Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICJ8_LEIDO

TriTrypDb:

LdBPK_160980.1 , LdCL_160015000 , LDHU3_16.1170

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.476
CLV_C14_Caspase3-7	278	282	PF00656	0.402
CLV_C14_Caspase3-7	508	512	PF00656	0.502
CLV_C14_Caspase3-7	589	593	PF00656	0.403
CLV_NRD_NRD_1	164	166	PF00675	0.510
CLV_NRD_NRD_1	172	174	PF00675	0.557
CLV_NRD_NRD_1	310	312	PF00675	0.724
CLV_NRD_NRD_1	427	429	PF00675	0.482
CLV_NRD_NRD_1	606	608	PF00675	0.563
CLV_NRD_NRD_1	647	649	PF00675	0.652
CLV_PCSK_FUR_1	645	649	PF00082	0.627
CLV_PCSK_KEX2_1	164	166	PF00082	0.452
CLV_PCSK_KEX2_1	172	174	PF00082	0.491
CLV_PCSK_KEX2_1	197	199	PF00082	0.599
CLV_PCSK_KEX2_1	310	312	PF00082	0.705
CLV_PCSK_KEX2_1	427	429	PF00082	0.482
CLV_PCSK_KEX2_1	496	498	PF00082	0.429
CLV_PCSK_KEX2_1	606	608	PF00082	0.554
CLV_PCSK_KEX2_1	647	649	PF00082	0.648
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.599
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.429
CLV_PCSK_SKI1_1	121	125	PF00082	0.546
CLV_PCSK_SKI1_1	247	251	PF00082	0.589
CLV_PCSK_SKI1_1	428	432	PF00082	0.543
CLV_PCSK_SKI1_1	462	466	PF00082	0.502
CLV_PCSK_SKI1_1	480	484	PF00082	0.433
CLV_PCSK_SKI1_1	57	61	PF00082	0.470
CLV_PCSK_SKI1_1	704	708	PF00082	0.446
DEG_APCC_DBOX_1	475	483	PF00400	0.432
DEG_APCC_DBOX_1	546	554	PF00400	0.499
DEG_APCC_DBOX_1	56	64	PF00400	0.440
DEG_APCC_DBOX_1	657	665	PF00400	0.565
DEG_SPOP_SBC_1	693	697	PF00917	0.389
DOC_CKS1_1	681	686	PF01111	0.447
DOC_CYCLIN_RxL_1	244	253	PF00134	0.594
DOC_CYCLIN_RxL_1	476	484	PF00134	0.433
DOC_CYCLIN_RxL_1	701	710	PF00134	0.471
DOC_MAPK_gen_1	545	553	PF00069	0.512
DOC_MAPK_gen_1	623	630	PF00069	0.545
DOC_MAPK_MEF2A_6	476	485	PF00069	0.434
DOC_MAPK_MEF2A_6	751	759	PF00069	0.501
DOC_PP1_RVXF_1	460	466	PF00149	0.480
DOC_PP1_RVXF_1	565	571	PF00149	0.548
DOC_PP2B_LxvP_1	679	682	PF13499	0.660
DOC_PP2B_PxIxI_1	257	263	PF00149	0.328
DOC_PP4_FxxP_1	299	302	PF00568	0.491
DOC_PP4_FxxP_1	364	367	PF00568	0.378
DOC_USP7_MATH_1	236	240	PF00917	0.759
DOC_USP7_MATH_1	327	331	PF00917	0.706
DOC_USP7_MATH_1	4	8	PF00917	0.364
DOC_USP7_MATH_1	44	48	PF00917	0.460
DOC_USP7_MATH_1	454	458	PF00917	0.506
DOC_USP7_MATH_1	530	534	PF00917	0.575
DOC_USP7_MATH_1	657	661	PF00917	0.574
DOC_WW_Pin1_4	199	204	PF00397	0.744
DOC_WW_Pin1_4	418	423	PF00397	0.628
DOC_WW_Pin1_4	440	445	PF00397	0.542
DOC_WW_Pin1_4	520	525	PF00397	0.393
DOC_WW_Pin1_4	680	685	PF00397	0.648
DOC_WW_Pin1_4	695	700	PF00397	0.381
DOC_WW_Pin1_4	95	100	PF00397	0.582
LIG_14-3-3_CanoR_1	32	38	PF00244	0.499
