Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ICG0_LEIDO

TriTrypDb:

LdBPK_160250.1 , LdCL_160007400 , LDHU3_16.0300

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005819	spindle	5	1

Expansion

Sequence features

A0A3Q8ICG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICG0

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	1
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	2
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	19
GO:0003676	nucleic acid binding	3	19
GO:0003723	RNA binding	4	19
GO:0003824	catalytic activity	1	19
GO:0005488	binding	1	19
GO:0016407	acetyltransferase activity	5	19
GO:0016740	transferase activity	2	19
GO:0016746	acyltransferase activity	3	19
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	19
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19
GO:0051536	iron-sulfur cluster binding	3	19
GO:0051539	4 iron, 4 sulfur cluster binding	4	19
GO:0051540	metal cluster binding	2	19
GO:0097159	organic cyclic compound binding	2	19
GO:1901363	heterocyclic compound binding	2	19
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.327
CLV_C14_Caspase3-7	45	49	PF00656	0.371
CLV_C14_Caspase3-7	652	656	PF00656	0.573
CLV_NRD_NRD_1	222	224	PF00675	0.235
CLV_NRD_NRD_1	291	293	PF00675	0.297
CLV_NRD_NRD_1	332	334	PF00675	0.270
CLV_NRD_NRD_1	520	522	PF00675	0.361
CLV_NRD_NRD_1	633	635	PF00675	0.317
CLV_NRD_NRD_1	682	684	PF00675	0.709
CLV_NRD_NRD_1	731	733	PF00675	0.623
CLV_NRD_NRD_1	80	82	PF00675	0.446
CLV_NRD_NRD_1	84	86	PF00675	0.451
CLV_PCSK_KEX2_1	222	224	PF00082	0.235
CLV_PCSK_KEX2_1	291	293	PF00082	0.302
CLV_PCSK_KEX2_1	332	334	PF00082	0.265
CLV_PCSK_KEX2_1	520	522	PF00082	0.378
CLV_PCSK_KEX2_1	632	634	PF00082	0.312
CLV_PCSK_KEX2_1	682	684	PF00082	0.709
CLV_PCSK_KEX2_1	733	735	PF00082	0.548
CLV_PCSK_KEX2_1	84	86	PF00082	0.598
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.363
CLV_PCSK_PC1ET2_1	733	735	PF00082	0.524
CLV_PCSK_PC7_1	628	634	PF00082	0.281
CLV_PCSK_SKI1_1	274	278	PF00082	0.235
CLV_PCSK_SKI1_1	368	372	PF00082	0.247
CLV_PCSK_SKI1_1	394	398	PF00082	0.320
CLV_PCSK_SKI1_1	480	484	PF00082	0.245
CLV_PCSK_SKI1_1	500	504	PF00082	0.250
CLV_PCSK_SKI1_1	506	510	PF00082	0.440
CLV_PCSK_SKI1_1	513	517	PF00082	0.406
CLV_PCSK_SKI1_1	84	88	PF00082	0.405
CLV_PCSK_SKI1_1	89	93	PF00082	0.337
CLV_PCSK_SKI1_1	97	101	PF00082	0.383
DEG_APCC_DBOX_1	291	299	PF00400	0.476
DOC_ANK_TNKS_1	744	751	PF00023	0.469
DOC_CDC14_PxL_1	28	36	PF14671	0.403
DOC_CKS1_1	155	160	PF01111	0.637
DOC_CKS1_1	417	422	PF01111	0.435
DOC_CKS1_1	556	561	PF01111	0.272
DOC_CKS1_1	589	594	PF01111	0.199
DOC_CYCLIN_yClb1_LxF_4	224	229	PF00134	0.435
