Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICH3_LEIDO

TriTrypDb:

LdBPK_251110.1 , LdCL_250016500 , LDHU3_25.1430

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ICH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.643
CLV_C14_Caspase3-7	229	233	PF00656	0.597
CLV_C14_Caspase3-7	263	267	PF00656	0.625
CLV_C14_Caspase3-7	595	599	PF00656	0.522
CLV_C14_Caspase3-7	777	781	PF00656	0.507
CLV_NRD_NRD_1	104	106	PF00675	0.790
CLV_NRD_NRD_1	295	297	PF00675	0.535
CLV_NRD_NRD_1	304	306	PF00675	0.548
CLV_NRD_NRD_1	328	330	PF00675	0.638
CLV_NRD_NRD_1	331	333	PF00675	0.596
CLV_NRD_NRD_1	357	359	PF00675	0.654
CLV_NRD_NRD_1	382	384	PF00675	0.672
CLV_NRD_NRD_1	385	387	PF00675	0.723
CLV_NRD_NRD_1	56	58	PF00675	0.726
CLV_NRD_NRD_1	629	631	PF00675	0.603
CLV_NRD_NRD_1	637	639	PF00675	0.713
CLV_NRD_NRD_1	725	727	PF00675	0.601
CLV_NRD_NRD_1	759	761	PF00675	0.489
CLV_PCSK_FUR_1	329	333	PF00082	0.617
CLV_PCSK_FUR_1	383	387	PF00082	0.623
CLV_PCSK_FUR_1	54	58	PF00082	0.728
CLV_PCSK_KEX2_1	104	106	PF00082	0.790
CLV_PCSK_KEX2_1	295	297	PF00082	0.538
CLV_PCSK_KEX2_1	304	306	PF00082	0.554
CLV_PCSK_KEX2_1	328	330	PF00082	0.643
CLV_PCSK_KEX2_1	331	333	PF00082	0.600
CLV_PCSK_KEX2_1	355	357	PF00082	0.600
CLV_PCSK_KEX2_1	384	386	PF00082	0.807
CLV_PCSK_KEX2_1	416	418	PF00082	0.689
CLV_PCSK_KEX2_1	512	514	PF00082	0.563
CLV_PCSK_KEX2_1	56	58	PF00082	0.726
CLV_PCSK_KEX2_1	629	631	PF00082	0.603
CLV_PCSK_KEX2_1	637	639	PF00082	0.550
CLV_PCSK_KEX2_1	725	727	PF00082	0.538
CLV_PCSK_KEX2_1	759	761	PF00082	0.486
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.587
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.766
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.689
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.563
CLV_PCSK_PC7_1	380	386	PF00082	0.676
CLV_PCSK_SKI1_1	295	299	PF00082	0.530
CLV_PCSK_SKI1_1	306	310	PF00082	0.550
CLV_PCSK_SKI1_1	385	389	PF00082	0.786
CLV_PCSK_SKI1_1	451	455	PF00082	0.628
CLV_PCSK_SKI1_1	509	513	PF00082	0.567
CLV_PCSK_SKI1_1	615	619	PF00082	0.480
CLV_PCSK_SKI1_1	659	663	PF00082	0.673
CLV_PCSK_SKI1_1	719	723	PF00082	0.489
CLV_PCSK_SKI1_1	747	751	PF00082	0.579
DEG_APCC_DBOX_1	479	487	PF00400	0.530
DEG_ODPH_VHL_1	145	156	PF01847	0.661
DOC_CKS1_1	452	457	PF01111	0.579
DOC_CKS1_1	459	464	PF01111	0.546
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.526
DOC_MAPK_gen_1	310	318	PF00069	0.577
DOC_MAPK_gen_1	491	500	PF00069	0.588
