RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICH8_LEIDO

TriTrypDb:

LdBPK_221520.1 , LdCL_220022500 , LDHU3_22.2170

Length:

919

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICH8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.629
CLV_NRD_NRD_1	532	534	PF00675	0.458
CLV_NRD_NRD_1	659	661	PF00675	0.448
CLV_NRD_NRD_1	713	715	PF00675	0.533
CLV_NRD_NRD_1	856	858	PF00675	0.383
CLV_PCSK_FUR_1	9	13	PF00082	0.577
CLV_PCSK_KEX2_1	11	13	PF00082	0.632
CLV_PCSK_KEX2_1	526	528	PF00082	0.401
CLV_PCSK_KEX2_1	659	661	PF00082	0.484
CLV_PCSK_KEX2_1	713	715	PF00082	0.504
CLV_PCSK_KEX2_1	856	858	PF00082	0.383
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.471
CLV_PCSK_SKI1_1	107	111	PF00082	0.500
CLV_PCSK_SKI1_1	11	15	PF00082	0.658
CLV_PCSK_SKI1_1	150	154	PF00082	0.401
CLV_PCSK_SKI1_1	175	179	PF00082	0.462
CLV_PCSK_SKI1_1	202	206	PF00082	0.404
CLV_PCSK_SKI1_1	333	337	PF00082	0.441
CLV_PCSK_SKI1_1	369	373	PF00082	0.447
CLV_PCSK_SKI1_1	41	45	PF00082	0.625
CLV_PCSK_SKI1_1	477	481	PF00082	0.413
CLV_PCSK_SKI1_1	71	75	PF00082	0.489
CLV_PCSK_SKI1_1	714	718	PF00082	0.478
DEG_APCC_DBOX_1	113	121	PF00400	0.536
DEG_APCC_DBOX_1	149	157	PF00400	0.393
DEG_APCC_DBOX_1	705	713	PF00400	0.418
DEG_Nend_UBRbox_1	1	4	PF02207	0.605
DOC_CKS1_1	195	200	PF01111	0.447
DOC_CYCLIN_RxL_1	147	155	PF00134	0.414
DOC_CYCLIN_RxL_1	175	186	PF00134	0.426
DOC_CYCLIN_RxL_1	474	482	PF00134	0.415
DOC_CYCLIN_RxL_1	68	79	PF00134	0.490
DOC_CYCLIN_RxL_1	710	720	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.492
DOC_MAPK_gen_1	46	53	PF00069	0.539
DOC_MAPK_gen_1	481	490	PF00069	0.492
DOC_MAPK_gen_1	659	666	PF00069	0.478
DOC_MAPK_gen_1	713	719	PF00069	0.422
DOC_MAPK_gen_1	880	889	PF00069	0.413
DOC_MAPK_MEF2A_6	659	668	PF00069	0.479
DOC_MAPK_MEF2A_6	880	889	PF00069	0.413
DOC_PP1_RVXF_1	663	669	PF00149	0.359
DOC_PP2B_LxvP_1	143	146	PF13499	0.579
DOC_PP2B_LxvP_1	192	195	PF13499	0.412
DOC_PP2B_LxvP_1	372	375	PF13499	0.454
DOC_PP2B_LxvP_1	419	422	PF13499	0.369
DOC_PP2B_LxvP_1	66	69	PF13499	0.499
DOC_PP4_FxxP_1	20	23	PF00568	0.524
DOC_PP4_FxxP_1	806	809	PF00568	0.444
DOC_USP7_MATH_1	414	418	PF00917	0.533
DOC_USP7_MATH_1	522	526	PF00917	0.450
DOC_USP7_MATH_1	705	709	PF00917	0.388
DOC_USP7_MATH_1	766	770	PF00917	0.391
DOC_USP7_MATH_1	909	913	PF00917	0.531
DOC_USP7_UBL2_3	549	553	PF12436	0.423
DOC_WW_Pin1_4	163	168	PF00397	0.549
