Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICI9_LEIDO

TriTrypDb:

LdBPK_230810.1 , LdCL_230014700 , LDHU3_23.1110

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 0
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8ICI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICI9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006887	exocytosis	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0032940	secretion by cell	3	1
GO:0045055	regulated exocytosis	5	1
GO:0046903	secretion	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0140352	export from cell	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0019899	enzyme binding	3	5
GO:0031267	small GTPase binding	5	5
GO:0051020	GTPase binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.447
CLV_C14_Caspase3-7	469	473	PF00656	0.370
CLV_C14_Caspase3-7	532	536	PF00656	0.660
CLV_NRD_NRD_1	10	12	PF00675	0.599
CLV_NRD_NRD_1	101	103	PF00675	0.608
CLV_NRD_NRD_1	118	120	PF00675	0.579
CLV_NRD_NRD_1	128	130	PF00675	0.526
CLV_NRD_NRD_1	136	138	PF00675	0.565
CLV_NRD_NRD_1	148	150	PF00675	0.515
CLV_NRD_NRD_1	156	158	PF00675	0.522
CLV_NRD_NRD_1	168	170	PF00675	0.545
CLV_NRD_NRD_1	176	178	PF00675	0.520
CLV_NRD_NRD_1	188	190	PF00675	0.609
CLV_NRD_NRD_1	198	200	PF00675	0.577
CLV_NRD_NRD_1	89	91	PF00675	0.634
CLV_PCSK_FUR_1	146	150	PF00082	0.544
CLV_PCSK_FUR_1	166	170	PF00082	0.500
CLV_PCSK_FUR_1	186	190	PF00082	0.588
CLV_PCSK_FUR_1	195	199	PF00082	0.690
CLV_PCSK_FUR_1	99	103	PF00082	0.556
CLV_PCSK_KEX2_1	101	103	PF00082	0.608
CLV_PCSK_KEX2_1	117	119	PF00082	0.579
CLV_PCSK_KEX2_1	128	130	PF00082	0.522
CLV_PCSK_KEX2_1	135	137	PF00082	0.569
CLV_PCSK_KEX2_1	148	150	PF00082	0.518
CLV_PCSK_KEX2_1	155	157	PF00082	0.652
CLV_PCSK_KEX2_1	168	170	PF00082	0.599
CLV_PCSK_KEX2_1	175	177	PF00082	0.667
CLV_PCSK_KEX2_1	188	190	PF00082	0.597
CLV_PCSK_KEX2_1	197	199	PF00082	0.669
CLV_PCSK_KEX2_1	262	264	PF00082	0.588
CLV_PCSK_KEX2_1	374	376	PF00082	0.600
CLV_PCSK_KEX2_1	521	523	PF00082	0.450
CLV_PCSK_KEX2_1	89	91	PF00082	0.634
CLV_PCSK_KEX2_1	9	11	PF00082	0.604
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.702
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.588
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.545
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.450
CLV_PCSK_SKI1_1	11	15	PF00082	0.623
CLV_PCSK_SKI1_1	521	525	PF00082	0.365
DEG_APCC_DBOX_1	9	17	PF00400	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.625
DOC_CYCLIN_RxL_1	323	331	PF00134	0.302
DOC_MAPK_gen_1	117	126	PF00069	0.342
DOC_MAPK_gen_1	385	391	PF00069	0.316
DOC_MAPK_gen_1	9	18	PF00069	0.470
DOC_MAPK_MEF2A_6	427	434	PF00069	0.370
DOC_MAPK_MEF2A_6	9	18	PF00069	0.440
DOC_MAPK_NFAT4_5	427	435	PF00069	0.307
DOC_PP1_RVXF_1	311	318	PF00149	0.335
DOC_USP7_MATH_1	302	306	PF00917	0.410
DOC_USP7_MATH_1	450	454	PF00917	0.395
DOC_USP7_MATH_1	529	533	PF00917	0.681
DOC_USP7_MATH_1	62	66	PF00917	0.424
DOC_USP7_UBL2_3	348	352	PF12436	0.333
DOC_WW_Pin1_4	341	346	PF00397	0.418
DOC_WW_Pin1_4	521	526	PF00397	0.566
LIG_14-3-3_CanoR_1	207	214	PF00244	0.372
LIG_14-3-3_CanoR_1	232	239	PF00244	0.476
LIG_14-3-3_CanoR_1	319	329	PF00244	0.449
LIG_14-3-3_CanoR_1	9	14	PF00244	0.552
LIG_Actin_WH2_2	444	461	PF00022	0.305
LIG_BIR_III_2	299	303	PF00653	0.304
LIG_BIR_III_4	41	45	PF00653	0.436
LIG_FHA_1	342	348	PF00498	0.356
LIG_FHA_1	349	355	PF00498	0.300
LIG_FHA_2	36	42	PF00498	0.467
LIG_FHA_2	55	61	PF00498	0.628
LIG_LIR_Gen_1	362	371	PF02991	0.373
LIG_LIR_Gen_1	462	471	PF02991	0.355
LIG_LIR_Nem_3	341	346	PF02991	0.376
LIG_LIR_Nem_3	362	368	PF02991	0.366