DOC_MAPK_gen_1	805	815	PF00069	0.594
DOC_MAPK_MEF2A_6	131	139	PF00069	0.710
DOC_MAPK_MEF2A_6	557	566	PF00069	0.642
DOC_MAPK_MEF2A_6	808	817	PF00069	0.642
DOC_PP1_RVXF_1	162	169	PF00149	0.667
DOC_PP1_RVXF_1	628	635	PF00149	0.501
DOC_PP2B_LxvP_1	538	541	PF13499	0.663
DOC_PP4_FxxP_1	452	455	PF00568	0.562
DOC_SPAK_OSR1_1	241	245	PF12202	0.670
DOC_USP7_MATH_1	170	174	PF00917	0.662
DOC_USP7_MATH_1	372	376	PF00917	0.736
DOC_USP7_MATH_1	405	409	PF00917	0.637
DOC_USP7_MATH_1	423	427	PF00917	0.590
DOC_USP7_MATH_1	721	725	PF00917	0.492
DOC_USP7_MATH_1	763	767	PF00917	0.512
DOC_USP7_MATH_1	823	827	PF00917	0.636
DOC_USP7_MATH_1	833	837	PF00917	0.639
DOC_USP7_MATH_1	842	846	PF00917	0.639
DOC_USP7_MATH_2	50	56	PF00917	0.686
DOC_USP7_UBL2_3	306	310	PF12436	0.562
DOC_USP7_UBL2_3	512	516	PF12436	0.450
DOC_WW_Pin1_4	11	16	PF00397	0.758
DOC_WW_Pin1_4	113	118	PF00397	0.669
DOC_WW_Pin1_4	213	218	PF00397	0.625
DOC_WW_Pin1_4	368	373	PF00397	0.639
DOC_WW_Pin1_4	385	390	PF00397	0.584
DOC_WW_Pin1_4	435	440	PF00397	0.649
DOC_WW_Pin1_4	451	456	PF00397	0.577
DOC_WW_Pin1_4	458	463	PF00397	0.524
DOC_WW_Pin1_4	546	551	PF00397	0.614
DOC_WW_Pin1_4	555	560	PF00397	0.609
DOC_WW_Pin1_4	806	811	PF00397	0.535
DOC_WW_Pin1_4	819	824	PF00397	0.607
DOC_WW_Pin1_4	88	93	PF00397	0.668
LIG_14-3-3_CanoR_1	109	113	PF00244	0.745
LIG_14-3-3_CanoR_1	220	224	PF00244	0.662
LIG_14-3-3_CanoR_1	235	242	PF00244	0.563
LIG_14-3-3_CanoR_1	319	326	PF00244	0.650
LIG_14-3-3_CanoR_1	363	372	PF00244	0.621
LIG_14-3-3_CanoR_1	542	550	PF00244	0.737
LIG_14-3-3_CanoR_1	552	561	PF00244	0.626
LIG_14-3-3_CanoR_1	586	591	PF00244	0.718
LIG_14-3-3_CanoR_1	808	814	PF00244	0.570
LIG_14-3-3_CanoR_1	840	850	PF00244	0.587
LIG_Actin_WH2_2	470	486	PF00022	0.446
LIG_APCC_ABBA_1	562	567	PF00400	0.663
LIG_BRCT_BRCA1_1	150	154	PF00533	0.644
LIG_BRCT_BRCA1_1	164	168	PF00533	0.661
LIG_BRCT_BRCA1_1	221	225	PF00533	0.651
LIG_FHA_1	123	129	PF00498	0.711
LIG_FHA_1	177	183	PF00498	0.719
LIG_FHA_1	255	261	PF00498	0.689
LIG_FHA_1	556	562	PF00498	0.714
LIG_FHA_1	6	12	PF00498	0.693
LIG_FHA_1	810	816	PF00498	0.711
LIG_FHA_2	186	192	PF00498	0.583
LIG_FHA_2	331	337	PF00498	0.720
LIG_FHA_2	42	48	PF00498	0.749
LIG_FHA_2	459	465	PF00498	0.593
LIG_FHA_2	660	666	PF00498	0.577
LIG_FHA_2	756	762	PF00498	0.449
LIG_Integrin_RGD_1	120	122	PF01839	0.671
LIG_LIR_Apic_2	75	80	PF02991	0.634
LIG_LIR_Gen_1	313	320	PF02991	0.529
