Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ICG3_LEIDO

TriTrypDb:

LdBPK_230360.1 , LdCL_230009000 , LDHU3_23.0530

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.457
CLV_C14_Caspase3-7	184	188	PF00656	0.625
CLV_NRD_NRD_1	154	156	PF00675	0.379
CLV_NRD_NRD_1	176	178	PF00675	0.606
CLV_NRD_NRD_1	243	245	PF00675	0.467
CLV_NRD_NRD_1	44	46	PF00675	0.556
CLV_PCSK_KEX2_1	156	158	PF00082	0.459
CLV_PCSK_KEX2_1	176	178	PF00082	0.606
CLV_PCSK_KEX2_1	243	245	PF00082	0.467
CLV_PCSK_KEX2_1	44	46	PF00082	0.559
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.459
DOC_CKS1_1	197	202	PF01111	0.571
DOC_CKS1_1	5	10	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.348
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.557
DOC_MAPK_DCC_7	218	226	PF00069	0.427
DOC_MAPK_MEF2A_6	218	226	PF00069	0.427
DOC_PP2B_LxvP_1	74	77	PF13499	0.381
DOC_USP7_MATH_1	104	108	PF00917	0.591
DOC_USP7_MATH_1	112	116	PF00917	0.544
DOC_USP7_MATH_1	142	146	PF00917	0.549
DOC_USP7_MATH_1	150	154	PF00917	0.513
DOC_USP7_MATH_1	64	68	PF00917	0.449
DOC_USP7_UBL2_3	152	156	PF12436	0.452
DOC_WW_Pin1_4	165	170	PF00397	0.560
DOC_WW_Pin1_4	196	201	PF00397	0.595
DOC_WW_Pin1_4	211	216	PF00397	0.410
DOC_WW_Pin1_4	4	9	PF00397	0.685
DOC_WW_Pin1_4	88	93	PF00397	0.619
LIG_14-3-3_CanoR_1	14	20	PF00244	0.626
LIG_14-3-3_CanoR_1	218	222	PF00244	0.543
LIG_14-3-3_CanoR_1	44	50	PF00244	0.548
LIG_Actin_WH2_2	128	143	PF00022	0.453
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_eIF4E_1	234	240	PF01652	0.465
LIG_FHA_1	208	214	PF00498	0.401
LIG_FHA_2	129	135	PF00498	0.340
LIG_FHA_2	57	63	PF00498	0.531
LIG_Integrin_RGD_1	244	246	PF01839	0.469
LIG_LIR_Apic_2	194	200	PF02991	0.623
LIG_LIR_Apic_2	252	258	PF02991	0.537
LIG_LIR_Gen_1	67	77	PF02991	0.484
LIG_LIR_Nem_3	67	72	PF02991	0.478
LIG_NRP_CendR_1	271	273	PF00754	0.464
LIG_SH2_CRK	197	201	PF00017	0.587
LIG_SH2_CRK	69	73	PF00017	0.419
LIG_SH2_NCK_1	255	259	PF00017	0.488
LIG_SH2_STAT5	69	72	PF00017	0.469
LIG_SH3_3	28	34	PF00018	0.594
LIG_SH3_3	5	11	PF00018	0.596
LIG_SH3_3	84	90	PF00018	0.694
MOD_CDK_SPxK_1	170	176	PF00069	0.525
MOD_CDK_SPxxK_3	170	177	PF00069	0.525
MOD_CDK_SPxxK_3	196	203	PF00069	0.564
MOD_CDK_SPxxK_3	211	218	PF00069	0.501
MOD_CDK_SPxxK_3	7	14	PF00069	0.540
MOD_CK1_1	107	113	PF00069	0.705
MOD_CK1_1	12	18	PF00069	0.587
MOD_CK1_1	168	174	PF00069	0.556
MOD_CK2_1	112	118	PF00069	0.682
MOD_CK2_1	128	134	PF00069	0.328
MOD_Cter_Amidation	174	177	PF01082	0.586
MOD_GlcNHglycan	1	4	PF01048	0.749
MOD_GlcNHglycan	114	117	PF01048	0.683
MOD_GlcNHglycan	15	18	PF01048	0.611
MOD_GlcNHglycan	170	173	PF01048	0.785
MOD_GlcNHglycan	236	239	PF01048	0.433
MOD_GlcNHglycan	28	31	PF01048	0.552
MOD_GSK3_1	104	111	PF00069	0.742
MOD_GSK3_1	164	171	PF00069	0.730
MOD_GSK3_1	207	214	PF00069	0.486
MOD_GSK3_1	265	272	PF00069	0.461
MOD_GSK3_1	3	10	PF00069	0.731
MOD_GSK3_1	64	71	PF00069	0.423
MOD_GSK3_1	75	82	PF00069	0.524
MOD_N-GLC_1	185	190	PF02516	0.526
MOD_NEK2_1	108	113	PF00069	0.680
MOD_NEK2_1	209	214	PF00069	0.464
MOD_PIKK_1	79	85	PF00454	0.683
MOD_PKA_2	13	19	PF00069	0.622
MOD_PKA_2	217	223	PF00069	0.440
MOD_PKA_2	43	49	PF00069	0.532
MOD_Plk_1	128	134	PF00069	0.453
MOD_Plk_2-3	185	191	PF00069	0.524
MOD_Plk_4	128	134	PF00069	0.406
MOD_Plk_4	217	223	PF00069	0.481
MOD_Plk_4	68	74	PF00069	0.457
MOD_ProDKin_1	165	171	PF00069	0.563
MOD_ProDKin_1	196	202	PF00069	0.580
MOD_ProDKin_1	211	217	PF00069	0.407
MOD_ProDKin_1	4	10	PF00069	0.685
MOD_ProDKin_1	88	94	PF00069	0.619
MOD_SUMO_rev_2	148	158	PF00179	0.438
TRG_ENDOCYTIC_2	69	72	PF00928	0.442
TRG_ER_diArg_1	242	244	PF00400	0.470
TRG_ER_diArg_1	43	45	PF00400	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Y3	Leptomonas seymouri	53%	93%
A0A1X0NXL5	Trypanosomatidae	34%	100%
A0A422NW27	Trypanosoma rangeli	25%	100%
A4HCP6	Leishmania braziliensis	72%	98%
A4I072	Leishmania infantum	100%	100%
C9ZUY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AW35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBE2	Leishmania major	94%	100%