LeishMANIAdb
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Poly(A)-specific_ribonuclease_PARN_putative/GeneD B:LmjF.23.1630

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Poly(A)-specific_ribonuclease_PARN_putative/GeneD B:LmjF.23.1630
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8ICI3_LEIDO
TriTrypDb:
LdBPK_230660.1 , LdCL_230012100 , LDHU3_23.0910
Length:
601

Annotations

Annotations by Jardim et al.

RNA Processing, poly(A)-specific ribonuclease PARN Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 3
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A0A3Q8ICI3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICI3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 26
GO:0005488 binding 1 26
GO:0097159 organic cyclic compound binding 2 26
GO:1901363 heterocyclic compound binding 2 26
GO:0000175 3'-5'-RNA exonuclease activity 7 4
GO:0003824 catalytic activity 1 4
GO:0004518 nuclease activity 4 4
GO:0004527 exonuclease activity 5 4
GO:0004532 RNA exonuclease activity 5 4
GO:0004535 poly(A)-specific ribonuclease activity 8 1
GO:0004540 RNA nuclease activity 4 4
GO:0008408 3'-5' exonuclease activity 6 4
GO:0016787 hydrolase activity 2 4
GO:0016788 hydrolase activity, acting on ester bonds 3 4
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 4
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6 4
GO:0140098 catalytic activity, acting on RNA 3 4
GO:0140640 catalytic activity, acting on a nucleic acid 2 4
GO:0003723 RNA binding 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 328 332 PF00656 0.401
CLV_C14_Caspase3-7 506 510 PF00656 0.344
CLV_NRD_NRD_1 130 132 PF00675 0.232
CLV_NRD_NRD_1 195 197 PF00675 0.354
CLV_NRD_NRD_1 260 262 PF00675 0.250
CLV_NRD_NRD_1 310 312 PF00675 0.356
CLV_NRD_NRD_1 361 363 PF00675 0.373
CLV_NRD_NRD_1 4 6 PF00675 0.308
CLV_NRD_NRD_1 528 530 PF00675 0.531
CLV_NRD_NRD_1 589 591 PF00675 0.692
CLV_NRD_NRD_1 72 74 PF00675 0.319
CLV_PCSK_FUR_1 258 262 PF00082 0.324
CLV_PCSK_FUR_1 597 601 PF00082 0.523
CLV_PCSK_KEX2_1 130 132 PF00082 0.245
CLV_PCSK_KEX2_1 195 197 PF00082 0.365
CLV_PCSK_KEX2_1 260 262 PF00082 0.232
CLV_PCSK_KEX2_1 361 363 PF00082 0.373
CLV_PCSK_KEX2_1 4 6 PF00082 0.301
CLV_PCSK_KEX2_1 528 530 PF00082 0.488
CLV_PCSK_KEX2_1 54 56 PF00082 0.255
CLV_PCSK_KEX2_1 589 591 PF00082 0.692
CLV_PCSK_KEX2_1 599 601 PF00082 0.694
CLV_PCSK_KEX2_1 72 74 PF00082 0.178
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.262
CLV_PCSK_SKI1_1 292 296 PF00082 0.310
CLV_PCSK_SKI1_1 301 305 PF00082 0.206
CLV_PCSK_SKI1_1 346 350 PF00082 0.290