DOC_CYCLIN_yClb5_NLxxxL_5	474	483	PF00134	0.445
DOC_MAPK_gen_1	171	181	PF00069	0.406
DOC_MAPK_gen_1	222	229	PF00069	0.435
DOC_MAPK_gen_1	238	245	PF00069	0.435
DOC_MAPK_gen_1	291	297	PF00069	0.483
DOC_MAPK_gen_1	449	458	PF00069	0.435
DOC_MAPK_gen_1	84	93	PF00069	0.401
DOC_MAPK_HePTP_8	446	458	PF00069	0.435
DOC_MAPK_MEF2A_6	449	458	PF00069	0.431
DOC_PP1_RVXF_1	164	171	PF00149	0.516
DOC_PP1_RVXF_1	224	230	PF00149	0.435
DOC_PP2B_PxIxI_1	453	459	PF00149	0.540
DOC_PP4_FxxP_1	170	173	PF00568	0.517
DOC_PP4_FxxP_1	284	287	PF00568	0.540
DOC_USP7_MATH_1	142	146	PF00917	0.718
DOC_USP7_MATH_1	151	155	PF00917	0.693
DOC_USP7_MATH_1	594	598	PF00917	0.382
DOC_USP7_MATH_1	743	747	PF00917	0.493
DOC_WW_Pin1_4	137	142	PF00397	0.729
DOC_WW_Pin1_4	14	19	PF00397	0.691
DOC_WW_Pin1_4	149	154	PF00397	0.693
DOC_WW_Pin1_4	386	391	PF00397	0.334
DOC_WW_Pin1_4	400	405	PF00397	0.355
DOC_WW_Pin1_4	416	421	PF00397	0.381
DOC_WW_Pin1_4	431	436	PF00397	0.435
DOC_WW_Pin1_4	555	560	PF00397	0.271
DOC_WW_Pin1_4	588	593	PF00397	0.250
DOC_WW_Pin1_4	690	695	PF00397	0.684
LIG_14-3-3_CanoR_1	238	243	PF00244	0.435
LIG_14-3-3_CanoR_1	688	693	PF00244	0.699
LIG_14-3-3_CanoR_1	722	726	PF00244	0.497
LIG_Actin_WH2_2	667	684	PF00022	0.515
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BIR_III_4	747	751	PF00653	0.463
LIG_eIF4E_1	436	442	PF01652	0.463
LIG_FHA_1	126	132	PF00498	0.780
LIG_FHA_1	155	161	PF00498	0.460
LIG_FHA_1	507	513	PF00498	0.580
LIG_FHA_1	687	693	PF00498	0.754
LIG_FHA_1	710	716	PF00498	0.559
LIG_FHA_2	280	286	PF00498	0.474
LIG_FHA_2	316	322	PF00498	0.442
LIG_FHA_2	357	363	PF00498	0.488
LIG_FHA_2	5	11	PF00498	0.582
LIG_FHA_2	514	520	PF00498	0.514
LIG_FHA_2	579	585	PF00498	0.316
LIG_FHA_2	68	74	PF00498	0.534
LIG_LIR_Apic_2	262	267	PF02991	0.423
LIG_LIR_Apic_2	282	287	PF02991	0.455
LIG_LIR_Gen_1	165	173	PF02991	0.529
LIG_LIR_Gen_1	20	29	PF02991	0.579
LIG_LIR_Gen_1	418	428	PF02991	0.459
LIG_LIR_Gen_1	528	537	PF02991	0.333
LIG_LIR_Gen_1	557	568	PF02991	0.269
LIG_LIR_Gen_1	613	622	PF02991	0.313
LIG_LIR_LC3C_4	177	182	PF02991	0.389
LIG_LIR_Nem_3	165	170	PF02991	0.516
LIG_LIR_Nem_3	196	202	PF02991	0.267
LIG_LIR_Nem_3	20	24	PF02991	0.588
LIG_LIR_Nem_3	228	232	PF02991	0.446
LIG_LIR_Nem_3	260	264	PF02991	0.459
LIG_LIR_Nem_3	409	414	PF02991	0.454
LIG_LIR_Nem_3	418	424	PF02991	0.459
LIG_LIR_Nem_3	430	436	PF02991	0.459
LIG_LIR_Nem_3	528	534	PF02991	0.308
LIG_LIR_Nem_3	557	563	PF02991	0.383
LIG_LIR_Nem_3	613	619	PF02991	0.284
LIG_MYND_3	31	35	PF01753	0.411
LIG_NRBOX	33	39	PF00104	0.397
LIG_NRBOX	478	484	PF00104	0.438
LIG_Pex14_1	199	203	PF04695	0.435
LIG_Pex14_1	556	560	PF04695	0.281
