SNF1-related_protein_kinase_regulatory_subunit_be ta_putative/GeneDB:LmjF.23.0490

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5'-AMP-activated protein kinase subunit beta, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICH1_LEIDO

TriTrypDb:

LdBPK_230530.1 , LdCL_230010800 , LDHU3_23.0750

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0031588	nucleotide-activated protein kinase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1902911	protein kinase complex	5	12
GO:1990234	transferase complex	3	12
GO:0005634	nucleus	5	1
GO:0005777	peroxisome	6	1
GO:0005929	cilium	4	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0120025	plasma membrane bounded cell projection	3	1

Phosphorylation

Promastigote: 71
Promastigote/Amastigote: 73

Expansion

Sequence features

A0A3Q8ICH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICH1

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	12
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0019220	regulation of phosphate metabolic process	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031399	regulation of protein modification process	6	12
GO:0042325	regulation of phosphorylation	7	12
GO:0043549	regulation of kinase activity	5	12
GO:0045859	regulation of protein kinase activity	6	12
GO:0050789	regulation of biological process	2	12
GO:0050790	regulation of catalytic activity	3	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051174	regulation of phosphorus metabolic process	5	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0051338	regulation of transferase activity	4	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0065009	regulation of molecular function	2	12
GO:0080090	regulation of primary metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.470
CLV_C14_Caspase3-7	217	221	PF00656	0.728
CLV_NRD_NRD_1	106	108	PF00675	0.575
CLV_NRD_NRD_1	12	14	PF00675	0.699
CLV_NRD_NRD_1	235	237	PF00675	0.587
CLV_NRD_NRD_1	299	301	PF00675	0.412
CLV_PCSK_KEX2_1	10	12	PF00082	0.719
CLV_PCSK_KEX2_1	299	301	PF00082	0.397
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.842
DEG_APCC_DBOX_1	62	70	PF00400	0.746
DEG_ODPH_VHL_1	160	173	PF01847	0.761
DEG_SCF_FBW7_1	246	253	PF00400	0.403
DEG_SPOP_SBC_1	58	62	PF00917	0.663
DOC_CKS1_1	123	128	PF01111	0.488
DOC_CKS1_1	173	178	PF01111	0.680
DOC_CKS1_1	251	256	PF01111	0.403
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.403
DOC_MAPK_DCC_7	236	244	PF00069	0.419
DOC_MAPK_gen_1	107	114	PF00069	0.421
DOC_MAPK_gen_1	195	205	PF00069	0.646
DOC_MAPK_gen_1	236	244	PF00069	0.431
DOC_MAPK_gen_1	259	268	PF00069	0.523
DOC_MAPK_gen_1	7	16	PF00069	0.837
DOC_MAPK_JIP1_4	178	184	PF00069	0.624
DOC_MAPK_MEF2A_6	107	114	PF00069	0.421
DOC_MAPK_MEF2A_6	236	244	PF00069	0.438
DOC_PP2B_LxvP_1	135	138	PF13499	0.488
DOC_PP2B_LxvP_1	284	287	PF13499	0.389
DOC_SPAK_OSR1_1	145	149	PF12202	0.419
DOC_USP7_MATH_1	17	21	PF00917	0.741
DOC_USP7_MATH_1	273	277	PF00917	0.550
DOC_USP7_MATH_1	332	336	PF00917	0.772
DOC_USP7_MATH_1	76	80	PF00917	0.789
DOC_WW_Pin1_4	122	127	PF00397	0.447
DOC_WW_Pin1_4	172	177	PF00397	0.769
DOC_WW_Pin1_4	246	251	PF00397	0.403
LIG_14-3-3_CanoR_1	51	55	PF00244	0.745
LIG_14-3-3_CanoR_1	63	67	PF00244	0.819
LIG_deltaCOP1_diTrp_1	223	232	PF00928	0.663
LIG_FHA_1	155	161	PF00498	0.456
LIG_FHA_1	183	189	PF00498	0.825
LIG_FHA_1	200	206	PF00498	0.485
LIG_FHA_1	315	321	PF00498	0.428
LIG_FHA_1	79	85	PF00498	0.779
