Ankyrin_repeats_(3_copies)/Ankyrin_repeats_(Many_ copies)/Ankyrin_repeat_putative/Pfam:PF12796/Pfam:PF13637/P fam:PF13857/Pfam:PF13606/Pfam:PF00023

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ICG2_LEIDO

TriTrypDb:

LdBPK_250960.1 , LdCL_250014900 , LDHU3_25.1230

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.466
CLV_PCSK_SKI1_1	165	169	PF00082	0.399
DEG_APCC_DBOX_1	238	246	PF00400	0.595
DEG_SPOP_SBC_1	118	122	PF00917	0.589
DOC_CDC14_PxL_1	1	9	PF14671	0.528
DOC_CKS1_1	95	100	PF01111	0.504
DOC_CYCLIN_RxL_1	162	170	PF00134	0.398
DOC_PP4_FxxP_1	95	98	PF00568	0.439
DOC_USP7_MATH_1	101	105	PF00917	0.608
DOC_USP7_MATH_1	118	122	PF00917	0.504
DOC_USP7_MATH_1	125	129	PF00917	0.644
DOC_USP7_MATH_1	142	146	PF00917	0.248
DOC_USP7_MATH_1	177	181	PF00917	0.362
DOC_USP7_MATH_1	254	258	PF00917	0.536
DOC_WW_Pin1_4	114	119	PF00397	0.393
DOC_WW_Pin1_4	123	128	PF00397	0.715
DOC_WW_Pin1_4	147	152	PF00397	0.261
DOC_WW_Pin1_4	26	31	PF00397	0.458
DOC_WW_Pin1_4	94	99	PF00397	0.443
LIG_14-3-3_CanoR_1	41	45	PF00244	0.326
LIG_14-3-3_CanoR_1	53	61	PF00244	0.305
LIG_14-3-3_CanoR_1	63	68	PF00244	0.374
LIG_14-3-3_CanoR_1	80	90	PF00244	0.412
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BRCT_BRCA1_1	215	219	PF00533	0.579
LIG_EH1_1	195	203	PF00400	0.378
LIG_FHA_1	11	17	PF00498	0.406
LIG_FHA_1	54	60	PF00498	0.383
LIG_FHA_2	182	188	PF00498	0.340
LIG_LIR_Gen_1	227	237	PF02991	0.547
LIG_LIR_Nem_3	227	232	PF02991	0.553
LIG_PCNA_PIPBox_1	160	169	PF02747	0.305
LIG_SH2_NCK_1	116	120	PF00017	0.707
LIG_SH2_PTP2	229	232	PF00017	0.546
LIG_SH2_SRC	229	232	PF00017	0.622
LIG_SH2_STAT5	116	119	PF00017	0.710
LIG_SH2_STAT5	166	169	PF00017	0.313
LIG_SH2_STAT5	229	232	PF00017	0.559
LIG_SH2_STAT5	35	38	PF00017	0.417
LIG_TYR_ITIM	164	169	PF00017	0.305
MOD_CK1_1	121	127	PF00069	0.597
MOD_CK1_1	128	134	PF00069	0.463
MOD_GlcNHglycan	104	107	PF01048	0.599
MOD_GlcNHglycan	123	126	PF01048	0.550
MOD_GlcNHglycan	144	147	PF01048	0.383
MOD_GlcNHglycan	157	160	PF01048	0.418
MOD_GlcNHglycan	20	24	PF01048	0.472
MOD_GlcNHglycan	224	227	PF01048	0.501
MOD_GlcNHglycan	83	86	PF01048	0.375
MOD_GlcNHglycan	99	102	PF01048	0.459
MOD_GSK3_1	110	117	PF00069	0.535
MOD_GSK3_1	119	126	PF00069	0.662
MOD_GSK3_1	177	184	PF00069	0.372
MOD_GSK3_1	218	225	PF00069	0.530
MOD_GSK3_1	3	10	PF00069	0.539
MOD_GSK3_1	59	66	PF00069	0.402
MOD_GSK3_1	93	100	PF00069	0.369
MOD_N-GLC_1	202	207	PF02516	0.531
MOD_N-GLC_1	213	218	PF02516	0.692
MOD_N-GLC_1	26	31	PF02516	0.499
MOD_N-GLC_1	33	38	PF02516	0.461
MOD_NEK2_1	167	172	PF00069	0.386
MOD_NEK2_1	202	207	PF00069	0.538
MOD_NEK2_1	59	64	PF00069	0.344
MOD_NEK2_1	7	12	PF00069	0.468
MOD_PIKK_1	10	16	PF00454	0.384
MOD_PIKK_1	219	225	PF00454	0.622
MOD_PIKK_1	54	60	PF00454	0.305
MOD_PKA_2	110	116	PF00069	0.690
MOD_PKA_2	177	183	PF00069	0.364
MOD_PKA_2	40	46	PF00069	0.296
MOD_Plk_1	19	25	PF00069	0.500
MOD_Plk_1	202	208	PF00069	0.540
MOD_Plk_1	254	260	PF00069	0.535
MOD_Plk_4	125	131	PF00069	0.632
MOD_Plk_4	40	46	PF00069	0.261
MOD_ProDKin_1	114	120	PF00069	0.392
MOD_ProDKin_1	123	129	PF00069	0.706
MOD_ProDKin_1	147	153	PF00069	0.261
MOD_ProDKin_1	26	32	PF00069	0.452
MOD_ProDKin_1	94	100	PF00069	0.454
TRG_ENDOCYTIC_2	166	169	PF00928	0.305
TRG_ENDOCYTIC_2	229	232	PF00928	0.564
TRG_NES_CRM1_1	187	199	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I922	Leptomonas seymouri	63%	100%
A0A0S4IRG3	Bodo saltans	30%	100%
A0A1X0NNH1	Trypanosomatidae	36%	100%
A0A422NXA4	Trypanosoma rangeli	36%	100%
A4HE28	Leishmania braziliensis	82%	100%
A4I1D4	Leishmania infantum	100%	100%
C9ZKX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AXH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QA01	Leishmania major	93%	100%
Q6P6B7	Homo sapiens	29%	73%
V5BBP8	Trypanosoma cruzi	37%	100%