LIG_Pex14_2	195	199	PF04695	0.267
LIG_SH2_CRK	575	579	PF00017	0.325
LIG_SH2_CRK	616	620	PF00017	0.270
LIG_SH2_CRK	636	640	PF00017	0.455
LIG_SH2_CRK	718	722	PF00017	0.431
LIG_SH2_CRK	83	87	PF00017	0.445
LIG_SH2_NCK_1	616	620	PF00017	0.320
LIG_SH2_STAP1	616	620	PF00017	0.320
LIG_SH2_STAT3	414	417	PF00017	0.435
LIG_SH2_STAT5	167	170	PF00017	0.359
LIG_SH2_STAT5	203	206	PF00017	0.459
LIG_SH2_STAT5	214	217	PF00017	0.459
LIG_SH2_STAT5	405	408	PF00017	0.405
LIG_SH2_STAT5	433	436	PF00017	0.549
LIG_SH2_STAT5	469	472	PF00017	0.459
LIG_SH2_STAT5	582	585	PF00017	0.405
LIG_SH3_1	202	208	PF00018	0.435
LIG_SH3_2	287	292	PF14604	0.540
LIG_SH3_3	136	142	PF00018	0.710
LIG_SH3_3	156	162	PF00018	0.412
LIG_SH3_3	202	208	PF00018	0.459
LIG_SH3_3	284	290	PF00018	0.502
LIG_SH3_3	380	386	PF00018	0.484
LIG_SH3_3	531	537	PF00018	0.360
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.375
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.459
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.320
LIG_SUMO_SIM_par_1	177	183	PF11976	0.375
LIG_SxIP_EBH_1	688	701	PF03271	0.519
LIG_TRAF2_1	116	119	PF00917	0.551
LIG_TRAF2_1	516	519	PF00917	0.362
LIG_TRAF2_1	611	614	PF00917	0.250
LIG_UBA3_1	441	449	PF00899	0.281
MOD_CDK_SPxxK_3	149	156	PF00069	0.560
MOD_CK1_1	154	160	PF00069	0.639
MOD_CK1_1	2	8	PF00069	0.686
MOD_CK1_1	525	531	PF00069	0.312
MOD_CK2_1	2	8	PF00069	0.641
MOD_CK2_1	355	361	PF00069	0.325
MOD_CK2_1	419	425	PF00069	0.264
MOD_CK2_1	513	519	PF00069	0.444
MOD_CK2_1	578	584	PF00069	0.321
MOD_CK2_1	67	73	PF00069	0.573
MOD_CK2_1	743	749	PF00069	0.552
MOD_GlcNHglycan	12	15	PF01048	0.734
MOD_GlcNHglycan	123	126	PF01048	0.779
MOD_GlcNHglycan	144	147	PF01048	0.705
MOD_GlcNHglycan	176	179	PF01048	0.411
MOD_GlcNHglycan	186	189	PF01048	0.354
MOD_GlcNHglycan	305	308	PF01048	0.326
MOD_GlcNHglycan	513	516	PF01048	0.474
MOD_GlcNHglycan	596	599	PF01048	0.346
MOD_GlcNHglycan	622	625	PF01048	0.267
MOD_GlcNHglycan	729	732	PF01048	0.594
MOD_GSK3_1	10	17	PF00069	0.764
MOD_GSK3_1	121	128	PF00069	0.530
MOD_GSK3_1	142	149	PF00069	0.731
MOD_GSK3_1	180	187	PF00069	0.330
MOD_GSK3_1	315	322	PF00069	0.290
MOD_GSK3_1	356	363	PF00069	0.279
MOD_GSK3_1	415	422	PF00069	0.300
MOD_GSK3_1	535	542	PF00069	0.494
MOD_GSK3_1	655	662	PF00069	0.699
MOD_GSK3_1	686	693	PF00069	0.602
MOD_N-GLC_1	193	198	PF02516	0.365
MOD_N-GLC_1	303	308	PF02516	0.267
MOD_N-GLC_1	686	691	PF02516	0.718
MOD_NEK2_1	100	105	PF00069	0.527
MOD_NEK2_1	180	185	PF00069	0.354
MOD_NEK2_1	303	308	PF00069	0.281
MOD_NEK2_1	334	339	PF00069	0.312
MOD_NEK2_1	370	375	PF00069	0.279
MOD_NEK2_1	721	726	PF00069	0.628
MOD_NEK2_1	87	92	PF00069	0.461
MOD_NEK2_2	279	284	PF00069	0.300