LIG_14-3-3_CanoR_1	42	52	PF00244	0.424
LIG_14-3-3_CanoR_1	476	480	PF00244	0.356
LIG_14-3-3_CanoR_1	538	548	PF00244	0.683
LIG_14-3-3_CanoR_1	658	662	PF00244	0.714
LIG_Actin_WH2_2	565	583	PF00022	0.381
LIG_APCC_ABBA_1	431	436	PF00400	0.532
LIG_BIR_II_1	1	5	PF00653	0.348
LIG_BIR_III_3	1	5	PF00653	0.443
LIG_BIR_III_4	218	222	PF00653	0.591
LIG_Clathr_ClatBox_1	249	253	PF01394	0.553
LIG_eIF4E_1	387	393	PF01652	0.473
LIG_FHA_1	155	161	PF00498	0.496
LIG_FHA_1	202	208	PF00498	0.634
LIG_FHA_1	296	302	PF00498	0.581
LIG_FHA_1	335	341	PF00498	0.549
LIG_FHA_1	476	482	PF00498	0.344
LIG_FHA_1	521	527	PF00498	0.544
LIG_FHA_1	53	59	PF00498	0.417
LIG_FHA_1	612	618	PF00498	0.486
LIG_FHA_2	103	109	PF00498	0.684
LIG_FHA_2	20	26	PF00498	0.455
LIG_FHA_2	312	318	PF00498	0.704
LIG_FHA_2	32	38	PF00498	0.432
LIG_FHA_2	399	405	PF00498	0.466
LIG_FHA_2	629	635	PF00498	0.394
LIG_FHA_2	681	687	PF00498	0.568
LIG_Integrin_isoDGR_2	78	80	PF01839	0.568
LIG_LIR_Apic_2	298	302	PF02991	0.610
LIG_LIR_Apic_2	362	367	PF02991	0.375
LIG_LIR_Gen_1	265	274	PF02991	0.338
LIG_LIR_Gen_1	351	361	PF02991	0.487
LIG_LIR_Gen_1	499	509	PF02991	0.417
LIG_LIR_Nem_3	245	249	PF02991	0.619
LIG_LIR_Nem_3	265	269	PF02991	0.343
LIG_LIR_Nem_3	351	357	PF02991	0.390
LIG_LIR_Nem_3	368	372	PF02991	0.459
LIG_LIR_Nem_3	384	389	PF02991	0.495
LIG_LIR_Nem_3	421	426	PF02991	0.614
LIG_LIR_Nem_3	493	498	PF02991	0.419
LIG_LIR_Nem_3	499	505	PF02991	0.439
LIG_LIR_Nem_3	585	590	PF02991	0.407
LIG_LIR_Nem_3	726	732	PF02991	0.466
LIG_LIR_Nem_3	88	93	PF02991	0.632
LIG_LYPXL_S_1	89	93	PF13949	0.666
LIG_LYPXL_yS_3	729	732	PF13949	0.450
LIG_LYPXL_yS_3	90	93	PF13949	0.665
LIG_MAD2	462	470	PF02301	0.494
LIG_MYND_1	525	529	PF01753	0.555
LIG_NRBOX	478	484	PF00104	0.431
LIG_PCNA_PIPBox_1	708	717	PF02747	0.431
LIG_PCNA_yPIPBox_3	24	32	PF02747	0.583
LIG_PCNA_yPIPBox_3	704	715	PF02747	0.493
LIG_Pex14_2	17	21	PF04695	0.421
LIG_Pex14_2	584	588	PF04695	0.368
LIG_RPA_C_Fungi	505	517	PF08784	0.444
LIG_SH2_CRK	246	250	PF00017	0.596
LIG_SH2_CRK	354	358	PF00017	0.381
LIG_SH2_CRK	502	506	PF00017	0.357
LIG_SH2_STAP1	152	156	PF00017	0.374
LIG_SH2_STAP1	354	358	PF00017	0.468
LIG_SH2_STAP1	372	376	PF00017	0.468
LIG_SH2_STAP1	387	391	PF00017	0.371
LIG_SH2_STAP1	498	502	PF00017	0.445
LIG_SH2_STAP1	548	552	PF00017	0.369
LIG_SH2_STAT5	154	157	PF00017	0.479
LIG_SH2_STAT5	365	368	PF00017	0.386
LIG_SH3_3	173	179	PF00018	0.506
LIG_SH3_3	429	435	PF00018	0.636
LIG_SH3_3	441	447	PF00018	0.605
LIG_SH3_3	461	467	PF00018	0.405
LIG_SH3_3	519	525	PF00018	0.567
LIG_SH3_3	755	761	PF00018	0.524