DOC_WW_Pin1_4	194	199	PF00397	0.450
DOC_WW_Pin1_4	33	38	PF00397	0.685
DOC_WW_Pin1_4	623	628	PF00397	0.455
DOC_WW_Pin1_4	654	659	PF00397	0.547
DOC_WW_Pin1_4	742	747	PF00397	0.363
LIG_14-3-3_CanoR_1	12	22	PF00244	0.691
LIG_14-3-3_CanoR_1	238	244	PF00244	0.426
LIG_14-3-3_CanoR_1	271	276	PF00244	0.386
LIG_14-3-3_CanoR_1	341	346	PF00244	0.394
LIG_14-3-3_CanoR_1	429	435	PF00244	0.338
LIG_14-3-3_CanoR_1	48	54	PF00244	0.641
LIG_14-3-3_CanoR_1	665	669	PF00244	0.546
LIG_14-3-3_CanoR_1	706	710	PF00244	0.378
LIG_14-3-3_CanoR_1	713	717	PF00244	0.390
LIG_14-3-3_CanoR_1	786	792	PF00244	0.453
LIG_Actin_WH2_2	187	204	PF00022	0.406
LIG_Actin_WH2_2	240	258	PF00022	0.384
LIG_Actin_WH2_2	356	371	PF00022	0.418
LIG_BRCT_BRCA1_1	16	20	PF00533	0.644
LIG_BRCT_BRCA1_1	263	267	PF00533	0.510
LIG_BRCT_BRCA1_1	439	443	PF00533	0.387
LIG_BRCT_BRCA1_1	744	748	PF00533	0.467
LIG_BRCT_BRCA1_1	766	770	PF00533	0.434
LIG_CaM_NSCaTE_8	364	371	PF13499	0.435
LIG_Clathr_ClatBox_1	716	720	PF01394	0.448
LIG_CtBP_PxDLS_1	357	361	PF00389	0.423
LIG_CtBP_PxDLS_1	50	54	PF00389	0.551
LIG_FHA_1	195	201	PF00498	0.387
LIG_FHA_1	26	32	PF00498	0.680
LIG_FHA_1	423	429	PF00498	0.348
LIG_FHA_1	721	727	PF00498	0.325
LIG_FHA_1	903	909	PF00498	0.489
LIG_FHA_1	99	105	PF00498	0.526
LIG_FHA_2	786	792	PF00498	0.376
LIG_LIR_Apic_2	17	23	PF02991	0.525
LIG_LIR_Apic_2	538	542	PF02991	0.353
LIG_LIR_Gen_1	237	247	PF02991	0.358
LIG_LIR_Gen_1	263	270	PF02991	0.460
LIG_LIR_Gen_1	313	323	PF02991	0.427
LIG_LIR_Gen_1	430	435	PF02991	0.392
LIG_LIR_Gen_1	440	450	PF02991	0.305
LIG_LIR_Gen_1	791	799	PF02991	0.369
LIG_LIR_Gen_1	91	99	PF02991	0.479
LIG_LIR_Nem_3	126	132	PF02991	0.499
LIG_LIR_Nem_3	263	268	PF02991	0.452
LIG_LIR_Nem_3	313	318	PF02991	0.435
LIG_LIR_Nem_3	380	385	PF02991	0.312
LIG_LIR_Nem_3	430	434	PF02991	0.354
LIG_LIR_Nem_3	440	446	PF02991	0.347
LIG_LIR_Nem_3	791	795	PF02991	0.392
LIG_LIR_Nem_3	826	832	PF02991	0.438
LIG_LIR_Nem_3	91	97	PF02991	0.567
LIG_NRBOX	295	301	PF00104	0.397
LIG_NRBOX	318	324	PF00104	0.402
LIG_NRBOX	475	481	PF00104	0.435
LIG_Pex14_1	279	283	PF04695	0.435
LIG_PTB_Apo_2	228	235	PF02174	0.356
LIG_REV1ctd_RIR_1	232	242	PF16727	0.474
LIG_SH2_NCK_1	698	702	PF00017	0.395
LIG_SH2_PTP2	315	318	PF00017	0.429
LIG_SH2_STAP1	913	917	PF00017	0.606
LIG_SH2_STAT3	799	802	PF00017	0.394
LIG_SH2_STAT5	160	163	PF00017	0.424
LIG_SH2_STAT5	315	318	PF00017	0.316
