RNA-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICI4_LEIDO

TriTrypDb:

LdBPK_230900.1 , LdCL_230015600 , LDHU3_23.1220

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICI4

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.605
CLV_C14_Caspase3-7	233	237	PF00656	0.759
CLV_C14_Caspase3-7	320	324	PF00656	0.733
CLV_NRD_NRD_1	128	130	PF00675	0.522
CLV_NRD_NRD_1	234	236	PF00675	0.784
CLV_NRD_NRD_1	242	244	PF00675	0.710
CLV_NRD_NRD_1	248	250	PF00675	0.643
CLV_NRD_NRD_1	254	256	PF00675	0.670
CLV_PCSK_FUR_1	232	236	PF00082	0.816
CLV_PCSK_FUR_1	240	244	PF00082	0.690
CLV_PCSK_KEX2_1	128	130	PF00082	0.522
CLV_PCSK_KEX2_1	234	236	PF00082	0.819
CLV_PCSK_KEX2_1	242	244	PF00082	0.786
CLV_PCSK_KEX2_1	248	250	PF00082	0.690
CLV_PCSK_KEX2_1	254	256	PF00082	0.613
DEG_SCF_FBW7_1	363	368	PF00400	0.728
DEG_SCF_FBW7_2	113	118	PF00400	0.715
DEG_SPOP_SBC_1	316	320	PF00917	0.693
DOC_MAPK_FxFP_2	440	443	PF00069	0.780
DOC_PP2B_LxvP_1	225	228	PF13499	0.796
DOC_PP2B_LxvP_1	392	395	PF13499	0.667
DOC_PP4_FxxP_1	303	306	PF00568	0.648
DOC_PP4_FxxP_1	440	443	PF00568	0.780
DOC_USP7_MATH_1	26	30	PF00917	0.727
DOC_USP7_MATH_1	286	290	PF00917	0.719
DOC_USP7_MATH_1	365	369	PF00917	0.691
DOC_USP7_MATH_1	395	399	PF00917	0.683
DOC_USP7_MATH_1	452	456	PF00917	0.662
DOC_USP7_MATH_1	46	50	PF00917	0.642
DOC_USP7_MATH_1	516	520	PF00917	0.816
DOC_USP7_MATH_1	547	551	PF00917	0.615
DOC_USP7_MATH_1	95	99	PF00917	0.800
DOC_USP7_UBL2_3	89	93	PF12436	0.724
DOC_WW_Pin1_4	1	6	PF00397	0.813
DOC_WW_Pin1_4	103	108	PF00397	0.708
DOC_WW_Pin1_4	111	116	PF00397	0.727
DOC_WW_Pin1_4	207	212	PF00397	0.605
DOC_WW_Pin1_4	328	333	PF00397	0.756
DOC_WW_Pin1_4	337	342	PF00397	0.703
DOC_WW_Pin1_4	354	359	PF00397	0.726
DOC_WW_Pin1_4	361	366	PF00397	0.683
DOC_WW_Pin1_4	383	388	PF00397	0.687
DOC_WW_Pin1_4	390	395	PF00397	0.674
DOC_WW_Pin1_4	435	440	PF00397	0.641
DOC_WW_Pin1_4	512	517	PF00397	0.744
DOC_WW_Pin1_4	80	85	PF00397	0.760
LIG_14-3-3_CanoR_1	97	102	PF00244	0.712
LIG_BIR_II_1	1	5	PF00653	0.811
LIG_BIR_III_4	425	429	PF00653	0.809
LIG_BRCT_BRCA1_1	141	145	PF00533	0.546
LIG_BRCT_BRCA1_1	18	22	PF00533	0.724
LIG_BRCT_BRCA1_1	332	336	PF00533	0.720
LIG_FHA_1	312	318	PF00498	0.728
LIG_FHA_1	45	51	PF00498	0.780
LIG_FHA_1	460	466	PF00498	0.719
LIG_FHA_2	470	476	PF00498	0.725
LIG_LIR_Apic_2	438	443	PF02991	0.759
LIG_LIR_Apic_2	473	479	PF02991	0.709
LIG_LIR_Gen_1	52	61	PF02991	0.707