LIG_LIR_Gen_1	848	856	PF02991	0.661
LIG_LIR_Nem_3	313	318	PF02991	0.599
LIG_LIR_Nem_3	36	41	PF02991	0.659
LIG_LIR_Nem_3	848	854	PF02991	0.604
LIG_NRP_CendR_1	857	858	PF00754	0.599
LIG_PTAP_UEV_1	438	443	PF05743	0.645
LIG_Rb_LxCxE_1	461	476	PF01857	0.505
LIG_SH2_CRK	315	319	PF00017	0.612
LIG_SH2_CRK	673	677	PF00017	0.478
LIG_SH2_NCK_1	444	448	PF00017	0.560
LIG_SH2_NCK_1	77	81	PF00017	0.713
LIG_SH2_STAP1	427	431	PF00017	0.567
LIG_SH2_STAP1	576	580	PF00017	0.657
LIG_SH2_STAP1	604	608	PF00017	0.604
LIG_SH2_STAP1	673	677	PF00017	0.478
LIG_SH2_STAP1	697	701	PF00017	0.543
LIG_SH2_STAP1	732	736	PF00017	0.438
LIG_SH2_STAT5	41	44	PF00017	0.613
LIG_SH3_1	436	442	PF00018	0.709
LIG_SH3_1	77	83	PF00018	0.759
LIG_SH3_3	129	135	PF00018	0.703
LIG_SH3_3	250	256	PF00018	0.681
LIG_SH3_3	4	10	PF00018	0.643
LIG_SH3_3	436	442	PF00018	0.626
LIG_SH3_3	77	83	PF00018	0.671
LIG_SUMO_SIM_anti_2	461	469	PF11976	0.552
LIG_SUMO_SIM_par_1	586	595	PF11976	0.591
LIG_TRAF2_1	300	303	PF00917	0.536
LIG_TRAF2_1	432	435	PF00917	0.638
LIG_TRAF2_1	46	49	PF00917	0.616
LIG_TRAF2_1	742	745	PF00917	0.580
LIG_WW_3	101	105	PF00397	0.784
MOD_CDC14_SPxK_1	549	552	PF00782	0.615
MOD_CDK_SPK_2	113	118	PF00069	0.669
MOD_CDK_SPK_2	819	824	PF00069	0.689
MOD_CDK_SPK_2	88	93	PF00069	0.674
MOD_CDK_SPxK_1	546	552	PF00069	0.598
MOD_CDK_SPxxK_3	113	120	PF00069	0.676
MOD_CDK_SPxxK_3	213	220	PF00069	0.584
MOD_CDK_SPxxK_3	88	95	PF00069	0.731
MOD_CK1_1	108	114	PF00069	0.671
MOD_CK1_1	141	147	PF00069	0.672
MOD_CK1_1	148	154	PF00069	0.739
MOD_CK1_1	16	22	PF00069	0.678
MOD_CK1_1	237	243	PF00069	0.819
MOD_CK1_1	334	340	PF00069	0.751
MOD_CK1_1	36	42	PF00069	0.715
MOD_CK1_1	371	377	PF00069	0.753
MOD_CK1_1	391	397	PF00069	0.747
MOD_CK1_1	426	432	PF00069	0.639
MOD_CK1_1	43	49	PF00069	0.658
MOD_CK1_1	437	443	PF00069	0.665
MOD_CK1_1	543	549	PF00069	0.709
MOD_CK1_1	589	595	PF00069	0.589
MOD_CK1_1	809	815	PF00069	0.704
MOD_CK1_1	836	842	PF00069	0.637
MOD_CK2_1	185	191	PF00069	0.633
MOD_CK2_1	319	325	PF00069	0.688
MOD_CK2_1	330	336	PF00069	0.631
MOD_CK2_1	429	435	PF00069	0.591
MOD_CK2_1	43	49	PF00069	0.747
MOD_CK2_1	458	464	PF00069	0.604
MOD_CK2_1	499	505	PF00069	0.606
MOD_CK2_1	589	595	PF00069	0.614
MOD_CK2_1	596	602	PF00069	0.439
MOD_CK2_1	659	665	PF00069	0.537
MOD_CK2_1	711	717	PF00069	0.608
MOD_CK2_1	72	78	PF00069	0.641
MOD_CK2_1	739	745	PF00069	0.570
MOD_CK2_1	755	761	PF00069	0.425
MOD_CK2_1	763	769	PF00069	0.539
