Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICI6_LEIDO

TriTrypDb:

LdBPK_252360.1 , LdCL_250029400 , LDHU3_25.2840

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8ICI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.450
CLV_NRD_NRD_1	182	184	PF00675	0.273
CLV_NRD_NRD_1	226	228	PF00675	0.609
CLV_NRD_NRD_1	238	240	PF00675	0.529
CLV_NRD_NRD_1	95	97	PF00675	0.421
CLV_PCSK_KEX2_1	182	184	PF00082	0.273
CLV_PCSK_KEX2_1	226	228	PF00082	0.609
CLV_PCSK_KEX2_1	250	252	PF00082	0.621
CLV_PCSK_KEX2_1	94	96	PF00082	0.419
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.621
CLV_PCSK_PC7_1	91	97	PF00082	0.411
CLV_PCSK_SKI1_1	23	27	PF00082	0.622
DEG_Nend_UBRbox_2	1	3	PF02207	0.440
DOC_CYCLIN_yCln2_LP_2	25	31	PF00134	0.410
DOC_MAPK_gen_1	179	188	PF00069	0.473
DOC_MAPK_MEF2A_6	179	188	PF00069	0.473
DOC_PP2B_LxvP_1	106	109	PF13499	0.650
DOC_PP2B_LxvP_1	25	28	PF13499	0.403
DOC_PP2B_LxvP_1	64	67	PF13499	0.419
DOC_PP4_FxxP_1	161	164	PF00568	0.655
DOC_PP4_FxxP_1	45	48	PF00568	0.439
DOC_USP7_MATH_1	219	223	PF00917	0.421
DOC_USP7_MATH_1	60	64	PF00917	0.400
DOC_USP7_MATH_1	80	84	PF00917	0.282
DOC_WW_Pin1_4	5	10	PF00397	0.533
LIG_14-3-3_CanoR_1	239	244	PF00244	0.404
LIG_14-3-3_CanoR_1	69	74	PF00244	0.453
LIG_BRCT_BRCA1_1	111	115	PF00533	0.619
LIG_FHA_1	115	121	PF00498	0.636
LIG_FHA_1	168	174	PF00498	0.636
LIG_FHA_1	187	193	PF00498	0.302
LIG_FHA_1	41	47	PF00498	0.457
LIG_FHA_1	85	91	PF00498	0.302
LIG_FHA_2	240	246	PF00498	0.406
LIG_LIR_Apic_2	159	164	PF02991	0.651
LIG_LIR_Apic_2	42	48	PF02991	0.441
LIG_LIR_Gen_1	13	24	PF02991	0.407
LIG_LIR_Gen_1	50	60	PF02991	0.447
LIG_LIR_Gen_1	68	77	PF02991	0.403
LIG_LIR_Nem_3	13	19	PF02991	0.416
LIG_LIR_Nem_3	229	235	PF02991	0.542
LIG_LIR_Nem_3	245	249	PF02991	0.368
LIG_LIR_Nem_3	50	56	PF02991	0.594
LIG_LIR_Nem_3	68	73	PF02991	0.411
LIG_NRBOX	21	27	PF00104	0.417
LIG_NRP_CendR_1	265	267	PF00754	0.684
LIG_OCRL_FandH_1	28	40	PF00620	0.429
LIG_Pex14_2	93	97	PF04695	0.613
LIG_REV1ctd_RIR_1	159	163	PF16727	0.651
LIG_SH2_NCK_1	149	153	PF00017	0.673
LIG_SH2_STAP1	149	153	PF00017	0.659
LIG_SH2_STAT3	235	238	PF00017	0.410
LIG_SH2_STAT5	201	204	PF00017	0.587
LIG_SH2_STAT5	206	209	PF00017	0.515
LIG_SH2_STAT5	24	27	PF00017	0.487
LIG_SH3_3	121	127	PF00018	0.595
LIG_SH3_3	193	199	PF00018	0.282
LIG_SH3_3	3	9	PF00018	0.558
LIG_TRAF2_1	255	258	PF00917	0.448
LIG_TRAF2_1	49	52	PF00917	0.441
LIG_TRFH_1	24	28	PF08558	0.489
LIG_WRC_WIRS_1	16	21	PF05994	0.485
MOD_CK1_1	18	24	PF00069	0.491
MOD_CK2_1	239	245	PF00069	0.483
MOD_CK2_1	252	258	PF00069	0.446
MOD_CK2_1	46	52	PF00069	0.543
MOD_CMANNOS	243	246	PF00535	0.495
MOD_GlcNHglycan	150	153	PF01048	0.731
MOD_GlcNHglycan	179	182	PF01048	0.530
MOD_GlcNHglycan	254	257	PF01048	0.667
MOD_GlcNHglycan	60	63	PF01048	0.580
MOD_GlcNHglycan	82	85	PF01048	0.354
MOD_GSK3_1	109	116	PF00069	0.506
MOD_GSK3_1	11	18	PF00069	0.514
MOD_GSK3_1	35	42	PF00069	0.535
MOD_GSK3_1	65	72	PF00069	0.553
MOD_GSK3_1	80	87	PF00069	0.302
MOD_N-GLC_1	252	257	PF02516	0.531
MOD_NEK2_1	114	119	PF00069	0.554
MOD_NEK2_1	15	20	PF00069	0.507
MOD_NEK2_1	186	191	PF00069	0.302
MOD_NEK2_1	234	239	PF00069	0.515
MOD_PIKK_1	109	115	PF00454	0.483
MOD_PIKK_1	234	240	PF00454	0.488
MOD_PKA_1	239	245	PF00069	0.483
MOD_PKA_2	217	223	PF00069	0.470
MOD_PKB_1	94	102	PF00069	0.514
MOD_Plk_4	11	17	PF00069	0.498
MOD_Plk_4	188	194	PF00069	0.293
MOD_Plk_4	219	225	PF00069	0.479
MOD_ProDKin_1	5	11	PF00069	0.663
TRG_DiLeu_BaEn_4	51	57	PF01217	0.547
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.481
TRG_ENDOCYTIC_2	70	73	PF00928	0.498
TRG_ER_diArg_1	162	165	PF00400	0.563
TRG_ER_diArg_1	182	184	PF00400	0.302
TRG_ER_diArg_1	93	96	PF00400	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I1S5	Leishmania infantum	97%	100%
Q4Q9L1	Leishmania major	85%	100%