Cell division protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cell division protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICJ0_LEIDO

TriTrypDb:

LdBPK_120130.1 , LdCL_120006400 , LDHU3_12.0190

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8ICJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0051301	cell division	2	2
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.668
CLV_NRD_NRD_1	139	141	PF00675	0.453
CLV_PCSK_KEX2_1	139	141	PF00082	0.453
CLV_PCSK_KEX2_1	562	564	PF00082	0.473
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.473
CLV_PCSK_SKI1_1	139	143	PF00082	0.355
CLV_PCSK_SKI1_1	160	164	PF00082	0.476
CLV_PCSK_SKI1_1	211	215	PF00082	0.782
CLV_PCSK_SKI1_1	553	557	PF00082	0.387
CLV_PCSK_SKI1_1	562	566	PF00082	0.399
CLV_PCSK_SKI1_1	83	87	PF00082	0.352
CLV_PCSK_SKI1_1	96	100	PF00082	0.349
DEG_APCC_DBOX_1	138	146	PF00400	0.355
DEG_SCF_FBW7_1	350	355	PF00400	0.335
DEG_SCF_FBW7_2	424	430	PF00400	0.388
DOC_CKS1_1	354	359	PF01111	0.335
DOC_CKS1_1	424	429	PF01111	0.404
DOC_CYCLIN_RxL_1	550	559	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	168	174	PF00134	0.470
DOC_MAPK_gen_1	160	169	PF00069	0.335
DOC_MAPK_gen_1	79	88	PF00069	0.453
DOC_PP2B_PxIxI_1	133	139	PF00149	0.453
DOC_PP4_FxxP_1	312	315	PF00568	0.586
DOC_PP4_FxxP_1	574	577	PF00568	0.581
DOC_SPAK_OSR1_1	8	12	PF12202	0.335
DOC_USP7_MATH_1	107	111	PF00917	0.453
DOC_USP7_MATH_1	184	188	PF00917	0.769
DOC_USP7_MATH_1	202	206	PF00917	0.590
DOC_USP7_MATH_1	518	522	PF00917	0.704
DOC_WW_Pin1_4	313	318	PF00397	0.711
DOC_WW_Pin1_4	348	353	PF00397	0.335
DOC_WW_Pin1_4	423	428	PF00397	0.401
DOC_WW_Pin1_4	573	578	PF00397	0.541
DOC_WW_Pin1_4	64	69	PF00397	0.453
LIG_14-3-3_CanoR_1	231	235	PF00244	0.642
LIG_14-3-3_CanoR_1	369	375	PF00244	0.389
LIG_14-3-3_CanoR_1	519	523	PF00244	0.708
LIG_14-3-3_CanoR_1	563	570	PF00244	0.423
LIG_14-3-3_CanoR_1	8	12	PF00244	0.335
LIG_Actin_WH2_2	41	57	PF00022	0.384
LIG_APCC_ABBA_1	234	239	PF00400	0.594
LIG_APCC_ABBAyCdc20_2	155	161	PF00400	0.342
LIG_CtBP_PxDLS_1	92	96	PF00389	0.335
LIG_deltaCOP1_diTrp_1	375	384	PF00928	0.313
LIG_FHA_1	335	341	PF00498	0.335
LIG_FHA_1	353	359	PF00498	0.424
LIG_FHA_1	39	45	PF00498	0.335
LIG_FHA_1	424	430	PF00498	0.528
LIG_FHA_2	239	245	PF00498	0.567
LIG_FHA_2	31	37	PF00498	0.453
LIG_FHA_2	370	376	PF00498	0.335
LIG_FHA_2	484	490	PF00498	0.697
LIG_FHA_2	563	569	PF00498	0.422
LIG_FHA_2	8	14	PF00498	0.335
LIG_LIR_Apic_2	309	315	PF02991	0.584
LIG_LIR_Apic_2	356	362	PF02991	0.335
LIG_LIR_Gen_1	409	417	PF02991	0.482
LIG_LIR_Gen_1	538	549	PF02991	0.479
LIG_LIR_Gen_1	7	15	PF02991	0.335
LIG_LIR_Nem_3	17	23	PF02991	0.335
LIG_LIR_Nem_3	390	395	PF02991	0.335
LIG_LIR_Nem_3	430	435	PF02991	0.431
LIG_LIR_Nem_3	538	544	PF02991	0.495
LIG_LIR_Nem_3	7	12	PF02991	0.335
LIG_LIR_Nem_3	89	93	PF02991	0.335
LIG_MYND_1	318	322	PF01753	0.520
LIG_MYND_1	573	577	PF01753	0.584
LIG_NRBOX	551	557	PF00104	0.398
LIG_Pex14_2	98	102	PF04695	0.335
LIG_PTB_Apo_2	97	104	PF02174	0.335
LIG_PTB_Phospho_1	97	103	PF10480	0.335
LIG_REV1ctd_RIR_1	226	235	PF16727	0.653
LIG_SH2_CRK	20	24	PF00017	0.335
LIG_SH2_PTP2	90	93	PF00017	0.335
LIG_SH2_SRC	541	544	PF00017	0.508
LIG_SH2_SRC	558	561	PF00017	0.362
LIG_SH2_STAT3	103	106	PF00017	0.389
LIG_SH2_STAT5	103	106	PF00017	0.335
LIG_SH2_STAT5	137	140	PF00017	0.335
LIG_SH2_STAT5	359	362	PF00017	0.354
LIG_SH2_STAT5	411	414	PF00017	0.470
LIG_SH2_STAT5	90	93	PF00017	0.335
LIG_SH3_3	178	184	PF00018	0.577
LIG_SH3_3	196	202	PF00018	0.734
LIG_SH3_3	210	216	PF00018	0.626
LIG_SH3_3	312	318	PF00018	0.661
LIG_SH3_3	351	357	PF00018	0.335
LIG_SUMO_SIM_anti_2	467	475	PF11976	0.545
LIG_SUMO_SIM_par_1	91	97	PF11976	0.453
LIG_TRAF2_1	207	210	PF00917	0.823
LIG_TRAF2_1	342	345	PF00917	0.453
LIG_TRAF2_1	428	431	PF00917	0.422
LIG_TRAF2_2	207	212	PF00917	0.595
LIG_TYR_ITIM	88	93	PF00017	0.335
LIG_WRC_WIRS_1	185	190	PF05994	0.637
LIG_WRC_WIRS_1	398	403	PF05994	0.515
LIG_WRC_WIRS_1	95	100	PF05994	0.413
LIG_WW_3	522	526	PF00397	0.697
MOD_CK1_1	110	116	PF00069	0.389
MOD_CK1_1	498	504	PF00069	0.695
MOD_CK1_1	7	13	PF00069	0.335
MOD_CK2_1	238	244	PF00069	0.696
MOD_CK2_1	339	345	PF00069	0.335
MOD_CK2_1	425	431	PF00069	0.410
MOD_CK2_1	483	489	PF00069	0.630
MOD_CK2_1	562	568	PF00069	0.429
MOD_CK2_1	7	13	PF00069	0.335
MOD_GlcNHglycan	109	112	PF01048	0.453
MOD_GlcNHglycan	124	127	PF01048	0.250
MOD_GlcNHglycan	16	19	PF01048	0.335
MOD_GlcNHglycan	246	249	PF01048	0.591
MOD_GlcNHglycan	330	333	PF01048	0.335
MOD_GlcNHglycan	341	344	PF01048	0.335
MOD_GlcNHglycan	401	404	PF01048	0.658
MOD_GlcNHglycan	474	477	PF01048	0.808
MOD_GlcNHglycan	497	500	PF01048	0.706
MOD_GlcNHglycan	528	531	PF01048	0.761
MOD_GlcNHglycan	546	549	PF01048	0.366
MOD_GlcNHglycan	565	568	PF01048	0.437
MOD_GSK3_1	106	113	PF00069	0.313
MOD_GSK3_1	184	191	PF00069	0.553
MOD_GSK3_1	276	283	PF00069	0.643
MOD_GSK3_1	348	355	PF00069	0.335
MOD_GSK3_1	491	498	PF00069	0.708
MOD_N-GLC_1	509	514	PF02516	0.688
MOD_N-GLC_1	534	539	PF02516	0.526
MOD_N-GLC_2	285	287	PF02516	0.681
MOD_NEK2_1	281	286	PF00069	0.601
MOD_NEK2_1	44	49	PF00069	0.453
MOD_NEK2_1	551	556	PF00069	0.392
MOD_NEK2_2	394	399	PF00069	0.526
MOD_PIKK_1	211	217	PF00454	0.676
MOD_PIKK_1	285	291	PF00454	0.695
MOD_PK_1	55	61	PF00069	0.313
MOD_PKA_1	562	568	PF00069	0.483
MOD_PKA_2	219	225	PF00069	0.632
MOD_PKA_2	230	236	PF00069	0.577
MOD_PKA_2	495	501	PF00069	0.684
MOD_PKA_2	518	524	PF00069	0.708
MOD_PKA_2	562	568	PF00069	0.429
MOD_PKA_2	7	13	PF00069	0.335
MOD_Plk_1	467	473	PF00069	0.537
MOD_Plk_1	491	497	PF00069	0.581
MOD_Plk_1	55	61	PF00069	0.313
MOD_Plk_2-3	30	36	PF00069	0.335
MOD_Plk_4	19	25	PF00069	0.335
MOD_Plk_4	467	473	PF00069	0.608
MOD_ProDKin_1	313	319	PF00069	0.703
MOD_ProDKin_1	348	354	PF00069	0.335
MOD_ProDKin_1	423	429	PF00069	0.404
MOD_ProDKin_1	573	579	PF00069	0.547
MOD_ProDKin_1	64	70	PF00069	0.453
MOD_SUMO_for_1	162	165	PF00179	0.335
MOD_SUMO_rev_2	277	284	PF00179	0.683
MOD_SUMO_rev_2	303	313	PF00179	0.655
MOD_SUMO_rev_2	474	480	PF00179	0.756
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.453
TRG_ENDOCYTIC_2	20	23	PF00928	0.335
TRG_ENDOCYTIC_2	24	27	PF00928	0.335
TRG_ENDOCYTIC_2	411	414	PF00928	0.468
TRG_ENDOCYTIC_2	541	544	PF00928	0.499
TRG_ENDOCYTIC_2	90	93	PF00928	0.335
TRG_ER_diArg_1	138	140	PF00400	0.453
TRG_ER_diArg_1	261	264	PF00400	0.626
TRG_ER_diArg_1	338	341	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4P5	Leptomonas seymouri	55%	92%
A4H6S9	Leishmania braziliensis	78%	100%
A4HV57	Leishmania infantum	99%	100%
E9ANU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QGT0	Leishmania major	91%	100%