MOD_DYRK1A_RPxSP_1	819	823	PF00069	0.697
MOD_GlcNHglycan	26	29	PF01048	0.826
MOD_GlcNHglycan	266	270	PF01048	0.641
MOD_GlcNHglycan	336	339	PF01048	0.697
MOD_GlcNHglycan	368	371	PF01048	0.724
MOD_GlcNHglycan	376	379	PF01048	0.688
MOD_GlcNHglycan	390	393	PF01048	0.570
MOD_GlcNHglycan	651	654	PF01048	0.604
MOD_GlcNHglycan	714	717	PF01048	0.689
MOD_GlcNHglycan	741	744	PF01048	0.548
MOD_GlcNHglycan	835	838	PF01048	0.670
MOD_GSK3_1	141	148	PF00069	0.642
MOD_GSK3_1	158	165	PF00069	0.659
MOD_GSK3_1	16	23	PF00069	0.696
MOD_GSK3_1	176	183	PF00069	0.723
MOD_GSK3_1	199	206	PF00069	0.690
MOD_GSK3_1	215	222	PF00069	0.654
MOD_GSK3_1	227	234	PF00069	0.646
MOD_GSK3_1	24	31	PF00069	0.590
MOD_GSK3_1	310	317	PF00069	0.495
MOD_GSK3_1	33	40	PF00069	0.655
MOD_GSK3_1	330	337	PF00069	0.714
MOD_GSK3_1	364	371	PF00069	0.640
MOD_GSK3_1	372	379	PF00069	0.679
MOD_GSK3_1	403	410	PF00069	0.573
MOD_GSK3_1	423	430	PF00069	0.641
MOD_GSK3_1	5	12	PF00069	0.627
MOD_GSK3_1	540	547	PF00069	0.730
MOD_GSK3_1	551	558	PF00069	0.615
MOD_GSK3_1	644	651	PF00069	0.625
MOD_GSK3_1	659	666	PF00069	0.548
MOD_GSK3_1	751	758	PF00069	0.464
MOD_GSK3_1	763	770	PF00069	0.508
MOD_GSK3_1	819	826	PF00069	0.645
MOD_GSK3_1	832	839	PF00069	0.696
MOD_GSK3_1	93	100	PF00069	0.724
MOD_LATS_1	838	844	PF00433	0.717
MOD_N-GLC_1	177	182	PF02516	0.709
MOD_N-GLC_1	235	240	PF02516	0.725
MOD_N-GLC_1	372	377	PF02516	0.768
MOD_N-GLC_1	827	832	PF02516	0.733
MOD_NEK2_1	314	319	PF00069	0.573
MOD_NEK2_1	703	708	PF00069	0.584
MOD_NEK2_1	767	772	PF00069	0.619
MOD_NEK2_2	72	77	PF00069	0.640
MOD_PIKK_1	138	144	PF00454	0.671
MOD_PIKK_1	16	22	PF00454	0.718
MOD_PIKK_1	203	209	PF00454	0.699
MOD_PIKK_1	499	505	PF00454	0.417
MOD_PIKK_1	645	651	PF00454	0.606
MOD_PIKK_1	97	103	PF00454	0.754
MOD_PK_1	557	563	PF00069	0.646
MOD_PK_1	586	592	PF00069	0.714
MOD_PKA_1	331	337	PF00069	0.602
MOD_PKA_1	637	643	PF00069	0.573
MOD_PKA_2	108	114	PF00069	0.654
MOD_PKA_2	219	225	PF00069	0.739
MOD_PKA_2	234	240	PF00069	0.545
MOD_PKA_2	330	336	PF00069	0.609
MOD_PKA_2	543	549	PF00069	0.734
MOD_PKA_2	551	557	PF00069	0.602
MOD_PKA_2	637	643	PF00069	0.573
MOD_PKA_2	751	757	PF00069	0.507
MOD_PKA_2	823	829	PF00069	0.775
MOD_PKA_2	852	858	PF00069	0.610
MOD_PKB_1	329	337	PF00069	0.609
MOD_PKB_1	491	499	PF00069	0.457
MOD_PKB_1	542	550	PF00069	0.577
MOD_PKB_1	95	103	PF00069	0.728
MOD_Plk_1	148	154	PF00069	0.630
MOD_Plk_1	180	186	PF00069	0.641