LIG_SH2_STAT5	698	701	PF00017	0.378
LIG_SH2_STAT5	783	786	PF00017	0.447
LIG_SH2_STAT5	792	795	PF00017	0.481
LIG_SH3_3	192	198	PF00018	0.369
LIG_SH3_3	2	8	PF00018	0.574
LIG_SH3_3	213	219	PF00018	0.362
LIG_SH3_3	247	253	PF00018	0.443
LIG_SH3_3	878	884	PF00018	0.582
LIG_SH3_CIN85_PxpxPR_1	4	9	PF14604	0.568
LIG_SUMO_SIM_par_1	715	720	PF11976	0.444
LIG_SUMO_SIM_par_1	82	88	PF11976	0.558
LIG_WRC_WIRS_1	206	211	PF05994	0.297
LIG_WRC_WIRS_1	428	433	PF05994	0.446
MOD_CDK_SPK_2	654	659	PF00069	0.416
MOD_CDK_SPxK_1	654	660	PF00069	0.421
MOD_CK1_1	236	242	PF00069	0.484
MOD_CK1_1	430	436	PF00069	0.504
MOD_CK1_1	535	541	PF00069	0.439
MOD_CK1_1	601	607	PF00069	0.499
MOD_CK1_1	647	653	PF00069	0.391
MOD_CK1_1	654	660	PF00069	0.406
MOD_CK1_1	708	714	PF00069	0.472
MOD_CK1_1	762	768	PF00069	0.448
MOD_CK1_1	85	91	PF00069	0.474
MOD_CK1_1	98	104	PF00069	0.575
MOD_CK2_1	483	489	PF00069	0.361
MOD_CK2_1	859	865	PF00069	0.435
MOD_GlcNHglycan	163	166	PF01048	0.559
MOD_GlcNHglycan	285	288	PF01048	0.437
MOD_GlcNHglycan	333	336	PF01048	0.464
MOD_GlcNHglycan	416	419	PF01048	0.446
MOD_GlcNHglycan	485	488	PF01048	0.469
MOD_GlcNHglycan	53	56	PF01048	0.618
MOD_GlcNHglycan	534	537	PF01048	0.461
MOD_GlcNHglycan	61	64	PF01048	0.612
MOD_GlcNHglycan	764	767	PF01048	0.500
MOD_GlcNHglycan	817	821	PF01048	0.539
MOD_GlcNHglycan	848	851	PF01048	0.444
MOD_GlcNHglycan	861	864	PF01048	0.516
MOD_GlcNHglycan	97	100	PF01048	0.665
MOD_GSK3_1	14	21	PF00069	0.655
MOD_GSK3_1	171	178	PF00069	0.498
MOD_GSK3_1	190	197	PF00069	0.295
MOD_GSK3_1	33	40	PF00069	0.627
MOD_GSK3_1	49	56	PF00069	0.568
MOD_GSK3_1	551	558	PF00069	0.492
MOD_GSK3_1	644	651	PF00069	0.464
MOD_GSK3_1	708	715	PF00069	0.420
MOD_GSK3_1	742	749	PF00069	0.420
MOD_GSK3_1	755	762	PF00069	0.401
MOD_GSK3_1	790	797	PF00069	0.485
MOD_LATS_1	179	185	PF00433	0.428
MOD_N-GLC_1	261	266	PF02516	0.558
MOD_N-GLC_1	644	649	PF02516	0.394
MOD_N-GLC_2	573	575	PF02516	0.529
MOD_NEK2_1	14	19	PF00069	0.721
MOD_NEK2_1	161	166	PF00069	0.430
MOD_NEK2_1	205	210	PF00069	0.434
MOD_NEK2_1	323	328	PF00069	0.473
MOD_NEK2_1	427	432	PF00069	0.398
MOD_NEK2_1	51	56	PF00069	0.654
MOD_NEK2_1	532	537	PF00069	0.513
MOD_NEK2_1	644	649	PF00069	0.394
MOD_NEK2_1	664	669	PF00069	0.402
MOD_NEK2_1	712	717	PF00069	0.473
MOD_NEK2_1	785	790	PF00069	0.403
MOD_NEK2_2	705	710	PF00069	0.475
MOD_NEK2_2	755	760	PF00069	0.477
