Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICI2_LEIDO

TriTrypDb:

LdBPK_311190.1 , LdCL_310018600 , LDHU3_31.1950

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8ICI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICI2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.554
CLV_PCSK_KEX2_1	76	78	PF00082	0.348
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.354
CLV_PCSK_SKI1_1	31	35	PF00082	0.247
CLV_PCSK_SKI1_1	40	44	PF00082	0.250
DOC_MAPK_gen_1	89	97	PF00069	0.445
DOC_USP7_MATH_1	3	7	PF00917	0.627
DOC_USP7_MATH_1	49	53	PF00917	0.475
DOC_USP7_MATH_1	64	68	PF00917	0.502
LIG_14-3-3_CanoR_1	89	99	PF00244	0.418
LIG_14-3-3_CterR_2	109	112	PF00244	0.341
LIG_Actin_WH2_2	95	111	PF00022	0.250
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BRCT_BRCA1_1	5	9	PF00533	0.477
LIG_deltaCOP1_diTrp_1	84	90	PF00928	0.537
LIG_TRAF2_1	45	48	PF00917	0.411
LIG_UBA3_1	34	40	PF00899	0.425
MOD_CK1_1	2	8	PF00069	0.520
MOD_CK1_1	21	27	PF00069	0.402
MOD_CK2_1	64	70	PF00069	0.527
MOD_GlcNHglycan	1	4	PF01048	0.379
MOD_GlcNHglycan	65	69	PF01048	0.333
MOD_NEK2_2	3	8	PF00069	0.493
MOD_PKA_2	90	96	PF00069	0.415
MOD_Plk_4	18	24	PF00069	0.450
TRG_DiLeu_BaEn_1	70	75	PF01217	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX76	Leptomonas seymouri	35%	79%
A0A0N1I3U0	Leptomonas seymouri	32%	84%
A0A0N1IH82	Leptomonas seymouri	76%	100%
A0A3Q8IG43	Leishmania donovani	34%	84%
A0A3Q8IGB7	Leishmania donovani	36%	86%
A0A3Q8ILC3	Leishmania donovani	35%	91%
A0A3S7WPP2	Leishmania donovani	37%	91%
A0A3S7X4C9	Leishmania donovani	28%	93%
A4H4U1	Leishmania braziliensis	42%	100%
A4HJ97	Leishmania braziliensis	31%	93%
A4HJ98	Leishmania braziliensis	86%	100%
A4HJA0	Leishmania braziliensis	36%	86%
A4HJA1	Leishmania braziliensis	36%	85%
A4HT20	Leishmania infantum	39%	100%
A4I6P2	Leishmania infantum	28%	93%
A4I6P3	Leishmania infantum	100%	100%
A4I6P5	Leishmania infantum	37%	86%
A4I6P6	Leishmania infantum	32%	100%
E9ACS1	Leishmania major	38%	100%
E9AGY1	Leishmania infantum	38%	100%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	93%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B1R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	86%
E9B1R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	83%
O43169	Homo sapiens	28%	75%
Q4Q6E3	Leishmania major	32%	100%
Q4Q6E4	Leishmania major	38%	86%
Q4Q6E6	Leishmania major	96%	100%
Q4QIU6	Leishmania major	38%	100%
Q5RDJ5	Pongo abelii	28%	75%
Q874I5	Candida tropicalis	37%	87%
Q9HFV1	Rhizopus stolonifer	38%	85%