LIG_SUMO_SIM_anti_2	549	558	PF11976	0.563
LIG_SUMO_SIM_par_1	248	253	PF11976	0.553
LIG_SUMO_SIM_par_1	549	558	PF11976	0.563
LIG_SUMO_SIM_par_1	626	631	PF11976	0.389
LIG_TRAF2_1	190	193	PF00917	0.585
LIG_TRAF2_1	22	25	PF00917	0.466
LIG_TRAF2_1	558	561	PF00917	0.598
LIG_TRAF2_1	6	9	PF00917	0.473
LIG_WRC_WIRS_1	492	497	PF05994	0.367
MOD_CDK_SPxxK_3	680	687	PF00069	0.669
MOD_CK1_1	237	243	PF00069	0.611
MOD_CK1_1	43	49	PF00069	0.511
MOD_CK1_1	53	59	PF00069	0.375
MOD_CK1_1	554	560	PF00069	0.503
MOD_CK1_1	660	666	PF00069	0.638
MOD_CK2_1	102	108	PF00069	0.598
MOD_CK2_1	187	193	PF00069	0.500
MOD_CK2_1	19	25	PF00069	0.445
MOD_CK2_1	272	278	PF00069	0.440
MOD_CK2_1	311	317	PF00069	0.656
MOD_CK2_1	398	404	PF00069	0.509
MOD_CK2_1	418	424	PF00069	0.369
MOD_CK2_1	555	561	PF00069	0.579
MOD_CK2_1	628	634	PF00069	0.529
MOD_CK2_1	643	649	PF00069	0.563
MOD_CK2_1	680	686	PF00069	0.588
MOD_CK2_1	713	719	PF00069	0.379
MOD_CK2_1	744	750	PF00069	0.493
MOD_GlcNHglycan	108	111	PF01048	0.637
MOD_GlcNHglycan	139	142	PF01048	0.485
MOD_GlcNHglycan	238	242	PF01048	0.725
MOD_GlcNHglycan	287	290	PF01048	0.510
MOD_GlcNHglycan	329	332	PF01048	0.738
MOD_GlcNHglycan	42	45	PF01048	0.476
MOD_GlcNHglycan	456	459	PF01048	0.524
MOD_GlcNHglycan	507	510	PF01048	0.457
MOD_GlcNHglycan	555	560	PF01048	0.578
MOD_GlcNHglycan	563	566	PF01048	0.526
MOD_GlcNHglycan	572	575	PF01048	0.357
MOD_GlcNHglycan	715	718	PF01048	0.391
MOD_GSK3_1	102	109	PF00069	0.650
MOD_GSK3_1	119	126	PF00069	0.356
MOD_GSK3_1	137	144	PF00069	0.466
MOD_GSK3_1	15	22	PF00069	0.444
MOD_GSK3_1	252	259	PF00069	0.477
MOD_GSK3_1	321	328	PF00069	0.666
MOD_GSK3_1	394	401	PF00069	0.532
MOD_GSK3_1	40	47	PF00069	0.467
MOD_GSK3_1	501	508	PF00069	0.532
MOD_GSK3_1	551	558	PF00069	0.522
MOD_GSK3_1	593	600	PF00069	0.530
MOD_GSK3_1	740	747	PF00069	0.389
MOD_N-GLC_1	102	107	PF02516	0.605
MOD_N-GLC_1	53	58	PF02516	0.475
MOD_NEK2_1	106	111	PF00069	0.539
MOD_NEK2_1	123	128	PF00069	0.385
MOD_NEK2_1	155	160	PF00069	0.447
MOD_NEK2_1	475	480	PF00069	0.305
MOD_NEK2_1	501	506	PF00069	0.391
MOD_NEK2_1	52	57	PF00069	0.431
MOD_NEK2_1	539	544	PF00069	0.709
MOD_NEK2_1	694	699	PF00069	0.443
MOD_NEK2_1	707	712	PF00069	0.431
MOD_NEK2_1	94	99	PF00069	0.619
MOD_NEK2_2	530	535	PF00069	0.532
MOD_NEK2_2	593	598	PF00069	0.412
MOD_NEK2_2	657	662	PF00069	0.560
MOD_NEK2_2	666	671	PF00069	0.414
MOD_PIKK_1	123	129	PF00454	0.468
MOD_PIKK_1	19	25	PF00454	0.446
MOD_PIKK_1	192	198	PF00454	0.616
MOD_PIKK_1	252	258	PF00454	0.561
MOD_PIKK_1	305	311	PF00454	0.683
MOD_PK_1	187	193	PF00069	0.457