MOD_PIKK_1	12	18	PF00454	0.519
MOD_PIKK_1	172	178	PF00454	0.384
MOD_PIKK_1	614	620	PF00454	0.458
MOD_PIKK_1	709	715	PF00454	0.616
MOD_PK_1	688	694	PF00069	0.493
MOD_PKA_2	100	106	PF00069	0.532
MOD_PKA_2	355	361	PF00069	0.324
MOD_PKA_2	687	693	PF00069	0.658
MOD_PKA_2	721	727	PF00069	0.502
MOD_Plk_1	52	58	PF00069	0.343
MOD_Plk_1	539	545	PF00069	0.379
MOD_Plk_1	670	676	PF00069	0.656
MOD_Plk_2-3	4	10	PF00069	0.586
MOD_Plk_2-3	535	541	PF00069	0.405
MOD_Plk_4	180	186	PF00069	0.360
MOD_Plk_4	279	285	PF00069	0.330
MOD_Plk_4	349	355	PF00069	0.362
MOD_Plk_4	539	545	PF00069	0.266
MOD_Plk_4	578	584	PF00069	0.368
MOD_Plk_4	87	93	PF00069	0.342
MOD_ProDKin_1	137	143	PF00069	0.730
MOD_ProDKin_1	14	20	PF00069	0.678
MOD_ProDKin_1	149	155	PF00069	0.688
MOD_ProDKin_1	386	392	PF00069	0.333
MOD_ProDKin_1	400	406	PF00069	0.349
MOD_ProDKin_1	416	422	PF00069	0.192
MOD_ProDKin_1	431	437	PF00069	0.267
MOD_ProDKin_1	555	561	PF00069	0.271
MOD_ProDKin_1	588	594	PF00069	0.250
MOD_ProDKin_1	690	696	PF00069	0.683
MOD_SUMO_for_1	665	668	PF00179	0.497
MOD_SUMO_rev_2	20	29	PF00179	0.597
MOD_SUMO_rev_2	425	434	PF00179	0.272
TRG_DiLeu_BaEn_3	52	58	PF01217	0.343
TRG_DiLeu_BaEn_4	584	590	PF01217	0.199
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.420
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.360
TRG_DiLeu_BaLyEn_6	634	639	PF01217	0.348
TRG_ENDOCYTIC_2	167	170	PF00928	0.506
TRG_ENDOCYTIC_2	232	235	PF00928	0.281
TRG_ENDOCYTIC_2	575	578	PF00928	0.300
TRG_ENDOCYTIC_2	616	619	PF00928	0.320
TRG_ENDOCYTIC_2	636	639	PF00928	0.300
TRG_ENDOCYTIC_2	718	721	PF00928	0.573
TRG_ENDOCYTIC_2	83	86	PF00928	0.449
TRG_ENDOCYTIC_2	96	99	PF00928	0.400
TRG_ER_diArg_1	221	223	PF00400	0.267
TRG_ER_diArg_1	290	292	PF00400	0.360
TRG_ER_diArg_1	331	333	PF00400	0.308
TRG_ER_diArg_1	497	500	PF00400	0.359
TRG_ER_diArg_1	520	522	PF00400	0.378
TRG_ER_diArg_1	547	550	PF00400	0.300
TRG_ER_diArg_1	681	683	PF00400	0.655
TRG_ER_diArg_1	83	85	PF00400	0.583
TRG_NLS_MonoExtC_3	731	736	PF00514	0.646
TRG_NLS_MonoExtC_3	80	85	PF00514	0.467
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFU7	Leptomonas seymouri	71%	100%
A0A0S4KPU1	Bodo saltans	59%	100%
A0A1X0NG94	Trypanosomatidae	61%	100%
A0A1X0NX69	Trypanosomatidae	45%	100%
A0A3S7WXV4	Leishmania donovani	46%	100%
A0A422NDG5	Trypanosoma rangeli	61%	100%
A4H8F0	Leishmania braziliensis	85%	100%
A4HD08	Leishmania braziliensis	45%	100%
A4HWS3	Leishmania infantum	100%	100%
A4I0J4	Leishmania infantum	46%	100%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4QB17	Leishmania major	46%	100%
Q4QEZ6	Leishmania major	94%	100%
V5B5L2	Trypanosoma cruzi	60%	100%