LIG_FHA_1	86	92	PF00498	0.642
LIG_FHA_2	100	106	PF00498	0.582
LIG_FHA_2	209	215	PF00498	0.651
LIG_LIR_Gen_1	129	139	PF02991	0.403
LIG_LIR_Nem_3	129	135	PF02991	0.457
LIG_LIR_Nem_3	235	241	PF02991	0.420
LIG_LIR_Nem_3	88	92	PF02991	0.564
LIG_LYPXL_yS_3	238	241	PF13949	0.419
LIG_PDZ_Class_2	333	338	PF00595	0.772
LIG_SH2_CRK	144	148	PF00017	0.460
LIG_SH2_CRK	248	252	PF00017	0.403
LIG_SH2_CRK	316	320	PF00017	0.444
LIG_SH2_PTP2	111	114	PF00017	0.419
LIG_SH2_STAP1	316	320	PF00017	0.419
LIG_SH2_STAT3	95	98	PF00017	0.623
LIG_SH2_STAT5	111	114	PF00017	0.419
LIG_SH2_STAT5	248	251	PF00017	0.403
LIG_SH2_STAT5	296	299	PF00017	0.403
LIG_SH2_STAT5	312	315	PF00017	0.403
LIG_SH2_STAT5	316	319	PF00017	0.219
LIG_SH3_1	237	243	PF00018	0.419
LIG_SH3_3	11	17	PF00018	0.851
LIG_SH3_3	120	126	PF00018	0.482
LIG_SH3_3	156	162	PF00018	0.487
LIG_SH3_3	173	179	PF00018	0.840
LIG_SH3_3	181	187	PF00018	0.813
LIG_SH3_3	237	243	PF00018	0.390
LIG_SH3_3	323	329	PF00018	0.680
LIG_SUMO_SIM_par_1	286	291	PF11976	0.460
LIG_TYR_ITAM	129	147	PF00017	0.488
LIG_TYR_ITIM	246	251	PF00017	0.403
LIG_TYR_ITIM	320	325	PF00017	0.523
MOD_CDK_SPxK_1	172	178	PF00069	0.639
MOD_CK1_1	127	133	PF00069	0.419
MOD_CK1_1	47	53	PF00069	0.823
MOD_CK1_1	57	63	PF00069	0.726
MOD_CK2_1	208	214	PF00069	0.706
MOD_CK2_1	99	105	PF00069	0.627
MOD_GlcNHglycan	126	129	PF01048	0.472
MOD_GlcNHglycan	21	24	PF01048	0.752
MOD_GlcNHglycan	46	49	PF01048	0.767
MOD_GlcNHglycan	56	59	PF01048	0.728
MOD_GlcNHglycan	70	73	PF01048	0.852
MOD_GSK3_1	15	22	PF00069	0.765
MOD_GSK3_1	246	253	PF00069	0.403
MOD_GSK3_1	43	50	PF00069	0.841
MOD_GSK3_1	53	60	PF00069	0.655
MOD_GSK3_1	70	77	PF00069	0.839
MOD_GSK3_1	99	106	PF00069	0.621
MOD_NEK2_1	103	108	PF00069	0.592
MOD_NEK2_1	182	187	PF00069	0.831
MOD_NEK2_1	232	237	PF00069	0.597
MOD_NEK2_1	288	293	PF00069	0.403
MOD_NEK2_1	306	311	PF00069	0.403
MOD_NEK2_2	199	204	PF00069	0.621
MOD_NMyristoyl	1	7	PF02799	0.688
MOD_PIKK_1	154	160	PF00454	0.419
MOD_PIKK_1	182	188	PF00454	0.824
MOD_PKA_2	25	31	PF00069	0.729
MOD_PKA_2	258	264	PF00069	0.426
MOD_PKA_2	50	56	PF00069	0.743
MOD_PKA_2	62	68	PF00069	0.829
MOD_Plk_2-3	99	105	PF00069	0.580
MOD_Plk_4	127	133	PF00069	0.419
MOD_Plk_4	199	205	PF00069	0.619
MOD_Plk_4	253	259	PF00069	0.523
MOD_Plk_4	315	321	PF00069	0.463
MOD_Plk_4	35	41	PF00069	0.797
MOD_Plk_4	99	105	PF00069	0.490
MOD_ProDKin_1	122	128	PF00069	0.447
MOD_ProDKin_1	172	178	PF00069	0.770
MOD_ProDKin_1	246	252	PF00069	0.403
TRG_ENDOCYTIC_2	111	114	PF00928	0.419
TRG_ENDOCYTIC_2	132	135	PF00928	0.404
TRG_ENDOCYTIC_2	144	147	PF00928	0.405
TRG_ENDOCYTIC_2	238	241	PF00928	0.410
TRG_ENDOCYTIC_2	248	251	PF00928	0.389
TRG_ENDOCYTIC_2	316	319	PF00928	0.397
TRG_ENDOCYTIC_2	322	325	PF00928	0.492
TRG_ER_diArg_1	11	13	PF00400	0.779
TRG_NLS_MonoCore_2	9	14	PF00514	0.746
TRG_NLS_MonoExtN_4	7	14	PF00514	0.746

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9V7	Leptomonas seymouri	74%	100%
A0A0S4IRW9	Bodo saltans	41%	91%
A0A1X0NX44	Trypanosomatidae	45%	100%
A0A3R7K3F4	Trypanosoma rangeli	51%	100%
A4HCR3	Leishmania braziliensis	88%	100%
A4I088	Leishmania infantum	100%	100%
C9ZV05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AW52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P80386	Rattus norvegicus	27%	100%
Q4QBC5	Leishmania major	96%	100%
Q5BIS9	Bos taurus	26%	100%
Q5R801	Pongo abelii	25%	100%
Q9R078	Mus musculus	27%	100%
Q9Y478	Homo sapiens	25%	100%
V5ASF8	Trypanosoma cruzi	46%	100%