SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ICJ1_LEIDO

TriTrypDb:

LdBPK_311370.1 , LdCL_310020600 , LDHU3_31.2240

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	260	262	PF00675	0.662
CLV_PCSK_FUR_1	278	282	PF00082	0.423
CLV_PCSK_KEX2_1	280	282	PF00082	0.440
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.428
CLV_PCSK_SKI1_1	249	253	PF00082	0.748
CLV_PCSK_SKI1_1	304	308	PF00082	0.597
DEG_SPOP_SBC_1	187	191	PF00917	0.572
DOC_CDC14_PxL_1	295	303	PF14671	0.449
DOC_CKS1_1	44	49	PF01111	0.573
DOC_CKS1_1	58	63	PF01111	0.580
DOC_MAPK_HePTP_8	463	478	PF00069	0.494
DOC_MAPK_MEF2A_6	418	427	PF00069	0.400
DOC_PP1_RVXF_1	416	422	PF00149	0.396
DOC_PP2B_LxvP_1	230	233	PF13499	0.678
DOC_PP2B_LxvP_1	448	451	PF13499	0.599
DOC_PP2B_LxvP_1	477	480	PF13499	0.437
DOC_PP4_FxxP_1	410	413	PF00568	0.366
DOC_USP7_MATH_1	14	18	PF00917	0.622
DOC_USP7_MATH_1	201	205	PF00917	0.608
DOC_USP7_MATH_1	207	211	PF00917	0.583
DOC_USP7_MATH_1	221	225	PF00917	0.666
DOC_USP7_MATH_1	4	8	PF00917	0.579
DOC_USP7_MATH_1	414	418	PF00917	0.451
DOC_USP7_MATH_1	48	52	PF00917	0.608
DOC_USP7_MATH_1	491	495	PF00917	0.710
DOC_USP7_MATH_1	502	506	PF00917	0.581
DOC_USP7_MATH_1	76	80	PF00917	0.532
DOC_WW_Pin1_4	20	25	PF00397	0.693
DOC_WW_Pin1_4	254	259	PF00397	0.686
DOC_WW_Pin1_4	321	326	PF00397	0.683
DOC_WW_Pin1_4	33	38	PF00397	0.645
DOC_WW_Pin1_4	43	48	PF00397	0.629
DOC_WW_Pin1_4	57	62	PF00397	0.587
LIG_14-3-3_CanoR_1	380	386	PF00244	0.512
LIG_14-3-3_CanoR_1	492	500	PF00244	0.602
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_1	1	5	PF00653	0.581
LIG_BIR_III_2	326	330	PF00653	0.645
LIG_BIR_III_3	1	5	PF00653	0.581
LIG_BRCT_BRCA1_1	182	186	PF00533	0.679
LIG_BRCT_BRCA1_1	511	515	PF00533	0.491
LIG_eIF4E_1	295	301	PF01652	0.420
LIG_EVH1_1	230	234	PF00568	0.613
LIG_FHA_1	159	165	PF00498	0.656
LIG_FHA_1	255	261	PF00498	0.672
LIG_FHA_1	292	298	PF00498	0.381
LIG_FHA_1	52	58	PF00498	0.657
LIG_FHA_2	173	179	PF00498	0.673
LIG_FHA_2	382	388	PF00498	0.504
LIG_FHA_2	494	500	PF00498	0.621
LIG_LIR_Gen_1	136	143	PF02991	0.740
LIG_LIR_Nem_3	136	142	PF02991	0.743
LIG_LIR_Nem_3	292	298	PF02991	0.395
LIG_LIR_Nem_3	387	392	PF02991	0.452
LIG_LIR_Nem_3	512	517	PF02991	0.490
LIG_MLH1_MIPbox_1	511	515	PF16413	0.491
LIG_MYND_1	299	303	PF01753	0.415
LIG_PDZ_Class_2	512	517	PF00595	0.490
LIG_SH2_CRK	139	143	PF00017	0.682
LIG_SH2_CRK	236	240	PF00017	0.699
LIG_SH2_CRK	288	292	PF00017	0.376
LIG_SH2_CRK	295	299	PF00017	0.388
LIG_SH2_CRK	392	396	PF00017	0.450
LIG_SH2_STAP1	236	240	PF00017	0.699
LIG_SH2_STAT3	104	107	PF00017	0.671
LIG_SH2_STAT5	127	130	PF00017	0.593
LIG_SH2_STAT5	372	375	PF00017	0.660
LIG_SH2_STAT5	91	94	PF00017	0.619
LIG_SH3_3	228	234	PF00018	0.611
LIG_SH3_3	237	243	PF00018	0.540
LIG_SH3_3	376	382	PF00018	0.387
LIG_SH3_3	408	414	PF00018	0.479
LIG_SH3_3	422	428	PF00018	0.396
LIG_SH3_3	475	481	PF00018	0.427
LIG_SH3_3	95	101	PF00018	0.659
LIG_SH3_CIN85_PxpxPR_1	325	330	PF14604	0.667
LIG_SUMO_SIM_anti_2	475	480	PF11976	0.428
LIG_SUMO_SIM_par_1	344	354	PF11976	0.575
LIG_TRAF2_1	451	454	PF00917	0.536
LIG_TRFH_1	295	299	PF08558	0.401
LIG_TYR_ITIM	390	395	PF00017	0.436
LIG_UBA3_1	297	302	PF00899	0.402
LIG_WRC_WIRS_1	106	111	PF05994	0.518
LIG_WRC_WIRS_1	181	186	PF05994	0.606
LIG_WRC_WIRS_1	202	207	PF05994	0.541
LIG_WRC_WIRS_1	511	516	PF05994	0.489
LIG_WW_1	233	236	PF00397	0.699
MOD_CDK_SPxxK_3	254	261	PF00069	0.677
MOD_CDK_SPxxK_3	321	328	PF00069	0.669
MOD_CK1_1	12	18	PF00069	0.648
MOD_CK1_1	121	127	PF00069	0.624
MOD_CK1_1	130	136	PF00069	0.598
MOD_CK1_1	137	143	PF00069	0.629
MOD_CK1_1	165	171	PF00069	0.629
MOD_CK1_1	177	183	PF00069	0.585
MOD_CK1_1	185	191	PF00069	0.587
MOD_CK1_1	210	216	PF00069	0.671
MOD_CK1_1	224	230	PF00069	0.554
MOD_CK1_1	254	260	PF00069	0.678
MOD_CK1_1	314	320	PF00069	0.722
MOD_CK1_1	43	49	PF00069	0.633
MOD_CK1_1	505	511	PF00069	0.580
MOD_CK1_1	51	57	PF00069	0.560
MOD_CK2_1	172	178	PF00069	0.676
MOD_CK2_1	313	319	PF00069	0.753
MOD_CK2_1	493	499	PF00069	0.621
MOD_GlcNHglycan	120	123	PF01048	0.657
MOD_GlcNHglycan	129	132	PF01048	0.568
MOD_GlcNHglycan	14	17	PF01048	0.692
MOD_GlcNHglycan	151	154	PF01048	0.673
MOD_GlcNHglycan	205	208	PF01048	0.568
MOD_GlcNHglycan	221	224	PF01048	0.747
MOD_GlcNHglycan	226	229	PF01048	0.667
MOD_GlcNHglycan	244	247	PF01048	0.609
MOD_GlcNHglycan	291	294	PF01048	0.414
MOD_GlcNHglycan	334	337	PF01048	0.613
MOD_GlcNHglycan	361	364	PF01048	0.515
MOD_GlcNHglycan	493	496	PF01048	0.714
MOD_GlcNHglycan	502	505	PF01048	0.565
MOD_GSK3_1	121	128	PF00069	0.629
MOD_GSK3_1	130	137	PF00069	0.597
MOD_GSK3_1	14	21	PF00069	0.759
MOD_GSK3_1	158	165	PF00069	0.656
MOD_GSK3_1	182	189	PF00069	0.685
MOD_GSK3_1	203	210	PF00069	0.595
MOD_GSK3_1	311	318	PF00069	0.671
MOD_GSK3_1	491	498	PF00069	0.605
MOD_GSK3_1	500	507	PF00069	0.530
MOD_GSK3_1	53	60	PF00069	0.728
MOD_GSK3_1	76	83	PF00069	0.570
MOD_N-GLC_1	149	154	PF02516	0.573
MOD_NEK2_1	105	110	PF00069	0.610
MOD_NEK2_1	118	123	PF00069	0.623
MOD_NEK2_1	125	130	PF00069	0.553
MOD_NEK2_1	134	139	PF00069	0.503
MOD_NEK2_1	149	154	PF00069	0.551
MOD_NEK2_1	186	191	PF00069	0.653
MOD_NEK2_1	211	216	PF00069	0.553
MOD_NEK2_1	306	311	PF00069	0.623
MOD_NEK2_1	40	45	PF00069	0.693
MOD_PIKK_1	165	171	PF00454	0.609
MOD_PIKK_1	46	52	PF00454	0.629
MOD_PKA_2	491	497	PF00069	0.591
MOD_PKB_1	328	336	PF00069	0.646
MOD_Plk_1	165	171	PF00069	0.593
MOD_Plk_1	177	183	PF00069	0.688
MOD_Plk_4	137	143	PF00069	0.579
MOD_Plk_4	207	213	PF00069	0.511
MOD_Plk_4	235	241	PF00069	0.699
MOD_Plk_4	35	41	PF00069	0.570
MOD_Plk_4	510	516	PF00069	0.489
MOD_Plk_4	53	59	PF00069	0.630
MOD_Plk_4	76	82	PF00069	0.652
MOD_ProDKin_1	20	26	PF00069	0.695
MOD_ProDKin_1	254	260	PF00069	0.678
MOD_ProDKin_1	321	327	PF00069	0.683
MOD_ProDKin_1	33	39	PF00069	0.647
MOD_ProDKin_1	43	49	PF00069	0.629
MOD_ProDKin_1	57	63	PF00069	0.588
MOD_SUMO_for_1	421	424	PF00179	0.398
MOD_SUMO_rev_2	335	344	PF00179	0.705
MOD_SUMO_rev_2	436	441	PF00179	0.481
TRG_DiLeu_BaEn_1	454	459	PF01217	0.496
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.421
TRG_DiLeu_LyEn_5	345	350	PF01217	0.533
TRG_ENDOCYTIC_2	139	142	PF00928	0.687
TRG_ENDOCYTIC_2	236	239	PF00928	0.701
TRG_ENDOCYTIC_2	288	291	PF00928	0.374
TRG_ENDOCYTIC_2	295	298	PF00928	0.378
TRG_ENDOCYTIC_2	392	395	PF00928	0.455
TRG_ENDOCYTIC_2	471	474	PF00928	0.391
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J5	Leptomonas seymouri	37%	89%
A4HJB8	Leishmania braziliensis	58%	100%
A4HJX4	Leishmania braziliensis	56%	100%
A4I6R1	Leishmania infantum	99%	100%
E9B1T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q6C8	Leishmania major	87%	100%