LIG_LIR_Gen_1	535	546	PF02991	0.545
LIG_LIR_Nem_3	142	148	PF02991	0.507
LIG_LIR_Nem_3	333	339	PF02991	0.784
LIG_LIR_Nem_3	483	489	PF02991	0.660
LIG_LIR_Nem_3	493	499	PF02991	0.672
LIG_LIR_Nem_3	52	56	PF02991	0.698
LIG_LIR_Nem_3	535	541	PF02991	0.545
LIG_MYND_1	556	560	PF01753	0.768
LIG_Pex14_2	18	22	PF04695	0.812
LIG_Pex14_2	440	444	PF04695	0.777
LIG_PTAP_UEV_1	562	567	PF05743	0.743
LIG_SH2_SRC	561	564	PF00017	0.787
LIG_SH2_STAT5	132	135	PF00017	0.546
LIG_SH2_STAT5	300	303	PF00017	0.770
LIG_SH2_STAT5	540	543	PF00017	0.655
LIG_SH2_STAT5	561	564	PF00017	0.787
LIG_SH3_1	81	87	PF00018	0.791
LIG_SH3_2	116	121	PF14604	0.680
LIG_SH3_2	84	89	PF14604	0.695
LIG_SH3_3	110	116	PF00018	0.740
LIG_SH3_3	274	280	PF00018	0.715
LIG_SH3_3	433	439	PF00018	0.677
LIG_SH3_3	446	452	PF00018	0.722
LIG_SH3_3	484	490	PF00018	0.611
LIG_SH3_3	510	516	PF00018	0.691
LIG_SH3_3	553	559	PF00018	0.632
LIG_SH3_3	560	566	PF00018	0.583
LIG_SH3_3	81	87	PF00018	0.761
LIG_SxIP_EBH_1	254	268	PF03271	0.597
LIG_WRC_WIRS_1	50	55	PF05994	0.702
LIG_WW_1	137	140	PF00397	0.546
MOD_CDK_SPK_2	342	347	PF00069	0.663
MOD_CK1_1	179	185	PF00069	0.546
MOD_CK1_1	207	213	PF00069	0.610
MOD_CK1_1	21	27	PF00069	0.657
MOD_CK1_1	241	247	PF00069	0.828
MOD_CK1_1	33	39	PF00069	0.712
MOD_CK1_1	331	337	PF00069	0.742
MOD_CK1_1	345	351	PF00069	0.632
MOD_CK1_1	383	389	PF00069	0.696
MOD_CK1_1	398	404	PF00069	0.792
MOD_CK1_1	407	413	PF00069	0.695
MOD_CK1_1	49	55	PF00069	0.699
MOD_CK1_1	550	556	PF00069	0.738
MOD_CK2_1	11	17	PF00069	0.684
MOD_CK2_1	26	32	PF00069	0.818
MOD_CK2_1	469	475	PF00069	0.724
MOD_Cter_Amidation	252	255	PF01082	0.828
MOD_GlcNHglycan	1	4	PF01048	0.742
MOD_GlcNHglycan	133	136	PF01048	0.327
MOD_GlcNHglycan	180	184	PF01048	0.346
MOD_GlcNHglycan	243	246	PF01048	0.732
MOD_GlcNHglycan	26	29	PF01048	0.733
MOD_GlcNHglycan	269	272	PF01048	0.667
MOD_GlcNHglycan	288	291	PF01048	0.709
MOD_GlcNHglycan	319	322	PF01048	0.738
MOD_GlcNHglycan	32	35	PF01048	0.703
MOD_GlcNHglycan	367	370	PF01048	0.644
MOD_GlcNHglycan	382	385	PF01048	0.663
MOD_GlcNHglycan	409	412	PF01048	0.725
MOD_GlcNHglycan	454	457	PF01048	0.667
MOD_GlcNHglycan	509	512	PF01048	0.825
MOD_GlcNHglycan	518	521	PF01048	0.669
MOD_GlcNHglycan	563	566	PF01048	0.702
MOD_GlcNHglycan	577	580	PF01048	0.555
MOD_GlcNHglycan	97	100	PF01048	0.719
MOD_GSK3_1	12	19	PF00069	0.721
MOD_GSK3_1	24	31	PF00069	0.652
MOD_GSK3_1	244	251	PF00069	0.835
MOD_GSK3_1	311	318	PF00069	0.712
