LeishMANIAdb
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Acyl carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Acyl carrier protein
Gene product:
acyl carrier protein, mitochondrial, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ICI1_LEIDO
TriTrypDb:
LdBPK_270300.1 , LdCL_270007800 , LDHU3_27.0370
Length:
150

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0005747 mitochondrial respiratory chain complex I 4 1
GO:0005759 mitochondrial matrix 5 1
GO:0030964 NADH dehydrogenase complex 3 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0045271 respiratory chain complex I 4 1
GO:0070013 intracellular organelle lumen 4 1
GO:0098796 membrane protein complex 2 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0098800 inner mitochondrial membrane protein complex 3 1
GO:0098803 respiratory chain complex 3 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1
GO:1902495 transmembrane transporter complex 3 1
GO:1990204 oxidoreductase complex 3 1
GO:1990351 transporter complex 2 1

Expansion

Sequence features

A0A3Q8ICI1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICI1

PDB structure(s): 2m5r_A , 5zws_A , 5zws_B , 5zwt_A , 5zwt_B , 7am2_CC

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 11
GO:0006629 lipid metabolic process 3 11
GO:0006631 fatty acid metabolic process 4 11
GO:0006633 fatty acid biosynthetic process 5 11
GO:0008152 metabolic process 1 11
GO:0008610 lipid biosynthetic process 4 11
GO:0009058 biosynthetic process 2 11
GO:0009987 cellular process 1 11
GO:0016053 organic acid biosynthetic process 4 11
GO:0019752 carboxylic acid metabolic process 5 11
GO:0032787 monocarboxylic acid metabolic process 6 11
GO:0043436 oxoacid metabolic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044255 cellular lipid metabolic process 3 11
GO:0044281 small molecule metabolic process 2 11
GO:0044283 small molecule biosynthetic process 3 11
GO:0046394 carboxylic acid biosynthetic process 5 11
GO:0071704 organic substance metabolic process 2 11
GO:0072330 monocarboxylic acid biosynthetic process 6 11
GO:1901576 organic substance biosynthetic process 3 11
Molecular functions
Term Name Level Count
GO:0000035 acyl binding 2 1
GO:0000036 acyl carrier activity 3 1
GO:0005488 binding 1 1
GO:0044620 ACP phosphopantetheine attachment site binding 3 1
GO:0051192 prosthetic group binding 2 1
GO:0140104 molecular carrier activity 1 1
GO:0140414 phosphopantetheine-dependent carrier activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 135 139 PF00656 0.549
CLV_C14_Caspase3-7 86 90 PF00656 0.549
CLV_NRD_NRD_1 7 9 PF00675 0.657
CLV_PCSK_KEX2_1 7 9 PF00082 0.742
CLV_PCSK_PC7_1 3 9 PF00082 0.787
CLV_PCSK_SKI1_1 12 16 PF00082 0.660
DEG_Nend_UBRbox_3 1 3 PF02207 0.719
DOC_PP2B_LxvP_1 123 126 PF13499 0.549
DOC_USP7_MATH_1 22 26 PF00917 0.761
DOC_USP7_MATH_1 34 38 PF00917 0.716
DOC_USP7_UBL2_3 83 87 PF12436 0.538
DOC_WW_Pin1_4 91 96 PF00397 0.542
LIG_14-3-3_CanoR_1 12 18 PF00244 0.677
LIG_14-3-3_CanoR_1 23 31 PF00244 0.744
LIG_FHA_1 74 80 PF00498 0.403
LIG_LIR_Gen_1 13 22 PF02991 0.705
LIG_LIR_Nem_3 13 18 PF02991 0.753
LIG_PCNA_yPIPBox_3 71 79 PF02747 0.639
LIG_SH2_STAT3 142 145 PF00017 0.672
LIG_SH2_STAT5 142 145 PF00017 0.672
LIG_SH2_STAT5 67 70 PF00017 0.631
LIG_SH3_3 28 34 PF00018 0.665
LIG_SUMO_SIM_anti_2 107 112 PF11976 0.550
LIG_SUMO_SIM_par_1 120 127 PF11976 0.549
LIG_WRC_WIRS_1 42 47 PF05994 0.778
MOD_CK1_1 13 19 PF00069 0.692
MOD_CK1_1 61 67 PF00069 0.738
MOD_CK1_1 91 97 PF00069 0.422
MOD_GlcNHglycan 12 15 PF01048 0.762
MOD_GlcNHglycan 28 31 PF01048 0.599
MOD_GlcNHglycan 34 37 PF01048 0.711
MOD_GlcNHglycan 52 55 PF01048 0.582
MOD_GlcNHglycan 63 66 PF01048 0.684
MOD_GSK3_1 22 29 PF00069 0.683
MOD_GSK3_1 41 48 PF00069 0.650
MOD_N-GLC_1 10 15 PF02516 0.761
MOD_NEK2_1 45 50 PF00069 0.657
MOD_PIKK_1 22 28 PF00454 0.788
MOD_PK_1 132 138 PF00069 0.403
MOD_PKA_2 22 28 PF00069 0.762
MOD_Plk_1 10 16 PF00069 0.763
MOD_Plk_4 41 47 PF00069 0.780
MOD_ProDKin_1 91 97 PF00069 0.392
TRG_ER_diArg_1 6 8 PF00400 0.740

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5S1 Leptomonas seymouri 82% 100%
A0A0S4KI16 Bodo saltans 81% 100%
A0A1X0NLX3 Trypanosomatidae 61% 100%
A0A422NXN1 Trypanosoma rangeli 62% 100%
A4HFE7 Leishmania braziliensis 86% 100%
A4I2L8 Leishmania infantum 99% 100%
C9ZKW7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 100%
E9AD06 Leishmania major 93% 100%
E9AYT1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
P11943 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 40% 100%
P32463 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 100%
P52412 Cuphea lanceolata 33% 100%
P52413 Cuphea lanceolata 36% 100%
P53665 Arabidopsis thaliana 51% 100%
Q10217 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS