Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICI7_LEIDO

TriTrypDb:

LdBPK_251420.1 , LdCL_250019800 , LDHU3_25.1760

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.660
CLV_NRD_NRD_1	115	117	PF00675	0.399
CLV_NRD_NRD_1	198	200	PF00675	0.677
CLV_NRD_NRD_1	226	228	PF00675	0.700
CLV_NRD_NRD_1	41	43	PF00675	0.585
CLV_PCSK_KEX2_1	115	117	PF00082	0.400
CLV_PCSK_KEX2_1	225	227	PF00082	0.586
CLV_PCSK_KEX2_1	41	43	PF00082	0.585
CLV_PCSK_SKI1_1	116	120	PF00082	0.408
CLV_PCSK_SKI1_1	137	141	PF00082	0.550
DEG_Nend_UBRbox_1	1	4	PF02207	0.645
DOC_ANK_TNKS_1	225	232	PF00023	0.674
DOC_MAPK_MEF2A_6	103	110	PF00069	0.451
DOC_MAPK_MEF2A_6	213	222	PF00069	0.635
DOC_USP7_MATH_1	118	122	PF00917	0.452
DOC_USP7_MATH_1	29	33	PF00917	0.546
DOC_USP7_MATH_1	94	98	PF00917	0.498
DOC_USP7_MATH_1	99	103	PF00917	0.443
DOC_WW_Pin1_4	139	144	PF00397	0.551
DOC_WW_Pin1_4	201	206	PF00397	0.643
LIG_14-3-3_CanoR_1	137	142	PF00244	0.509
LIG_14-3-3_CanoR_1	42	52	PF00244	0.597
LIG_14-3-3_CanoR_1	54	59	PF00244	0.432
LIG_14-3-3_CanoR_1	70	74	PF00244	0.427
LIG_14-3-3_CterR_2	233	236	PF00244	0.710
LIG_BRCT_BRCA1_1	96	100	PF00533	0.582
LIG_deltaCOP1_diTrp_1	128	134	PF00928	0.406
LIG_FHA_1	217	223	PF00498	0.610
LIG_FHA_2	168	174	PF00498	0.591
LIG_FHA_2	70	76	PF00498	0.373
LIG_LIR_Gen_1	85	94	PF02991	0.592
LIG_LIR_Nem_3	204	209	PF02991	0.629
LIG_LIR_Nem_3	85	91	PF02991	0.419
LIG_Pex14_1	130	134	PF04695	0.414
LIG_TRAF2_1	181	184	PF00917	0.569
MOD_CK1_1	69	75	PF00069	0.392
MOD_CK2_1	201	207	PF00069	0.614
MOD_CK2_1	29	35	PF00069	0.539
MOD_CK2_1	69	75	PF00069	0.391
MOD_Cter_Amidation	197	200	PF01082	0.685
MOD_GSK3_1	106	113	PF00069	0.447
MOD_GSK3_1	25	32	PF00069	0.633
MOD_N-GLC_1	33	38	PF02516	0.494
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	106	111	PF00069	0.432
MOD_NEK2_1	126	131	PF00069	0.467
MOD_NEK2_1	33	38	PF00069	0.544
MOD_NEK2_1	68	73	PF00069	0.426
MOD_PIKK_1	161	167	PF00454	0.670
MOD_PIKK_1	43	49	PF00454	0.569
MOD_PKA_2	1	7	PF00069	0.604
MOD_PKA_2	69	75	PF00069	0.371
MOD_Plk_1	33	39	PF00069	0.478
MOD_Plk_2-3	216	222	PF00069	0.603
MOD_ProDKin_1	139	145	PF00069	0.548
MOD_ProDKin_1	201	207	PF00069	0.641
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.499
TRG_ER_diArg_1	114	116	PF00400	0.398
TRG_ER_diArg_1	224	227	PF00400	0.690
TRG_ER_diArg_1	40	42	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4H8	Leptomonas seymouri	63%	100%
A0A1X0NMP7	Trypanosomatidae	48%	91%
A4HE54	Leishmania braziliensis	78%	97%
A4I1I2	Leishmania infantum	100%	100%
C9ZJY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	96%
E9AXL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9V5	Leishmania major	95%	100%
V5D3X1	Trypanosoma cruzi	50%	95%