MOD_PKA_2	304	310	PF00069	0.631
MOD_PKA_2	31	37	PF00069	0.583
MOD_PKA_2	321	327	PF00069	0.790
MOD_PKA_2	475	481	PF00069	0.340
MOD_PKA_2	657	663	PF00069	0.710
MOD_PKB_1	738	746	PF00069	0.373
MOD_Plk_1	102	108	PF00069	0.594
MOD_Plk_1	348	354	PF00069	0.412
MOD_Plk_1	398	404	PF00069	0.448
MOD_Plk_1	490	496	PF00069	0.357
MOD_Plk_1	53	59	PF00069	0.293
MOD_Plk_1	702	708	PF00069	0.437
MOD_Plk_1	9	15	PF00069	0.406
MOD_Plk_4	119	125	PF00069	0.494
MOD_Plk_4	141	147	PF00069	0.432
MOD_Plk_4	272	278	PF00069	0.398
MOD_Plk_4	279	285	PF00069	0.357
MOD_Plk_4	381	387	PF00069	0.448
MOD_Plk_4	44	50	PF00069	0.402
MOD_Plk_4	501	507	PF00069	0.436
MOD_Plk_4	530	536	PF00069	0.642
MOD_Plk_4	702	708	PF00069	0.437
MOD_Plk_4	744	750	PF00069	0.483
MOD_Plk_4	85	91	PF00069	0.672
MOD_Plk_4	9	15	PF00069	0.462
MOD_ProDKin_1	199	205	PF00069	0.745
MOD_ProDKin_1	418	424	PF00069	0.625
MOD_ProDKin_1	440	446	PF00069	0.544
MOD_ProDKin_1	520	526	PF00069	0.407
MOD_ProDKin_1	680	686	PF00069	0.636
MOD_ProDKin_1	695	701	PF00069	0.379
MOD_ProDKin_1	95	101	PF00069	0.582
TRG_DiLeu_BaEn_1	69	74	PF01217	0.592
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.563
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.384
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.510
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.415
TRG_ENDOCYTIC_2	152	155	PF00928	0.488
TRG_ENDOCYTIC_2	246	249	PF00928	0.596
TRG_ENDOCYTIC_2	354	357	PF00928	0.541
TRG_ENDOCYTIC_2	386	389	PF00928	0.363
TRG_ENDOCYTIC_2	434	437	PF00928	0.670
TRG_ENDOCYTIC_2	498	501	PF00928	0.410
TRG_ENDOCYTIC_2	502	505	PF00928	0.391
TRG_ENDOCYTIC_2	548	551	PF00928	0.368
TRG_ENDOCYTIC_2	587	590	PF00928	0.425
TRG_ENDOCYTIC_2	729	732	PF00928	0.433
TRG_ENDOCYTIC_2	90	93	PF00928	0.665
TRG_ER_diArg_1	163	165	PF00400	0.554
TRG_ER_diArg_1	310	312	PF00400	0.615
TRG_ER_diArg_1	426	428	PF00400	0.504
TRG_ER_diArg_1	545	548	PF00400	0.441
TRG_ER_diArg_1	577	580	PF00400	0.427
TRG_ER_diArg_1	605	607	PF00400	0.554
TRG_ER_diArg_1	613	616	PF00400	0.509
TRG_ER_diArg_1	645	648	PF00400	0.553
TRG_ER_diArg_1	738	741	PF00400	0.565
TRG_NES_CRM1_1	589	602	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V3	Leptomonas seymouri	57%	100%
A0A1X0NZ87	Trypanosomatidae	25%	100%
A0A422NAP0	Trypanosoma rangeli	28%	100%
A4H8M1	Leishmania braziliensis	79%	100%
A4HWZ2	Leishmania infantum	100%	100%
C9ZW10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AQQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QES3	Leishmania major	94%	100%
V5B3X0	Trypanosoma cruzi	28%	100%