Translation initiation factor eIF3 subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit j

Species:

Leishmania donovani

UniProt:

A0A3Q8ICH6_LEIDO

TriTrypDb:

LdBPK_252210.1 , LdCL_250027900 , LDHU3_25.2680

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	8
GO:0032991	protein-containing complex	1	8
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICH6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003743	translation initiation factor activity	4	8
GO:0005488	binding	1	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.543
CLV_C14_Caspase3-7	94	98	PF00656	0.542
CLV_PCSK_KEX2_1	169	171	PF00082	0.312
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.318
CLV_PCSK_PC7_1	165	171	PF00082	0.360
CLV_PCSK_SKI1_1	170	174	PF00082	0.344
CLV_PCSK_SKI1_1	52	56	PF00082	0.327
DEG_Nend_UBRbox_2	1	3	PF02207	0.692
DOC_USP7_MATH_1	87	91	PF00917	0.560
DOC_USP7_UBL2_3	169	173	PF12436	0.527
DOC_USP7_UBL2_3	177	181	PF12436	0.523
LIG_14-3-3_CanoR_1	123	128	PF00244	0.501
LIG_FHA_1	143	149	PF00498	0.585
LIG_LIR_Gen_1	130	141	PF02991	0.501
LIG_LIR_Nem_3	130	136	PF02991	0.525
LIG_LIR_Nem_3	139	144	PF02991	0.525
LIG_SH2_CRK	133	137	PF00017	0.560
LIG_SH2_NCK_1	20	24	PF00017	0.525
LIG_SH2_SRC	20	23	PF00017	0.560
LIG_SH2_STAP1	133	137	PF00017	0.560
LIG_SH2_STAP1	20	24	PF00017	0.525
LIG_SH3_4	177	184	PF00018	0.570
LIG_TRAF2_1	31	34	PF00917	0.520
LIG_WRC_WIRS_1	124	129	PF05994	0.501
MOD_GlcNHglycan	129	132	PF01048	0.338
MOD_GlcNHglycan	186	189	PF01048	0.350
MOD_GlcNHglycan	87	90	PF01048	0.309
MOD_GlcNHglycan	93	96	PF01048	0.314
MOD_GSK3_1	123	130	PF00069	0.501
MOD_GSK3_1	142	149	PF00069	0.501
MOD_GSK3_1	87	94	PF00069	0.532
MOD_NEK2_1	127	132	PF00069	0.536
MOD_NEK2_1	148	153	PF00069	0.560
MOD_PIKK_1	182	188	PF00454	0.598
MOD_PKA_2	122	128	PF00069	0.598
MOD_PKA_2	142	148	PF00069	0.362
MOD_Plk_4	115	121	PF00069	0.545
MOD_SUMO_for_1	59	62	PF00179	0.511
MOD_SUMO_rev_2	166	171	PF00179	0.528
TRG_ENDOCYTIC_2	133	136	PF00928	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC3	Leptomonas seymouri	70%	100%
A0A3R7NVZ4	Trypanosoma rangeli	34%	94%
A4HEB5	Leishmania braziliensis	83%	100%
A4I1R1	Leishmania infantum	99%	100%
C9ZKB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
E9AXU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9M6	Leishmania major	97%	100%