CLV_PCSK_SKI1_1 362 366 PF00082 0.168
CLV_PCSK_SKI1_1 449 453 PF00082 0.338
CLV_Separin_Metazoa 17 21 PF03568 0.385
DEG_APCC_DBOX_1 291 299 PF00400 0.524
DEG_COP1_1 28 39 PF00400 0.488
DEG_Nend_UBRbox_3 1 3 PF02207 0.322
DOC_CKS1_1 85 90 PF01111 0.504
DOC_MAPK_gen_1 130 136 PF00069 0.452
DOC_MAPK_gen_1 209 218 PF00069 0.508
DOC_MAPK_gen_1 238 248 PF00069 0.492
DOC_MAPK_MEF2A_6 241 248 PF00069 0.476
DOC_MAPK_MEF2A_6 250 257 PF00069 0.467
DOC_MAPK_MEF2A_6 60 68 PF00069 0.463
DOC_MAPK_NFAT4_5 241 249 PF00069 0.524
DOC_PP1_RVXF_1 299 305 PF00149 0.449
DOC_PP4_FxxP_1 568 571 PF00568 0.677
DOC_USP7_MATH_1 162 166 PF00917 0.532
DOC_USP7_MATH_1 329 333 PF00917 0.488
DOC_USP7_MATH_1 553 557 PF00917 0.689
DOC_USP7_MATH_1 563 567 PF00917 0.616
DOC_USP7_MATH_1 75 79 PF00917 0.468
DOC_WW_Pin1_4 119 124 PF00397 0.439
DOC_WW_Pin1_4 272 277 PF00397 0.494
DOC_WW_Pin1_4 383 388 PF00397 0.461
DOC_WW_Pin1_4 549 554 PF00397 0.613
DOC_WW_Pin1_4 84 89 PF00397 0.421
LIG_14-3-3_CanoR_1 187 194 PF00244 0.543
LIG_14-3-3_CanoR_1 589 593 PF00244 0.692
LIG_Actin_WH2_2 523 541 PF00022 0.315
LIG_APCC_ABBA_1 172 177 PF00400 0.384
LIG_BRCT_BRCA1_1 366 370 PF00533 0.446
LIG_deltaCOP1_diTrp_1 322 325 PF00928 0.524
LIG_eIF4E_1 400 406 PF01652 0.524
LIG_eIF4E_1 96 102 PF01652 0.524
LIG_FHA_1 167 173 PF00498 0.514
LIG_FHA_1 268 274 PF00498 0.468
LIG_FHA_1 303 309 PF00498 0.560
LIG_FHA_1 353 359 PF00498 0.407
LIG_FHA_1 38 44 PF00498 0.439
LIG_FHA_1 422 428 PF00498 0.417
LIG_FHA_1 510 516 PF00498 0.342
LIG_FHA_2 109 115 PF00498 0.463
LIG_FHA_2 174 180 PF00498 0.419
LIG_FHA_2 331 337 PF00498 0.404
LIG_FHA_2 463 469 PF00498 0.467
LIG_LIR_Apic_2 566 571 PF02991 0.676
LIG_LIR_Gen_1 322 330 PF02991 0.501
LIG_LIR_Gen_1 416 427 PF02991 0.421
LIG_LIR_Gen_1 59 68 PF02991 0.446
LIG_LIR_Nem_3 21 27 PF02991 0.447
LIG_LIR_Nem_3 251 255 PF02991 0.399
LIG_LIR_Nem_3 290 294 PF02991 0.480
LIG_LIR_Nem_3 297 303 PF02991 0.476
LIG_LIR_Nem_3 322 326 PF02991 0.498
LIG_LIR_Nem_3 367 373 PF02991 0.456
LIG_LIR_Nem_3 398 403 PF02991 0.494
LIG_LIR_Nem_3 416 422 PF02991 0.432
LIG_LIR_Nem_3 59 64 PF02991 0.442
LIG_LIR_Nem_3 6 11 PF02991 0.431
LIG_LYPXL_yS_3 252 255 PF13949 0.372
LIG_NRBOX 427 433 PF00104 0.464
LIG_NRP_CendR_1 599 601 PF00754 0.639
LIG_Pex14_1 353 357 PF04695 0.524
LIG_Pex14_2 300 304 PF04695 0.432
LIG_Pex14_2 349 353 PF04695 0.453
LIG_Pex14_2 8 12 PF04695 0.414
LIG_RPA_C_Fungi 182 194 PF08784 0.432
LIG_SH2_CRK 400 404 PF00017 0.338
LIG_SH2_CRK 419 423 PF00017 0.263
LIG_SH2_CRK 61 65 PF00017 0.316
LIG_SH2_NCK_1 400 404 PF00017 0.428