LIG_LIR_Nem_3	431	436	PF02991	0.325
LIG_LIR_Nem_3	462	466	PF02991	0.347
LIG_LIR_Nem_3	483	489	PF02991	0.369
LIG_PCNA_TLS_4	427	434	PF02747	0.307
LIG_Pex14_1	429	433	PF04695	0.303
LIG_Pex14_2	505	509	PF04695	0.370
LIG_REV1ctd_RIR_1	315	323	PF16727	0.327
LIG_SH2_CRK	343	347	PF00017	0.399
LIG_SH2_CRK	393	397	PF00017	0.307
LIG_SH2_CRK	486	490	PF00017	0.316
LIG_SH2_NCK_1	393	397	PF00017	0.307
LIG_SH2_SRC	422	425	PF00017	0.281
LIG_SH2_STAP1	350	354	PF00017	0.336
LIG_SH2_STAP1	365	369	PF00017	0.302
LIG_SH2_STAP1	422	426	PF00017	0.370
LIG_SH2_STAT3	274	277	PF00017	0.296
LIG_SH2_STAT5	224	227	PF00017	0.323
LIG_SH2_STAT5	316	319	PF00017	0.363
LIG_SH2_STAT5	329	332	PF00017	0.407
LIG_SH2_STAT5	343	346	PF00017	0.409
LIG_SH2_STAT5	350	353	PF00017	0.356
LIG_SH2_STAT5	357	360	PF00017	0.417
LIG_SH2_STAT5	424	427	PF00017	0.311
LIG_SH2_STAT5	437	440	PF00017	0.339
LIG_SH2_STAT5	493	496	PF00017	0.310
LIG_SH3_3	248	254	PF00018	0.357
LIG_SH3_3	373	379	PF00018	0.292
LIG_SH3_3	408	414	PF00018	0.291
LIG_SH3_3	475	481	PF00018	0.328
LIG_SH3_4	45	52	PF00018	0.494
LIG_Sin3_3	408	415	PF02671	0.401
LIG_SUMO_SIM_anti_2	497	502	PF11976	0.307
LIG_TRAF2_1	209	212	PF00917	0.393
LIG_TRAF2_1	220	223	PF00917	0.313
LIG_TRAF2_1	57	60	PF00917	0.478
LIG_TYR_ITIM	391	396	PF00017	0.307
LIG_TYR_ITIM	420	425	PF00017	0.273
LIG_UBA3_1	380	386	PF00899	0.450
MOD_CDK_SPxxK_3	341	348	PF00069	0.392
MOD_CK1_1	305	311	PF00069	0.425
MOD_CK1_1	52	58	PF00069	0.688
MOD_CK2_1	206	212	PF00069	0.447
MOD_CK2_1	217	223	PF00069	0.371
MOD_CK2_1	303	309	PF00069	0.426
MOD_CK2_1	54	60	PF00069	0.638
MOD_Cter_Amidation	372	375	PF01082	0.412
MOD_Cter_Amidation	518	521	PF01082	0.556
MOD_GlcNHglycan	208	211	PF01048	0.457
MOD_GlcNHglycan	361	364	PF01048	0.389
MOD_GlcNHglycan	371	374	PF01048	0.449
MOD_GlcNHglycan	531	534	PF01048	0.539
MOD_GSK3_1	282	289	PF00069	0.469
MOD_GSK3_1	346	353	PF00069	0.432
MOD_GSK3_1	446	453	PF00069	0.497
MOD_GSK3_1	462	469	PF00069	0.466
MOD_GSK3_1	48	55	PF00069	0.823
MOD_GSK3_1	5	12	PF00069	0.563
MOD_GSK3_1	529	536	PF00069	0.745
MOD_NEK2_1	318	323	PF00069	0.533
MOD_NEK2_1	328	333	PF00069	0.421
MOD_NEK2_1	339	344	PF00069	0.414
MOD_NEK2_1	494	499	PF00069	0.307
MOD_NEK2_1	508	513	PF00069	0.425
MOD_OFUCOSY	507	512	PF10250	0.307
MOD_PK_1	199	205	PF00069	0.547
MOD_PKA_1	9	15	PF00069	0.550
MOD_PKA_2	206	212	PF00069	0.447
MOD_PKA_2	318	324	PF00069	0.569
MOD_PKA_2	62	68	PF00069	0.514
MOD_PKA_2	9	15	PF00069	0.550
MOD_Plk_1	302	308	PF00069	0.431
MOD_Plk_2-3	303	309	PF00069	0.426
MOD_Plk_4	25	31	PF00069	0.532
MOD_Plk_4	466	472	PF00069	0.439
MOD_ProDKin_1	341	347	PF00069	0.515
MOD_ProDKin_1	521	527	PF00069	0.444
TRG_DiLeu_BaEn_4	121	127	PF01217	0.470
TRG_DiLeu_BaEn_4	91	97	PF01217	0.530
TRG_ENDOCYTIC_2	343	346	PF00928	0.434
TRG_ENDOCYTIC_2	365	368	PF00928	0.442
TRG_ENDOCYTIC_2	393	396	PF00928	0.273
TRG_ENDOCYTIC_2	422	425	PF00928	0.303
TRG_ENDOCYTIC_2	486	489	PF00928	0.471
TRG_ER_diArg_1	116	119	PF00400	0.530
TRG_ER_diArg_1	135	137	PF00400	0.475
TRG_ER_diArg_1	146	149	PF00400	0.419
TRG_ER_diArg_1	155	157	PF00400	0.353
TRG_ER_diArg_1	166	169	PF00400	0.382
TRG_ER_diArg_1	175	177	PF00400	0.428
TRG_ER_diArg_1	186	189	PF00400	0.415
TRG_ER_diArg_1	198	200	PF00400	0.663
TRG_ER_diArg_1	9	11	PF00400	0.494
TRG_ER_diArg_1	99	102	PF00400	0.511
TRG_ER_diLys_1	555	558	PF00400	0.544
TRG_NLS_MonoExtN_4	518	524	PF00514	0.462
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD68	Leptomonas seymouri	45%	100%
A4H6H3	Leishmania braziliensis	66%	100%
A4I0B5	Leishmania infantum	98%	100%
Q9U0V4	Leishmania major	82%	100%