Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICK6_LEIDO

TriTrypDb:

LdBPK_260090.1 , LdCL_260005900 , LdCL_260006200 , LdCL_260006500 , LDHU3_26.0130 , LDHU3_26.0170

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.501
CLV_NRD_NRD_1	249	251	PF00675	0.526
CLV_NRD_NRD_1	270	272	PF00675	0.645
CLV_NRD_NRD_1	273	275	PF00675	0.615
CLV_NRD_NRD_1	342	344	PF00675	0.673
CLV_NRD_NRD_1	62	64	PF00675	0.387
CLV_PCSK_FUR_1	246	250	PF00082	0.536
CLV_PCSK_KEX2_1	248	250	PF00082	0.537
CLV_PCSK_KEX2_1	342	344	PF00082	0.712
CLV_PCSK_KEX2_1	62	64	PF00082	0.382
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.537
CLV_PCSK_PC7_1	244	250	PF00082	0.520
CLV_PCSK_PC7_1	58	64	PF00082	0.410
CLV_PCSK_SKI1_1	249	253	PF00082	0.539
CLV_PCSK_SKI1_1	285	289	PF00082	0.535
CLV_PCSK_SKI1_1	342	346	PF00082	0.501
CLV_PCSK_SKI1_1	84	88	PF00082	0.491
DOC_MAPK_gen_1	79	88	PF00069	0.463
DOC_MAPK_MEF2A_6	82	90	PF00069	0.434
DOC_PP2B_LxvP_1	90	93	PF13499	0.533
DOC_SPAK_OSR1_1	71	75	PF12202	0.384
DOC_USP7_MATH_1	108	112	PF00917	0.449
DOC_USP7_MATH_1	313	317	PF00917	0.529
DOC_USP7_MATH_1	329	333	PF00917	0.482
DOC_USP7_MATH_1	77	81	PF00917	0.453
DOC_USP7_UBL2_3	285	289	PF12436	0.559
DOC_WW_Pin1_4	218	223	PF00397	0.549
DOC_WW_Pin1_4	349	354	PF00397	0.746
LIG_14-3-3_CanoR_1	16	20	PF00244	0.561
LIG_14-3-3_CanoR_1	186	195	PF00244	0.447
LIG_14-3-3_CanoR_1	294	300	PF00244	0.405
LIG_14-3-3_CanoR_1	312	318	PF00244	0.250
LIG_14-3-3_CanoR_1	342	351	PF00244	0.515
LIG_Actin_WH2_2	275	291	PF00022	0.523
LIG_Actin_WH2_2	298	314	PF00022	0.472
LIG_APCC_ABBAyCdc20_2	239	245	PF00400	0.440
LIG_BRCT_BRCA1_1	110	114	PF00533	0.416
LIG_BRCT_BRCA1_1	315	319	PF00533	0.489
LIG_Clathr_ClatBox_1	125	129	PF01394	0.414
LIG_FHA_1	121	127	PF00498	0.374
LIG_FHA_1	47	53	PF00498	0.459
LIG_FHA_2	150	156	PF00498	0.475
LIG_FHA_2	333	339	PF00498	0.511
LIG_LIR_Apic_2	127	133	PF02991	0.499
LIG_LIR_Apic_2	96	102	PF02991	0.429
LIG_LIR_Gen_1	189	199	PF02991	0.347
LIG_LIR_Gen_1	301	311	PF02991	0.463
LIG_LIR_Gen_1	316	327	PF02991	0.414
LIG_LIR_Nem_3	189	194	PF02991	0.345
LIG_LIR_Nem_3	277	282	PF02991	0.543
LIG_LIR_Nem_3	293	299	PF02991	0.338
LIG_LIR_Nem_3	301	307	PF02991	0.492
LIG_LIR_Nem_3	316	322	PF02991	0.325
LIG_NRBOX	336	342	PF00104	0.551
LIG_PTB_Apo_2	153	160	PF02174	0.460
LIG_RPA_C_Fungi	239	251	PF08784	0.510
LIG_SH2_NCK_1	237	241	PF00017	0.492
LIG_SH2_SRC	304	307	PF00017	0.565
LIG_SH2_STAP1	178	182	PF00017	0.435
LIG_SH2_STAP1	48	52	PF00017	0.492
LIG_SH2_STAT5	191	194	PF00017	0.454
LIG_SH2_STAT5	233	236	PF00017	0.347
LIG_SH2_STAT5	304	307	PF00017	0.460
LIG_SH2_STAT5	48	51	PF00017	0.499
LIG_SH2_STAT5	99	102	PF00017	0.356
LIG_SH3_3	133	139	PF00018	0.504
LIG_SH3_3	347	353	PF00018	0.716
LIG_SH3_3	47	53	PF00018	0.466
LIG_SH3_3	71	77	PF00018	0.430
LIG_Sin3_3	22	29	PF02671	0.469
LIG_SUMO_SIM_anti_2	120	127	PF11976	0.477
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.433
LIG_SUMO_SIM_anti_2	332	341	PF11976	0.543
LIG_SUMO_SIM_par_1	120	127	PF11976	0.482
LIG_TRAF2_1	251	254	PF00917	0.511
LIG_TYR_ITIM	302	307	PF00017	0.439
LIG_WW_3	13	17	PF00397	0.642
LIG_WW_3	268	272	PF00397	0.605
MOD_CK1_1	120	126	PF00069	0.478
MOD_CK1_1	218	224	PF00069	0.548
MOD_CK1_1	295	301	PF00069	0.405
MOD_CK1_1	332	338	PF00069	0.464
MOD_CK2_1	149	155	PF00069	0.465
MOD_CK2_1	332	338	PF00069	0.505
MOD_Cter_Amidation	1	4	PF01082	0.705
MOD_GlcNHglycan	110	113	PF01048	0.373
MOD_GlcNHglycan	79	82	PF01048	0.504
MOD_GSK3_1	313	320	PF00069	0.477
MOD_GSK3_1	329	336	PF00069	0.375
MOD_N-GLC_1	186	191	PF02516	0.405
MOD_N-GLC_1	280	285	PF02516	0.573
MOD_NEK2_1	159	164	PF00069	0.370
MOD_NEK2_1	215	220	PF00069	0.431
MOD_NEK2_1	280	285	PF00069	0.511
MOD_NEK2_1	311	316	PF00069	0.564
MOD_NEK2_2	292	297	PF00069	0.531
MOD_NEK2_2	93	98	PF00069	0.503
MOD_PKA_1	3	9	PF00069	0.699
MOD_PKA_1	342	348	PF00069	0.507
MOD_PKA_2	15	21	PF00069	0.585
MOD_PKA_2	311	317	PF00069	0.537
MOD_PKA_2	342	348	PF00069	0.507
MOD_PKB_1	184	192	PF00069	0.479
MOD_Plk_1	264	270	PF00069	0.624
MOD_Plk_1	292	298	PF00069	0.528
MOD_Plk_1	333	339	PF00069	0.576
MOD_Plk_4	120	126	PF00069	0.464
MOD_Plk_4	313	319	PF00069	0.539
MOD_ProDKin_1	218	224	PF00069	0.548
MOD_ProDKin_1	349	355	PF00069	0.752
MOD_SUMO_rev_2	267	276	PF00179	0.657
TRG_DiLeu_BaEn_4	210	216	PF01217	0.483
TRG_ENDOCYTIC_2	191	194	PF00928	0.428
TRG_ENDOCYTIC_2	304	307	PF00928	0.447
TRG_ENDOCYTIC_2	64	67	PF00928	0.390
TRG_ER_diArg_1	341	343	PF00400	0.627
TRG_ER_diArg_1	62	64	PF00400	0.383
TRG_NLS_MonoExtN_4	246	252	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL9	Leptomonas seymouri	59%	89%
A0A0S4IRP2	Bodo saltans	28%	100%
A0A1X0NU99	Trypanosomatidae	40%	100%
A0A422N352	Trypanosoma rangeli	38%	100%
A4HEL6	Leishmania braziliensis	89%	100%
A4I1U9	Leishmania infantum	100%	100%
E9AHA8	Leishmania infantum	100%	100%
E9AXZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q9I0	Leishmania major	97%	100%
V5DR77	Trypanosoma cruzi	40%	100%