LIG_SH2_NCK_1 61 65 PF00017 0.313
LIG_SH2_PTP2 543 546 PF00017 0.331
LIG_SH2_SRC 400 403 PF00017 0.230
LIG_SH2_SRC 543 546 PF00017 0.511
LIG_SH2_STAP1 419 423 PF00017 0.260
LIG_SH2_STAP1 457 461 PF00017 0.376
LIG_SH2_STAT5 110 113 PF00017 0.347
LIG_SH2_STAT5 267 270 PF00017 0.434
LIG_SH2_STAT5 357 360 PF00017 0.267
LIG_SH2_STAT5 382 385 PF00017 0.282
LIG_SH2_STAT5 437 440 PF00017 0.415
LIG_SH2_STAT5 543 546 PF00017 0.479
LIG_SH3_1 539 545 PF00018 0.313
LIG_SH3_3 117 123 PF00018 0.314
LIG_SH3_3 270 276 PF00018 0.327
LIG_SH3_3 388 394 PF00018 0.272
LIG_SH3_3 539 545 PF00018 0.456
LIG_SH3_3 82 88 PF00018 0.401
LIG_SUMO_SIM_anti_2 270 275 PF11976 0.401
LIG_SUMO_SIM_anti_2 401 407 PF11976 0.230
LIG_SUMO_SIM_par_1 267 272 PF11976 0.387
LIG_SUMO_SIM_par_1 475 480 PF11976 0.302
LIG_TRAF2_1 111 114 PF00917 0.351
LIG_TRAF2_1 275 278 PF00917 0.357
LIG_TRFH_1 100 104 PF08558 0.291
LIG_WW_1 90 93 PF00397 0.195
LIG_WW_3 89 93 PF00397 0.195
MOD_CK1_1 167 173 PF00069 0.346
MOD_CK1_1 256 262 PF00069 0.345
MOD_CK1_1 45 51 PF00069 0.432
MOD_CK1_1 503 509 PF00069 0.448
MOD_CK1_1 556 562 PF00069 0.692
MOD_CK1_1 59 65 PF00069 0.386
MOD_CK2_1 108 114 PF00069 0.316
MOD_CK2_1 162 168 PF00069 0.413
MOD_CK2_1 173 179 PF00069 0.257
MOD_CK2_1 272 278 PF00069 0.376
MOD_CK2_1 330 336 PF00069 0.215
MOD_CK2_1 462 468 PF00069 0.509
MOD_GlcNHglycan 123 126 PF01048 0.377
MOD_GlcNHglycan 264 267 PF01048 0.288
MOD_GlcNHglycan 327 330 PF01048 0.230
MOD_GlcNHglycan 366 369 PF01048 0.364
MOD_GlcNHglycan 44 47 PF01048 0.321
MOD_GlcNHglycan 521 524 PF01048 0.439
MOD_GlcNHglycan 555 558 PF01048 0.481
MOD_GlcNHglycan 77 80 PF01048 0.356
MOD_GSK3_1 162 169 PF00069 0.333
MOD_GSK3_1 325 332 PF00069 0.266
MOD_GSK3_1 37 44 PF00069 0.259
MOD_GSK3_1 505 512 PF00069 0.442
MOD_GSK3_1 549 556 PF00069 0.599
MOD_N-GLC_1 462 467 PF02516 0.507
MOD_N-GLC_1 532 537 PF02516 0.467
MOD_NEK2_1 218 223 PF00069 0.335
MOD_NEK2_1 294 299 PF00069 0.351
MOD_NEK2_1 307 312 PF00069 0.278
MOD_NEK2_1 325 330 PF00069 0.237
MOD_NEK2_1 352 357 PF00069 0.360
MOD_NEK2_1 423 428 PF00069 0.272
MOD_NEK2_1 452 457 PF00069 0.381
MOD_NEK2_1 56 61 PF00069 0.316
MOD_NEK2_1 588 593 PF00069 0.656
MOD_NEK2_2 253 258 PF00069 0.401
MOD_PIKK_1 162 168 PF00454 0.412
MOD_PIKK_1 444 450 PF00454 0.265
MOD_PK_1 369 375 PF00069 0.252
MOD_PKA_2 186 192 PF00069 0.230
MOD_PKA_2 259 265 PF00069 0.330
MOD_PKA_2 588 594 PF00069 0.690
MOD_PKA_2 59 65 PF00069 0.358
MOD_Plk_1 167 173 PF00069 0.415
MOD_Plk_1 178 184 PF00069 0.285
MOD_Plk_1 330 336 PF00069 0.360
MOD_Plk_1 500 506 PF00069 0.489
