Ribosomal protein L21e family protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L21, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICH0_LEIDO

TriTrypDb:

LdBPK_343440.1 , LdCL_160009600 , LdCL_340043800 , LDHU3_16.0550 , LDHU3_34.5670

Length:

159

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L21

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	16
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Phosphorylation

Promastigote: 26

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8ICH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICH0

PDB structure(s): 6az3_S

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	17
GO:0006518	peptide metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009058	biosynthetic process	2	17
GO:0009059	macromolecule biosynthetic process	4	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	17
GO:0043043	peptide biosynthetic process	5	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043603	amide metabolic process	3	17
GO:0043604	amide biosynthetic process	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044249	cellular biosynthetic process	3	17
GO:0044260	obsolete cellular macromolecule metabolic process	3	17
GO:0044271	cellular nitrogen compound biosynthetic process	4	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901566	organonitrogen compound biosynthetic process	4	17
GO:1901576	organic substance biosynthetic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.527
CLV_NRD_NRD_1	19	21	PF00675	0.262
CLV_NRD_NRD_1	85	87	PF00675	0.254
CLV_NRD_NRD_1	96	98	PF00675	0.254
CLV_PCSK_KEX2_1	148	150	PF00082	0.510
CLV_PCSK_KEX2_1	87	89	PF00082	0.254
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.254
CLV_PCSK_PC7_1	83	89	PF00082	0.254
CLV_PCSK_SKI1_1	12	16	PF00082	0.263
DOC_MAPK_gen_1	83	93	PF00069	0.454
DOC_MAPK_MEF2A_6	86	93	PF00069	0.472
DOC_USP7_MATH_1	25	29	PF00917	0.482
DOC_USP7_UBL2_3	119	123	PF12436	0.567
DOC_USP7_UBL2_3	17	21	PF12436	0.462
DOC_WW_Pin1_4	65	70	PF00397	0.454
LIG_14-3-3_CanoR_1	81	86	PF00244	0.528
LIG_FHA_1	59	65	PF00498	0.450
LIG_FHA_1	80	86	PF00498	0.560
LIG_FHA_1	9	15	PF00498	0.472
LIG_LIR_Gen_1	152	159	PF02991	0.528
LIG_LIR_Gen_1	38	47	PF02991	0.462
LIG_LIR_Nem_3	109	115	PF02991	0.476
LIG_LIR_Nem_3	38	42	PF02991	0.462
LIG_Pex14_2	15	19	PF04695	0.454
LIG_SH2_PTP2	39	42	PF00017	0.482
LIG_SH2_SRC	39	42	PF00017	0.482
LIG_SH2_STAP1	153	157	PF00017	0.523
LIG_SH2_STAT5	115	118	PF00017	0.505
LIG_SH2_STAT5	39	42	PF00017	0.482
LIG_SUMO_SIM_anti_2	38	46	PF11976	0.462
LIG_UBA3_1	30	35	PF00899	0.560
MOD_CDK_SPK_2	65	70	PF00069	0.454
MOD_CK1_1	26	32	PF00069	0.478
MOD_GlcNHglycan	45	48	PF01048	0.273
MOD_GlcNHglycan	8	11	PF01048	0.328
MOD_GSK3_1	25	32	PF00069	0.462
MOD_N-GLC_1	65	70	PF02516	0.254
MOD_NEK2_1	1	6	PF00069	0.465
MOD_NEK2_1	128	133	PF00069	0.709
MOD_PKA_1	129	135	PF00069	0.524
MOD_PKA_2	96	102	PF00069	0.454
MOD_Plk_4	26	32	PF00069	0.455
MOD_ProDKin_1	65	71	PF00069	0.454
TRG_ENDOCYTIC_2	153	156	PF00928	0.528
TRG_ENDOCYTIC_2	39	42	PF00928	0.482
TRG_ER_diArg_1	148	150	PF00400	0.651
TRG_ER_diArg_1	80	83	PF00400	0.458
TRG_ER_diArg_1	85	88	PF00400	0.449
TRG_NLS_Bipartite_1	86	101	PF00514	0.454
TRG_NLS_MonoExtC_3	16	21	PF00514	0.462
TRG_NLS_MonoExtN_4	83	90	PF00514	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JD84	Bodo saltans	77%	100%
A0A0S4JRZ0	Bodo saltans	78%	100%
A0A1X0PA26	Trypanosomatidae	87%	100%
A0A3R7NZ63	Trypanosoma rangeli	86%	100%
A0A3R7RE25	Trypanosoma rangeli	87%	100%
A0A422N2X9	Trypanosoma rangeli	87%	100%
A4H8H2	Leishmania braziliensis	97%	100%
A4HB84	Leishmania braziliensis	97%	100%
A4HWU4	Leishmania infantum	99%	100%
A4IAD2	Leishmania infantum	100%	100%
C9ZLW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
D0A5K0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9AQK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O82574	Cyanophora paradoxa	51%	99%
P20280	Rattus norvegicus	41%	99%
P34334	Caenorhabditis elegans	46%	99%
P38653	Entamoeba histolytica	43%	96%
P49667	Pyura stolonifera	44%	100%
Q23TC8	Tetrahymena thermophila (strain SB210)	46%	100%
Q43291	Arabidopsis thaliana	53%	97%
Q4Q2H9	Leishmania major	98%	100%
Q4QEX4	Leishmania major	98%	100%
Q54X53	Dictyostelium discoideum	45%	99%
Q8SRW8	Encephalitozoon cuniculi (strain GB-M1)	49%	99%
Q9FDZ9	Arabidopsis thaliana	53%	97%