Hypothetical_protein_conserved

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICG4_LEIDO

TriTrypDb:

LdBPK_230540.1 , LdCL_230010900 , LDHU3_23.0760

Length:

284

Annotations

LeishMANIAdb annotations

An absolutely unique fold restricted to kinetoplastids. most predictions are too weak to assume any secure topology.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Phosphorylation

Amastigote: 276

Expansion

Sequence features

A0A3Q8ICG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.483
CLV_NRD_NRD_1	142	144	PF00675	0.486
CLV_NRD_NRD_1	260	262	PF00675	0.457
CLV_PCSK_KEX2_1	260	262	PF00082	0.457
DEG_Nend_UBRbox_1	1	4	PF02207	0.696
DOC_CKS1_1	94	99	PF01111	0.498
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.563
DOC_MAPK_MEF2A_6	2	10	PF00069	0.551
DOC_MAPK_NFAT4_5	2	10	PF00069	0.551
DOC_MAPK_RevD_3	245	261	PF00069	0.424
DOC_USP7_MATH_1	25	29	PF00917	0.482
DOC_USP7_MATH_1	30	34	PF00917	0.435
DOC_USP7_MATH_1	99	103	PF00917	0.534
DOC_WW_Pin1_4	267	272	PF00397	0.744
DOC_WW_Pin1_4	93	98	PF00397	0.494
LIG_14-3-3_CanoR_1	146	151	PF00244	0.599
LIG_14-3-3_CanoR_1	49	58	PF00244	0.504
LIG_FHA_1	215	221	PF00498	0.487
LIG_FHA_1	226	232	PF00498	0.406
LIG_FHA_1	239	245	PF00498	0.254
LIG_LIR_Gen_1	213	224	PF02991	0.430
LIG_LIR_Gen_1	238	248	PF02991	0.356
LIG_LIR_Nem_3	213	219	PF02991	0.430
LIG_LIR_Nem_3	238	243	PF02991	0.356
LIG_MAD2	64	72	PF02301	0.471
LIG_MYND_1	207	211	PF01753	0.430
LIG_NRBOX	158	164	PF00104	0.462
LIG_Pex14_1	223	227	PF04695	0.663
LIG_Pex14_2	219	223	PF04695	0.421
LIG_RPA_C_Fungi	46	58	PF08784	0.621
LIG_SH2_STAP1	216	220	PF00017	0.430
LIG_SH2_STAT3	139	142	PF00017	0.642
LIG_SH2_STAT5	180	183	PF00017	0.527
LIG_SH2_STAT5	201	204	PF00017	0.416
LIG_SH2_STAT5	216	219	PF00017	0.501
LIG_SH3_1	64	70	PF00018	0.564
LIG_SH3_3	184	190	PF00018	0.504
LIG_SH3_3	204	210	PF00018	0.171
LIG_SH3_3	265	271	PF00018	0.751
LIG_SH3_3	64	70	PF00018	0.512
LIG_SH3_3	91	97	PF00018	0.591
LIG_Sin3_3	158	165	PF02671	0.353
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.430
LIG_SUMO_SIM_par_1	158	164	PF11976	0.414
LIG_TRAF2_1	270	273	PF00917	0.723
LIG_TYR_ITIM	178	183	PF00017	0.601
LIG_WRC_WIRS_1	147	152	PF05994	0.287
MOD_CK1_1	28	34	PF00069	0.728
MOD_CK2_1	267	273	PF00069	0.665
MOD_GlcNHglycan	101	104	PF01048	0.594
MOD_GlcNHglycan	20	23	PF01048	0.452
MOD_GlcNHglycan	212	215	PF01048	0.430
MOD_GlcNHglycan	231	234	PF01048	0.630
MOD_GlcNHglycan	257	260	PF01048	0.614
MOD_GlcNHglycan	43	46	PF01048	0.646
MOD_GSK3_1	14	21	PF00069	0.447
MOD_GSK3_1	146	153	PF00069	0.508
MOD_GSK3_1	210	217	PF00069	0.399
MOD_GSK3_1	225	232	PF00069	0.609
MOD_GSK3_1	24	31	PF00069	0.520
MOD_NEK2_1	110	115	PF00069	0.576
MOD_NEK2_1	150	155	PF00069	0.430
MOD_NEK2_1	170	175	PF00069	0.262
MOD_NEK2_1	181	186	PF00069	0.417
MOD_NEK2_1	231	236	PF00069	0.624
MOD_NEK2_1	253	258	PF00069	0.473
MOD_PIKK_1	182	188	PF00454	0.578
MOD_PIKK_1	231	237	PF00454	0.628
MOD_PKA_2	50	56	PF00069	0.600
MOD_Plk_1	171	177	PF00069	0.520
MOD_Plk_2-3	273	279	PF00069	0.694
MOD_Plk_4	146	152	PF00069	0.322
MOD_Plk_4	171	177	PF00069	0.484
MOD_Plk_4	196	202	PF00069	0.403
MOD_Plk_4	83	89	PF00069	0.492
MOD_ProDKin_1	267	273	PF00069	0.693
MOD_ProDKin_1	93	99	PF00069	0.631
TRG_ENDOCYTIC_2	180	183	PF00928	0.611
TRG_ENDOCYTIC_2	216	219	PF00928	0.430
TRG_NLS_MonoExtN_4	140	147	PF00514	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P307	Leptomonas seymouri	59%	100%
A4HCR4	Leishmania braziliensis	83%	100%
A4I089	Leishmania infantum	100%	100%
C9ZV06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AW53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QBC4	Leishmania major	94%	100%