MOD_Plk_1 532 538 PF00069 0.414
MOD_Plk_4 218 224 PF00069 0.201
MOD_Plk_4 269 275 PF00069 0.195
MOD_Plk_4 401 407 PF00069 0.397
MOD_Plk_4 423 429 PF00069 0.237
MOD_Plk_4 500 506 PF00069 0.414
MOD_Plk_4 532 538 PF00069 0.399
MOD_Plk_4 59 65 PF00069 0.359
MOD_ProDKin_1 119 125 PF00069 0.283
MOD_ProDKin_1 272 278 PF00069 0.359
MOD_ProDKin_1 383 389 PF00069 0.313
MOD_ProDKin_1 549 555 PF00069 0.616
MOD_ProDKin_1 84 90 PF00069 0.258
TRG_DiLeu_BaEn_1 290 295 PF01217 0.230
TRG_DiLeu_BaEn_1 532 537 PF01217 0.272
TRG_ENDOCYTIC_2 141 144 PF00928 0.272
TRG_ENDOCYTIC_2 252 255 PF00928 0.330
TRG_ENDOCYTIC_2 400 403 PF00928 0.272
TRG_ENDOCYTIC_2 419 422 PF00928 0.237
TRG_ENDOCYTIC_2 61 64 PF00928 0.298
TRG_ER_diArg_1 129 131 PF00400 0.291
TRG_ER_diArg_1 155 158 PF00400 0.297
TRG_ER_diArg_1 194 196 PF00400 0.455
TRG_ER_diArg_1 257 260 PF00400 0.279
TRG_ER_diArg_1 3 5 PF00400 0.378
TRG_ER_diArg_1 528 530 PF00400 0.534
TRG_ER_diArg_1 588 590 PF00400 0.675
TRG_ER_diArg_1 596 599 PF00400 0.639
TRG_ER_diArg_1 71 73 PF00400 0.381
TRG_Pf-PMV_PEXEL_1 292 296 PF00026 0.329
TRG_Pf-PMV_PEXEL_1 528 532 PF00026 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P603 Leptomonas seymouri 27% 100%
A0A0N1ILJ1 Leptomonas seymouri 67% 99%
A0A0S4IMW3 Bodo saltans 26% 100%
A0A0S4IR41 Bodo saltans 28% 94%
A0A0S4J225 Bodo saltans 28% 83%
A0A1X0NLC6 Trypanosomatidae 24% 100%
A0A1X0NXI3 Trypanosomatidae 42% 99%
A0A3R7K5K5 Trypanosoma rangeli 26% 100%
A0A3S7X9D8 Leishmania donovani 27% 89%
A0A3S7XC77 Leishmania donovani 26% 100%
A0A422N5N5 Trypanosoma rangeli 48% 100%
A4HCS6 Leishmania braziliensis 87% 99%
A4HQF5 Leishmania braziliensis 26% 100%
A4I0A0 Leishmania infantum 100% 100%
A4IBC6 Leishmania infantum 27% 89%
A4IC91 Leishmania infantum 26% 100%
B2RXZ1 Mus musculus 26% 100%
C9ZV58 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3T2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AF58 Leishmania major 26% 89%
E9AU71 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AW65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
E9B6B4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 89%
H9JAQ7 Bombyx mori 23% 100%
O95453 Homo sapiens 22% 94%
P69341 Bos taurus 22% 94%
Q4Q0C3 Leishmania major 26% 100%
Q4QBB3 Leishmania major 93% 100%
Q5RC51 Pongo abelii 22% 94%
Q7ZU92 Danio rerio 25% 91%
Q8NA58 Homo sapiens 22% 100%
Q8VDG3 Mus musculus 24% 96%
Q90ZA1 Xenopus laevis 23% 95%
Q9LG26 Arabidopsis thaliana 21% 87%
V5ASU9 Trypanosoma cruzi 26% 100%
V5BCG2 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS