Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICJ3_LEIDO

TriTrypDb:

LdBPK_230200.1 , LdCL_230006900 , LDHU3_23.0240

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.766
CLV_NRD_NRD_1	219	221	PF00675	0.382
CLV_NRD_NRD_1	251	253	PF00675	0.554
CLV_NRD_NRD_1	260	262	PF00675	0.501
CLV_NRD_NRD_1	57	59	PF00675	0.617
CLV_NRD_NRD_1	79	81	PF00675	0.516
CLV_PCSK_KEX2_1	251	253	PF00082	0.554
CLV_PCSK_KEX2_1	260	262	PF00082	0.501
CLV_PCSK_KEX2_1	57	59	PF00082	0.617
CLV_PCSK_KEX2_1	79	81	PF00082	0.595
DEG_APCC_DBOX_1	259	267	PF00400	0.548
DEG_APCC_DBOX_1	27	35	PF00400	0.589
DEG_Nend_UBRbox_4	1	3	PF02207	0.566
DEG_SPOP_SBC_1	110	114	PF00917	0.742
DOC_MAPK_gen_1	220	226	PF00069	0.405
DOC_PP2B_LxvP_1	127	130	PF13499	0.590
DOC_PP2B_LxvP_1	146	149	PF13499	0.519
DOC_PP4_FxxP_1	5	8	PF00568	0.516
DOC_USP7_MATH_1	110	114	PF00917	0.731
DOC_USP7_MATH_1	196	200	PF00917	0.558
DOC_USP7_MATH_1	94	98	PF00917	0.523
DOC_WW_Pin1_4	10	15	PF00397	0.495
DOC_WW_Pin1_4	111	116	PF00397	0.689
DOC_WW_Pin1_4	4	9	PF00397	0.519
DOC_WW_Pin1_4	51	56	PF00397	0.693
LIG_14-3-3_CanoR_1	28	32	PF00244	0.600
LIG_14-3-3_CanoR_1	79	88	PF00244	0.532
LIG_APCC_ABBA_1	88	93	PF00400	0.576
LIG_FHA_1	28	34	PF00498	0.702
LIG_FHA_2	148	154	PF00498	0.586
LIG_LIR_Apic_2	4	8	PF02991	0.462
LIG_LIR_Gen_1	159	170	PF02991	0.521
LIG_LIR_Gen_1	241	250	PF02991	0.457
LIG_LIR_Gen_1	282	290	PF02991	0.541
LIG_LIR_Nem_3	128	134	PF02991	0.565
LIG_LIR_Nem_3	150	154	PF02991	0.498
LIG_LIR_Nem_3	157	161	PF02991	0.469
LIG_LIR_Nem_3	241	247	PF02991	0.459
LIG_LIR_Nem_3	282	288	PF02991	0.534
LIG_MYND_1	273	277	PF01753	0.636
LIG_SH2_CRK	285	289	PF00017	0.549
LIG_SH2_STAP1	151	155	PF00017	0.545
LIG_SH2_STAP1	158	162	PF00017	0.540
LIG_SH2_STAP1	167	171	PF00017	0.547
LIG_SH2_STAP1	244	248	PF00017	0.469
LIG_SH2_STAT5	154	157	PF00017	0.437
LIG_SH2_STAT5	158	161	PF00017	0.453
LIG_TYR_ITIM	242	247	PF00017	0.454
LIG_UBA3_1	71	77	PF00899	0.496
MOD_CDC14_SPxK_1	54	57	PF00782	0.477
MOD_CDK_SPK_2	10	15	PF00069	0.478
MOD_CDK_SPxK_1	51	57	PF00069	0.510
MOD_CDK_SPxxK_3	10	17	PF00069	0.541
MOD_CDK_SPxxK_3	51	58	PF00069	0.635
MOD_CK1_1	113	119	PF00069	0.628
MOD_CK1_1	82	88	PF00069	0.556
MOD_CK2_1	41	47	PF00069	0.755
MOD_GlcNHglycan	107	110	PF01048	0.712
MOD_GlcNHglycan	118	122	PF01048	0.575
MOD_GlcNHglycan	35	38	PF01048	0.672
MOD_GlcNHglycan	81	84	PF01048	0.581
MOD_GSK3_1	105	112	PF00069	0.715
MOD_GSK3_1	113	120	PF00069	0.594
MOD_N-GLC_2	10	12	PF02516	0.471
MOD_NEK2_1	156	161	PF00069	0.581
MOD_NEK2_1	62	67	PF00069	0.384
MOD_NEK2_2	189	194	PF00069	0.443
MOD_PKA_1	79	85	PF00069	0.506
MOD_PKA_2	27	33	PF00069	0.594
MOD_PKA_2	62	68	PF00069	0.430
MOD_PKA_2	79	85	PF00069	0.468
MOD_Plk_1	156	162	PF00069	0.501
MOD_Plk_1	196	202	PF00069	0.520
MOD_Plk_4	156	162	PF00069	0.537
MOD_ProDKin_1	111	117	PF00069	0.686
MOD_ProDKin_1	4	10	PF00069	0.521
MOD_ProDKin_1	51	57	PF00069	0.685
TRG_ENDOCYTIC_2	167	170	PF00928	0.486
TRG_ENDOCYTIC_2	244	247	PF00928	0.464
TRG_ENDOCYTIC_2	285	288	PF00928	0.587
TRG_ER_diArg_1	14	17	PF00400	0.635
TRG_ER_diArg_1	56	58	PF00400	0.641
TRG_ER_diArg_1	60	63	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAY1	Leptomonas seymouri	56%	100%
A0A1X0NG66	Trypanosomatidae	36%	100%
A0A422NVZ5	Trypanosoma rangeli	37%	100%
A4HCN2	Leishmania braziliensis	75%	100%
A4I056	Leishmania infantum	99%	100%
E9AW19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QBF7	Leishmania major	91%	100%
V5AYT6	Trypanosoma cruzi	35%	100%
V5D0F5	Trypanosoma cruzi	36%	100%