycan	25	28	PF01048	0.545
MOD_GlcNHglycan	79	82	PF01048	0.680
MOD_GlcNHglycan	84	87	PF01048	0.728
MOD_GlcNHglycan	95	98	PF01048	0.658
MOD_GSK3_1	111	118	PF00069	0.489
MOD_GSK3_1	147	154	PF00069	0.458
MOD_GSK3_1	217	224	PF00069	0.484
MOD_GSK3_1	77	84	PF00069	0.654
MOD_GSK3_1	87	94	PF00069	0.765
MOD_NEK2_1	76	81	PF00069	0.585
MOD_NEK2_1	93	98	PF00069	0.630
MOD_PIKK_1	202	208	PF00454	0.478
MOD_PIKK_1	50	56	PF00454	0.559
MOD_PKA_1	147	153	PF00069	0.505
MOD_PKA_1	15	21	PF00069	0.462
MOD_PKA_2	178	184	PF00069	0.595
MOD_PKA_2	202	208	PF00069	0.464
MOD_PKA_2	91	97	PF00069	0.630
MOD_Plk_1	38	44	PF00069	0.482
MOD_Plk_2-3	151	157	PF00069	0.459
MOD_Plk_4	204	210	PF00069	0.413
MOD_ProDKin_1	2	8	PF00069	0.698
MOD_SUMO_rev_2	118	127	PF00179	0.490
MOD_SUMO_rev_2	150	160	PF00179	0.545
MOD_SUMO_rev_2	4	13	PF00179	0.626
TRG_DiLeu_BaEn_1	196	201	PF01217	0.463
TRG_DiLeu_BaEn_1	9	14	PF01217	0.538
TRG_ENDOCYTIC_2	223	226	PF00928	0.528
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG3	Leptomonas seymouri	47%	99%
A0A1X0NYD1	Trypanosomatidae	28%	90%
A0A3R7KGK2	Trypanosoma rangeli	26%	100%
A4HCW9	Leishmania braziliensis	59%	100%
A4I0E9	Leishmania infantum	100%	100%
E9AWB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QB63	Leishmania major	90%	100%