Peptidylprolyl isomerase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fk506-binding protein 1-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ICF9_LEIDO

TriTrypDb:

LdBPK_221280.1 , LdCL_220019900 , LDHU3_22.1840

Length:

111

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Peptidyl-prolyl cis-trans isomerase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ICF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ICF9

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	1
GO:0006457	protein folding	2	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	9
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016859	cis-trans isomerase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CYCLIN_yCln2_LP_2	94	97	PF00134	0.367
DOC_PP2B_LxvP_1	78	81	PF13499	0.260
DOC_PP2B_LxvP_1	94	97	PF13499	0.357
LIG_14-3-3_CanoR_1	75	81	PF00244	0.262
LIG_FHA_1	1	7	PF00498	0.361
LIG_FHA_2	104	110	PF00498	0.257
LIG_LIR_Nem_3	27	33	PF02991	0.257
LIG_LIR_Nem_3	89	94	PF02991	0.293
LIG_MYND_1	92	96	PF01753	0.385
LIG_PDZ_Class_3	106	111	PF00595	0.313
LIG_SH2_STAT5	30	33	PF00017	0.272
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.233
LIG_SUMO_SIM_par_1	24	29	PF11976	0.233
MOD_CK1_1	24	30	PF00069	0.233
MOD_CK1_1	76	82	PF00069	0.270
MOD_CK2_1	39	45	PF00069	0.233
MOD_CK2_1	68	74	PF00069	0.233
MOD_GlcNHglycan	21	24	PF01048	0.285
MOD_GSK3_1	15	22	PF00069	0.308
MOD_GSK3_1	35	42	PF00069	0.197
MOD_GSK3_1	76	83	PF00069	0.271
MOD_N-GLC_1	97	102	PF02516	0.349
MOD_NEK2_1	103	108	PF00069	0.319
MOD_PK_1	21	27	PF00069	0.256
MOD_Plk_1	40	46	PF00069	0.233
MOD_Plk_1	97	103	PF00069	0.245
MOD_Plk_4	21	27	PF00069	0.234
MOD_Plk_4	97	103	PF00069	0.234
MOD_SUMO_rev_2	9	19	PF00179	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	39%	72%
A0A0N1HUP7	Leptomonas seymouri	91%	100%
A0A0N1PEA6	Leptomonas seymouri	47%	91%
A0A0S4KLH1	Bodo saltans	44%	100%
A0A1X0NUY2	Trypanosomatidae	83%	99%
A0A1X0P8C6	Trypanosomatidae	48%	100%
A0A3Q8IB31	Leishmania donovani	38%	70%
A0A3R7LCV9	Trypanosoma rangeli	51%	100%
A0A3S5H813	Leishmania donovani	42%	100%
A0A422N485	Trypanosoma rangeli	80%	99%
A4H677	Leishmania braziliensis	38%	100%
A4HNN1	Leishmania braziliensis	47%	100%
A4HUK1	Leishmania infantum	38%	70%
A4I002	Leishmania infantum	100%	100%
A4ICW4	Leishmania infantum	42%	100%
C9ZSQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	99%
D0A2I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9ASE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AVX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O04287	Vicia faba	41%	99%
O42123	Xenopus laevis	54%	100%
O42993	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	99%
O94746	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	54%	100%
P0A0W2	Neisseria meningitidis serogroup B (strain MC58)	45%	100%
P0A0W3	Neisseria meningitidis serogroup C	45%	100%
P0C1J3	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	50%	100%
P0CP94	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	53%	100%
P0CP95	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	53%	100%
P0CP96	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	53%	79%
P0CP97	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	53%	79%
P0CY37	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	92%
P18203	Bos taurus	53%	100%
P20080	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	92%
P20081	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	56%	97%
P26883	Mus musculus	51%	100%
P26885	Homo sapiens	52%	78%
P28725	Streptomyces anulatus	40%	90%
P28870	Candida albicans (strain SC5314 / ATCC MYA-2876)	48%	90%
P32472	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	51%	82%
P42458	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	41%	94%
P45878	Mus musculus	52%	79%
P48375	Drosophila melanogaster	55%	100%
P56989	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	45%	100%
P62942	Homo sapiens	53%	100%
P62943	Oryctolagus cuniculus	53%	100%
P68106	Homo sapiens	52%	100%
P68107	Bos taurus	52%	100%
P97534	Rattus norvegicus	52%	100%
Q2U316	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	96%
Q2UPT7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	45%	83%
Q32PA9	Bos taurus	52%	79%
Q38935	Arabidopsis thaliana	43%	73%
Q38936	Arabidopsis thaliana	46%	68%
Q41649	Vicia faba	46%	74%
Q4HZB8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	46%	100%
Q4Q255	Leishmania major	42%	100%
Q4QBK4	Leishmania major	98%	100%
Q4QHC5	Leishmania major	38%	70%
Q4W9R2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	51%	92%
Q4WHX4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	43%	83%
Q4WLV6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	52%	99%
Q54SR7	Dictyostelium discoideum	46%	83%
Q554J3	Dictyostelium discoideum	54%	100%
Q5ATN7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	48%	82%
Q62658	Rattus norvegicus	52%	100%
Q6BP84	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	47%	82%
Q6BX45	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	59%	99%
Q6CF41	Yarrowia lipolytica (strain CLIB 122 / E 150)	53%	100%
Q6CGG3	Yarrowia lipolytica (strain CLIB 122 / E 150)	45%	77%
Q6CUZ8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	43%	79%
Q6CX30	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	53%	97%
Q6FMA3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	57%	97%
Q6FSC1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	48%	82%
Q6KBA8	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	52%	100%
Q6M981	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	98%
Q754K8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	55%	97%
Q8HYX6	Oryctolagus cuniculus	52%	100%
Q8LGG0	Arabidopsis thaliana	44%	99%
Q9FLB3	Arabidopsis thaliana	44%	78%
Q9Z2I2	Mus musculus	52%	100%
V5BA38	Trypanosoma cruzi	43%	100%