MOD_Plk_1	199	205	PF00069	0.609
MOD_Plk_1	235	241	PF00069	0.704
MOD_Plk_1	310	316	PF00069	0.643
MOD_Plk_1	493	499	PF00069	0.563
MOD_Plk_1	505	511	PF00069	0.387
MOD_Plk_1	697	703	PF00069	0.441
MOD_Plk_1	767	773	PF00069	0.507
MOD_Plk_2-3	594	600	PF00069	0.520
MOD_Plk_2-3	745	751	PF00069	0.480
MOD_Plk_4	124	130	PF00069	0.721
MOD_Plk_4	13	19	PF00069	0.675
MOD_Plk_4	37	43	PF00069	0.612
MOD_Plk_4	557	563	PF00069	0.646
MOD_Plk_4	586	592	PF00069	0.603
MOD_Plk_4	72	78	PF00069	0.641
MOD_ProDKin_1	11	17	PF00069	0.762
MOD_ProDKin_1	113	119	PF00069	0.668
MOD_ProDKin_1	213	219	PF00069	0.624
MOD_ProDKin_1	368	374	PF00069	0.643
MOD_ProDKin_1	385	391	PF00069	0.585
MOD_ProDKin_1	435	441	PF00069	0.647
MOD_ProDKin_1	451	457	PF00069	0.574
MOD_ProDKin_1	458	464	PF00069	0.521
MOD_ProDKin_1	546	552	PF00069	0.615
MOD_ProDKin_1	555	561	PF00069	0.609
MOD_ProDKin_1	806	812	PF00069	0.544
MOD_ProDKin_1	819	825	PF00069	0.610
MOD_ProDKin_1	88	94	PF00069	0.668
MOD_SUMO_rev_2	157	166	PF00179	0.576
MOD_SUMO_rev_2	245	254	PF00179	0.697
MOD_SUMO_rev_2	401	411	PF00179	0.636
MOD_SUMO_rev_2	614	623	PF00179	0.544
MOD_SUMO_rev_2	712	721	PF00179	0.479
TRG_AP2beta_CARGO_1	848	858	PF09066	0.584
TRG_DiLeu_BaEn_1	621	626	PF01217	0.472
TRG_DiLeu_BaEn_1	745	750	PF01217	0.504
TRG_DiLeu_BaEn_2	12	18	PF01217	0.674
TRG_DiLeu_BaEn_2	447	453	PF01217	0.724
TRG_ENDOCYTIC_2	315	318	PF00928	0.536
TRG_ENDOCYTIC_2	444	447	PF00928	0.563
TRG_ENDOCYTIC_2	575	578	PF00928	0.677
TRG_ENDOCYTIC_2	673	676	PF00928	0.481
TRG_ER_diArg_1	103	105	PF00400	0.672
TRG_ER_diArg_1	117	120	PF00400	0.596
TRG_ER_diArg_1	328	331	PF00400	0.607
TRG_ER_diArg_1	356	358	PF00400	0.622
TRG_ER_diArg_1	383	386	PF00400	0.695
TRG_ER_diArg_1	490	493	PF00400	0.472
TRG_ER_diArg_1	54	57	PF00400	0.732
TRG_ER_diArg_1	541	544	PF00400	0.745
TRG_ER_diArg_1	636	638	PF00400	0.532
TRG_ER_diArg_1	679	682	PF00400	0.406
TRG_ER_diArg_1	92	95	PF00400	0.765
TRG_NLS_MonoCore_2	382	387	PF00514	0.595
TRG_NLS_MonoExtN_4	380	387	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	527	532	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	630	635	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	747	751	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT63	Leptomonas seymouri	43%	89%
A4HE43	Leishmania braziliensis	62%	100%
A4I1E9	Leishmania infantum	99%	100%
E9AXI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9Y6	Leishmania major	88%	100%