MOD_GSK3_1	327	334	PF00069	0.555
MOD_GSK3_1	361	368	PF00069	0.651
MOD_GSK3_1	386	393	PF00069	0.684
MOD_GSK3_1	395	402	PF00069	0.686
MOD_GSK3_1	403	410	PF00069	0.699
MOD_GSK3_1	45	52	PF00069	0.756
MOD_GSK3_1	498	505	PF00069	0.664
MOD_GSK3_1	512	519	PF00069	0.609
MOD_GSK3_1	532	539	PF00069	0.719
MOD_GSK3_1	95	102	PF00069	0.705
MOD_N-GLC_1	11	16	PF02516	0.790
MOD_N-GLC_1	190	195	PF02516	0.346
MOD_N-GLC_1	221	226	PF02516	0.698
MOD_N-GLC_1	238	243	PF02516	0.714
MOD_N-GLC_1	257	262	PF02516	0.728
MOD_N-GLC_1	328	333	PF02516	0.740
MOD_N-GLC_1	532	537	PF02516	0.680
MOD_N-GLC_1	548	553	PF02516	0.572
MOD_N-GLC_1	567	572	PF02516	0.725
MOD_NEK2_1	18	23	PF00069	0.733
MOD_NEK2_1	190	195	PF00069	0.520
MOD_NEK2_1	204	209	PF00069	0.584
MOD_NEK2_1	317	322	PF00069	0.742
MOD_NEK2_1	39	44	PF00069	0.700
MOD_NEK2_1	45	50	PF00069	0.651
MOD_NEK2_1	459	464	PF00069	0.710
MOD_NEK2_1	548	553	PF00069	0.691
MOD_NEK2_2	332	337	PF00069	0.587
MOD_NEK2_2	395	400	PF00069	0.787
MOD_PIKK_1	248	254	PF00454	0.752
MOD_PIKK_1	26	32	PF00454	0.748
MOD_PIKK_1	33	39	PF00454	0.672
MOD_PIKK_1	430	436	PF00454	0.782
MOD_PIKK_1	64	70	PF00454	0.800
MOD_PKA_1	248	254	PF00069	0.832
MOD_PKA_2	241	247	PF00069	0.768
MOD_PKA_2	248	254	PF00069	0.704
MOD_Plk_1	16	22	PF00069	0.808
MOD_Plk_1	221	227	PF00069	0.698
MOD_Plk_1	257	263	PF00069	0.690
MOD_Plk_4	190	196	PF00069	0.546
MOD_Plk_4	332	338	PF00069	0.588
MOD_Plk_4	46	52	PF00069	0.698
MOD_Plk_4	580	586	PF00069	0.648
MOD_ProDKin_1	1	7	PF00069	0.809
MOD_ProDKin_1	103	109	PF00069	0.707
MOD_ProDKin_1	111	117	PF00069	0.725
MOD_ProDKin_1	207	213	PF00069	0.610
MOD_ProDKin_1	328	334	PF00069	0.757
MOD_ProDKin_1	337	343	PF00069	0.700
MOD_ProDKin_1	354	360	PF00069	0.721
MOD_ProDKin_1	361	367	PF00069	0.685
MOD_ProDKin_1	383	389	PF00069	0.686
MOD_ProDKin_1	390	396	PF00069	0.677
MOD_ProDKin_1	435	441	PF00069	0.646
MOD_ProDKin_1	512	518	PF00069	0.739
MOD_ProDKin_1	80	86	PF00069	0.759
TRG_ENDOCYTIC_2	300	303	PF00928	0.668
TRG_ENDOCYTIC_2	488	491	PF00928	0.648
TRG_ENDOCYTIC_2	496	499	PF00928	0.679
TRG_ENDOCYTIC_2	540	543	PF00928	0.655
TRG_ER_diArg_1	127	129	PF00400	0.541
TRG_ER_diArg_1	240	243	PF00400	0.756
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P747	Leptomonas seymouri	39%	99%
A4HCU3	Leishmania braziliensis	74%	100%
A4I0C4	Leishmania infantum	99%	100%
E9AW88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QB90	Leishmania major	93%	100%