MOD_NEK2_2	766	771	PF00069	0.491
MOD_OFUCOSY	552	559	PF10250	0.488
MOD_PIKK_1	422	428	PF00454	0.537
MOD_PIKK_1	551	557	PF00454	0.411
MOD_PK_1	760	766	PF00069	0.598
MOD_PKA_2	18	24	PF00069	0.554
MOD_PKA_2	25	31	PF00069	0.569
MOD_PKA_2	270	276	PF00069	0.505
MOD_PKA_2	532	538	PF00069	0.496
MOD_PKA_2	664	670	PF00069	0.532
MOD_PKA_2	682	688	PF00069	0.314
MOD_PKA_2	705	711	PF00069	0.418
MOD_PKA_2	712	718	PF00069	0.454
MOD_PKA_2	785	791	PF00069	0.394
MOD_PKB_1	481	489	PF00069	0.461
MOD_PKB_1	857	865	PF00069	0.420
MOD_Plk_1	181	187	PF00069	0.575
MOD_Plk_1	236	242	PF00069	0.462
MOD_Plk_1	261	267	PF00069	0.471
MOD_Plk_1	436	442	PF00069	0.468
MOD_Plk_1	44	50	PF00069	0.691
MOD_Plk_1	601	607	PF00069	0.375
MOD_Plk_1	644	650	PF00069	0.372
MOD_Plk_4	187	193	PF00069	0.415
MOD_Plk_4	242	248	PF00069	0.427
MOD_Plk_4	271	277	PF00069	0.385
MOD_Plk_4	295	301	PF00069	0.427
MOD_Plk_4	310	316	PF00069	0.322
MOD_Plk_4	430	436	PF00069	0.382
MOD_Plk_4	439	445	PF00069	0.348
MOD_Plk_4	449	455	PF00069	0.210
MOD_Plk_4	535	541	PF00069	0.407
MOD_Plk_4	644	650	PF00069	0.445
MOD_Plk_4	664	670	PF00069	0.401
MOD_Plk_4	766	772	PF00069	0.518
MOD_Plk_4	79	85	PF00069	0.548
MOD_Plk_4	88	94	PF00069	0.517
MOD_ProDKin_1	163	169	PF00069	0.540
MOD_ProDKin_1	194	200	PF00069	0.446
MOD_ProDKin_1	33	39	PF00069	0.685
MOD_ProDKin_1	623	629	PF00069	0.464
MOD_ProDKin_1	654	660	PF00069	0.552
MOD_ProDKin_1	742	748	PF00069	0.360
TRG_DiLeu_BaEn_1	468	473	PF01217	0.382
TRG_DiLeu_BaEn_1	810	815	PF01217	0.498
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.378
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.376
TRG_ENDOCYTIC_2	315	318	PF00928	0.429
TRG_ENDOCYTIC_2	792	795	PF00928	0.488
TRG_ER_diArg_1	46	49	PF00400	0.529
TRG_ER_diArg_1	658	660	PF00400	0.451
TRG_ER_diArg_1	712	714	PF00400	0.496
TRG_ER_diArg_1	8	11	PF00400	0.587
TRG_ER_diArg_1	856	859	PF00400	0.482
TRG_NES_CRM1_1	470	482	PF08389	0.286
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	830	834	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG1	Leptomonas seymouri	55%	97%
A0A0S4JKR3	Bodo saltans	29%	81%
A0A1X0P744	Trypanosomatidae	33%	100%
A4HCK8	Leishmania braziliensis	83%	100%
A4I026	Leishmania infantum	100%	100%
D0A544	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AVZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBI0	Leishmania major	93%	100%