Tim10/DDP_family_zinc_finger_containing_protein_p utative/Pfam:PF02953

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICJ9_LEIDO

TriTrypDb:

LdBPK_251610.1 , LdCL_250021800 , LDHU3_25.2050

Length:

102

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	39	43	PF00082	0.440
DEG_Nend_UBRbox_3	1	3	PF02207	0.616
DOC_MAPK_gen_1	65	74	PF00069	0.555
DOC_USP7_MATH_1	3	7	PF00917	0.701
LIG_BIR_III_2	47	51	PF00653	0.667
LIG_FHA_2	12	18	PF00498	0.577
LIG_LIR_Gen_1	88	99	PF02991	0.578
LIG_PTB_Apo_2	27	34	PF02174	0.537
LIG_PTB_Apo_2	65	72	PF02174	0.518
LIG_PTB_Phospho_1	65	71	PF10480	0.514
LIG_SH2_STAT5	35	38	PF00017	0.529
LIG_SH3_3	47	53	PF00018	0.520
MOD_CK1_1	6	12	PF00069	0.590
MOD_CK2_1	11	17	PF00069	0.630
MOD_GlcNHglycan	85	88	PF01048	0.646
MOD_NEK2_1	11	16	PF00069	0.676
MOD_NEK2_1	34	39	PF00069	0.485
MOD_PIKK_1	11	17	PF00454	0.630
MOD_Plk_4	6	12	PF00069	0.690
MOD_SUMO_rev_2	75	84	PF00179	0.496
TRG_ENDOCYTIC_2	71	74	PF00928	0.519
TRG_ENDOCYTIC_2	91	94	PF00928	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBG3	Leptomonas seymouri	70%	100%
A0A1X0NYW6	Trypanosomatidae	60%	98%
A0A3S5IRE3	Trypanosoma rangeli	60%	100%
A4HEJ7	Leishmania braziliensis	86%	100%
A4I1K1	Leishmania infantum	100%	100%
C9ZK35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AXN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q9T6	Leishmania major	98%	100%